DGAP-News: Defence Therapeutics Inc.
/ Key word(s): Miscellaneous
30.11.2021 / 08:30
The issuer is solely responsible for the content of this announcement.
CSE: DTC FSE: DTC USOTC: DTCFF PRESS RELEASE
DEFENCE THERAPEUTICS VACCINES AND PROGRAM DEVELOPMENT
Vancouver, BC, Canada, November 30th 2021 – Defence Therapeutics Inc. (“Defence” or the “Company“), is a publicly-traded biotechnology company working on engineering the next generation vaccines, Antibody Drug Conjugates, ADC products, and cancer therapeutics using its proprietary AccumTM platform. The core of Defence Therapeutics platform is its AccumTM technology, which enables precision delivery of proteins of pharmacological interest to target cells and increases the intracellular accumulation to these targeted cells. As a result, increased efficacy and potency can be reached against catastrophic illness such as cancer and infectious diseases. With four new patents filed over the last year, Defence is providing increased company IP with its technologies. Defence’s research activities conducted over the last year along with future clinical plans to prove validation is ongoing.
Development of the core Technology
Effective Cellular Vaccine Design
Research conducted by the Company has found that the addition of Accum-linked antigens to allogeneic DCs (AccuVAC-D001) enhances the therapeutic efficacy of the vaccine leading to a survival rate of 70-80% in contrast to 0-20% obtained with current experimental DC-based vaccines. With the completion of such study, Defence has signed an agreement with a Canadian-based clean room to initiate dry runs of its DC vaccine. The objective is to complete all needed GLP studies by Q1 2022 and initiate a Phase I trial against melanoma in the UK by mid 2022.
The development of protein-based vaccines for infectious diseases (COVID and HPV)
The second vaccine formulation (DTC-IN003) is a transmission-blocking vaccine designed to halt infection as opposed to lowering the pathophysiology of the virus. In this case, the vaccine is delivered intranasally with a special adjuvant (designed for intranasal vaccination). This vaccine not only triggered the production of IgAs at mucosal sites (entry site of the virus), but systemic immunity was also observed and generated antibodies cross-reacted with all tested variants. A GLP challenge study is currently ongoing with final data to be obtained by the end of December 2021.
Another infectious disease vaccine in development at Defence Therapeutics is AccuVAC-PT009 targeting HPV. This vaccine is using a mixture of L1 proteins (derived from different HPV strains) linked to AccumTM and tested for their ability to confer protective antibodies against the HPV virus. The potency of the AccuVAC-PT009 vaccine will be compared to the commercially available Gardasil-9 vaccine in terms of its immunogenicity (prophylactic vaccine). In addition, Defence is working on a second HPV-related vaccine but targeting cervical cancer (AccuVAC-PT0067). The objective of this vaccine is to modify both E6 and E7 proteins to covalently link AccumTM then test the vaccine for its ability to treat pre-established cervical cancer. Results of the pre-clinical studies will be available by early 2022.
Effective Design of ADCs
The AccuTOX Program
Cautionary Statement Regarding “Forward-Looking” Information
This release includes certain statements that may be deemed “forward-looking statements”. All statements in this release, other than statements of historical facts, that address events or developments that the Company expects to occur, are forward-looking statements. Forward-looking statements are statements that are not historical facts and are generally, but not always, identified by the words “expects”, “plans”, “anticipates”, “believes”, “intends”, “estimates”, “projects”, “potential” and similar expressions, or that events or conditions “will”, “would”, “may”, “could” or “should” occur. Although the Company believes the expectations expressed in such forward-looking statements are based on reasonable assumptions, such statements are not guarantees of future performance and actual results may differ materially from those in the forward-looking statements. Factors that could cause the actual results to differ materially from those in forward-looking statements include regulatory actions, market prices, and continued availability of capital and financing, and general economic, market or business conditions. Investors are cautioned that any such statements are not guarantees of future performance and actual results or developments may differ materially from those projected in the forward-looking statements. Forward-looking statements are based on the beliefs, estimates and opinions of the Company’s management on the date the statements are made. Except as required by applicable securities laws, the Company undertakes no obligation to update these forward-looking statements in the event that management’s beliefs, estimates or opinions, or other factors, should change.
Neither the CSE nor its market regulator, as that term is defined in the policies of the CSE, accepts responsibility for the adequacy or accuracy of this release.
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|Company:||Defence Therapeutics Inc.|
|1680 – 200 Burrard St|
|Listed:||Regulated Unofficial Market in Frankfurt, Stuttgart; Toronto|
|EQS News ID:||1252708|
|End of News||DGAP News Service|