DGAP-News: MOLOGEN AG / Key word(s): Conference
15.04.2019 / 10:00
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Press release N 8 / 2019 of 15 April 2019
MOLOGEN AG: Impressive extended EnanDIM(R) preclinical data presented at the ITOC6 conference
Berlin, 15 April 2019 – The biopharmaceutical company MOLOGEN AG presented data of its EnanDIM(R)molecules, a new generation of potent non chemically-modified TLR9 agonists, at the ITOC6 CONFERENCE 2019, (THE 6TH LEADING INTERNATIONAL CANCER IMMUNOTHERAPY CONFERENCE IN EUROPE) in Vienna, Austria (11 – 13 April 2019). In murine tumor models, monotherapy with one of its EnanDIM(R) candidates induced persistent immune memory which results not only in specific immune responses against the original tumor but also in recognition and killing of tumors of different origin.
In previous studies it was already shown that in murine tumor models monotherapy with EnanDIM(R) candidates resultedin a beneficial modulation of the tumor microenvironment (TME) translating into remarkable anti-tumor effects with remarkably increased survival rates.
One EnanDIM(R) candidate led to complete tumor regression in the majority of mice and a subsequent re-challenge with the same tumor cells resulted in tumor rejection without further treatment. This indicates a sustained anti-tumor memory of the immune system. Notably, in a breast cancer model a re-challenge of surviving mice with malignant cells from a different tumor, colon cancer, led to rejection of these malignant cells as well. The broad anti-tumor immune response induced by EnanDIM(R) was confirmed and extended in the surviving mice by apparent immune recognition and rejection of not only the initial breast cancer but also tumor cells of different origin (colon cancer, renal cancer). Thus, the data presented prove impressively the EnanDIM(R)-induced generation of a systemic immune memory against shared tumor antigens expressed across various tumor indications and therefore provide an excellent basis for further development of EnanDIM(R)in cancer.
For more information on ITOC6 CONFERENCE (2019) please visit the website:
The focus of the development work is on the product family of DNA-based TLR9 agonists. This includes the lead compound lefitolimod and the next-generation molecule family EnanDIM(R).
The immunotherapeutic agent lefitolimod is the Company’s lead compound and is currently being investigated in a pivotal trial. It is regarded as the best-in-class TLR9 agonist. Treatment with lefitolimod triggers a broad and strong activation of the immune system. On account of this mode of action, lefitolimod could potentially be used in various indications. Lefitolimod is currently being developed within the framework of a pivotal study for first line maintenance therapy for colorectal cancer. Key data of the phase II IMPULSE study in extensive-stage small cell lung cancer (ES-SCLC) and the data from the extension phase of the TEACH study in HIV have been published.
MOLOGEN AG is a publicly listed Company, headquartered in Berlin. The shares (ISIN, DE000A2LQ900/SIN: A2L Q90) are listed in the Prime Standard of the German Stock Exchange.
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