DUBLIN–(BUSINESS WIRE)–The “Competitor
Analysis: WT1-Targeted Immunotherapy” report has been added to ResearchAndMarkets.com’s
This Competitive Intelligence report analyzes the competitive field of
WT1-Targeted Immunotherapies as of June 2018 in a tabulated format with
structured listings of industry-relevant data.
The report includes a compilation of currently active projects in
research and development of vaccines, TCR-engineered T-cells, Cytotoxic
T-Lymphocytes and recombinant antibodies targeting Wilms Tumor 1 (WT1).
In addition, the report lists company- and institution-specific R&D
pipelines of WT1-Targeted Immunotherapies.
Wilms tumor 1 (WT1) oncoprotein is a zinc finger transcription factor
whose expression in normal adult tissue is rare but is overexpressed in
leukemias of multiple lineages and a wide range of solid tumors. WT1
expression is a biomarker and a prognostic indicator.
RNA interference knockdown studies of WT1 suggest that it has oncogenic
potential and it appears to be expressed in leukemia stem cell
populations. A National Institutes of Health-convened panel ranked WT1
as a top cancer target for immunotherapy.
WT1 is a nuclear protein, inaccessible to classical antibody therapy,
but vaccine approaches are under way to generate WT1-specific cytotoxic
T cell (CTL) responses that recognize peptides presented on the cell
surface by MHC class I molecules. Engineering autologous T-cells with a
WT1-specific T-cell receptor (TCR) is another approach currently pursued.
Competitor projects are listed in a tabular format providing
- Drug Codes
- Target/Mechanism of Action
- Class of Compound
- Product Category
- R&D Stage
Additional comments with a hyperlink leading to the source of
Key Topics Covered
1. WT1-Targeted Immunotherapy
- Selective WT1-Targeted Vaccines
- WT1-Specific, Multi-Target Vaccines
- WT1-Selective Adoptive Cell Therapy
- WT1-Specific, Multi-Target Adoptive Cell Therapy
- WT1-Targeted Antibodies
2. Corporate & Institutional WT1 Immunotherapy R&D Pipelines
For more information about this report visit https://www.researchandmarkets.com/research/fh877t/2018_competitor?w=4
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