SNIPR Biome Granted New US Patent Covering Lytic CRISPR Phage

SNIPR Biome Granted New US Patent Covering Lytic CRISPR Phage

SNIPR Biome Granted New US Patent Covering Lytic CRISPR Phage

SNIPR Biome Granted New US Patent Covering Lytic CRISPR Phage

Copenhagen, August 2nd, 2022: SNIPR Biome ApS (or “the Company”), a clinical-stage biotechnology company developing CRISPR-based precision medicines, announces today the grant of patent number US11,400,110 by the US Patent and Trademark Office (USPTO), further strengthening its intellectual property portfolio which now contains more than 20 granted patents in the USA and Europe for editing prokaryotes using CRISPR/Cas.

SNIPR Biome has exclusive, worldwide rights to this patent estate for medical applications, which supports the company’s pipeline and lead program (SNIPR001), a CRISPR-armed bacteriophage cocktail that targets the prevention of antibiotic-resistant E. coli infections in hematological cancer patients. This experimental medicine is currently in clinical trials in the United States. SNIPR Biome is the first company to orally dose humans with a CRISPR therapeutic and SNIPR001 has been granted Fast-Track designation by the FDA. SNIPR001 is being developed in collaboration with the US non-profit organization CARB-X.

The new patent covers lytic phage armed with CRISPR gene editing systems. CRISPR and phage lysis of target bacteria is a potent combination for therapeutics, and the patent includes the use of any CRISPR system, for example, Cas9, Cas3, or any other Cas nuclease. It has broad applications, including the targeting of any bacteria for any medical use.

SNIPR has developed a technology platform that uses CRISPR/Cas to precisely target and edit prokaryotes without harming patient cells. The new patent adds to the company’s extensive patent estate protecting this technology, including granted patent number US10,920,222 with a fundamental scope protecting fast and durable action of CRISPR targeting in E coli. This patent has been upheld several times by the USPTO despite re-examination proceedings instigated by third parties.

Dr Christian Grøndahl, Co-founder and CEO of SNIPR Biome, commented: We are very pleased that the USPTO has granted this new patent, as it recognizes the continued pioneering work by SNIPR scientists as innovators of CRISPR/Cas editing of prokaryotes. Our broad patent estate underpins our clinical development program, which is focused on developing a CRISPR-based medicine for the benefit of patients suffering with life-threatening diseases.”



SNIPR Biome is a clinical stage company developing precision medicines for vulnerable patients with difficult-to-treat conditions. We are pioneering a novel use of CRISPR/Cas technology to better treat and prevent human diseases through precision killing of bacteria or gene modification. SNIPR Biome is a leader in this transformational area of science, with a clinical trial underway, strong IP, and a diverse and experienced team. We are the first company to orally dose humans with a CRISPR therapeutic and the first company to have been granted a patent for the use of CRISPR for targeting microbiomes. In addition, SNIPR has developed a platform that uses CRISPR technology to achieve gut-directed gene therapy. SNIPR is headquartered in Copenhagen, Denmark. For more details, visit and follow us on LinkedIn and Twitter.

Acknowledgement and disclaimer: 

Research reported in this communication is supported by CARB-X. CARB-X’s funding for this project is sponsored by the Other Transaction Agreement Number 75A50122C00028 from ASPR/BARDA and by an award from Wellcome. The content is solely the responsibility of the authors and does not necessarily represent the official views of CARB-X or any of its funders. 

About CARB-X

Combating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator (CARB-X) is a global non-profit partnership dedicated to accelerating early development antibacterial R&D to address the rising global threat of drug-resistant bacteria. CARB-X is led by Boston University and funding is provided by the Biomedical Advanced Research and Development Authority (BARDA), part of the Office of the Assistant Secretary for Preparedness and Response (ASPR) in the U.S. Department of Health and Human Services, Wellcome, a global charity working to improve health worldwide, Germany’s Federal Ministry of Education and Research (BMBF), the U.K. Department of Health and Social Care’s Global Antimicrobial Resistance Innovation Fund (GAMRIF), the Bill & Melinda Gates Foundation, and with in-kind support from National Institute of Allergy and Infectious Diseases (NIAID), part of the U.S. National Institutes of Health (NIH). CARB-X supports the world’s largest and most innovative pipeline of preclinical and early-stage development products against antibiotic-resistant infections. CARB-X is headquartered at Boston University School of Law. For more information, view a fact sheet on CARB-X’s first five years and the 2020-2021 annual report. Visit and follow CARB-X on Twitter @CARB_X


Dr. Christian Grøndahl, Co-founder and CEO
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Consilium Strategic Communications
Mary-Jane Elliott, Tracy Cheung, Chris Welsh
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