Milliman Retiree Health Cost Index: A 65-year-old couple needs $395,000 in savings for healthcare in retirement

Milliman Retiree Health Cost Index: A 65-year-old couple needs $395,000 in savings for healthcare in retirement




Milliman Retiree Health Cost Index: A 65-year-old couple needs $395,000 in savings for healthcare in retirement

SEATTLE–(BUSINESS WIRE)–Milliman, Inc., a premier global consulting and actuarial firm, recently released its 2024 Retiree Health Cost Index which projects how much money, on average, a healthy 65-year-old can expect to spend on healthcare costs in retirement. The index explains how factors like when a person retires, where a person lives, and which coverage a person chooses will impact the total cost of premiums and out-of-pocket expenses.




The two most common healthcare coverage options chosen by Medicare-eligible retirees are Medicare Advantage Part D (MAPD) and Original Medicare with Medigap plus Part D. A healthy 65-year-old male retiring in 2024 with an MAPD plan is projected to spend $128,000 on healthcare in his remaining lifetime. A female with the same coverage is projected to spend $147,000 in her remaining lifetime. The difference in cost is largely because women on average live longer than men.

Under Original Medicare with Medigap plus Part D instead, these projections increase to $281,000 for a male and $320,000 for a female, or a combined total of $601,000 for a 65-year-old couple. In today’s dollars (assuming a 3% investment return), this reflects $395,000 in savings needed.

In 2024, Medicare Advantage costs decreased about 4% and Medigap costs increased about 2% when compared to 2023. The largest drivers of these changes include:

  • Increased drug spending, including weight-loss and diabetes drugs such as Ozempic and Jardiance
  • Higher Medicare Part B premiums
  • Lower MAPD premiums and out-of-pocket costs
  • The Inflation Reduction Act, which required changes to Medicare Part D

“Healthcare expenses are an important and sometimes overlooked component of retirement planning,” said Robert Schmidt, a Milliman principal and co-author of the Retiree Health Cost Index. “By taking a realistic look at their health status and healthcare expenses, and then budgeting accordingly, people can take steps to enjoy a less stressful, financially healthier retirement.”

To view the complete Retiree Health Cost Index, visit https://www.milliman.com/retireehealthcosts.

About Milliman

Milliman is among the world’s largest providers of actuarial, risk management, and technology solutions. Our consulting and advanced analytics capabilities encompass healthcare, property & casualty insurance, life insurance and financial services, and employee benefits. Founded in 1947, Milliman is an independent firm with offices in major cities around the globe. Visit us at milliman.com.

Contacts

Robert Schmidt

Milliman, Inc.

Tel: 1 208 342 3487

Email: Robert.Schmidt@milliman.com

Biogennix Launches Agilon Surgical Matrix

Biogennix Launches Agilon Surgical Matrix




Biogennix Launches Agilon Surgical Matrix

Osteobiologics Leader Enters Wound Care Space with Cutting Edge Solution

IRVINE, Calif.–(BUSINESS WIRE)–#agilonBiogennix, an osteobiologics company specializing in innovative healing solutions for surgical procedures, has announced the launch of its new Agilon Surgical Matrix wound care product.

Agilon Surgical Matrix is a wound care solution derived from 100% bovine Type 1 collagen. Upon contact with a new or open wound, whether surgically or naturally occurring, Agilon Surgical Matrix transforms into a gel, enveloping the entire wound area. This coverage maintains a low pH wound environment that aids in the formation of tissue and epithelialization, which is conducive to successful wound healing.

Backed by in vitro performance data, Agilon Surgical Matrix demonstrates wide-ranging antimicrobial properties, offering added protection against infections. The product’s versatility extends to various surgical applications, serving as an alternative to close-suction drains, blood vessel ligation, or surgical site immobilization in preventing postoperative seromas.

With its sterile, single-use packaging, Agilon Surgical Matrix provides a safe and effective option for healthcare professionals and patients.

“Based on the enthusiastic feedback we’ve received from surgeons, we anticipate Agilon Surgical Matrix to be a significant addition to our product offering that will open the doors to a wide variety of indications,” said Greg Yocum, Biogennix’s VP of Business Development. “Because Agilon Surgical Matrix is purified low pH, bovine Type 1 collagen, it represents a significant advancement in surgical and post-operative care management, offering a myriad of benefits – including antibacterial properties – which enhance patient outcomes and facilitate healing. This product also opens the door for Biogennix to participate in the wound care market.”

Agilon Surgical Matrix can be used in the management of partial and full thickness wounds, pressure (stage I – IV) and venous ulcers, ulcers caused by mixed vascular etiologies, venous stasis and diabetic ulcers, first and second degree burns, cuts, abrasions, and surgical wounds.

Surgical areas include orthopedic, podiatry, cardiovascular, abdominal, neurologic, plastic/breast reconstruction, general, OB/GYN, trauma, vascular, burns, and ulcers.

About Biogennix:

Biogennix is a pioneering osteobiologics company based in Irvine, California, committed to developing, manufacturing, and distributing advanced products for surgical procedures. Its focus on innovation, quality, and customer satisfaction continues to set it apart as a leader in the medical device industry.

“Agilon” is a registered trademark of Biogennix.

Contacts

Paul Williams

(310) 569-0023

paul@medialinecommunications.com

United States Tuberculosis Drugs Market Prospects, Trends Analysis, Size and Forecasts up to 2032 – ResearchAndMarkets.com

United States Tuberculosis Drugs Market Prospects, Trends Analysis, Size and Forecasts up to 2032 – ResearchAndMarkets.com




United States Tuberculosis Drugs Market Prospects, Trends Analysis, Size and Forecasts up to 2032 – ResearchAndMarkets.com

DUBLIN–(BUSINESS WIRE)–The “United States Tuberculosis Drugs Market: Prospects, Trends Analysis, Market Size and Forecasts up to 2032” report has been added to ResearchAndMarkets.com’s offering.


The country research report on United States tuberculosis drugs market is a customer intelligence and competitive study of the United States market. Moreover, the report provides deep insights into demand forecasts, market trends, and, micro and macro indicators in the United States market. Also, factors that are driving and restraining the tuberculosis drugs market are highlighted in the study.

This is an in-depth business intelligence report based on qualitative and quantitative parameters of the market. Additionally, this report provides readers with market insights and detailed analysis of market segments to possible micro levels. The companies and dealers/distributors profiled in the report include manufacturers & suppliers of tuberculosis drugs market in United States.

Highlights of the report

1) Demand and supply conditions of the tuberculosis drugs market

2) Factor affecting the tuberculosis drugs market in the short run and the long run

3) The dynamics including drivers, restraints, opportunities, political, socioeconomic factors, and technological factors

4) Key trends and future prospects

5) Leading companies operating in tuberculosis drugs market and their competitive position in United States

6) The dealers/distributors profiles provide basic information of top 10 dealers & distributors operating in (United States) tuberculosis drugs market

7) Matrix: to position the product types

8) Market estimates up to 2032

The report answers questions such as:

1) What is the market size of tuberculosis drugs market in United States?

2) What are the factors that affect the growth in tuberculosis drugs market over the forecast period?

3) What is the competitive position in United States tuberculosis drugs market?

4) What are the opportunities in United States tuberculosis drugs market?

5) What are the modes of entering United States tuberculosis drugs market?

Key Topics Covered:

1. Report Overview

1.1. Report Description

1.2. Research Methods

1.3. Research Approach

3. Market Overview

3.1. Introduction

3.2. Market Dynamics

3.2.1. Drivers

3.2.2. Restraints

3.2.3. Opportunities

3.2.4. Challenges

3.3. PEST-Analysis

3.4. Porter’s Diamond Model for United States Tuberculosis Drugs Market

3.5. Growth Matrix Analysis

3.6. Competitive Landscape in United States Tuberculosis Drugs Market

4. United States Tuberculosis Drugs Market by Disease Type

4.1. Active TB

4.2. Latent TB

5. United States Tuberculosis Drugs Market by Drug Class

5.1. First-line Anti-TB Drugs

5.1.1. Isoniazid

5.1.2. Rifampin

5.1.3. Pyrazinamide

5.1.4. Ethambutol

5.1.5. Others

5.2. Second-line Anti-TB Drugs

5.2.1. Capreomycin

5.2.2. Streptomycin

5.2.3. Levofloxacin

5.2.4. Ethionamide

5.2.5. Others

5.3. Combination Drugs

6. Company Profiles

6.1. Manufacturer’s & Suppliers

6.2. Dealer’s/Distributor’s Profile

For more information about this report visit https://www.researchandmarkets.com/r/wis5f7

About ResearchAndMarkets.com

ResearchAndMarkets.com is the world’s leading source for international market research reports and market data. We provide you with the latest data on international and regional markets, key industries, the top companies, new products and the latest trends.

Contacts

ResearchAndMarkets.com

Laura Wood, Senior Press Manager

press@researchandmarkets.com
For E.S.T Office Hours Call 1-917-300-0470

For U.S./ CAN Toll Free Call 1-800-526-8630

For GMT Office Hours Call +353-1-416-8900

OS Therapies Announces Positive Safety Data from Phase 1 Clinical Trial of OST-HER2 in HER2-Expressing Breast Cancer and in Preclinical Efficacy in Models of Breast Cancer

OS Therapies Announces Positive Safety Data from Phase 1 Clinical Trial of OST-HER2 in HER2-Expressing Breast Cancer and in Preclinical Efficacy in Models of Breast Cancer




OS Therapies Announces Positive Safety Data from Phase 1 Clinical Trial of OST-HER2 in HER2-Expressing Breast Cancer and in Preclinical Efficacy in Models of Breast Cancer

  • 10 of 12 patients treated in HER2 expressing solid tumor Phase 1b trial were breast cancer patients
  • Dose selected for ongoing Phase 2b clinical trial in Osteosarcoma was shown to be well tolerated in breast cancer patients
  • Preclinical breast cancer efficacy models showed positive data to prevent breast cancer metastases to the brain, reduce tumor growth by over 90% in combination with HER2-targeted antibodies, and prevent the formation of breast cancer compared with controls

ROCKVILLE, Md.–(BUSINESS WIRE)–OS Therapies, Inc. (NYSE-A: OSTX), a clinical-stage oncology-focused immunotherapy company developing cancer vaccines and antibody drug conjugate (ADC) therapeutic candidates, today announced positive data from a Phase 1 clinical trial of OST-HER2 in patients with HER2-expressing solid tumors in breast cancer and other cancers. Additionally, the Company announced positive preclinical efficacy data for OST-HER2 in multiple models of breast cancer.

The FDA has granted Rare Pediatric Disease Designation (RPDD), Orphan Drug Designation (ODD), and Fast Track Designation (FTD) for OST-HER2 in Osteosarcoma. OST-HER2, a biologic therapeutic candidate, is a Lm (Listeria monocytogenes) vector-based off-the-shelf immunotherapeutic vaccine designed to prevent metastasis, delay recurrence, and increase overall survival in patients with osteosarcoma and other solid tumors. The proposed OST-HER2 mechanism of action is based on innate and adaptive immune stimulating responses activated by the Lm vector. This treatment generates T cells that can eliminate or slow potential micrometastases that can grow into recurrent osteosarcoma and other solid tumors, including breast cancer. T cell responses home in on HER2 expressed by the tumor and then kill the cell, releasing additional tumor targets. There are currently no approved adjuvant treatments for recurrent osteosarcoma in the United States.

A total of twelve (12) patients with a history of HER2 positive cancer were enrolled in the Phase 1b clinical study, comprised of ten (10) patients with breast cancer, one (1) patient with esophageal cancer and one (1) patient with GE junction cancer. OST-HER2 was determined to be safe and well tolerated in patients with HER2-expressing solid tumors, including at the dose currently being used in the Company’s ongoing Phase 2b clinical trial in recurrent, resected osteosarcoma (AOST-2121, NCT04974008). The Company previously announced positive AOST-2121 interim data and is now in active discussions with the US FDA regarding a Breakthrough Therapy (BTD) designation application submitted for OST-HER2 based on the interim results. The Company is focused on approval for OST-HER2 in osteosarcoma, and thereafter plans to expand development into breast cancer and other HER2 expressing cancers such as esophageal cancer and colorectal cancer.

In addition, the Company announced positive data from multiple preclinical models of breast cancer. The key data for OST-HER2 include:

  • 78% reduction in tumor size (3mm for OST-HER2 treated vs. 14mm for control arm) in FVB/N HER2 transgenic mouse model of breast cancer treatment at day 75
  • 33% prevention of breast cancer in OST-HER2 treated mice vs. 0% prevention of breast cancer in FVB/N HER2 transgenic model of breast cancer prevention at week 50
  • 20% reduction of tumor size for OST-HER2 plus HER2-targeted antibody vs. HER2-targeted antibody alone Tg tumor regression model of breast cancer at day 42
  • 65% reduction cellular concentration of metastatic cells for OST-HER2-treated mice compared with controls in brain metastasis model of primary breast cancer

About OS Therapies

OS Therapies, Inc. (NYSE-A: OSTX) is a clinical stage oncology company focused on the identification, development and commercialization of treatments for Osteosarcoma (OS) and other solid tumors. OST-HER2 is an immunotherapy leveraging the immune stimulatory effects of Listeria bacteria to initiate a strong immune response targeting the HER2 protein. The Company has fully-enrolled a 41-patient Phase 2b clinical trial of OST-HER2 in resected, recurrent osteosarcoma, with results expected in the fourth quarter of 2024. OST-HER2 has also completed a Phase 1b clinical trial in other solid tumors and has demonstrated efficacy in multiple preclinical models of breast cancer. OS Therapies is also developing the next generations Antibody Drug Conjugate (ADC) platform tunable ADC (tADC) centered around tunable, tailored antibody-linker-payload candidates built around the Company’s unique silicone linker technology that allows for multiple payloads to be delivered per linker.

About OST-HER2

The OST-HER2 Lm vector platform technology has been administered to over 450 cancer patients in ongoing and completed clinical trials. AOST-2121 is a Phase IIB clinical trial intended to prevent or delay metastasis and improve Overall Survival (OS) in Osteosarcoma. OST-HER2 has already received Fast-Track, Orphan, and Rare Disease Designation (RDD). OST hopes to seek a Break-Through Designation (BTD) based on data from this Phase IIb clinical trial. OST31-164 has previously received USDA provisional approval for treatment of Osteosarcoma in canines. In a completed Phase III study in canines (n=180), early data demonstrated a clear separation of treated and untreated canine patients (p=.0007) in Overall Survival (OS) and Disease Progression.

For more information, please see the Company’s website at www.ostherapies.com

Contacts

media@ostherapies.com

Exai Bio Appoints Dave Daly as Chief Executive Officer

Exai Bio Appoints Dave Daly as Chief Executive Officer




Exai Bio Appoints Dave Daly as Chief Executive Officer

Exai to accelerate product development and partnering of its novel oncRNA- and generative AI-based liquid biopsy platform

Dave Daly brings more than 30 years of extensive cancer diagnostics and executive leadership experience

PALO ALTO, Calif.–(BUSINESS WIRE)–Exai Bio, a next-generation oncRNA- and generative AI-based liquid biopsy company, today announced the appointment of Dave Daly as Chief Executive Officer. With more than 30 years of cancer diagnostics and executive leadership experience, including at Thrive Earlier Detection (acquired by Exact Science ‘EXAS’) and Foundation Medicine (acquired by Roche), Daly is ideally positioned to spearhead Exai’s accelerated product development and partnering strategy.


Exai’s liquid biopsy platform uses RNA sequencing to identify a novel category of cancer-associated, small non-coding RNAs, termed orphan non-coding RNAs (oncRNAs). oncRNAs are actively secreted from living cancer cells and are abundant in the blood. When combined with proprietary artificial intelligence, oncRNAs have multiple advantages over tests that utilize circulating tumor DNA, including superior sensitivity and specificity, low cost of goods, as well as the ability to reveal dynamic changes in the biology of a patient’s tumor over time.

“Since its founding, Exai has amassed the largest oncRNA dataset and honed its proprietary generative AI models to deliver unprecedented sensitivity across the major cancer types,” stated Michael Pellini, General Partner at Section 32 and Board member of Exai Bio. “As the company accelerates product development of its novel platform, we are thrilled to welcome Dave Daly, who has the deep diagnostics expertise and leadership qualities to lead the next chapter of Exai.”

Most recently, Daly was President and Chief Operating Officer at Singular Genomics. Prior to this role, Daly served as CEO at Thrive Earlier Detection, a liquid biopsy company focused on multi-cancer early detection that was acquired by Exact Sciences Corporation. During his extensive career in diagnostics, Daly has also served in key leadership roles at Illumina where he was Senior Vice President and General Manager of Commercial Operations for the Americas Region, Foundation Medicine where he was Chief Commercial Officer, Life Technologies where he led the oncology business unit, and Clarient where he served as Chief Commercial Officer.

“Decades spent in the diagnostics industry allowed me to clearly see that Exai’s novel liquid biopsy platform stands out as one that can be both truly high performing and accessible for a broad array of patients,” stated Dave Daly, Chief Executive Officer of Exai Bio. “I look forward to leading the team as we build our tests and establish key partnerships that will unlock the platform’s full potential for cancer care.”

About Exai Bio

Exai Bio is a next-generation liquid biopsy company. Its mission is to enable a world where cancer can be detected early, diagnosed accurately, treated in a personalized and targeted way, and ultimately cured. The company’s proprietary oncRNA- and AI-based liquid biopsy technology delivers clinical insights into cancer biology to enable the earliest, most accurate diagnosis of cancer. For more information, please visit us on www.exai.bio and follow us on Twitter and LinkedIn.

Contacts

Kim Maxwell Brown
kimb@exai.bio
Phone: 650-262-4516

Pharmaceutical Industry Chief Kåre Schultz Joins Hims & Hers Board

Pharmaceutical Industry Chief Kåre Schultz Joins Hims & Hers Board




Pharmaceutical Industry Chief Kåre Schultz Joins Hims & Hers Board

Bringing experience from Novo Nordisk and Teva Pharmaceutical Industries, Schultz joins the Hims & Hers Board of Directors to help the company increase access to health and wellness solutions

SAN FRANCISCO–(BUSINESS WIRE)–Hims & Hers Health, Inc. (“Hims & Hers”, NYSE: HIMS), the leading health and wellness platform, today announced the appointment of Kåre Schultz to the company’s Board of Directors.




Kåre Schultz brings a unique global perspective on the healthcare and pharmaceutical industries from his decades of leadership experience at several international organizations, including Teva Pharmaceutical Industries, Lundbeck, and Novo Nordisk. Mr. Schultz spent over 25 years at Novo Nordisk, where he served in many capacities, most notably as President and COO as the company established itself as a leading company in diabetes care. As CEO of Teva Pharmaceutical Industries, Mr. Schultz streamlined operations to focus the company on its core strengths in generics and specialty medicines. Mr. Schultz also served as CEO of Lundbeck, where he helped position the company as a leader in the pharmaceutical industry.

“We are in a transformative moment for healthcare with the opportunity to make life-changing treatments accessible to all who need it. Kåre’s experience gives us an incredible wealth of expertise as we bring together the most valuable elements of clinical excellence, healthcare, and technology to redefine health and wellness for our customers,” said Andrew Dudum, CEO and co-founder of Hims & Hers. “We’re honored to have Kåre join us to share his perspective and leadership as we continue to serve more customers across our platform.”

“Hims & Hers is on a trajectory to upend the healthcare industry,” said Kåre Schultz. “In my long career in the pharmaceutical industry, this is the first company I have seen that is leveraging today’s modern tools to truly break down barriers and change the status quo of how people access the health solutions they need to live their fullest lives. I’m thrilled to be a part of this journey.”

Mr. Schultz joins leaders from across industries on the Hims & Hers Board of Directors including: former CEO of the Cleveland Clinic, Dr. Toby Cosgrove; tech industry leader, Christopher Payne; US regulatory and foreign policy expert, Anja Manuel; former Chief Medical Officer of Walgreens and current Chief Medical Officer of Hims & Hers, Patrick Carroll; former CFO of Netflix, David Wells; consumer retail expert, Christiane Pendarvis; and former Nike and Sony marketing executive, Andrea Perez.

About Hims & Hers Health, Inc

Hims & Hers is the leading health and wellness platform on a mission to help the world feel great through the power of better health. We believe how you feel in your body and mind transforms how you show up in life. That’s why we’re building a future where nothing stands in the way of harnessing this power. Hims & Hers normalizes health & wellness challenges—and innovates on their solutions—to make feeling happy and healthy easy to achieve. No two people are the same, so the company provides access to personalized care designed for results. For more information, please visit www.hims.com and www.forhers.com.

Contacts

Press Contact

Abby Reisinger

press@forhims.com

Lario Therapeutics Awarded $6M Grant From The Michael J. Fox Foundation for Parkinson’s Research

Lario Therapeutics Awarded $6M Grant From The Michael J. Fox Foundation for Parkinson’s Research




Lario Therapeutics Awarded $6M Grant From The Michael J. Fox Foundation for Parkinson’s Research

  • Award supports preclinical research of Lario’s CaV2.3 calcium channel inhibitors as a novel disease-modifying approach for treatment of Parkinson’s disease
  • Programme in collaboration with the Oxford Parkinson’s Disease Centre

EDINBURGH, Scotland–(BUSINESS WIRE)–Lario Therapeutics (‘Lario’, or ‘the Company’), a biopharmaceutical company developing first-in-class precision medicines for epileptic and neurological disorders, today announced it has been awarded a $6 million USD grant from The Michael J. Fox Foundation for Parkinson’s Research (MJFF). The programme is in collaboration with the Oxford Parkinson’s Disease Centre, which will also be delivering key science as part of the grant.


The grant will be used to fund Lario’s preclinical programme investigating selective CaV2.3 calcium channel inhibition as a novel and disease-modifying approach for treatment of Parkinson’s disease. There is extensive literature linking calcium channels to pathology of the disease, and it has been demonstrated in preclinical experimental studies that the deletion of CaV2.3 can have a protective effect against Parkinson’s disease progression. Lario is partnering with Professor Richard Wade-Martins and the Oxford Parkinson’s Disease Centre (OPDC) for the study, for the evaluation of Lario compounds in state-of-the-art patient-derived stem cell models of Parkinson’s disease.

Parkinson’s disease is a progressive neurodegenerative disorder occurring when brain cells that make dopamine, which coordinates movement, stop working or die. Symptoms are lifelong and worsen over time, including motor disfunction, such as tremor, slowness, stiffness, walking and balance problems, as well as problems such as depression and memory problems. More than 10 million people worldwide are estimated to be living with Parkinson’s, with no current cure.

Tom Otis, Ph.D., Professor of Neuroscience UCL and Chief Scientific Officer of Lario Therapeutics, said: We are grateful to MJFF for their funding support for Lario’s efforts to test and develop a potential new therapy designed to prevent the loss of neurons that causes Parkinson’s disease. If our research is successful, this will represent an important new treatment option for patients.”

“This significant funding from The Michael J. Fox Foundation will aid the work out of our therapeutic pipeline and the work we have achieved so far in advancing research in the field. We would like to thank the MJFF team for their support,” added Henning Steinhagen, Ph.D., Co-Founder and CEO of Lario Therapeutics. “This grant will help drive our ambition to progress our Cav2.3 program swiftly towards the clinic, to provide a new, effective treatment option for people with Parkinson’s disease.”

MJFF is dedicated to funding innovative research, such as the work done at Lario Therapeutics, to develop a pipeline of novel therapies that can improve the lives of people with Parkinson’s disease,” said Gaia Skibinski, Ph.D., director of research programs at MJFF. “We look forward to seeing the results of Lario’s research on CaV2.3 as a novel disease-modifying approach for Parkinson’s.”

Richard Wade-Martins, MA, DPhil, Professor of Molecular Neuroscience, University of Oxford, and head of the Oxford Parkinson’s Disease Centre, said: I am excited to partner with the team at Lario Therapeutics – having grant funding from MJFF is a testament to the impact this study aims to bring to patients. Our research centre works to understand the development of Parkinson’s, with the ultimate aim of targeting the molecular mechanisms of disease, to prevent disease onset or to delay progression. We see great potential in the CaV2.3 programme and are very happy to collaborate to study patient stem cell-derived neuronal models as part of the research.”

For more information about Lario Therapeutics’ pipeline please visit https://www.lariotx.com/pipeline.

Contacts

Zyme Communications
Katie Odgaard

Tel: +44(0)7787 502 947

Email: katie.odgaard@zymecommunications.com

Gilead and the Elton John AIDS Foundation Announce Additional Five Years of RADIAN Partnership to Help Address the Growing HIV Crisis in Eastern Europe and Central Asia

Gilead and the Elton John AIDS Foundation Announce Additional Five Years of RADIAN Partnership to Help Address the Growing HIV Crisis in Eastern Europe and Central Asia




Gilead and the Elton John AIDS Foundation Announce Additional Five Years of RADIAN Partnership to Help Address the Growing HIV Crisis in Eastern Europe and Central Asia

RADIAN’s Five-Year, $25 Million Extension Will Increase Support for Local Organizations and Drive Progress to Help Turn the Tide on HIV Across the Region –

RADIAN Will Expand Geographic Focus to Provide Key Populations and Communities Impacted by the Conflict in Ukraine with HIV Prevention and Care Services –

FOSTER CITY, Calif.–(BUSINESS WIRE)–Gilead Sciences, Inc. (Nasdaq: GILD) and the Elton John AIDS Foundation (EJAF) today announced a five-year extension of the RADIAN® partnership to help meet the needs of the most vulnerable key populations in Eastern Europe and Central Asia (EECA) where the HIV epidemic is growing. RADIAN will continue supporting the initiatives of trusted, grassroots organizations who are working to address HIV-related challenges in the region.




While HIV is declining globally, EECA is one of the few regions in the world where the epidemic is getting worse, with new HIV diagnoses and AIDS-related deaths increasing by 20% and 34%, respectively, since 2010.1 Of the 2.1 million people in EECA living with HIV, 41% are not aware of their HIV status and 50% are not on treatment – way below global 95-95-95-95 targets.1

We are committed to ensuring that the EECA region is not left behind because ending the HIV epidemic means ending it for everyone, everywhere,” said Daniel O’Day, Chairman and Chief Executive Officer, Gilead Sciences. “During a recent visit to Kazakhstan, I met with RADIAN-supported community leaders who emphasized the importance of doubling down on our collaborative efforts. Over the next five years, RADIAN 2.0 will continue to address the structural drivers of the epidemic, strengthen HIV health systems, and enhance the capacities of local organizations for lasting impact.”

Since RADIAN was launched in 2019 it has had a significant impact on the HIV response in the region, reaching more than 271,000 people with HIV services, providing over 114,000 HIV tests, (re-) initiating over 26,500 people on antiretroviral therapy, and training more than 14,000 frontline workers to reduce stigma and discrimination.2 These efforts are having an impact on communities most in need, however the situation in the region has escalated dramatically in recent years with the conflict in Ukraine further exacerbating the crisis.3 Anti-LGBTQ+ legislation, human rights violations, stigma and discrimination are also hindering the HIV response across the region.4

At the Elton John AIDS Foundation, we have a long history of supporting people living with or at risk of HIV across Eastern Europe and Central Asia – a region too often overlooked in the global HIV response. Because of insufficient access to HIV testing and effective treatment, 384 people newly acquire HIV every day in EECA and 120 people die of AIDS-related causes,” said Anne Aslett, CEO of the Elton John AIDS Foundation.1We are incredibly proud of our RADIAN partnership with Gilead Sciences, which is genuinely helping to turn the tide on the HIV epidemic in the region. Over the next few years, RADIAN will continue to help meet the needs of people most affected by HIV in EECA through innovative, scalable solutions and we are incredibly grateful to our resilient and determined local partners who share our ambition of leaving nobody behind.”

Over the next five years, RADIAN will extend its efforts to support collaborative, community-based initiatives to help meet the needs of the most vulnerable key populations across EECA, including people who use drugs, men who have sex with men, sex workers and Transgender people.

RADIAN will also expand its geographic reach to include countries hosting refugees fleeing Ukraine, including Hungary, Poland, Slovakia and Germany, where there is an acute need for additional HIV services. Language barriers, social isolation and internalized stigma are all greatly hindering the ability of refugees living with or at risk of HIV to access the treatment and care they urgently need.5 RADIAN’s geographic expansion will provide more support to these vulnerable communities, improving access to HIV services and supporting their mental and social wellbeing.

RADIAN will continue to build on successes and learnings from the first five years of the partnership to help close gaps in HIV testing, prevention and care. Additionally, to support innovations that increase the effectiveness of the HIV response in EECA, RADIAN will introduce an innovation fund. The fund will accept creative applications on a rolling basis to allow for flexibility of funding opportunities as innovations emerge.

About RADIAN

RADIAN is a ground-breaking partnership between Gilead Sciences and the Elton John AIDS Foundation that supports grassroots organizations and partners in Eastern Europe and Central Asia (EECA) to meaningfully address the HIV-related challenges in the region. By supporting the delivery of community-based services and health systems, and by addressing structural barriers impeding the HIV response, RADIAN helps address the needs of key populations and marginalized communities – including people who use drugs, men who have sex with men, sex workers and Transgender people. RADIAN works closely with local leaders and community partners – RADIAN Changemakers and grantees – who are committed to creating change in the region through on-the-ground initiatives tackling the unique challenges of the HIV epidemic in EECA.

To learn more about how RADIAN is working to end HIV in EECA, visit www.radianhiv.org.

About Gilead Sciences

Gilead Sciences, Inc. is a biopharmaceutical company that has pursued and achieved breakthroughs in medicine for more than three decades, with the goal of creating a healthier world for all people. The company is committed to advancing innovative medicines to prevent and treat life-threatening diseases, including HIV, viral hepatitis, COVID-19, and cancer. Gilead operates in more than 35 countries worldwide, with headquarters in Foster City, California.

For 35 years, Gilead has been a leading innovator in the field of HIV, driving advances in treatment, prevention and cure research. Gilead researchers have developed 12 HIV medications, including the first single-tablet regimen to treat HIV, the first antiretroviral for pre-exposure prophylaxis (PrEP) to help reduce new HIV infections, and the first long-acting injectable HIV treatment medication administered twice-yearly. Our advances in medical research have helped to transform HIV into a treatable, preventable, chronic condition for millions of people.

For more information on Gilead Sciences, please visit the company’s website at www.gilead.com.

About Elton John AIDS Foundation

The Elton John AIDS Foundation was established in 1992 and is one of the leading independent AIDS organizations in the world. The Foundation’s mission is simple: an end to the AIDS epidemic. The Elton John AIDS Foundation is committed to overcoming the stigma, discrimination and neglect that keep us from ending AIDS. With the mobilization of our network of generous supporters and partners, we fund local experts across four continents to challenge discrimination, prevent infections, and provide treatment as well as influencing governments to end AIDS. www.eltonjohnaidsfoundation.org

1 Data provided by UNAIDS (2024), https://www.unaids.org/en
2 Data provided by the Elton John AIDS Foundation – June 2024

3 Jonas, Kai J. et al. The war refugees from Ukraine: an HIV epidemic is fleeing as well. AIDS 36(12):p 1745-1746, October 1, 2022. | DOI: 10.1097/QAD.0000000000003271, last accessed June 2024

4 Schweitzer AM et al, Addressing HIV stigma in healthcare, community, and legislative settings in Central and Eastern Europe, 2023. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10714556/, last accessed June 2024

5 European Centre for Disease Prevention and Control, Migrant health: HIV testing and counselling in migrant populations and ethnic minorities in EU/EEA/EFTA Member States. Available at: https://www.ecdc.europa.eu/sites/default/files/media/en/publications/Publications/1108_TER_HIV_in_migrants.pdf, last accessed July 2024.

Contacts

Meaghan Smith, Media

public_affairs@gilead.com

Jacquie Ross, Investors

investor_relations@gilead.com

 

 

AHF Press Conference: Advocates Demand Gilead to Put Lives Before Profits at AIDS 2024

AHF Press Conference: Advocates Demand Gilead to Put Lives Before Profits at AIDS 2024




AHF Press Conference: Advocates Demand Gilead to Put Lives Before Profits at AIDS 2024

Tuesday, July 23, 13:15 CEST Munich, Germany, In-person and via Zoom

MUNICH–(BUSINESS WIRE)–AIDS Healthcare Foundation (AHF) will host an in-person and virtual press conference at the AHF booth (#111) during the 2024 International AIDS Conference (AIDS 2024) on Tuesday, July 23 at 13:15 CEST (7:15 a.m. US EDT) in Munich, Germany, at the Messe München Convention Center and virtually via Zoom.

During the press conference, public health advocates and experts will reiterate how global access to affordable medicines is being subverted by the pursuit of profit-at-all-cost strategy employed by Gilead Sciences and other Big Pharma companies. Unabated corporate greed keeps millions of people in low- and middle-income countries from accessing lifesaving medicines they need to stay alive and healthy.

WHAT:

AHF to host LIVE and VIRTUAL GREEDY GILEAD PRESS CONFERENCE during the International AIDS Conference 2024 (AIDS 2024).

WHEN:

Tuesday, July 23 at 13:15 CEST (7:15 a.m. US EDT) – Munich, Germany

WHERE:

AHF AIDS 2024 BOOTH 111 at Messe München Convention Center and VIRTUALLY VIA ZOOM.

WHO:

Public health experts and advocates:

  • Dr. V. Sam Prasad, Country Program Director, AHF India Cares
  • Dr. Victor Popoola, Medical Manager, AHF Sierra Leone
  • Guillermina Alaniz, Director of Global Advocacy & Policy, AHF
  • John Farina, Associate Director of Advocacy, AHF

NEWS DESK NOTE & B-ROLL VISUALS

Press conference will be live streamed on Zoom & Facebook from the AHF AIDS 2024 conference booth. Visit the AHF FACEBOOK page or ZOOM LINK to watch. Visit www.gilead.org for more information about the Greedy Gilead campaign.

MEDIA CONTACTS:

 

Denys Nazarov, Director of Global Policy & Communications, AHF, +1.323.308.1829, denys.nazarov@ahf.org

Brian Shepherd, Associate Director of Global Communications, AHF, +1.808.382.8570, brian.shepherd@ahf.org

“Gilead has harmed people living with HIV worldwide for two-plus decades by securing continual patents, known as ‘evergreening,’ and generating billions of dollars through monopolies on some of the most effective and well-tolerated antiretroviral HIV drugs. There’s no better place than AIDS 2024 to make everyone aware and demand that Gilead choose lives over its greedy tactics that limit access to medicines people worldwide desperately need,” said AHF Chief of Global Advocacy & Policy Terri Ford. “As a leading global HIV/AIDS organization with more than 2 million patients in care in 47 countries, AHF is taking a stand and calling out Gilead so that governments and decision-makers everywhere put collective pressure on it to prioritize lives over obscenely high profits.”

Advocates will also highlight the fact that HIV/AIDS is not over—as it remains a pandemic and a significant global public health crisis responsible for 630,000 deaths every year globally. According to UNAIDS, more than 39 million people were living with HIV in 2022, including 1.3 million people who had newly acquired the virus. Since the AIDS pandemic started, more than 40 million people have died from AIDS-related illnesses.

AIDS Healthcare Foundation (AHF) is a global non-profit organization providing cutting-edge medicine and advocacy to more than 2 million people in 47 countries worldwide in Africa, the Americas, the Asia/Pacific Region and Europe. We are currently the largest non-profit provider of HIV/AIDS medical care in the world. To learn more about AHF, please visit our website: www.aidshealth.org, find us on Facebook: www.facebook.com/aidshealth and follow us on Twitter: @aidshealthcare and Instagram: @aidshealthcare

Contacts

Denys Nazarov, Director of Global Policy & Communications, AHF, +1.323.308.1829, denys.nazarov@ahf.org
Brian Shepherd, Associate Director of Global Communications, AHF, +1.808.382.8570, brian.shepherd@ahf.org

TME Pharma Announces Strategic Plan to Externalize and Monetize Second Clinical Stage Asset NOX-E36

TME Pharma Announces Strategic Plan to Externalize and Monetize Second Clinical Stage Asset NOX-E36




TME Pharma Announces Strategic Plan to Externalize and Monetize Second Clinical Stage Asset NOX-E36

  • NOX-E36 presents promising opportunity for development in eye diseases with a high need for well-tolerated therapies with anti-fibrotic effect
  • Anti-fibrotic mode of action of NOX-E36 was demonstrated in preclinical eye disease model performed by leading Singapore Eye Research Institute
  • Preclinical, clinical data and available drug supply lay optimal framework for rapid path to Phase 2 clinical proof-of-concept
  • TME Pharma plans to enable separate corporate entity focused on NOX-E36 in ophthalmology to monetize the program and mobilize private investor support

BERLIN–(BUSINESS WIRE)–TME Pharma N.V. (Euronext Growth Paris: ALTME), a clinical-stage biotechnology company focused on developing novel therapies for treatment of cancer by targeting the tumor microenvironment (TME), announces its plan to externalize and monetize the company’s second clinical stage asset NOX-E36 – an L-stereoisomer RNA aptamer inhibiting the CCL2 chemokine. This decision leverages the compound’s potential, as shown by clinical and preclinical data, to safely address significant unmet medical needs in ophthalmic diseases impacted by fibrosis.


The presence of the target of NOX-E36, CCL2, has been shown to predict early failure of glaucoma surgical intervention in patients and inhibition of the pathway targeted by NOX-E36 in preclinical models of glaucoma surgery prevents fibrosis thereby prolonging the success of the intervention1. NOX-E36 has already been administered to 175 clinical trial participants with an excellent safety and tolerability profile and showing activity on its target, already derisking a number of steps in early clinical development.

Fibrosis is a significant cause of treatment failure or increased severity in many clinically important eye diseases2 with unmet needs such as diabetic retinopathy (9.6 million cases in the US, of which 1.84 million vision-threatening3), age-related macular degeneration (20 million cases in the US, of which 1.5 million vision-threatening4), and primary open angle glaucoma (>3 million cases in the US5).

Click here to read the full press release

1 Chong (2017) Invest Ophthalmol Vis Sci 58:3432 & Chong (2010) Ophthalmology 117:2353

2 Sorenson (2024) Frontiers in Ophthalmology 2024 Vol. 4

3 Lundeen (2023) JAMA Ophthalmol. 2023;141(8):747-754

4 Rein (2022) JAMA Ophthalmol. 2022;140(12):1202-1208

5 US National Eye Institute Glaucoma Tables, Link

Contacts

For more information, please contact:


TME Pharma N.V.
Aram Mangasarian, Ph.D., CEO

Tel. +49 (0) 30 16637082 0

investors@tmepharma.com

Investor and Media Relations:


NewCap
Arthur Rouillé

Tel. +33 (0) 1 44 71 00 15

arouille@newcap.fr