22nd Century Group to be Added to Russell 2000, Russell 3000, and Russell Global Indexes

WILLIAMSVILLE, N.Y.–(BUSINESS WIRE)–22nd Century Group, Inc. (NYSE American: XXII),
a plant biotechnology company that is a leader in tobacco harm
reduction, Very Low Nicotine tobacco, and hemp/cannabis research,
announced today that the Company will be added to the Russell 2000,
Russell 3000, and Russell Global Indexes when FTSE Russell (Russell)
reconstitutes its U.S. and global equity indexes on June 22, 2018.
Russell’s preliminary announcement of its annual reconstitution of these
Indexes, which includes 22nd Century Group, was posted on the Russell
website on Friday, June 8, 2018, after the U.S. stock market closed.

In 2017, Russell added 22nd Century to the Russell Microcap index. With
significant growth in the Company’s market capitalization over the last
year, 22nd Century has now earned its placement on the more selective
Russell Indexes. “22nd Century’s increasing market value reflects the
importance of our extraordinary technology portfolio and the promise
that our VLN™ tobacco represents in reducing the harm caused by
smoking,” explained Henry Sicignano, III, President and Chief Executive
Officer at 22nd Century Group. “What’s more, Russell’s inclusion of 22nd
Century in its benchmark indexes will serve to generate further interest
in our Company among forward-looking investors.”

Russell determines inclusion of companies in its equity indexes by
market-capitalization rankings and style attributes. Russell indexes are
widely used by investment managers and institutional investors for index
funds and as benchmarks for active investment strategies. Approximately
$8.6 trillion in assets are benchmarked against Russell’s U.S. indexes.

About FTSE Russell

FTSE Russell is a leading global index provider creating and managing a
wide range of indexes, data and analytic solutions to meet client needs
across asset classes, style and strategies. Covering 98% of the
investable market, FTSE Russell indexes offer a true picture of global
markets, combined with the specialist knowledge gained from developing
local benchmarks around the world.

FTSE Russell index expertise and products are used extensively by
institutional and retail investors around the world. More than $10
trillion is currently benchmarked to FTSE Russell indexes. For more than
30 years, leading asset owners, asset managers, ETF providers and
investment banks have chosen FTSE Russell indexes to benchmark their
investment performance and create investment funds, ETFs, structured
products and index-based derivatives. FTSE Russell indexes also provide
clients with tools for asset allocation, investment strategy analysis
and risk management.

FTSE Russell is wholly-owned by London Stock Exchange Group. For more
information, visit www.ftserussell.com

About 22nd Century Group, Inc.

22nd Century is a plant biotechnology company focused on technology
which allows it to increase or decrease the level of nicotine in tobacco
plants and the level of cannabinoids in hemp/cannabis plants through
genetic engineering and plant breeding. The Company’s primary mission in
tobacco is to reduce the harm caused by smoking. The Company’s primary
mission in hemp/cannabis is to develop proprietary hemp strains for
important new medicines and agricultural crops. Visit www.xxiicentury.com
and www.botanicalgenetics.com
for more information.

Cautionary Note Regarding Forward-Looking Statements: This
press release contains forward-looking information, including all
statements that are not statements of historical fact regarding the
intent, belief or current expectations of 22nd Century Group, Inc., its
directors or its officers with respect to the contents of this press
release, including but not limited to our future revenue expectations.
The words “may,” “would,” “will,” “expect,” “estimate,” “anticipate,”
“believe,” “intend” and similar expressions and variations thereof are
intended to identify forward-looking statements. We cannot guarantee
future results, levels of activity or performance. You should not place
undue reliance on these forward-looking statements, which speak only as
of the date that they were made. These cautionary statements should be
considered with any written or oral forward-looking statements that we
may issue in the future. Except as required by applicable law, including
the securities laws of the United States, we do not intend to update any
of the forward-looking statements to conform these statements to reflect
actual results, later events or circumstances, or to reflect the
occurrence of unanticipated events. You should carefully review and
consider the various disclosures made by us in our annual report on Form
10-K for the fiscal year ended December 31, 2017, filed on March 7,
2018, including the section entitled “Risk Factors,” and our other
reports filed with the U.S. Securities and Exchange Commission which
attempt to advise interested parties of the risks and factors that may
affect our business, financial condition, results of operation and cash
flows. If one or more of these risks or uncertainties materialize, or if
the underlying assumptions prove incorrect, our actual results may vary
materially from those expected or projected.

Contacts

22nd Century Group
James Vail, 716-270-1523
Director of
Communications
jvail@xxiicentury.com