Probiodrug AG: Probiodrug AG to hold its Ordinary General Meeting of Shareholders on 29 May 2019

DGAP-News: Probiodrug AG / Key word(s): AGM/EGM

18.04.2019 / 15:06

The issuer is solely responsible for the content of this announcement.


Probiodrug AG to hold its Ordinary General Meeting of Shareholders
on 29 May 2019

HALLE (SAALE), Germany, 18 April 2019 – Probiodrug AG (Euronext Amsterdam: PBD; ISIN: DE0007921835), invites all shareholders to Probiodrugs ordinary general meeting of shareholders to be held on Thursday, May 29, 2019 at 10:00 am (CEST), at the registered office, Weinbergweg 22, 06120 Halle (Saale), Germany.

The relevant documents can be found at the company’s homepage: www.probiodrug.de/investors/ ordinary-general-meeting-of-shareholders-2019/

###

For more information, please contact:
Probiodrug
Dr. Ulrich Dauer, CEO
Email: contact@probiodrug.com

MC Services AG
Anne Hennecke, Susanne Kutter
Tel: +49 (0) 211 529 252 27
Email: probiodrug@mc-services.eu

Notes to Editors:
About Probiodrug AG

Headquartered in Halle (Saale), Germany, Probiodrug AG (Euronext Amsterdam: PBD) is a clinical stage biopharmaceutical company focused on the development of novel inhibitors for disease relevant enzymes. The company has a successful track record in bringing drugs targeted to post-translational modifying enzymes to the market. Current projects are focusing on the two isoenzymes of Glutaminyl Cyclase, QPCT and QPCTL. QPCT is the crucial enzyme for the generation of highly neurotoxic pyroglutamate species of Abeta. Its inhibition by Probiodrug’s lead molecule PQ912 is currently investigated in clinical Phase 2 trials (SAPHIR) for the treatment of Alzheimer’s disease (AD). Whereas QPCTL has been identified as a potential target in cancer therapy. Blocking the enzymatic function of QPTCL by small molecule inhibitors is a novel therapeutic approach in cancer immunotherapy. Probiodrug has a unique and exceptionally strong patent position on QPCT and QPCTL inhibitors.
www.probiodrug.com

About PQ912
PQ912, is a first in class, highly specific and potent inhibitor of Glutaminyl Cyclase (QPCT), – the enzyme that catalyses the formation of highly neurotoxic pGlu species. PQ912 has shown therapeutic effects in AD animal models. A Phase-1 study in healthy young and elderly volunteers revealed a dose dependent exposure and showed good safety and tolerability up to the highest dose resulting in >90% target occupancy in the spinal fluid. In June 2017, Probiodrug announced top-line data of the Phase-2a SAPHIR trial of PQ912 and presented the study results at CTAD 2017. Results strongly support that pGlu species of Abeta are especially neurotoxic and correlate with AD disease progression. The SAPHIR study provides important guidance how to move forward with the development of PQ912 as a disease-modifying drug for AD. Altogether, the results make the program highly attractive for further development; the company has initiated the preparation of a Phase 2b core program.

About Alzheimer’s disease
Alzheimer’s disease is a neurological disorder, which is the most common form of dementia. Today, 50 million people live with dementia worldwide, and this number is projected to treble to more than 152 million by 2050. Dementia also has a huge economic impact. Alzheimer’s has an estimated, global societal cost of US$ 1 trillion, and it will become 2 trillion-dollar disease by 2030. (World Alzheimer Report 2018).

Glutaminyl-peptide cyclotransferase-like protein (QPCTL)
Glutaminyl-peptide cyclotransferase-like protein (QPCTL) is a posttranslational modifying enzyme that is responsible for the pyroglutamate formation on crucial proteins in the immune response to cancer.

Cancer immune checkpoint inhibitors
Checkpoint inhibitor therapy is a novel kind of cancer immunotherapy. The therapy targets immune checkpoints, key regulators of the immune system that stimulate or inhibit its actions, which tumors can use to protect themselves from attacks by the immune system. QPCTL inhibitor therapy can block inhibitory cancer checkpoints and thereby restore beneficial immune system functions.

Forward Looking Statements
Information set forth in this press release contains forward-looking statements, which involve a number of risks and uncertainties. The forward-looking statements contained herein represent the judgment of Probiodrug AG as of the date of this press release. Such forward-looking statements are neither promises nor guarantees but are subject to a variety of risks and uncertainties, many of which are beyond our control, and which could cause actual results to differ materially from those contemplated in these forward-looking statements. We expressly disclaim any obligation or undertaking to release publicly any updates or revisions to any such statements to reflect any change in our expectations or any change in events, conditions or circumstances on which any such statement is based.


18.04.2019 Dissemination of a Corporate News, transmitted by DGAP – a service of EQS Group AG.
The issuer is solely responsible for the content of this announcement.

The DGAP Distribution Services include Regulatory Announcements, Financial/Corporate News and Press Releases.
Archive at www.dgap.de


Language: English
Company: Probiodrug AG
Weinbergweg 22
06120 Halle/Saale
Germany
Phone: +49 (0)345 555 9900
Fax: +49 (0)345 555 9901
E-mail: contact@probiodrug.de
Internet: www.probiodrug.de
ISIN: DE0007921835
WKN: 792183
Listed: Regulated Unofficial Market in Berlin, Frankfurt, Munich, Stuttgart; Amsterdam
EQS News ID: 801885

 
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Elanix Biotechnologies AG: NOMINATION OF THE CHAIRMAN OF THE SUPERVISORY BOARD, THE VICE CHAIRMAN AND MEMBERS OF THE BOARD.

Elanix Biotechnologies AG / Key word(s): Personnel

Elanix Biotechnologies AG: NOMINATION OF THE CHAIRMAN OF THE SUPERVISORY BOARD, THE VICE CHAIRMAN AND MEMBERS OF THE BOARD.

18-Apr-2019 / 09:30 CET/CEST

Disclosure of an inside information acc. to Article 17 MAR of the Regulation (EU) No 596/2014, transmitted by DGAP – a service of EQS Group AG.

The issuer is solely responsible for the content of this announcement.


ELANIX BIOTECHNOLOGIES AG: NOMINATION OF THE CHAIRMAN OF THE SUPERVISORY BOARD, THE VICE CHAIRMAN AND MEMBERS OF THE BOARD.

Berlin, April 18 2019 – The Supervisory Board of Elanix Biotechnologies AG (“Company”, “Elanix”) has nominated by juridical order Professor Zhanfeng Cui and Anja Silling to become members of the Supervisory Board with immediate effect.

Today, the Supervisory Board of Elanix has nominated Anja Silling to become the Chairman of the Board and Fang Bao, an existing member of the board, to be the Vice Chairman.

Lee Ann Laurent-Applegate
CEO


18-Apr-2019 CET/CEST The DGAP Distribution Services include Regulatory Announcements, Financial/Corporate News and Press Releases.
Archive at www.dgap.de


Language: English
Company: Elanix Biotechnologies AG
Stadthausbrücke 1-3
20355 Hamburg
Germany
Phone: +41 22 363 66 40
Fax: +41 22 363 66 41
E-mail: info@elanix-bt.com
Internet: www.elanixbiotechnologies.com
ISIN: DE000A0WMJQ4
WKN: A0WMJQ
Listed: Regulated Market in Frankfurt (General Standard); Regulated Unofficial Market in Berlin, Dusseldorf, Munich, Stuttgart, Tradegate Exchange
EQS News ID: 801589

 
End of Announcement DGAP News Service

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Medios AG publishes Annual Report 2018

DGAP-News: Medios AG / Key word(s): Annual Results

18.04.2019 / 09:17

The issuer is solely responsible for the content of this announcement.


Corporate News

Medios AG publishes Annual Report 2018

  • Significant increase in group sales and earnings in financial year 2018
  • Sales in Drug Supply business unit climb by 37 per cent
  • Earnings in Patient-specific Therapies business unit rise by around three quarters
  • Positive outlook: Group sales and earnings are expected to increase significantly again in financial year 2019

Berlin, 18 April 2019 – Medios AG (‘Medios’), one of the leading Specialty Pharma companies in Germany, has published its Annual Report 2018. According to the audited IFRS financial statements, group sales in the period from January to December 2018 increased year on year by 29 per cent to EUR 327.8 million (previous year EUR 253.6 million). Group earnings before interest, taxes, depreciation and amortization (EBITDA), adjusted for extraordinary expenses*, rose by 37 per cent to EUR 11.7 million (previous year EUR 8.5 million). Group earnings before taxes (EBT), adjusted for extraordinary expenses*, climbed by 38 per cent to EUR 11.0 million (previous year EUR 8.0 million). Thereby, the guidance of the Management Board for the financial year 2018 was met.

The Drug Supply business unit generated sales of EUR 288.9 million, an increase of 37 per cent (previous year EUR 210.6 million). This was in particular due to the ongoing strong demand for Specialty Pharma medicines. Adjusted EBITDA* went up by 23 per cent to EUR 9.4 million (previous year EUR 7.6 million). Adjusted EBT* climbed by 23 per cent to EUR 9.2 million (previous year EUR 7.4 million).

The Patient-specific Therapies business unit registered a planned decline in sales of 9.7 per cent to EUR 38.8 million (previous year EUR 43.0 million) due to the strategic diversification of the indication areas through new products. Nonetheless, earnings increased disproportionately: adjusted EBITDA* was up by 76 per cent to EUR 3.3 million (previous year EUR 1.9 million) and adjusted EBT* climbed by 74 per cent to EUR 2.8 million (previous year EUR 1.6 million). Thereby, the adjusted EBT* margin rose from 3.8 to 7.3 per cent.

The internal Services business unit, which only provides services to the other companies in the Medios Group, reported a negative earnings contribution, as anticipated. This was in particular due to services which were rendered in the areas of information technology, human resources and finances to implement the growth strategy and cannot be charged in full to the subsidiaries.

Manfred Schneider, CEO of Medios AG: ‘By expanding our partner network, extending our product range and specializing in additional indication areas, we laid the foundations for further growth in 2018. The establishment of our new Drug Safety business unit and positioning of our new ‘Medios Apotheke’ brand will also make a contribution.’

Matthias Gärtner, CFO of Medios AG: ‘In 2018, we achieved significant growth in both sales and earnings in our Drug Supply business unit. Thanks to the diversification into additional indication areas, we have virtually doubled our operating profit margin in the Patient-specific Therapies business unit. In 2019, we also want to grow sales in this business unit again. We are very confident that we will be able to continue the dynamic growth course of the Medios Group in the current financial year and further improve profitability.’

As reported in February, the Management Board is expecting group sales of EUR 400 to 410 million, adjusted EBITDA* of EUR 16 to 17 million and adjusted EBT* of EUR 14 to 15 million for the financial year 2019. This represents a sales growth of 22 to 25 per cent and a further increase in adjusted operating earnings* with improved earnings margins. As far as currently foreseeable, the guidance includes both the effects of the planned ‘Act for more Drug Safety’ on the course of Medios’ business as well as additional investments in the Drug Safety business unit and the establishment of the ‘Medios Apotheke’ brand.

The Annual Report 2018 of Medios AG is available for download from the website http://medios.ag/en/investor-relations/financial-reports.

——————-

* EBITDA is adjusted for extraordinary expenses for a) stock options totalling EUR 2.59 million (non-cash) from the financial years 2017 and 2018 and b) start-up expenses of EUR 0.64 million for the laboratories acquired in September 2017. EBT is adjusted for extraordinary expenses for a) and b), plus amortization of EUR 0.35 million (non-cash) on the customer base following the acquisition of operating units of BerlinApotheke Schneider & Oleski oHG.

About Medios AG
Medios AG is one of the leading Specialty Pharma companies in Germany. As a specialist for the provision of Specialty Pharma drugs to patients and GMP-certified provider of patient-specific therapies, Medios covers substantial elements of the supply chain in this field and follows the highest international quality standards. Usually, Specialty Pharma drugs are high-priced medicines for rare and/or chronic diseases. Patient-specific therapies are, for example, infusions that are compiled and produced on the basis of individual diseases and parameters like body weight and surface. It is Medios’ aim to provide integrated solutions along the value chain to partners and clients, thereby ensuring an optimal pharmaceutical care for patients.

Medios AG is Germany’s first publicly listed Specialty Pharma company. The share (WKN: A1MMCC, ISIN: DE000A1MMCC8) is listed in the Regulated Market of the Frankfurt Stock Exchange (General Standard).

Contact
Kirchhoff Consult AG
Nikolaus Hammerschmidt
Borselstraße 20
22765 Hamburg
Germany
Tel.: +49 40 60918618
Fax: +49 40 60918660
E-mail: nikolaus.hammerschmidt@kirchhoff.de
www.kirchhoff.de

Disclaimer
This notification contains forward-looking statements that are subject to certain risks and uncertainties. Future results may significantly deviate from currently expected results, specifically due to various risk factors and uncertainties such as changes in business, economic, and competitive circumstances, exchange rate fluctuations, uncertainties about legal disputes or investigations, and the availability of financial resources. Medios AG assumes no responsibility whatsoever for updating the forward-looking statements contained in this notification.


18.04.2019 Dissemination of a Corporate News, transmitted by DGAP – a service of EQS Group AG.
The issuer is solely responsible for the content of this announcement.

The DGAP Distribution Services include Regulatory Announcements, Financial/Corporate News and Press Releases.
Archive at www.dgap.de


Language: English
Company: Medios AG
Friedrichstraße 113a
10117 Berlin
Germany
Phone: +49 30 232 566 – 800
Fax: +49 30 232 566 – 801
E-mail: ir@medios.ag
Internet: www.medios.ag
ISIN: DE000A1MMCC8
WKN: A1MMCC
Listed: Regulated Market in Frankfurt (General Standard), Hamburg; Regulated Unofficial Market in Dusseldorf
EQS News ID: 801579

 
End of News DGAP News Service

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4SC provides Q1 2019 update

DGAP-News: 4SC AG / Key word(s): Quarterly / Interim Statement

18.04.2019 / 07:30

The issuer is solely responsible for the content of this announcement.


4SC provides Q1 2019 update

Planegg-Martinsried, Germany, 18 April 2019 – 4SC AG (4SC, FSE Prime Standard: VSC) today published the Q1 Announcement 2019, presenting all material developments up to 31 March 2019 and the Company’s current outlook. The full communication is available for download on 4SC’s website.

Jason Loveridge, Ph.D., CEO of 4SC, commented: “4SC continued to deliver on its targets in the first quarter of 2019, moving our products through clinical trials and towards market approval. In particular, the SENSITIZE and EMERGE studies of domatinostat are progressing well and we expect data read-outs for both during the course of this year. Both studies are expected to provide the foundation for clinical trials in the aggressive rare skin cancer Merkel cell carcinoma (MCC). Furthermore, we have recruited more than two-thirds of patients in the pivotal RESMAIN study of resminostat in the rare cancer cutaneous T-cell lymphoma (CTCL), with positive safety outcomes so far, and expect top-line data in the first half of 2020.”

Key highlights in Q1 2019 and beyond

  • More than two thirds of patients recruited for pivotal RESMAIN study of resminostat in advanced-stage CTCL; positive safety outcomes to date.
  • Started third dose cohort of Phase Ib/II study SENSITIZE of domatinostat in combination with pembrolizumab in advanced-stage melanoma.
  • Started investigator-initiated Phase II study EMERGE of domatinostat in combination with avelumab in microsatellite-stable gastrointestinal tumors.
  • Dynavax Technologies Corporation (Dynavax) presented preclinical data at the American Association for Cancer Research Annual Meeting (AACR) on the combination of orally available domatinostat with Dynavax’s intra-tumoral TLR9 agonist SD-101. Dynavax also compared domatinostat to other class-I-selective HDAC inhibitors, with domatinostat demonstrating the most significant benefit in combination with SD-101.
  • A clinical cooperation partner presented preclinical data at the AACR that confirmed domatinostat’s mode of action in the aggressive skin cancer Merkel cell carcinoma.
  • As part of the agreement concluded in September 2016 to sell 4SC’s non-core immunology portfolio, 4SC now became a small shareholder of Immunic Inc. (NASDAQ: IMUX) and continues to be entitled to receive royalties.

Business outlook

  • Top-line data of the pivotal RESMAIN study expected in H1 2020.
  • Results of Yakult Honsha’s Phase II study of resminostat in biliary tract cancer to be available by mid-2020.
  • SENSITIZE study expected to complete in H1 2019.
  • Safety data of EMERGE expected in Q3 2019 and early efficacy data in Q4 2019.
  • Expand development for domatinostat and initiate clinical trials in MCC.

Development of cash balance in Q1 2019 and financial forecast

As of 31 March 2019, 4SC holds cash balance/funds of EUR21.2 million as compared to EUR25.0 million as of 31 December 2018. The monthly use of cash from operations amounted to EUR1.263 million on average in the first quarter of 2019 (Q1 2018: EUR1.812 million) and was below the range of EUR1.4 million and EUR1.6 million forecast for 2019.

The decrease in the monthly use of cash as compared to Q1 2018, and the decrease in cash balance/funds in the first quarter of 2019 as compared to the end of 2018, were both predominantly due to costs for the ongoing clinical studies RESMAIN and SENSITIZE.

The Management Board of 4SC believes that these funds should be sufficient to finance 4SC into Q2 2020.

– Press release ends –

 

Further information

 

About 4SC

4SC AG is a clinical-stage biopharmaceutical company developing small-molecule drugs that target key indications in cancer with high unmet medical need. 4SC’s pipeline is protected by a comprehensive portfolio of patents and currently comprises two drug candidates in clinical development: resminostat and domatinostat (4SC-202).

4SC aims to generate future growth and enhance its enterprise value by entering into partnerships with pharmaceutical and biotech companies and/or the eventual marketing and sales of approved drugs in select territories by 4SC itself.

4SC is headquartered in Planegg-Martinsried near Munich, Germany. The Company had 47 employees as of 31 March 2019 and is listed on the Prime Standard of the Frankfurt Stock Exchange (FSE Prime Standard: VSC; ISIN: DE000A14KL72).

Forward-looking information

Information set forth in this press release contains forward-looking statements, which involve risks and uncertainties. The forward-looking statements contained herein represent the judgement of 4SC as of the date of this press release. Such forward-looking statements are neither promises nor guarantees, but are subject to a variety of risks and uncertainties, many of which are beyond 4SC’s control, and which could cause actual results to differ materially from those contemplated in these forward-looking statements. 4SC expressly disclaims any obligation or undertaking to release any updates or revisions to any such statements to reflect any change in its expectations or any change in events, conditions or circumstances on which any such statement is based.

 

Contact

4SC
Anna Niedl, Ph.D., CIRO
Corporate Communications & Investor Relations
anna.niedl@4sc.com
+49 89 700763-66

LifeSci Advisors
Hans Herklots
Managing Director
hherklots@lifesciadvisors.com
+41 79 598 7149


18.04.2019 Dissemination of a Corporate News, transmitted by DGAP – a service of EQS Group AG.
The issuer is solely responsible for the content of this announcement.

The DGAP Distribution Services include Regulatory Announcements, Financial/Corporate News and Press Releases.
Archive at www.dgap.de


Language: English
Company: 4SC AG
Fraunhoferstr. 22
82152 Planegg-Martinsried
Germany
Phone: +49 89 700763-0
Fax: +49 89 700763-29
E-mail: public@4sc.com
Internet: www.4sc.com
ISIN: DE000A14KL72
WKN: A14KL7
Listed: Regulated Market in Frankfurt (Prime Standard); Regulated Unofficial Market in Berlin, Dusseldorf, Hamburg, Munich, Stuttgart, Tradegate Exchange
EQS News ID: 801229

 
End of News DGAP News Service

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EVOTEC COMPLETES REPAYMENT OF EUR 140 M ACQUISITION LOAN

DGAP-News: Evotec SE / Key word(s): Miscellaneous

18.04.2019 / 07:30

The issuer is solely responsible for the content of this announcement.


  • EUR 140 M BRIDGE LOAN WAS DRAWN TO SECURE EVOTEC’S VALUE CHAIN EXPANSION BY SUCCESSFUL ACQUISITION OF APTUIT IN AUGUST 2017
  • STRONG OPERATIONAL CASH FLOW ENABLES FULL REPAYMENT WITHIN LESS THAN TWO YEARS WHILE MAINTAINING STRONG CASH POSITION

Hamburg, Germany, 18 April 2019: Evotec SE (Frankfurt Stock Exchange: EVT, MDAX/TecDAX, ISIN: DE0005664809) today announced that it has completed the repayment of the EUR 140 m debt bridge facility Evotec drew down in context of the acquisition of Aptuit in 2017. Effective August 2017, Evotec acquired Aptuit, a partner research organisation for integrated outsourced drug discovery and development, for EUR 253.2 m in cash. This acquisition was financed through existing cash reserves and a new EUR 140 m senior debt bridge facility.

In July 2018, Evotec announced that the Company had repaid EUR 70 m of the EUR 140 m loan within the first year of the loan term. This repayment of the second half of the debt bridge less than nine months later was enabled mainly due to the strong cash inflow from Evotec’s operational activities and through refinancing at more attractive conditions.

Enno Spillner, Chief Financial Officer of Evotec, commented: “The swift repayment of the bridge loan ahead of schedule while maintaining a solid cash position is a further testament to Evotec’s strong financial performance. It demonstrates that through its strong operational progress, Evotec not only creates sustainable shareholder value but also adds to the Company’s cash-generating operations.”

ABOUT EVOTEC SE
Evotec is a drug discovery alliance and development partnership company focused on rapidly progressing innovative product approaches with leading pharmaceutical and biotechnology companies, academics, patient advocacy groups and venture capitalists. We operate worldwide and our more than 2,600 employees provide the highest quality
stand-alone and integrated drug discovery and development solutions. We cover all activities from target-to-clinic to meet the industry’s need for innovation and efficiency in drug discovery and development (EVT Execute). The Company has established a unique position by assembling top-class scientific experts and integrating state-of-the-art technologies as well as substantial experience and expertise in key therapeutic areas including neuronal diseases, diabetes and complications of diabetes, pain and inflammation, oncology, infectious diseases, respiratory diseases and fibrosis. On this basis, Evotec has built a broad and deep pipeline of approx. 100 co-owned product opportunities at clinical, pre-clinical and discovery stages (EVT Innovate). Evotec has established multiple long-term alliances with partners including, Bayer, Boehringer Ingelheim, Celgene, CHDI, Novartis, Novo Nordisk, Pfizer, Sanofi, Takeda, UCB and others. For additional information please go to www.evotec.com and follow us on Twitter @Evotec.

FORWARD LOOKING STATEMENTS
Information set forth in this press release contains forward-looking statements, which involve a number of risks and uncertainties. The forward-looking statements contained herein represent the judgement of Evotec as of the date of this press release. Such forward-looking statements are neither promises nor guarantees, but are subject to a variety of risks and uncertainties, many of which are beyond our control, and which could cause actual results to differ materially from those contemplated in these forward-looking statements. We expressly disclaim any obligation or undertaking to release publicly any updates or revisions to any such statements to reflect any change in our expectations or any change in events, conditions or circumstances on which any such statement is based.

Contact Evotec SE:
Gabriele Hansen, VP Corporate Communications, Marketing & Investor Relations, Phone: +49.(0)40.56081-255, gabriele.hansen@evotec.com


18.04.2019 Dissemination of a Corporate News, transmitted by DGAP – a service of EQS Group AG.
The issuer is solely responsible for the content of this announcement.

The DGAP Distribution Services include Regulatory Announcements, Financial/Corporate News and Press Releases.
Archive at www.dgap.de


Language: English
Company: Evotec SE
Manfred Eigen Campus / Essener Bogen 7
22419 Hamburg
Germany
Phone: +49 (0)40 560 81-0
Fax: +49 (0)40 560 81-222
E-mail: info@evotec.com
Internet: www.evotec.com
ISIN: DE0005664809
WKN: 566480
Indices: MDAX, TecDAX
Listed: Regulated Market in Berlin, Frankfurt (Prime Standard); Regulated Unofficial Market in Dusseldorf, Hamburg, Hanover, Munich, Stuttgart, Tradegate Exchange
EQS News ID: 801457

 
End of News DGAP News Service

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aap adopts package of measures to strengthen its financial base – Capital increase as attractive offer for shareholders

DGAP-News: aap Implantate AG / Key word(s): Financing/Capital Increase

17.04.2019 / 11:14

The issuer is solely responsible for the content of this announcement.


The information contained in this announcement is not intended for publication or distribution in or within the United States of America, Australia, Canada or Japan.

 

 

aap Implantate AG (“aap”) announces that it has adopted a package of measures to strengthen its financial base and will implement it at short notice. In this context, the capital increase resolved on today as integral part is an attractive offer for all shareholders of the company.
 

For the current and the coming years the Management Board targets to realize a significant sales increase and to further develop the pioneering and innovative silver coating technology of the company. With a view to the silver coating technology, aap strives for the start of a human clinical study in financial year 2019 as prerequisite for the planned market approval.

 

Based on these targets, different measures to strengthen the financial base are necessary. These contain besides a capital increase with subscription rights two asset-based financings. From the capital increase aap will obtain at least EUR 2.3 million on the basis of commitments it has already received from its shareholders. Accompanying to the implementation of the capital increase, the company intends to enter into sale-and-rent-back as well as factoring agreements, which shall lead to an inflow of further financial funds amounting to approx. EUR 1.7 million in financial year 2019. Thereby the company would have a total of at least around EUR 4.0 million available from the financing measures in the coming months. With these inflows and the realization of the planned sales growth the financing requirements are covered for at least the next twelve months.
 

Based on the underlying planning, the Management Board also expects to generate cash inflows to a similar extent from technology-related transactions (e.g. outlicensing of technologies, joint venture agreements with a carve-out of technologies or involving other companies in joint development of products), from public funds and due to the conclusion of legal disputes, which shall sustainably secure the company’s financing at least by end of 2020.
 

In the course of the capital increase with subscription rights aap‘s share capital shall be increased by up to EUR 4,784,485.00 by issuing up to 4,784,485 new shares from the current amount of EUR 28,706,910.00 to up to EUR 33,491,395.00 by partially using the authorized capital. The new shares shall be offered to the shareholders of the company for subscription at a subscription price of EUR 1.04 per new share in an indirect subscription offer. The shareholders can receive 1 new share per 6 held aap shares within a subscription period, which is expected to start on 25 April 2019 (00.00 hours CET) and to end on 9 May 2019 (24.00 hours CET)1). At this time, aap has commitments from its shareholders to exercise subscription and oversubscription rights in a volume of EUR 2.3 million in total. This corresponds to approx. 46% of the capital increase.
 

With a sales growth of 25% to EUR 3.5 million in the first quarter aap had a good start in 2019 and thereby showed a solid kick-off for the planned dynamic sales growth in the entire year. All regions registered double-digit growth rates compared to the previous year. With a view to the targeted market approval of its silver coating technology, aap submitted at the end of 2018 the application to conduct a human clinical study to the Federal Institute for Drugs and Medical Devices (“BfArM”) and is now involved in an intensive exchange with the Federal Institute. With this technology aap is addressing one of the biggest not adequately solved challenges in trauma: the reduction of surgical site infections (SSI). The silver coating technology developed by aap has, as a platform technology, a wide range of potential applications and can be used not only in orthopaedics but also in further areas such as cardiology, dentistry or for medical instruments and thereby offers an enormous market potential. The developments in silver coating technology, but also the further completion of the LOQTEQ(R) portfolio, are pursued with keen interest by global orthopaedic companies which reaffirmed their interest in the innovative silver coating technology and the products of aap‘s LOQTEQ(R) family during talks currently conducted.
 

Based on the aforementioned recent developments, the current price of the aap stock and the fixed confirmed support from our main shareholders, we are convinced that with the capital increase resolved on today we make an attractive offer to all shareholders to participate in the chances of a dynamically growing pure player in trauma.

 

1)For further details regarding the planned capital increase with subscription rights please refer to the subscription offer, which will be published before the start of the subscription period on the corporate website of the company (www.aap.de) in the section “Investors / Capital Increase” as well as in the Federal Gazette under www.bundesanzeiger.de.

This announcement constitutes neither an offer nor a solicitation to purchase or subscribe for securities in the United States, Australia, Canada, Japan or any other jurisdiction in which an offer is unlawful.

This announcement is not an offer of securities for sale in the United States. Securities may be offered or sold in the United States only upon prior registration or upon exemption from the obligation of prior registration pursuant to the Securities Act. If a public offering of securities were to take place in the United States, it would be effected by means of a securities prospectus which investors could obtain from the Company. This prospectus would contain detailed information about the Company and its management, as well as financial information. There will be no public offering of the securities referred to in this announcement in the United States.

Subject to certain exceptions, the securities referred to in this announcement may not be offered or sold in Australia, Canada or Japan, or to or for the account of persons resident in Australia, Canada or Japan.

——————————————————————————————————————————————-
aap
Implantate AG (ISIN DE0005066609) – Prime Standard/Regulated Market – All German stock markets –

About aap Implantate AG
aap Implantate AG is a globally operating medical device company headquartered in Berlin, Germany. The company develops, manufactures and markets trauma products for orthopaedics. The IP protected portfolio includes besides the innovative anatomical plating system LOQTEQ(R) and trauma complementary biomaterials a wide range of cannulated screws as well as standard plates and screws. Furthermore, aap Implantate AG has an innovation pipeline with promising development projects as the antibacterial silver coating technology and magnesium based implants. These technologies address critical problems in surgery that haven’t yet been resolved adequately. In German-speaking Europe aap Implantate AG directly sells its products to hospitals, buying syndicates and hospital groups while it uses a broad network of distributors in more than 25 countries at the international level. aap Implantate AG’s stock is listed in the Prime Standard segment of Frankfurt Stock Exchange (XETRA: AAQ.DE). For more information, please visit www.aap.de, or download the Company’s investor relations app from the Apple’s App Store or Google Play.

Forward-looking statement
This release may contain forward-looking statements based on current experience, estimates and projections of the management board and currently available information. They are not guarantees of future performance. Various known and unknown risks, uncertainties and other factors could lead to material differences between the actual future results, financial situation, development or performance of the company and the estimates given here. Many factors could cause the actual results, performance or achievements of aap to be materially different from those that may be expressed or implied by such statements. These factors include those discussed in aap‘s public reports. Forward-looking statements therefore speak only as of the date they are made. aap does not assume any obligation to update the forward-looking statements contained in this release or to conform them to future events or developments.

For inquiries please contact: aap Implantate AG; Fabian Franke; Investor Relations; Lorenzweg 5; D-12099 Berlin Tel.: +49/30/750 19 – 134; Fax.: +49/30/750 19 – 290; f.franke@aap.de


17.04.2019 Dissemination of a Corporate News, transmitted by DGAP – a service of EQS Group AG.
The issuer is solely responsible for the content of this announcement.

The DGAP Distribution Services include Regulatory Announcements, Financial/Corporate News and Press Releases.
Archive at www.dgap.de


Language: English
Company: aap Implantate AG
Lorenzweg 5
12099 Berlin
Germany
Phone: +49 (0) 30 75 01 90
Fax: +49 (0) 30 75 01 91 11
E-mail: info@aap.de
Internet: www.aap.de
ISIN: DE0005066609
WKN: 506660
Listed: Regulated Market in Frankfurt (Prime Standard); Regulated Unofficial Market in Berlin, Dusseldorf, Hamburg, Munich, Stuttgart, Tradegate Exchange
EQS News ID: 801119

 
End of News DGAP News Service

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aap Implantate AG resolves on capital increase with subscription rights

aap Implantate AG / Key word(s): Capital Increase/Financing

aap Implantate AG resolves on capital increase with subscription rights

17-Apr-2019 / 10:15 CET/CEST

Disclosure of an inside information acc. to Article 17 MAR of the Regulation (EU) No 596/2014, transmitted by DGAP – a service of EQS Group AG.

The issuer is solely responsible for the content of this announcement.


The information contained in this announcement is not intended for publication or distribution in or within the United States of America, Australia, Canada or Japan.

 

The Management Board of aap Implantate AG resolved on 17 April 2019 with the approval of the Supervisory Board of the same day on a capital increase against cash contributions out of the authorized capital 2014/I with subscription and oversubscription rights of the shareholders of the company. aap Implantate AG’s share capital shall be increased by up to EUR 4,784,485.00 by issuing up to 4,784,485 new no-par value bearer shares from the current amount of EUR 28,706,910.00 to up to EUR 33,491,395.00. The new shares shall be offered to the shareholders of the company at a subscription price of EUR 1.04 per new share based on a subscription ratio of 6:1. The new shares are entitled to participate in dividends as of 1 January 2018.
 

At this time, aap Implantate AG has commitments from its shareholders to exercise subscription and oversubscription rights in a volume of EUR 2.3 million in total. This corresponds to approx. 46% of the capital increase.
 

The capital increase with subscription rights is part of a package of measures aap Implantate AG will implement at short notice to strengthen its financial base. In this context, the net proceeds from the transaction shall be inter alia used to finance the company’s planned sales growth and to prepare and conduct a human clinical study for its silver coating technology.
 

The new shares will be offered to the shareholders of aap Implantate AG for subscription in an indirect subscription offer during a subscription period. The subscription period is expected to start on 25 April 2019 (00.00 hours CET) and to end on 9 May 2019 (24.00 hours CET). No trading of subscription rights will be organized and subscription rights which are not exercised will expire worthless. In addition to exercising their subscription rights, all shareholders of the company have the option to participate in the capital increase within an oversubscription. These oversubscription rights must also be exercised during the subscription period. New shares, which are not subscribed as part of the subscription offer, shall be offered to qualified institutional investors for sale by means of a private placement at a price at least equaling the subscription price.
 

The capital increase with subscription rights is accompanied by M.M.Warburg & CO (AG & Co.) KGaA. For further details regarding the transaction please refer to the subscription offer, which will be published before the start of the subscription period on the corporate website of the company (www.aap.de) in the section “Investors / Capital Increase” as well as in the Federal Gazette under www.bundesanzeiger.de.

 

This announcement constitutes neither an offer nor a solicitation to purchase or subscribe for securities in the United States, Australia, Canada, Japan or any other jurisdiction in which an offer is unlawful.

This announcement is not an offer of securities for sale in the United States. Securities may be offered or sold in the United States only upon prior registration or upon exemption from the obligation of prior registration pursuant to the Securities Act. If a public offering of securities were to take place in the United States, it would be effected by means of a securities prospectus which investors could obtain from the Company. This prospectus would contain detailed information about the Company and its management, as well as financial information. There will be no public offering of the securities referred to in this announcement in the United States.

Subject to certain exceptions, the securities referred to in this announcement may not be offered or sold in Australia, Canada or Japan, or to or for the account of persons resident in Australia, Canada or Japan.

 

_______________________________________________________________________________________
aap Implantate AG (ISIN DE0005066609) – Prime Standard/Regulated Market – All German stock markets –

About aap Implantate AG
aap Implantate AG is a globally operating medical device company headquartered in Berlin, Germany. The company develops, manufactures and markets trauma products for orthopaedics. The IP protected portfolio includes besides the innovative anatomical plating system LOQTEQ(R) and trauma complementary biomaterials a wide range of cannulated screws as well as standard plates and screws. Furthermore, aap Implantate AG has an innovation pipeline with promising development projects as the antibacterial silver coating technology and magnesium based implants. These technologies address critical problems in surgery that haven’t yet been resolved adequately. In German-speaking Europe aap Implantate AG directly sells its products to hospitals, buying syndicates and hospital groups while it uses a broad network of distributors in more than 25 countries at the international level. aap Implantate AG’s stock is listed in the Prime Standard segment of Frankfurt Stock Exchange (XETRA: AAQ.DE). For more information, please visit www.aap.de, or download the Company’s investor relations app from the Apple’s App Store or Google Play.

Forward-looking statement
This release may contain forward-looking statements based on current experience, estimates and projections of the management board and currently available information. They are not guarantees of future performance. Various known and unknown risks, uncertainties and other factors could lead to material differences between the actual future results, financial situation, development or performance of the company and the estimates given here. Many factors could cause the actual results, performance or achievements of aap to be materially different from those that may be expressed or implied by such statements. These factors include those discussed in aap‘s public reports. Forward-looking statements therefore speak only as of the date they are made. aap does not assume any obligation to update the forward-looking statements contained in this release or to conform them to future events or developments.

For inquiries please contact: aap Implantate AG; Fabian Franke; Investor Relations; Lorenzweg 5; D-12099 Berlin Tel.: +49/30/750 19 – 134; Fax.: +49/30/750 19 – 290; f.franke@aap.de


17-Apr-2019 CET/CEST The DGAP Distribution Services include Regulatory Announcements, Financial/Corporate News and Press Releases.
Archive at www.dgap.de


Language: English
Company: aap Implantate AG
Lorenzweg 5
12099 Berlin
Germany
Phone: +49 (0) 30 75 01 90
Fax: +49 (0) 30 75 01 91 11
E-mail: info@aap.de
Internet: www.aap.de
ISIN: DE0005066609
WKN: 506660
Listed: Regulated Market in Frankfurt (Prime Standard); Regulated Unofficial Market in Berlin, Dusseldorf, Hamburg, Munich, Stuttgart, Tradegate Exchange
EQS News ID: 801011

 
End of Announcement DGAP News Service

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Dermapharm confirms its profitable growth in 2018 and presents positive outlook for 2019

DGAP-News: Dermapharm Holding SE / Key word(s): Annual Results

17.04.2019 / 07:29

The issuer is solely responsible for the content of this announcement.


Dermapharm confirms its profitable growth in 2018 and presents positive outlook for 2019

  • Revenue and earnings growth in 2018 resulted from successful product development, further internationalization and successful acquisitions
  • Revenue of the highly profitable “Branded Pharmaceuticals and Other Healthcare Products” segment rose by 49.4%
  • Expansion of the product portfolio to include the new therapeutic area “Pain Treatment” and the new segment “Herbal Extracts”
  • Growth in revenue expected to continue in 2019 with a disproportionately high EBITDA increase
  • Proposed dividend of EUR 0.77 per share for 2018 planned

Grünwald, April 17, 2019 – Dermapharm Holding SE (“Dermapharm”), a leading manufacturer of patent-free branded pharmaceuticals for selected therapeutic areas in Germany with a growing international presence, today published its complete Annual Report 2018, confirming the preliminary IFRS Group financial figures for the year and the positive business development with significant revenue growth and a further increase in profitability. Dermapharm also plans to continue its profitable growth in 2019.

On the basis of final, audited IFRS Group financial figures, Dermapharm managed to increase its sales revenues by 22.5% year-on-year to EUR 572.4 million in 2018 (previous year: EUR 467.1 million). Adjusted earnings before interest, taxes, depreciation and amortization (EBITDA) amounted to EUR 143.4 million in fiscal year 2018[1] (previous year: EUR 112.9 million[2]). The adjusted EBITDA margin thus increased to 25.1% (previous year: 24.2%). Unadjusted EBITDA in 2018 amounted to EUR 139.6 million (previous year: EUR 110.2 million). The unadjusted EBITDA margin also improved to 24.4% (previous year: 23.6%).

“After our first year on the stock exchange, we see Dermapharm fully on course both operationally and strategically. We fully met our sales and EBITDA forecasts for 2018 and will therefore propose a dividend of EUR 0.77 per share to our shareholders at the Annual General Meeting. In addition, we have consistently implemented our strategy as planned and thus laid the foundation for further profitable growth,” commented Dr. Hans-Georg Feldmeier, CEO of Dermapharm Holding SE.

The “Branded Pharmaceuticals and Other Healthcare Products” segment, in which Dermapharm currently has more than 900 marketing authorizations for more than 250 active pharmaceutical ingredients, made a major contribution to sales and earnings growth in 2018. Segment sales increased by 49.4% to EUR 334.7 million (previous year: EUR 224.1 million), while segment EBITDA rose by 27.0% to EUR 132.8 million (previous year: EUR 104.6 million). The company thus continued to achieve a very high EBITDA margin of 39.7% (previous year: 46.4%) in this segment. Sales in the “Parallel Import Business” segment amounted to EUR 237.8 million (previous year: EUR 243.0 million). The slight decline in sales of 2.1% was mainly due to portfolio optimization in 2018, as the concentration on high-margin products was accompanied by dispensing with sales of high-priced products with very low margins. This strategy is also reflected in the positive EBITDA development: segment EBITDA increased by 26.8% to EUR 9.0 million (previous year: EUR 7.1 million). The EBITDA margin thus also improved to 3.8% (previous year: 2.9%). axicorp, the subsidiary responsible for the Parallel Import Business, was thus able to further expand its position as the No. 4 German importer and at the same time increase its profitability.

In order to continue its success story in 2019 and beyond, numerous measures were taken last year as part of the growth strategy. The company relies on three pillars: expanding its product portfolio by introducing new products developed in-house, expanding its international business activities and making successful acquisitions. Last year, Dermapharm received 33 new market approvals, including 10 for Germany. The market approvals relate to the muscle relaxant Myopridin(R), the wart-therapeutic Verrucutan(R) and the medical skin care product Physiotop with the OLT active system (patent pending). At the same time, the product pipeline of approximately 50 ongoing development projects was successfully developed further. With a view to expanding its international business activities, the first product approvals were already obtained for the subsidiaries in the United Kingdom and Italy in the preparatory year 2018. In addition, bite away(R) and Herpotherm(R), the hyperthermia products acquired at the end of 2017, were successfully rolled out in so far twelve European countries and international sales partners acquired.

Fiscal year 2018 was also marked by successful M&A activities. For instance, Dermapharm acquired the German pharmaceutical manufacturers Strathmann and Trommsdorff in January 2018. The acquisitions supplement the company’s portfolio with well-known brands for existing therapeutic areas such as the anti-inflammatory skin cream Ebenol(R) or Tromcardin(R) complex, an electrolyte combination with cardiac micronutrients. At the same time, products such as Myopridin(R) or Keltican(R) forte provide Dermapharm with access to the new therapeutic area “Pain Treatment.” The acquisition of the Spanish company Euromed S.A. was also initiated in December 2018 and completed in January 2019. The leading manufacturer of plant extracts and plant-based ingredients has access to and know-how on the Spanish pharmaceutical market and strengthens Dermapharm’s value chain and expertise in the growth market for herbal pharmaceuticals. With a 20% stake in the FYTA Group, a Dutch company specializing in the production of medical cannabis, Dermapharm also secured access to another growth market in March 2019.

“Our M&A strategy has always been an important part of Dermapharm’s success story. The many successful acquisitions at the end of 2017 and the beginning of 2018 are also reflected in the very positive sales and earnings development of the past year. At the same time, we are supplementing our product portfolio in selected niche markets and opening up new markets,” said Karin Samusch, member of the Management Board of Dermapharm Holding SE, in reference to the acquisitions.

For 2019, Dermapharm expects the scheduled launch of further attractive RX and OTC products as well as revenue and earnings contributions from the new segment “Herbal Extracts” for the first time. The company will also continue its international expansion in 2019. Through Euromed, Dermapharm plans to open up the Spanish market for its own products and further advance the international roll-out of hyperthermia products. Against the backdrop that the dynamic sales and earnings growth in 2018 was also significantly influenced by the numerous M&A activities and that Euromed S.A. will now be consolidated in the Group for the first time in 2019, Dermapharm expects revenue to increase by between 14% and 19% in fiscal year 2019 compared to the previous year with a disproportionately high increase in EBITDA of between 17% and 22%. This forecast does not include any sales and earnings contributions from the investment in the FYTA Group.

The complete Annual Report 2018 is available on the website ir.dermapharm.de as of today.

IFRS financial figures for 2018 compared to the previous year

in EUR millions 2018 2017 Change
       
Group revenue 572.4 467.1 + 22.5%
Branded Pharmaceuticals and Other Healthcare Products 334.7 224.1 + 49.4%
Parallel Import Business 237.8 243.0 (2.1%)
       
Adjusted Group EBITDA* 143.4 112.9 + 27.0%
Adjusted EBITDA margin* (in %) 25.1 24.2 + 0.9pp
       
Group EBITDA 139.6 110.2 + 26.7%
Branded Pharmaceuticals and Other Healthcare Products 132.8 104.6 + 27.0%
Parallel Import Business 9.0 7.1 + 26.8%
EBITDA margin (in %) 24.4 23.6 + 0.8pp
Branded Pharmaceuticals and Other Healthcare Products 39.7 46.4 (6.7pp)
Parallel Import Business 3.8 2.9 +0.9pp

 

* EBITDA 2017 and 2018 adjusted for one-time costs of EUR 2.7 million and EUR 3.8 million, respectively, for IPO preparations or the IPO and the acquisitions of Strathmann and Trommsdorff. Trommsdorff GmbH & Co. KG was consolidated for the first time as of February 1, 2018, when Dermapharm acquired full control of the company. Accordingly, the sales and earnings contribution was not included in the consolidated result until February 2018.

Company profile:

Dermapharm – Pharmaceutical Excellence “Made in Germany”

Dermapharm is a leading manufacturer of patent-free branded pharmaceuticals for selected markets in Germany. Founded in 1991, the company is based in Grünwald near Munich and has its main manufacturing facility in Brehna near Leipzig. The company’s integrated business model comprises in-house development, in-house production and distribution of pharmaceuticals and other healthcare products for specifically targeted markets by a medical and pharmaceutical sales force. Dermapharm holds approximately 900 marketing authorizations (Arzneimittelzulassungen) for more than 250 active pharmaceutical ingredients, which are marketed as pharmaceuticals, dietary supplements or supplemental balanced diets. This assortment makes the company unique. In addition to Germany, the company’s core markets also include Austria and Switzerland. The company plans to further expand its international presence. Dermapharm’s business model also includes a parallel import business, which operates under the “axicorp” brand. Based on revenues, Dermapharm was among the top five parallel import companies in Germany in 2018.

With a consistent development strategy and numerous successful product and company acquisitions over the past 25 years, Dermapharm has continuously optimized its business and provided external growth impulses in addition to organic growth. Dermapharm intends to continue this profitable growth course in the future. The company is focusing on a three-pillar strategy: in-house development of new products, increase of its international footprint and further acquisitions.

Contacts

Investor Relations
Britta Hamberger
Phone: +49 (0)89 – 64186-233
Fax: +49 (0)89 – 64186-165
e-mail: ir@dermapharm.com
cometis AG
Claudius Krause
Phone: +49 (0)611 – 205855-28
Fax: +49 (0)611 – 205855-66
e-mail: ir@dermapharm.com

 

[1] EBITDA for 2018 adjusted for one-time costs of EUR 3.8 million related to the stock exchange listing and the acquisitions of Strathmann and Trommsdorff.
[2] EBITDA for 2017 adjusted for one-time costs of EUR 2.7 million related to the preparation of the stock exchange listing.


17.04.2019 Dissemination of a Corporate News, transmitted by DGAP – a service of EQS Group AG.
The issuer is solely responsible for the content of this announcement.

The DGAP Distribution Services include Regulatory Announcements, Financial/Corporate News and Press Releases.
Archive at www.dgap.de


Language: English
Company: Dermapharm Holding SE
Lil-Dagover-Ring 7
82031 Grünwald
Germany
Phone: +49 (0)89 64 86-0
E-mail: ir@dermapharm.de
Internet: ir.dermapharm.de
ISIN: DE000A2GS5D8
WKN: A2GS5D
Listed: Regulated Market in Frankfurt (Prime Standard); Regulated Unofficial Market in Berlin, Dusseldorf, Hamburg, Stuttgart, Tradegate Exchange
EQS News ID: 800915

 
End of News DGAP News Service

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Polyphor presents new data at ECCMID from its lead antibiotic murepavadin and the new OMPTA POL7306

Polyphor AG / Key word(s): Conference

17-Apr-2019 / 07:00 CET/CEST

Release of an ad hoc announcement pursuant to Art. 53 KR

The issuer is solely responsible for the content of this announcement.


Allschwil, Switzerland, April 17, 2019

Polyphor presents new data at ECCMID from its lead antibiotic murepavadin and the new OMPTA POL7306
 

Murepavadin to be more potent than standard of care anti-Pseudomonas antibiotics against multidrug and colistin resistant Pseudomonas aeruginosa isolates

– Clinical development candidate POL7306 demonstrates potent bactericidal activity against a large collection of Gram-negative organisms including WHO priority 1 Gram-negative pathogens and shows a low propensity of resistance development in-vitro.

Polyphor AG (SIX: POLN) presented new data on its lead clinical antibacterial candidate, murepavadin, currently in Phase III, and its preclinical medium-spectrum anti Gram-negative antibiotic POL7306 at the European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) in Amsterdam, Netherlands.

The results from an in-vitro study, which investigated the activity of murepavadin and standard of care antibiotics* against a collection of 495 Pseudomonas aeruginosa (PA) recent clinical isolates, including 179 strains resistant to colistin, demonstrated that murepavadin was more potent than the comparator anti-Pseudomonas antibiotics tested and showed potent activity against colistin-resistant clinical isolates of PA. Murepavadin is the most advanced Outer Membrane Protein Targeting Antibiotic (OMPTA) and is currently in Phase III clinical trials.

Polyphor also presented data from different studies on its new medium-spectrum antibiotic POL7306 from its OMPTA class with a novel mechanism of action, which is in preclinical development for the treatment of infections caused by antimicrobial resistant Gram-negative bacteria. Results demonstrated that POL7306 shows a potent activity against a large collection of Gram-negative organisms collected worldwide that include colistin-resistant, extensively drug-resistant, and extended spectrum beta-lactamase- and carbapenemase-producing isolated for which there are currently limited treatment options. The spectrum of activity includes all Gram negative ESKAPE** and WHO priority 1 Gram-negative pathogens**. In addition, POL7306 demonstrated potent in vivo activity and has shown a low propensity of resistance development.

“We are encouraged by the strong activity of our new OMPTA class of antibiotics which have the potential to provide new treatment opportunities against resistant Gram-negative pathogens for which there are currently limited treatment options,” commented Daniel Obrecht, Chief Scientific Officer of Polyphor. “The in vitro study of murepavadin is a further confirmation of the excellent antimicrobial activity in multiple and extensively drug resistant (MDR/XDR), including colistin resistant strains. Thanks to the financial support from the Novo REPAIR Impact Fund and CARB-X, we were able to select a further antibiotic of the OMPTA class and accelerate the preclinical programs which have the potential to target all WHO priority 1 Gram-negative pathogens**.”

* Including Aztreonam, Cefepime, Ceftazidime, Ceftazidime / Avibactam, Ciprofloxacin, Piperacilline / Tazobactam, Doripenem, Gentamicin, Ticarcillin-clavulanic acid, Levofloxacin, Tobramycin

** WHO priority 1 pathogens: carbapenem-resistant Acinetobacter baumannii, carbapenem-resistant Pseudomonas aeruginosa, carbapenem-resistant and ESBL-producing Enterobacteriaceae, Gram-negative ESKAPE pathogens: Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp.

 

For further information please contact:

For Investors:
Kalina Scott
Chief Financial Officer
Polyphor Ltd.
Tel: +41 61 567 16 67
Email: IR@polyphor.com

For Media:
Alexandre Müller
Dynamics Group AG
Tel: +41 43 268 32 31
Email: amu@dynamicsgroup.ch

About Murepavadin (POL7080)
Murepavadin is Polyphor’s most advanced product candidate and the first OMPTA in clinical development. It is being developed for the treatment of nosocomial pneumonia (including both hospital-acquired (HABP) and ventilator-associated bacterial pneumonia (VABP)) due to Pseudomonas aeruginosa and has been granted Qualified Infectious Disease Product (QIDP) and fast track designation from the U.S. Food and Drug Administration (FDA) for the treatment of VABP due to Pseudomonas aeruginosa. Murepavadin is a pathogen specific antibiotic functioning through a novel mechanism of action involving binding to an outer membrane protein of Pseudomonas aeruginosa. In contrast to commonly used broad-spectrum antibiotics, murepavadin is a precision medicine and as such it supports the growing practice known as “antibiotic stewardship” which, among other things, seeks to reduce the excessive use of broad-spectrum products to avoid the buildup of resistance and to preserve the microbiome of the patients. Based on promising Phase II results, Polyphor has agreed on a streamlined development pathway for murepavadin with the FDA and EMA and has started its Phase III clinical program.

About Polyphor
Polyphor is a clinical stage, Swiss biopharmaceutical company focused on the discovery and development of antibiotics and immuno-oncology compounds. It has discovered and is developing the OMPTA (Outer Membrane Protein Targeting Antibiotics). The OMPTA are potentially the first new class of antibiotics against Gram-negative bacteria to have reached phase III stage in the last 50 years. The company’s lead OMPTA, murepavadin, (POL7080) is in Phase III development against Pseudomonas aeruginosa – recognized as a critical priority 1 pathogen by WHO; in addition, Polyphor is developing a pipeline of further preclinical antibiotics based on its OMPTA platform. In addition, Polyphor is developing an immuno-oncology candidate, balixafortide (POL6326), which is starting a Phase III trial in combination with eribulin in patients with advanced breast cancer, and exploring in parallel its potential for further combinations and indications. Polyphor is based in Allschwil near Basel and is listed on the SIX Swiss Exchange (SIX: POLN). For more information, please visit www.polyphor.com.

Disclaimer
This press release contains forward-looking statements which are based on current assumptions and forecasts of the Polyphor management. Known and unknown risks, uncertainties, and other factors could lead to material differences between the forward-looking statements made here and the actual development, in particular Polyphor’s results, financial situation, and performance. Readers are cautioned not to put undue reliance on forward-looking statements, which speak only of the date of this communication. Polyphor disclaims any intention or obligation to update and revise any forward-looking statements, whether as a result of new information, future events or otherwise.

Additional features:

Document: http://n.eqs.com/c/fncls.ssp?u=XSQKXIHTVU
Document title: Polyphor_ECCMID_17.4.2019


End of ad hoc announcement


Language: English
Company: Polyphor AG
Hegenheimermattweg 125
4123 Allschwil
Switzerland
Phone: +41 61 567 1600
Fax: +41 61 567 1601
E-mail: info@polyphor.com
Internet: www.polyphor.com
ISIN: CH0106213793
Listed: SIX Swiss Exchange
EQS News ID: 800899

 
End of Announcement EQS Group News Service

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Zur Rose Group grows 28 per cent in the first quarter of 2019

EQS Group-News: Zur Rose Group AG / Key word(s): Development of Sales

17.04.2019 / 06:55


Press release

Zur Rose Group grows 28 per cent in the first quarter of 2019

– 45.9 per cent sales growth in Germany including medpex

– Stable increase in revenue in Switzerland

– Successful rollout of the marketplace model in France

– Revenue forecast for the year as a whole reaffirmed

The Zur Rose Group continued its path of growth in the first quarter of 2019 as planned. After adding in medpex revenue, the Group achieved an increase in revenue of 28.1 per cent to CHF 381.1 million. In Germany, revenue in local currency increased by 45.9 per cent to EUR 212.8 million. The non-prescription drug business was the main driver of growth: the mail-order business of medpex in particular performed very well in this regard, increasing by 21.4 per cent. Since the separation of the mail-order business has not yet been completed, it was not possible to consolidate medpex revenue as of yet in the first quarter of 2019.

In Switzerland, Zur Rose managed to achieve revenue growth of 3.6 per cent to CHF 132.3 million despite regulatory drug price reductions. A key aspect of this positive development is the encouraging increase in new customers in the physicians segment. Due to higher-priced drugs in the specialty care segment, price reductions had a more pronounced impact in the B2C business than in the B2B business.

Thanks to the marketplace model, the Zur Rose Group has succeeded in strategically supplementing its business model and successfully promoting internationalisation in European core markets. In the “Rest of Europe”, the Group posted revenue growth of 40 per cent to EUR 7.1 million, which shows the potential of this business model. Following the acquisition of PromoFarma in Spain in September 2018, the Group took over the marketplace Doctipharma, which is to be integrated in PromoFarma, in France in February 2019. Preparations for the rollout in the second quarter of 2019 are currently underway in Italy, where the Group has already managed to acquire its first partner pharmacies.

The Zur Rose Group will structure its organisation according to customer segment. This means it will no longer be structured around prescription and non-prescription drugs, but around the business models B2C, professional services and marketplace, in each case including the entire pharmacy range. Segment reporting will adopt this approach starting with the 2019 financial year.

From the current perspective, management reaffirms the guidance for the Group for 2019 as a whole and expects revenue of approx. CHF 1.6 billion, which equates to year-on-year growth of over 30 per cent, with the aim of achieving break-even at the EBITDA level.

Revenue, in CHF thousands (unaudited) 1.1.-31.3.2019 1.1.-31.3.2018 Change
Zur Rose Group including medpex 381,128 297,633 28.1%
Zur Rose Group 327,058 297,633 9.9%
In local currency     11.5%
Markets      
Germany including medpex, in EUR thousands 212,797 145,822 45.9%
Germany, in EUR thousands 165,012 145,822 13.2%
Switzerland 132,346 127,749 3.6%
Rest of Europe, in EUR thousands 7,064 n.a.
Business models      
B2C including medpex 271,124 201,630 34.5%
B2C 217,054 201,630 7.6%
Professional Services 102,011 96,003 6.3%
Marketplace 7,993 n.a.

 

Key revenue figures
Nominal revenue growth indicates the change in percent of revenue compared to the previous year. Revenue growth in local currency terms shows the change in per cent of revenue without the impact of exchange rate effects (conversion is at the previous year’s rate).

Investors and analyst contact
Marcel Ziwica, Chief Financial Officer
Email: ir@zurrose.com, phone: +41 58 810 11 49

Media contact
Lisa Lüthi, Head of Corporate Communications
Email: media@zurrose.com, phone: +41 52 724 08 14

Financial Calendar
23 May 2019 Annual General Meeting
21 August 2019 2019 Half-Year Results
23 October 2019 Q3/2019 Trading Update

Zur Rose Group

The Swiss Zur Rose Group is Europe’s largest e-commerce pharmacy and one of the leading medical wholesalers in Switzerland. With its business model, it offers high-quality, safe and cost-effective pharmaceutical care and thus contributes to reducing healthcare costs. It is also characterized by the continuous further development of digital services in the field of drug management and actively promotes its positioning as a comprehensive, integrated cross-service healthcare platform. The creation of added value and a pronounced patient orientation make the Group an important strategic partner for service providers, cost units and industry.

The Zur Rose Group is internationally present with strong brands, including Germany’s best-known pharmacy brand DocMorris. The company employs over 1,300 people at various locations and generated a turnover of CHF 1,207 million in the 2018 financial year. The shares of Zur Rose Group AG are listed on the SIX Swiss Exchange (securities number 4261528, ISIN CH0042615283, ticker ROSE). The CHF 115 million corporate bond issued in July 2018 is also listed on the SIX Swiss Exchange (securities number 42146044, ISIN CH0421460442, ticker ZRO18). Further information at zurrosegroup.com


End of Corporate News


Language: English
Company: Zur Rose Group AG
Walzmühlestrasse 60
8500 Frauenfeld
Switzerland
Phone: +41 52 724 08 14
Internet: www.zurrosegroup.com
ISIN: CH0042615283
Listed: SIX Swiss Exchange
EQS News ID: 800905

 
End of News EQS Group News Service

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