DGAP-News: Heidelberg Pharma AG / Key word(s): Alliance
08.01.2018 / 18:03
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Heidelberg Pharma AG and Advanced Proteome Therapeutics Progress Collaborative Program
– Controlled site-selective conjugation of Amanitin to an antibody with the APC technology successfully demonstrated
– Resulting ATACs highly potent to target-expressing cancer cell lines
Ladenburg, Germany / Vancouver, Canada, 8 January 2018 – Heidelberg Pharma AG (ISIN DE000A11QVV0 / WL6) and Advanced Proteome Therapeutics Corporation (TSX:V APC), a therapeutics discovery and development company, announced today advances in their collaborative activities. The companies have agreed to test the combination of APC’s proprietary site-selective protein modification technology and Heidelberg Pharma’s proprietary ATAC technology in order to generate superior cancer therapeutics.
Since the inception of the partnership, activities have been centered on antibody-Amanitin conjugates that are produced using controlled conjugation methods and possess high target-specific cytotoxic potency. The companies have successfully demonstrated the generation of ATACs using APC’s proprietary protein modification technology.
“In a first step, we have succeeded in producing ADCs that are sufficiently cytotoxic to target-expressing cancer cell lines to proceed to the next level of in vivo testing. Results obtained from this collaboration will help us to increase the efficacy of our ATACs”, commented Professor Andreas Pahl, CSO of Heidelberg Pharma.
“We are delighted that the partnership with Heidelberg Pharma has started to generate positive results and look forward to continuing our work together, to the benefit of both companies”, commented Randal Chase, CEO of Advanced Proteome Therapeutics.
APC’s technology aims at the coupling of a cytotoxic payload site-selectively to an antibody of interest without the necessity of genetically engineering such antibody. This may lead to more homogeneous products with certain additional advantages such as an increase in stability in the circulation, fewer side effects and facilitating further preclinical and clinical drug development.
About Heidelberg Pharma AG
About Advanced Proteome Therapeutics
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|Company:||Heidelberg Pharma AG|
|Schriesheimer Str. 101|
|Phone:||+49 (0)89 41 31 38 – 0|
|Fax:||+49 (0)89 41 31 38 – 99|
|Listed:||Regulated Market in Frankfurt (Prime Standard); Regulated Unofficial Market in Berlin, Dusseldorf, Munich, Stuttgart, Tradegate Exchange|
|End of News||DGAP News Service|