Instem’s Genetox Software Solution Complements Litron’s State-of-the-Art Genetic Toxicology Testing Methods

Instem Reports that Leading R&D Organizations are Deploying Cyto Study
Manager & Cutting-Edge Flow-Cytometric Regulatory Genetox Testing
Techniques

CONSHOHOCKEN, Pa.–(BUSINESS WIRE)–Instem, a leading provider of IT
solutions
to the global life sciences market, is pleased to announce
that leading research organizations are deploying the Cyto
Study Manager
software solution to support pioneering regulatory
genetox testing techniques.

Clients across Europe and North America are using ‘MicroFlow®
micronucleus kits from Litron Laboratories, in conjunction with the
Micronucleus Module of Cyto Study Manager. By combining the MicroFlow
method with Cyto Study Manager’s experiment set-up and automatic
reporting, those clients are benefiting from considerable time savings,
while ensuring accurate and reproducible results.

Key Facts

  • MicroFlow micronucleus kits utilize flow cytometry to offer quick and
    reproduceable, high-quality data generated by an internationally
    validated method
  • Cyto Study Manager integrates genetox data acquisition, auditing,
    reporting and study management into a single GLP compliant system to
    deliver a range of measurable benefits
  • Organizations around the world are now able to make use of the
    extensive reporting capabilities within Cyto Study Manager and more
    efficiently submit their data to regulatory agencies

“Bringing flow-cytometric methodologies into regulatory genetox
testing is something we’re seeing increase in popularity,” comments Dr.
Stephen Dertinger, Director Research at Litron Laboratories. “The
ability to collect many thousands of data points in just a few minutes
has significant time savings compared to traditional, microscopic
analysis. Study management of all these data is critical.”

Gregor Grant, Executive Vice President Preclinical Solutions, Instem,
said: “We are delighted to see an increasing number of clients
recognizing the potential of Cyto Study Manager to deliver dramatic
efficiency gains in their genetic toxicology operations. Cyto Study
Manager is an extremely flexible solution that can be easily customized
to meet our clients’ individual genetox workflows.”

About Cyto Study Manager

Cyto Study Manager, originally developed by Perceptive Instruments and
now part of the Instem solution portfolio, integrates genetox data
acquisition, auditing, reporting and study management into a single
system. This GLP compliant solution is revolutionizing genetox study
workflows, and leading R&D organizations across the globe are deploying
Cyto Study Manager to help them streamline genetic toxicology
operations, reduce costs, increase efficiencies and improve regulatory
compliance.

Learn more at instem.com
or download a Case Study – Leading
EU Pharma Company Revolutionizes Genetox Study Workflow with Cyto Study
Manager

About MicroFlow®

Litron’s In Vivo MicroFlow kits use flow cytometry to measure a
type of chromosome damage known as a micronucleus event. Micronuclei
occur in immature red blood cells when chromosomal loss or breakage
leads to displaced chromatin, thereby creating a second nucleus
(micronucleus). OECD Test Guideline 474 requires that a variety of new
compounds be evaluated for their ability to induce micronuclei events in
order to keep dangerous products off the market. Importantly, each kit
also contains a calibration standard to ensure reproducible results,
day-to-day and lab-to-lab. With these benefits, scientists are able to
complete more studies in less time.

Data generated by MicroFlow meet global regulatory requirements and are
accepted by both domestic and international regulatory agencies.

About Litron Laboratories

Litron has a vision to transform the genetic toxicology industry with a
variety of research kits and services based on high-speed flow
cytometry. Litron scientists have developed flow cytometric research
kits for in vivo and in vitro micronucleus (MicroFlow), in
vivo
and in vitro gene mutation (MutaFlow Pig-a) and most
recently a suite of high-content in vitro screening kits
(MultiFlow).

At Litron, we like to stay close to our clients and collaboration is
important to us. We want our customers to have the ability to interact
with the same scientists who developed these advanced research kits.
Litron routinely provides these services to pharmaceutical, medical
device, government and contract research organizations around the world.

In this way, Litron is transforming the genetic toxicology industry one
test at a time.

Visit LitronLabs.com
for more information.

About Instem

Instem is
a global provider of leading software solutions and services that are
helping over 500 clients bring their life enhancing products to market
faster. We enable clients in the life sciences to more efficiently
collect, analyze, report and submit high quality regulatory data, while
maintaining compliance for their products around the world.

Instem
solutions
 are in use by customers worldwide, meeting the rapidly
expanding needs
 of life science and healthcare organizations for
data-driven decision making, leading to safer, more effective products.

Instem
supports
 its global roster of clients through offices in the United
States, United Kingdom, France, Japan, China and India.

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Contacts

Press Contacts:
Instem
Lara Wilkinson (UK HQ)
lara.wilkinson@instem.com
Tel:
+44 (0)1785 825600

Litron Laboratories
Ken Tometsko
ktometsko@litronlabs.com
Tel:
+1 781-330-1577