Kadmon to Present Preclinical Data on ROCK Inhibition in Pulmonary Fibrosis at IPF Summit 2017

NEW YORK–(BUSINESS WIRE)–Kadmon Holdings, Inc. (NYSE: KDMN) today announced that it will present
preclinical data demonstrating the therapeutic potential of the
Rho-associated coiled-coil kinase (ROCK) signaling pathway in pulmonary
fibrosis at the Inaugural Idiopathic Pulmonary Fibrosis (IPF) Summit
2017, taking place in Boston August 21-23, 2017.

Details of the presentation are listed below:

Presentation Session: Exploring Heterogeneity Within the
Mechanisms of Disease
Title: Looking Beyond TFG-Beta to ROCK
Inhibition as a Key Therapeutic Target in Fibrosis
Presenter:
Masha Poyurovsky, Ph.D., Kadmon’s Vice President of Molecular Signaling
Time:
August 22, 2017, 3:30 p.m. ET
Location: Boston, MA

Kadmon’s ROCK Inhibitor Platform in Fibrosis

Recent studies conducted by Kadmon and others have shown that ROCK
signaling plays a key role in the development of pulmonary fibrosis, or
scarring of the lungs that can lead to organ failure and death.
Preclinical research by Kadmon has demonstrated that ROCK inhibition
blocks multiple biochemical and biomechanical signals required for IPF
disease progression. Kadmon has a portfolio of ROCK inhibitors in
preclinical discovery for the treatment of fibrotic diseases. Kadmon is
conducting a Phase 2 clinical trial in IPF.

About Kadmon Holdings, Inc.

Kadmon Holdings, Inc. is a fully integrated biopharmaceutical company
developing innovative products for significant unmet medical needs. We
have a product pipeline focused on autoimmune and fibrotic diseases.

Forward Looking Statements

This press release contains forward-looking statements. Such statements
may be preceded by the words “may,” “will,” “should,” “expects,”
“plans,” “anticipates,” “could,” “intends,” “targets,” “projects,”
“contemplates,” “believes,” “estimates,” “predicts,” “potential” or
“continue” or the negative of these terms or other similar expressions.
Forward-looking statements involve known and unknown risks,
uncertainties and other important factors that may cause our actual
results, performance or achievements to be materially different from any
future results, performance or achievements expressed or implied by the
forward-looking statements. We believe that these factors include, but
are not limited to, (i) the initiation, timing, progress and results of
our preclinical studies and clinical trials, and our research and
development programs; (ii) our ability to advance product candidates
into, and successfully complete, clinical trials; (iii) our reliance on
the success of our product candidates; (iv) the timing or likelihood of
regulatory filings and approvals; (v) our ability to expand our sales
and marketing capabilities; (vi) the commercialization of our product
candidates, if approved; (vii) the pricing and reimbursement of our
product candidates, if approved; (viii) the implementation of our
business model, strategic plans for our business, product candidates and
technology; (ix) the scope of protection we are able to establish and
maintain for intellectual property rights covering our product
candidates and technology; (x) our ability to operate our business
without infringing the intellectual property rights and proprietary
technology of third parties; (xi) costs associated with defending
intellectual property infringement, product liability and other claims;
(xii) regulatory developments in the United States, Europe and other
jurisdictions; (xiii) estimates of our expenses, future revenues,
capital requirements and our needs for additional financing; (xiv) the
potential benefits of strategic collaboration agreements and our ability
to enter into strategic arrangements; (xv) our ability to maintain and
establish collaborations or obtain additional grant funding; (xvi) the
rate and degree of market acceptance of our product candidates; (xvii)
developments relating to our competitors and our industry, including
competing therapies; (xviii) our ability to effectively manage our
anticipated growth; (xix) our ability to attract and retain qualified
employees and key personnel; (xx) our ability to achieve cost savings
and other benefits from our efforts to streamline our operations and to
not harm our business with such efforts; and (xxi) the use of proceeds
from our recent private placement. More detailed information about
Kadmon and the risk factors that may affect the realization of
forward-looking statements is set forth in the Company’s filings with
the U.S. Securities and Exchange Commission (SEC), including the
Company’s Quarterly Report on Form 10-Q filed pursuant to Section 13 of
the Securities Exchange Act of 1934, as amended, with the SEC on August
3, 2017. Investors and security holders are urged to read these
documents free of charge on the SEC’s web site at www.sec.gov.
The Company assumes no obligation to publicly update or revise its
forward-looking statements as a result of new information, future events
or otherwise.

Contacts

Kadmon Holdings, Inc.
Ellen Tremaine, 646-490-2989
Investor
Relations
ellen.tremaine@kadmon.com
or
Maeve
Conneighton, 212-600-1902
maeve@argotpartners.com