Sekisui XenoTech Provides Pooled Human Liver Homogenate for Evaluation of Drug Metabolizing Enzymes and Proteins
Sekisui XenoTech now offers pooled human liver homogenate as part of its extensive catalog of cell and tissue-based products. This test system is ideal for metabolism identification when responsible enzymes are not known, proteomic assays, enzymatic activity studies, etc.
Sekisui XenoTech’s human liver homogenate is comprised of tissue from 20 donors that is homogenized, centrifuged at low speed to remove connective tissue, large pieces of cell membranes and intact cell nuclei, and diluted to a constant protein concentration. By removing the additional centrifugation steps that are typical in S9 or microsomal preparations, the resulting fraction is rich with drug metabolizing enzymes and proteins.
Homogenate from other species and tissue is available from Sekisui XenoTech as a custom preparation. Learn more at www.xenotech.com/products.
Sekisui XenoTech, LLC is a global Contract Research Organization with unparalleled experience and proven expertise from discovery through clinical support, providing cell and tissue-based products, screening, radiolabeling, API manufacturing, in vitro ADMET and pharmacology, in vivo ADMET and QWBA, metabolite ID and production, bioanalytical services and consulting. Sekisui XenoTech’s product selection includes a wide-range of high quality standard reagents, from subcellular fractions and hepatocytes to recombinant enzymes, substrates and metabolites. The company also regularly prepares and delivers custom-designed products and services in response to client requests. For additional information, please refer to the company’s website at www.xenotech.com or call your local Sekisui XenoTech representative.