DGAP-News: Heidelberg Pharma AG
/ Key word(s): Scientific publication
27.03.2020 / 07:20
The issuer is solely responsible for the content of this announcement.
Heidelberg Pharma Publishes Article on Chemical Amanitin Synthesis in Angewandte Chemie Journal
– Chemical synthesis of the natural compound Amanitin successfully established by Heidelberg Pharma
Ladenburg, Germany, 27 March 2020 – Heidelberg Pharma AG (FSE: WL6) today announced that a scientific article on the chemical synthesis of the fungal compound Amanitin has been published in Angewandte Chemie, a leading chemical journal. In this article, researchers from Group subsidiary Heidelberg Pharma Research GmbH describe a novel, scalable synthetic process for the mushroom toxin Amanitin, which was developed in the laboratories of Heidelberg Pharma Research. To the Company’s knowledge, Heidelberg Pharma Research is the first company together with its production partner Carbogen AMCIS AG, Bubendorf, Switzerland, to have succeeded in synthetically producing Amanitin in GMP in the gram range based on this synthesis process. The summary of this article is available at https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201914935?af=R.
In a related collaborative project, Professor Roderich Suessmuth, Rudolf Wiechert Professor of Biological Chemistry at the Technical University of Berlin, successfully established specific synthetic processes for Amanitin. The synthetic method he developed represents the first robust liquid-phase synthesis of Amanitin that is also suitable for larger-scale production and pharmaceutical applications. Heidelberg Pharma Research owns the exclusive patent rights to this method. This synthetic method was also published in the journal Angewandte Chemie at the end of last year https://doi.org/10.1002/anie.201914620.
Andreas Pahl, Chief Scientific Officer at Heidelberg Pharma, commented: “We are delighted with the publication of two articles in connection with the synthesis of Amanitin in the renowned scientific journal Angewandte Chemie. This demonstrates the significance of this important manufacturing process, which is essential for the development of ATACs. The exclusive license we obtained for Professor Suessmuth’s synthetic method, protects the manufacturing of the compound Amanitin – and our ATAC technology – on a very broad basis.”
About Heidelberg Pharma’s proprietary ATAC technology
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|Company:||Heidelberg Pharma AG|
|Schriesheimer Str. 101|
|Phone:||+49 (0)89 41 31 38 – 0|
|Fax:||+49 (0)89 41 31 38 – 99|
|Listed:||Regulated Market in Frankfurt (Prime Standard); Regulated Unofficial Market in Berlin, Dusseldorf, Munich, Stuttgart, Tradegate Exchange|
|EQS News ID:||1008611|
|End of News||DGAP News Service|