Heidelberg Pharma Signs License Agreement with The University of Texas MD Anderson Cancer Center

DGAP-News: Heidelberg Pharma AG / Key word(s): Alliance

01.03.2018 / 08:55

The issuer is solely responsible for the content of this announcement.


Heidelberg Pharma Signs License Agreement with The University of Texas MD Anderson Cancer Center

– Heidelberg Pharma has acquired an exclusive license from the University of Texas System, on behalf of MD Anderson, related to its patent rights for diagnosis and treatment of select patient groups with RNA polymerase II deletion based on data created in cooperation with Heidelberg Pharma

– The preclinical results demonstrate enhanced efficacy of Amanitin and Heidelberg Pharma’s Antibody Targeted Amanitin Conjugates (ATACs) in aggressive tumors with TP53 deletion demonstrated in vivo

Ladenburg, Germany, 1 March 2018 – Heidelberg Pharma AG (FSE:WL6 ) today announced the signing of a license agreement between its affiliate, Heidelberg Pharma Research GmbH and The University of Texas System, on behalf of MD Anderson Cancer Center (MD Anderson), for patent rights related to the diagnosis and treatment of patients with RNA polymerase II deletion. The application, filed in the name of the Board of Regents of The University of Texas System, covers important aspects of a potential personalized treatment based on Heidelberg Pharma’s ATAC technology (Antibody Targeted Amanitin Conjugates).

Heidelberg Pharma is developing a new cancer therapy based on the compound Amanitin. Due to its biological mode of action (inhibition of RNA polymerase II), it has the potential to be particularly effective against aggressive tumors in connection with a TP53 deletion. TP53 encodes for a tumor suppressor protein and tumors often lose a copy of the TP53 gene, which leads to uncontrolled growth of the tumor cells. Since RNA polymerase II is also frequently suppressed, the altered tumor cells are particularly sensitive to Amanitin and Heidelberg Pharma’s Antibody Targeted Amanitin Conjugates (ATACs). The TP53/RNA Polymerase II deletion is also part of the chromosomal deletion 17p which is frequently observed in tumor cells and connected to aggressive tumors with poor prognosis.

Professor Andreas Pahl, Chief Scientific Officer of Heidelberg Pharma AG, said: “With the exclusive license to use the important results from our research along with work by MD Anderson, we are in a strong position to advance the development of a new cancer therapy based on our ATAC technology. Work is already underway to develop a companion diagnostic to identify and quantify a TP53/RNA polymerase II deletion in patients, the next step to advance this program. We believe that this personalized medicine approach will enable us to identify those patients who are likely to benefit the most from our ATAC programs.”

The patent application is based on research that was co-published by MD Anderson and Heidelberg Pharma in the peer-reviewed journal, Nature, in April 2015. Heidelberg Pharma had the option to license the results of this research, which it has now exercised. This research is serving as the foundation to evaluate the potential of this drug candidate and advance the program into clinical testing.

The financial details of the license agreement are confidential but will not have an impact on Heidelberg Pharma’s cash reach.

About Heidelberg Pharma
Heidelberg Pharma AG is a biopharmaceutical company based in Ladenburg, Germany. Heidelberg Pharma is an oncology specialist and the first company to develop the toxin Amanitin into cancer therapies using its proprietary Antibody Targeted Amanitin Conjugate (ATAC) technology and to advance the biological mode of action of the toxin as a novel therapeutic principle. This proprietary technology platform is being applied to develop the Company’s proprietary therapeutic ATACs as well as in third-party collaborations to create a variety of ATAC candidates. The proprietary lead candidate HDP-101 is a BCMA ATAC for multiple myeloma. Heidelberg Pharma AG is listed on the Frankfurt Stock Exchange: ISIN DE000A11QVV0 / WKN A11QVV / Symbol WL6. More information is available at http://www.heidelberg-pharma.com/.

About MD Anderson
The University of Texas MD Anderson Cancer Center in Houston ranks as one of the world’s most respected centers focused on cancer patient care, research, education and prevention. The institution’s sole mission is to end cancer for patients and their families around the world. MD Anderson is one of only 49 comprehensive cancer centers designated by the National Cancer Institute (NCI). MD Anderson is ranked No.1 for cancer care in U.S. News & World Report’s “Best Hospitals” survey. It has ranked as one of the nation’s top two hospitals for cancer care since the survey began in 1990, and has ranked first 13 times in the last 16 years. MD Anderson receives a cancer center support grant from the NCI of the National Institutes of Health (P30 CA016672).


Heidelberg Pharma AG
Sylvia Wimmer
Tel.: +49 89 41 31 38-29
Email: investors[at]hdpharma.com
Schriesheimer Str. 101, 68526 Ladenburg
MC Services AG (IR/PR support)
Katja Arnold (CIRO)
Managing Director & Partner
Tel.: +49 89 210 228-40
Email: katja.arnold[at]mc-services.eu
Heidelberg Pharma Research GmbH
Business Development
Dr. Marcel Linssen
CBO, Executive Vice President
Tel.: +49 6203 1009-40
Email: m.linssen[at]hdpharma.com

This communication contains certain forward-looking statements relating to the Company’s business, which can be identified by the use of forward-looking terminology such as “estimates”, “believes”, “expects”, “may”, “will” “should” “future”, “potential” or similar expressions or by a general discussion of the Company’s strategy, plans or intentions. Such forward-looking statements involve known and unknown risks, uncertainties and other factors, which may cause our actual results of operations, financial condition, performance, or achievements, or industry results, to be materially different from any future results, performance or achievements expressed or implied by such forward-looking statements. Given these uncertainties, prospective investors and partners are cautioned not to place undue reliance on such forward-looking statements. We disclaim any obligation to update any such forward-looking statements to reflect future events or developments.

01.03.2018 Dissemination of a Corporate News, transmitted by DGAP – a service of EQS Group AG.
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Language: English
Company: Heidelberg Pharma AG
Schriesheimer Str. 101
68526 Ladenburg
Phone: +49 (0)89 41 31 38 – 0
Fax: +49 (0)89 41 31 38 – 99
E-mail: investors@hdpharma.com
Internet: www.heidelberg-pharma.com
Listed: Regulated Market in Frankfurt (Prime Standard); Regulated Unofficial Market in Berlin, Dusseldorf, Munich, Stuttgart, Tradegate Exchange

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