Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: A hybrid open-top light-sheet microscope for versatile multi-scale imaging .During image analysis, researchers use light sheet microscopy of cleared tissue as a preferred method for high throughput volumetric imaging. A flexible system can provide a range of sizes, resolution and tissue-clearing protocols. In a new report now published in Nature Methods, Adam K. Glaser and a team of interdisciplinary scientists in mechanical engineering, bioengineering, and synthetic biology in the U.S. and Japan presented a new hybrid imaging system. Using the new method, the team combined non-orthogonal dual-objective and conventional open-top light-sheet microscopy for multi-scale volumetric imaging to visualize an intact, cleared mouse brain at the sub-micron scale. The team achieved high-throughput automated imaging of multiple specimens, and compared the outcomes with existing light-sheet microscopy systems to show a unique combination of versatility and performance in the hybrid setup.
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