ImmunXperts offers services to support researchers in the risk assessment and mitigation of drug candidate’s immunogenicity profile.
Immunxperts – immunogenicity assessment
ImmunXperts offers a wide range of Immunogenicity Services to the broad Life Science community, either as a comprehensive package, allowing to outsource the full immunogenicity assessment, or allows to cherry-pick specific solutions or technologies. ImmunXperts is specialized in in vitro immunogenicity assessment. ImmunXperts offers several types of T cell activation assays:
- Whole PBMC assay: In the PBMC assay, complete test products are added to cultured peripheral blood mononuclear cells (PBMC). These cells contain all essential components to mount an immune reaction. After a period of incubation T cell activation is measured.
- DC-T assay: When test products interfere with the formation of an immune response, the DC-T assay type is preferred. Here, the test product is first loaded onto the surface MHC molecules of Antigen Presenting Cells (APC) and leftover product will be washed away. The APC will present all epitopes to autologous T cells and T cell activation is measured.
ImmunXperts also offers a comprehensive package of tools and services to measure immunogenicity during pre-clinical and clinical studies: In Vivo models for immunogenicity research, Pharmacokinetic (PK) assays, Pharmacodynamic (PD) marker analysis, Anti-drug antibody (ADA) analysis and characterization, Neutralising antibody (NAB) analysis, Potency assays, etc…
Immunxperts is a biotech company headquartered in Belgium. ImmunXperts’ Board of Directors is comprised of seasoned executives, each with many years of experience in managing Life Science companies: Philippe Janssens de Varebeke, Micheline Streel, Arno Kromminga, Philippe Stas and Sofie Pattijn. World leading experts in the field of Immunogenicity are members of ImmunXperts’ Scientific Advisory Board: Soren Buus, Robin Thorpe, Huub Schellekens and Michael Tovey. ImmunXperts provides a comprehensive package to its customers, allowing researchers to outsource the full immunogenicity assessment, or to cherry-pick the solutions or technologies needed/that fit its exact requirements. ImmunXperts offers great flexibility in dealing with specific demands and changing priorities. Its creative mind-set and long term experience in the field make ImmunXperts a reliable partner to meet your specific needs.
More about Immunxperts : www.immunxperts.com