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EQS Newswire / 30/12/2025 / 17:36 UTC+8 [Hong Kong, December 30th, 2025] Uni-Bio Science Group Limited (“Uni-Bio Science Group”, “Uni-Bio” or “the Group”) is pleased to announce the official signing of a tripartite strategic cooperation agreement in Wenzhou, Zhejiang, with the National Engineering Research Center for Cell Growth Factor Drugs and Protein Formulations of Wenzhou Medical University (“WMU NERC”) and the People’s Government of Ouhai District, Wenzhou. The parties also explored the subsequent co-establishment of the “Uni-Bio – WMU Joint Innovation Laboratory for Translational Medicine.” This collaboration marks a key step for Uni-Bio in deeply integrating with a national-level research platform and a regional industrial ecosystem. Through a synergistic “government-university-enterprise” model, the three parties will focus on the core regenerative medicine field of growth factors to establish an end-to-end innovation system spanning basic research, clinical translation, and industrial application. This represents a milestone for the Group in consolidating its R&D pipeline and accelerating its strategic execution.
Focusing on Growth Factor Frontiers, Unleashing “1+1>2” Clinical and Market Potential Growth factors are key signaling molecules that regulate cell proliferation, migration, and tissue repair, representing some of the most transformative bioactive substances in regenerative medicine. Both EGF (Epidermal Growth Factor) and FGF (Fibroblast Growth Factor) have demonstrated significant efficacy across major indications, including wound healing, ophthalmic diseases, and metabolic disorders, underscoring their substantial market potential. Uni-Bio possesses deep expertise in the EGF field, with its flagship products GeneTime® and GeneSoft® achieving large-scale production and nationwide commercial coverage. Concurrently, under the leadership of Academician Li Xiaokun, the WMU NERC has been a global pioneer in FGF drug R&D, having successfully translated several Class I New Drugs – including Recombinant Human Basic Fibroblast Growth Factor – and has accumulated substantial clinical data and authoritative expert consensus in trauma and metabolic diseases. Building on this foundation, the three parties will initiate collaborative research on combined EGF/FGF therapies for key areas, including burns, dermatology, and ophthalmology. The goal is to unlock powerful therapeutic synergies, develop superior combination products and advance delivery systems, set new treatment benchmarks, and establish a leadership position in shaping this multi-billion Yuan sector.
Empowered by Academician Leadership & Platform, Creating a Fast Track from R&D to Production The WMU NERC is an independent legal entity established by Wenzhou Medical University based on the national-level platform, the National Engineering Research Center for Cell Growth Factor Drugs and Protein Preparations. It undertakes downstream functions including engineering technology research and development, transformation of scientific and technological achievements, and technical services. In synergistic collaboration with the National Key Laboratory for Macromolecular Drugs and Large-Scale Preparation, which focuses on upstream basic research, the Center has built a next-generation growth factor drug pipeline targeting multiple systems such as metabolism and dermatology. Through the ongoing research of Academician Li Xiaokun’s team, the Center has achieved internationally leading breakthroughs in key technologies, including long-acting Modification, targeted delivery, and aerosol inhalation. The planned “Uni-Bio – WMU Joint Innovation Laboratory for Translational Medicine” will conduct in-depth research into the synergistic mechanisms of Epidermal Growth Factor (EGF) and Fibroblast Growth Factor (FGF) in regulating metabolic homeostasis, improving insulin sensitivity, and promoting tissue repair. It aims to develop novel compound formulations and drug delivery systems targeting conditions such as endocrine diseases represented by non-alcoholic steatohepatitis (NASH), respiratory diseases represented by asthma, as well as bone tissue repair. These diseases affect a large global patient population, yet there remains a significant unmet clinical need for innovative therapies. Through this collaboration, it is expected to address treatment gaps in multiple specific indications, further unlocking clinical and commercial value in the broad chronic disease market. The “Government-University-Enterprise ” Trinity, Systematically Strengthening Full-Chain Capabilities This collaboration extends beyond technological synergy to ecosystem co-development. The People’s Government of Ouhai District, Wenzhou, is a key facilitator and supporter of this strategic cooperation, committed to building a first-class biomedical industry ecosystem. Its core platform, the “China Gene Valley,” will provide comprehensive spatial support and specialized policy assistance for the cooperative projects across all stages – from R&D and pilot-scale testing to industrialization. For Uni-Bio, this tripartite cooperation delivers threefold empowerment:
This strategic partnership is a crucial step in the Group’s pursuit of its vision “To Be the Global Leader in Regenerative Medicine, Redefining How Science Restores and Extends Human Life” Moving forward, the Group will continue to deepen collaborations with national scientific institutions and local governments, driving the translation of more cutting-edge research into clinical and market value. This will further consolidate and enhance its comprehensive competitiveness and leadership in regenerative medicine.
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About Uni-Bio Science: Uni-Bio Science Group Limited is an innovative biopharmaceutical enterprise listed on the Main Board of The Stock Exchange of Hong Kong Limited in 2001(Stock Code: 00690.HK). The Group is committed to powering the advancement of regenerative medicine with next-generation synthetic biology and complex peptide innovation. Focusing on four core research areas—muscular-skeletal regeneration, skin regeneration, ocular regeneration, and ENT regeneration—the Group has built a diversified product pipeline encompassing innovative biologics, high-value generic drugs, and medical aesthetics. The Group operates GMP-compliant production bases in Beijing, Dongguan, and Shenzhen, with fully integrated capabilities spanning R&D, manufacturing, and commercial sales. Uni-Bio Science Group is dedicated to becoming a global leader in regenerative medicine, redefining how science restores and extends human life. About the National Engineering Research Center for Cell Growth Factor Drugs and Protein Formulations of Wenzhou Medical University: The WMU NERC is an independent legal entity established by Wenzhou Medical University based on the national-level platform, the National Engineering Research Center for Cell Growth Factor Drugs and Protein Preparations. It undertakes downstream functions including engineering technology research and development, transformation of scientific and technological achievements, and technical services. Under the leadership of Chinese Academy of Engineering Academician Li Xiaokun, the Center has long been engaged in foundational research and novel drug discovery for cell growth factor drugs, holding a globally leading position. It brings together top-tier scientific teams, undertakes major national science and technology projects, and has successfully developed a series of innovative FGF drugs with independent intellectual property rights. Through synergistic collaboration with the National Key Laboratory for Macromolecular Drugs and Large‑Scale Preparation, the Center forms a complete innovation chain from source discovery and key technological breakthroughs to industrial translation. As the important R&D engine of the China Gene Valley, it continuously promotes the incubation and translation of several original new drug candidates, including a long-acting FGF21 variant. About the People’s Government of Ouhai District, Wenzhou: The People’s Government of Ouhai District, Wenzhou, is a key facilitator and supporter of this strategic cooperation, committed to building a first-class biomedical industry ecosystem. Its core platform, the “China Gene Valley,” will provide comprehensive spatial support and specialized policy assistance for the cooperative projects across all stages – from R&D and pilot-scale testing to industrialization. Through specialized industrial policies, “full-cycle escort” services, and clinical resource coordination, Ouhai District empowers the implementation and growth of innovation projects, serving as a vital driver for regional biomedical industry innovation and development.
30/12/2025 Dissemination of a Financial Press Release, transmitted by EQS News. Media archive at www.todayir.com |
Category Archives: EQS Newsfeed
AEVIS VICTORIA SA successfully completes major Group-wide refinancing
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AEVIS VICTORIA SA / Key word(s): Financing AEVIS VICTORIA SA successfully completes major Group-wide refinancing 29.12.2025 / 07:00 CET/CEST Press release Fribourg, 29 December 2025 AEVIS VICTORIA SA successfully completes major Group-wide refinancing AEVIS VICTORIA SA (“AEVIS”) announces the successful completion of a comprehensive refinancing program across multiple levels of the Group, as part of its ongoing efforts to optimize its capital and financing structure. At the holding company level, AEVIS arranged a new syndicated financing facility, enhancing the Group’s overall financial flexibility and liquidity profile. Within the real estate segment, AEVIS completed the refinancing of an interim facility originally put in place in 2020 to finance the acquisition of several hotel assets. This interim financing has been replaced with long-term, traditional mortgage financings, further strengthening the stability of the Group’s balance sheet. In addition, AEVIS successfully secured a new financing facility for L’Oscar Hotel in London. Collectively, these transactions extend and diversify the Group’s debt maturity profile and, together with the significant reduction of the Group’s consolidated debt by more than CHF 100 million in H1 2025, are expected to materially reduce the Group’s cost of debt and financial expenses, resulting in interest expense savings in the high single-digit million range on an annualized basis. For further information: AEVIS VICTORIA SA – Investing for a better life End of Media Release |
2250980 29.12.2025 CET/CEST
FDA approves another interchangeable Ranibizumab Biosimilar, Nufymco® – Strengthening US Presence with Zydus as Commercialization Partner
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Formycon AG / Key word(s): Regulatory Approval/Alliance FDA approves another interchangeable Ranibizumab Biosimilar, Nufymco® – Strengthening US Presence with Zydus as Commercialization Partner 23.12.2025 / 14:02 CET/CEST The issuer is solely responsible for the content of this announcement.
Press Release // December 23, 2025 FDA approves another interchangeable Ranibizumab Biosimilar, Nufymco® – Strengthening US Presence with Zydus as Commercialization Partner
Planegg-Martinsried, Germany – Formycon AG (FWB: FYB, Prime Standard, “Formycon”) and Bioeq AG (“Bioeq”) announce that the U.S. Food and Drug Administration (FDA) has approved Nufymco®1 (ranibizumab-leyk), an interchangeable biosimilar to Lucentis®2. With its second FDA-approved ranibizumab biosimilar in the US, the companies are further underscoring their pioneering position in high-quality biosimilar development. Zydus Lifesciences Limited (including its subsidiaries and affiliates; “Zydus”) has been secured as another strong commercialization partner for the US market. The company has proven expertise with medically administered drugs (known as Medical Part B), a category that includes Nufymco®. Recently, Zydus also obtained exclusive rights to Formycon’s Keytruda®3 biosimilar FYB206 for the US and Canada – a strong testament to the attractiveness of and confidence in Formycon’s development platform. Nufymco® is an interchangeable biosimilar to Lucentis®, developed by Formycon, and will be available in the US for all approved indications, expanding access to essential retinal therapies by offering a more affordable treatment option for patients. “Our FDA approval for Nufymco® marks an important milestone for Formycon and reaffirms our role as an innovative leader in biosimilar development. With two strong and internationally established partners, we are ideally positioned to expand access to high-quality and affordable ranibizumab biosimilars for ophthalmic patients in the US. This expanded market coverage opens new growth opportunities by enabling a differentiated approach within the complex US healthcare and reimbursement landscape, supporting sustainable market penetration,” comments Dr. Stefan Glombitza, CEO of Formycon AG. Nufymco® is FDA approved for the treatment of patients with age-related neovascular (wet) macular degeneration (AMD) and other serious eye diseases such as diabetic macular edema (DME), diabetic retinopathy (DR), macular edema due to retinal vein occlusion (RVO), and myopic choroidal neovascularization (mCNV). 1) Nufymco® is a registered trademark of Formycon AG About Formycon: Formycon AG is headquartered in Munich, listed in the Prime Standard of the Frankfurt Stock Exchange: FYB / ISIN: DE000A1EWVY8 / WKN: A1EWVY. Further information can be found at: https://www.formycon.com/ About Bioeq: About Zydus Lifesciences Limited: About Biosimilars: Tel.: +49 (0) 89 – 86 46 67 149
Disclaimer:
23.12.2025 CET/CEST Dissemination of a Corporate News, transmitted by EQS News – a service of EQS Group. The EQS Distribution Services include Regulatory Announcements, Financial/Corporate News and Press Releases. |
| Language: | English |
| Company: | Formycon AG |
| Fraunhoferstraße 15 | |
| 82152 Planegg-Martinsried | |
| Germany | |
| Phone: | +49 89 864667 100 |
| Fax: | +49 89 864667 110 |
| E-mail: | ir@formycon.com |
| Internet: | www.formycon.com |
| ISIN: | DE000A1EWVY8, NO0013586024 |
| WKN: | A1EWVY, A4DFJH |
| Listed: | Regulated Market in Frankfurt (Prime Standard); Regulated Unofficial Market in Berlin, Dusseldorf, Hamburg, Munich, Stuttgart, Tradegate Exchange; Oslo |
| EQS News ID: | 2250924 |
| End of News | EQS News Service |
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2250924 23.12.2025 CET/CEST
Xlife Sciences AG Announces Transition to the Main Segment of SIX Swiss Exchange to Strengthen Market Presence
In addition, Xlife Sciences is investing in market-making and research activities to further enhance the visibility and tradability of its shares. The segment change is planned for the first quarter of 2026.
Oliver R. Baumann, CEO of Xlife Sciences AG, stated: «Transitioning to the main segment of SIX is the next logical step for Xlife Sciences: it increases visibility, improves the liquidity of our shares, and provides additional access to institutional investors. In parallel, we are intensifying efforts in market-making and research coverage to further enhance the attractiveness for existing and new shareholders.»
Financial calendar
| Annual Report 2025 | 28 April 2026 |
| Annual Shareholders Meeting 2026 | 26 June 2026 |
| Half-Year Report 2026 | 24 September 2026 |
MindMaze Therapeutics: Consolidating a Global Approach to Reimbursement for Next-Generation Therapeutics
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Relief Therapeutics Holding SA / Key word(s): Miscellaneous MindMaze Therapeutics: Consolidating a Global Approach to Reimbursement for Next-Generation Therapeutics 23.12.2025 / 07:00 CET/CEST MindMaze Therapeutics: Consolidating a Global Approach to Reimbursement for Next-Generation Therapeutics Geneva, Switzerland – December 23, 2025 — MindMaze Therapeutics Holding SA (SIX: MMTX) (MindMaze Therapeutics or the Company), a commercial-stage company delivering evidence-based, precision digital treatments for neurological diseases, today outlined the evolution of its global reimbursement strategy to enable scalable patient access and sustainable commercial growth for next-generation neurotherapeutics. Building on a decade of clinical development and five years of focused reimbursement engagement, the Company’s approach integrates reimbursed deployment in the United States, national evidence-generation programs in Switzerland, and guideline-aligned engagement in the United Kingdom, creating a coordinated framework for long-term reimbursement durability across major healthcare systems. Reimbursement Journey: From Vision to Scalable Reality The MindMaze platform began actively evaluating and engaging with U.S. reimbursement pathways for digital neurorehabilitation in 2020, recognizing that long-term scale in healthcare innovation requires formal reimbursement alignment. Over the subsequent five years, the MindMaze platform worked closely with clinical partners, payers, and policymakers to demonstrate real-world feasibility and utilization of technology-enabled care. This effort began with early clinic-to-home deployments at Vibra Healthcare hospitals, where MindMaze solutions were used to extend supervised neurorehabilitation beyond inpatient settings into the home, enabling patients to continue high-frequency therapy after discharge and generating real-world utilization and outcomes data that informed reimbursement discussions. This multi-year body of real-world evidence supported the establishment of a CMS Category III (CAT III) reimbursement code for home-based digital neurorehabilitation—one of the first reimbursement pathways designed to recognize high-intensity neurotherapeutic care delivered outside traditional clinical environments. CAT III reimbursement enables continued real-world deployment while utilization, outcomes, and payer engagement are further evaluated and documented. What CAT III Reimbursement Covers The CAT III code enables reimbursement for:
Rather than reimbursing hardware alone, CAT III supports a service-based care model, aligning reimbursement with patient usage, therapy intensity, and clinical oversight. This framework allows providers to extend therapy duration and reach more patients without proportional increases in staffing or infrastructure. Why This Is First of Its Kind MindMaze Therapeutics’ reimbursement framework is considered first-of-its-kind because it:
This represents a fundamental shift from episodic rehabilitation models toward continuous, data-driven neurological care. Geography-Specific Reimbursement Strategy United States (US): Reimbursed Scale Through CMS Category III In the U.S., CAT III reimbursement provides the foundation for near-term commercial scale. It enables providers to deploy MindMaze Therapeutics’ solutions across post-acute, outpatient, and home-based settings, driving increased patient onboarding, longer therapy duration, and recurring utilization. It also serves as a strategic foundation toward potential Category I (CAT I) reimbursement in the future. Real-world evidence from national programs such as SwissNeuroRehab, and multi-site deployments with hospital partners are designed to support this progression. “Reimbursement is what allows innovation to reach patients at scale,” said Alexandre Capet, CEO of MindMaze Therapeutics. “Our Category III reimbursement enables expanded patient access and utilization, while our Swiss and international clinical programs generate the evidence required for durable, long-term reimbursement models. Together, these initiatives support our ambition to build a globally scalable, reimbursed neurotherapeutics platform.” Switzerland (CH): National Evidence Generation via Innosuisse In Switzerland, MindMaze Therapeutics participates in SwissNeuroRehab, a CHF 11.2 million Innosuisse-backed national flagship consortium involving leading Swiss university hospitals and rehabilitation centers. SwissNeuroRehab is part of Innosuisse’s national flagship initiatives designed to accelerate innovation with system-level impact:
As a technology partner, MindMaze Therapeutics supports the deployment and validation of advanced digital neurorehabilitation pathways across institutional and home-based settings, generating high-quality clinical and health-economic evidence aligned with payer and policy expectations. United Kingdom (UK): Guideline-Driven Market Access In the UK, MindMaze Therapeutics is aligning its evidence-generation strategy with NICE evaluation frameworks for digital health technologies. Engagement focuses on demonstrating clinical effectiveness, system efficiency, and scalability within the NHS, supporting future reimbursement and adoption discussions. Positioned for Long-Term Growth With 27+ completed clinical studies, 11 regulatory clearances across major markets, and a data engine processing more than 1.2 billion data points per month, MindMaze Therapeutics continues to strengthen its position in AI-powered neurorehabilitation. By aligning reimbursement history, real-world patient usage, and national-scale evidence generation, the Company is building a durable foundation for long-term value creation—expanding patient access today while supporting future reimbursement durability across global markets.
About MindMaze Therapeutics MindMaze Therapeutics is a Swiss-based, commercial-stage company formed in December 2025 through the business combination of RELIEF THERAPEUTICS Holding SA (Relief) and NeuroX Group SA. The Company develops and commercializes first-of-its-kind digital treatments for neurological diseases and brain disorders. Built on an advanced brain technology platform integrating software, sensors, and telehealth, its solutions are deployed globally across clinics and home settings. MindMaze Therapeutics’ clinically validated neurotherapeutics have demonstrated significant medico-economic outcomes across conditions such as stroke, Parkinson’s disease, and at-risk aging. The Company continues to expand its R&D pipeline into adjacent neurological indications, including multiple sclerosis, spinal cord injury, traumatic brain injury, and Alzheimer’s disease. The Company also manages Relief’s preexisting portfolio of clinical and commercial biopharmaceutical assets focused on rare dermatological, metabolic, and respiratory diseases. MindMaze Therapeutics is listed on the SIX Swiss Exchange under the ticker MMTX and quoted in the U.S. on OTCQB under RLFTF and RLFTY. For more information, visit www.mindmazetherapeutics.com. Disclaimer This press release contains forward-looking statements, which may be identified by words such as “believe,” “assume,” “expect,” “intend,” “may,” “could,” “will,” or similar expressions. These statements are based on current plans and assumptions and are subject to risks and uncertainties that could cause actual results, financial condition, performance, or achievements to differ materially from those expressed or implied. Such factors include, among others, business, economic, financial, regulatory, and competitive factors, as well as the Company’s ability to execute its strategy. This communication is provided as of the date hereof, and MindMaze Therapeutics undertakes no obligation to update any forward-looking statements contained herein as a result of new information, future events or otherwise. Additional features: File: Press release_MindMaze_Reimbursement Patients End of Media Release |
| Language: | English |
| Company: | Relief Therapeutics Holding SA |
| Avenue de Secheron 15 | |
| 1202 Geneva | |
| Switzerland | |
| Phone: | +41 22 545 11 16 |
| E-mail: | contact@relieftherapeutics.com |
| Internet: | https://relieftherapeutics.com |
| ISIN: | CH1251125998 |
| Valor: | 125112599 |
| Listed: | SIX Swiss Exchange |
| EQS News ID: | 2250446 |
| End of News | EQS News Service |
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2250446 23.12.2025 CET/CEST
Gerresheimer AG: Gerresheimer AG corrects comprehensively revenues from bill-and-hold agreements
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Gerresheimer AG / Key word(s): Annual Results Gerresheimer AG: Gerresheimer AG corrects comprehensively revenues from bill-and-hold agreements 22-Dec-2025 / 16:28 CET/CEST Disclosure of an inside information acc. to Article 17 MAR of the Regulation (EU) No 596/2014, transmitted by EQS News – a service of EQS Group. The issuer is solely responsible for the content of this announcement. Gerresheimer AG corrects comprehensively revenues from bill-and-hold agreements Duesseldorf, December 22, 2025. The Management Board of Gerresheimer AG (ISIN: DE000A0LD6E6, “Gerresheimer”) today decided to correct all revenues from bill-and-hold agreements recognized in the 2024 consolidated financial statements in the amount of approximately EUR 28m. Following the audit of the consolidated financial statements and group management report for the 2024 financial year initiated by BaFin, Gerresheimer AG commissioned an investigation by an independent external law firm. This investigation revealed that the recognition of revenues from bill-and-hold agreements consistently did not comply with IFRS requirements and that these revenues were systematically recognized too early. Gerresheimer AG will correct this accounting error in the previous year’s figures when preparing the 2025 consolidated financial statements. The revenues from bill-and-hold agreements of around EUR 28 million recognized in the 2024 consolidated financial statements will be corrected and recognized in the revenues for the 2025 financial year. This will be partially offset by the correction of revenues from bill-and-hold agreements from the 2023 financial year amounting to around EUR 10 million, which will now be recognized in revenues for the 2024 financial year. As a result of the correction of these revenues from bill-and-hold agreements, the revenue of EUR 2.036 billion reported for the 2024 financial year is expected to decrease by around 1% (around EUR 18 million), the reported adjusted EBITDA of EUR 419.4 million by around 1% (around EUR 5 million) and the reported adjusted EPS of EUR 4.67 by around 2% (around EUR 0.10). Gerresheimer AG will not include any revenues from new bill-and-hold agreements in its 2025 consolidated financial statements and will also refrain from this practice in the future. To the extent that such revenues were already included in the revenues figures of the financial information published during the 2025 financial year, they will be corrected in the respective subsequent publications in the 2026 financial year by adjusting the previous year’s figures. In the 2025 half-year financial report, this is expected to account for revenues of around 4 million euros. The company will continue to cooperate fully with BaFin in the audit of the 2024 consolidated financial statements and group management report. End of Inside Information Information and Explanation of the Issuer to this announcement: Contact Gerresheimer AG Investor Relations Media 22-Dec-2025 CET/CEST The EQS Distribution Services include Regulatory Announcements, Financial/Corporate News and Press Releases. |
| Language: | English |
| Company: | Gerresheimer AG |
| Peter-Müller-Str. 3 | |
| 40468 Duesseldorf | |
| Germany | |
| Phone: | +49-(0)211/61 81-00 |
| Fax: | +49-(0)211/61 81-121 |
| E-mail: | gerresheimer.ir@gerresheimer.com |
| Internet: | http://www.gerresheimer.com |
| ISIN: | DE000A0LD6E6 |
| WKN: | A0LD6E |
| Indices: | SDAX (Aktie) |
| Listed: | Regulated Market in Frankfurt (Prime Standard); Regulated Unofficial Market in Berlin, Dusseldorf, Hamburg, Hanover, Munich, Stuttgart, Tradegate Exchange |
| EQS News ID: | 2250372 |
| End of Announcement | EQS News Service |
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2250372 22-Dec-2025 CET/CEST
Cantourage Group SE expects EBITDA for 2025 to exceed current market expectations based on preliminary figures
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Cantourage Group SE / Key word(s): Miscellaneous Cantourage Group SE expects EBITDA for 2025 to exceed current market expectations based on preliminary figures 19-Dec-2025 / 14:39 CET/CEST Disclosure of an inside information acc. to Article 17 MAR of the Regulation (EU) No 596/2014, transmitted by EQS News – a service of EQS Group. The issuer is solely responsible for the content of this announcement. Berlin, 19 December 2025 – Cantourage Group SE (ISIN: DE000A3DSV01), based on an analysis of preliminary, unaudited consolidated financial figures and corresponding current projections, has determined that operating earnings (EBITDA) for the period from January to November 2025 amount to approximately EUR 5.5 million. Current market expectations (consensus of the two analyst firms covering the Company) for the full 2025 financial year stand at EUR 4.8 million EBITDA. According to the Management Board’s current assessment, EBITDA for the full 2025 financial year is expected to be in a range of EUR 5.5 million to EUR 6.5 million, thereby exceeding current market expectations. Cantourage Group SE will publish the final and audited figures for the 2025 financial year as scheduled as part of its regular financial reporting. End of Inside Information 19-Dec-2025 CET/CEST The EQS Distribution Services include Regulatory Announcements, Financial/Corporate News and Press Releases. |
| Language: | English |
| Company: | Cantourage Group SE |
| Feurigstraße 54 | |
| 10827 Berlin | |
| Germany | |
| E-mail: | info@cantourage.com |
| Internet: | https://www.cantourage.com/ |
| ISIN: | DE000A3DSV01 |
| WKN: | A3DSV0 |
| Listed: | Regulated Unofficial Market in Berlin, Dusseldorf, Frankfurt (Scale), Munich, Stuttgart, Tradegate Exchange |
| EQS News ID: | 2249332 |
| End of Announcement | EQS News Service |
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2249332 19-Dec-2025 CET/CEST
Biotest announces US FDA approval of Grifols’ Fesilty™ (fibrinogen, human-chmt)
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Biotest AG / Key word(s): Regulatory Approval Biotest announces US FDA approval of Grifols’ Fesilty™ (fibrinogen, human-chmt) 19.12.2025 / 12:00 CET/CEST The issuer is solely responsible for the content of this announcement. PRESS RELEASE
Biotest announces US FDA approval of Grifols’ Fesilty™ (fibrinogen, human-chmt)
Dreieich, 19 December 2025. Biotest AG, part of the Grifols group, today announced that Grifols has received approval from the U.S. Food and Drug Administration (FDA) for Fesilty™ (fibrinogen, human-chmt), which is manufactured by Biotest and will be commercialized in the U.S. by Grifols. Within the U.S., Fesilty™ is indicated for the treatment of acute bleeding episodes in pediatric and adult patients with congenital fibrinogen deficiency (CFD), including hypo- or afibrinogenemia. This approval will allow Grifols to launch this product in the first half of 2026. Human fibrinogen is one of the Biotest pipeline products that contributes a significant benefit to the whole Grifols group – now and in the future. Biotest received approval for human fibrinogen under the brand name Prufibry® in Germany in November. Additional approvals in Europe are expected in 2026. “This FDA approval marks a major achievement for both Biotest and Grifols,” said Dr. Jörg Schüttrumpf, Chief Executive Officer of Biotest AG. “We are proud that our plasma expertise contributes directly to expanding patient access to life-saving fibrinogen therapies in the treatment of critical conditions worldwide.” Manufactured at Biotest Next Level Human fibrinogen is produced at the Biotest Next Level (BNL) facility in Dreieich, Germany — one of the most advanced plasma protein production plants in Europe. The plant combines high efficiency, robust viral safety, and sustainability in the use of plasma as a raw material. A shared success within the Grifols Group As part of the Grifols group, Biotest plays a key role in advancing plasma-derived therapies from research to large-scale manufacturing. With Prufibry® already approved in Germany, and now Fesilty™ approved in the United States, the companies together expand access to fibrinogen replacement therapy for patients around the world.
About FesiltyTM Fesilty is a human fibrinogen product commercialized in the U.S. by Grifols and indicated for treatment of acute bleeding episodes in pediatric and adult patients with congenital fibrinogen deficiency, including hypo- or afibrinogenemia. It was developed and is manufactured by Biotest AG in Dreieich, Germany. The newly developed manufacturing process of the product leads to high-purity fibrinogen with a defined concentration, high level of viral safety and good solubility.
About fibrinogen and fibrinogen deficiency Fibrinogen is a blood clotting factor that is produced in the liver. It plays a key role in primary haemostasis (stopping blood loss from bleeding wounds) and wound healing. In case of a lack or shortage of fibrinogen blood’s ability to clot is impaired which leads to a much greater risk of bleeding and delayed haemostasis. The fibrinogen concentrate alternatives fresh frozen plasma (FFP) and cryoprecipitate contain variable amounts of fibrinogen and must be thawed prior to treatment. The defined amount of fibrinogen in the fibrinogen concentrate will allow a tailor-made, patient specific and highly effective therapy.
About Biotest Biotest is a provider of biological therapeutics derived from human plasma. With a value-added chain that extends from pre-clinical and clinical development to worldwide sales, Biotest has specialised primarily in the areas of clinical immunology, haematology and intensive care medicine. Biotest develops and markets immunoglobulins, coagulation factors and albumin based on human blood plasma. These are used for diseases of the immune and haematopoietic systems. Biotest has more than 2,600 employees worldwide. Since May 2022, Biotest has been a part of the Grifols Group, based in Barcelona, Spain (www.grifols.com).
IR contact Dr Monika Baumann (Buttkereit)
PR contact Miriam Oehme Biotest AG, Landsteinerstr. 5, 63303 Dreieich, Germany, www.biotest.com Ordinary shares: securities’ ID No. 522720; ISIN DE0005227201
Disclaimer
19.12.2025 CET/CEST Dissemination of a Corporate News, transmitted by EQS News – a service of EQS Group. The EQS Distribution Services include Regulatory Announcements, Financial/Corporate News and Press Releases. |
2249224 19.12.2025 CET/CEST
Abivax to be Added to Nasdaq Biotechnology Index
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ABIVAX / Key word(s): Miscellaneous Abivax to be Added to Nasdaq Biotechnology Index 18.12.2025 / 22:05 CET/CEST The issuer is solely responsible for the content of this announcement. Abivax to be Added to Nasdaq Biotechnology Index PARIS, France – December 18, 2025 – 10:05 pm CET – Abivax SA (Euronext Paris: FR0012333284 – ABVX / Nasdaq: ABVX) (“Abivax” or the “Company”), a clinical-stage biotechnology company focused on developing therapeutics that harness the body’s natural regulatory mechanisms to stabilize the immune response in patients with chronic inflammatory diseases, today announced that it will be added to the Nasdaq Biotechnology Index (Nasdaq: NBI), effective prior to market open on Monday, December 22, 2025. Didier Blondel, Chief Financial Officer of Abivax commented: “Our inclusion in the Nasdaq Biotechnology Index marks a significant milestone for Abivax. It highlights the meaningful progress we’ve made as a company, particularly in advancing obefazimod through the successful Phase 3 ABTECT Induction trials for ulcerative colitis and reflects the increased visibility and perception of Abivax within the global biotechnology community.” The NBI is designed to track the performance of a set of securities listed on The Nasdaq Stock Market® that are classified as either biotechnology or pharmaceutical companies according to the Industry Classification Benchmark. Companies in the Nasdaq Biotechnology Index must meet eligibility requirements, including minimum market capitalization, average daily trading volume and seasoning as a public company, among other criteria. The NBI is evaluated annually in December and is calculated under a modified capitalization-weighted methodology. For more information about the NBI, visit: https://indexes.nasdaqomx.com/Index/Overview/NBI About Abivax Abivax is a clinical-stage biotechnology company focused on developing therapeutics that harness the body’s natural regulatory mechanisms to stabilize the immune response in patients with chronic inflammatory diseases. Based in France and the United States, Abivax’s lead drug candidate, obefazimod (ABX464), is in Phase 3 clinical trials for the treatment of moderately to severely active ulcerative colitis.
18.12.2025 CET/CEST Dissemination of a Corporate News, transmitted by EQS News – a service of EQS Group. The EQS Distribution Services include Regulatory Announcements, Financial/Corporate News and Press Releases. |
2248368 18.12.2025 CET/CEST
DOUGLAS Group achieves solid sales growth and doubles net income in volatile financial year 2024/25
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Douglas AG / Key word(s): Annual Results/Annual Report DOUGLAS Group achieves solid sales growth and doubles net income in volatile financial year 2024/25 18.12.2025 / 07:30 CET/CEST The issuer is solely responsible for the content of this announcement. Q4 & Full-Year 2024/25 (October 2024 – September 2025) DOUGLAS Group achieves solid sales growth and doubles net income in volatile financial year 2024/25
Düsseldorf, 18 December, 2025 – The DOUGLAS Group, Europe’s number one premium beauty retailer, has concluded the financial year 2024/25 with solid growth in sales and in line with its updated guidance. While the financial year got off to a good start in the first quarter (October – December 2024), consumer sentiment and spendings slowed down during the early months of 2025, especially in Germany and France. Following a turnaround in the third quarter, the July to September period saw a push in the E-Com business – overall profitability however was under pressure due to the challenging market conditions. For the full year and thanks in particular to significantly lower debt, the DOUGLAS Group more than doubled its net income. At the same time, it made major progress in the implementation of its targeted omnichannel strategy “Let it Bloom”. Sander van der Laan, CEO DOUGLAS Group: “In a very volatile and thus challenging year, we have accomplished results within expectations. Going forward, we anticipate solid overall growth in Europe’s premium beauty market, but observe a changing consumer behavior compared to the highly dynamic post-pandemic years. As a leading player, we want to take advantage of the opportunities in this phase of market consolidation and rebalancing. We have the strength and ambition to further grow and also expect momentum from the ongoing expansion of our store network and by tapping into new markets – also outside of continental Europe. That’s why we consider a market entry in the Middle East where we see a great potential for our premium beauty business.” FY 2024/25 results in line with expectations In the financial year 2024/25, sales grew by 2.8%, or 3.5% excluding the sold-off online pharmacy Disapo, to 4.58 billion euros. Both stores with 2.5% (lfl: +0.2%) and E‑Com with 5.6% (excluding Disapo) contributed to overall growth. Sales from cross-channel services like Click & Collect Express – allocated to E-Com sales – have also developed exceptionally well. Reported EBITDA was up 3.6%, amounting to 756.5 million euros and a rep. EBITDA margin of 16.5% (PY: 16.4%). Adjusted EBITDA declined 5.0% to 768.4 million euros and a margin of 16.8% (PY: 18.2%), also reflecting lower adjustments. Net income more than doubled to 175.4 million euros (PY: 84.0 million euros). Free Cash Flow was down -12.0% to 461.0 million euros (PY: 524.0 million euros). Average net working capital as a percentage of LTM Group sales improved to 4.4% (PY: 5.3%). The DOUGLAS Group therefore achieved its guidance for the financial year 2024/25 – as updated on 20 March 2025 to reflect the changed market environment – across all four KPIs. Final quarter of the financial year marked by strong E-Com performance The DOUGLAS Group concluded the financial year with a solid fourth quarter: Group sales increased by 2.3%, or 2.6% excluding Disapo, to 981.9 million euros (lfl: +1.2%). Growth was driven by a strong E-Com performance, whereas the increase in store sales was attributed to the expansion of the network. All segments contributed positively to total sales. In the French market, which has been facing a downward trend, NOCIBÉ improved its position and gained share, and the DOUGLAS Group also gained share in the slightly growing German premium market year in the financial year 2024/25. Store sales rose 0.6% year-on-year. Performance varied between segments: Compared to the prior-year period, sales increased in Central Eastern Europe (+6.4%) and Southern Europe (+2.2%), and were in line in the DACHNL region (-0.3%). In France, stationary sales saw a slight decline (-1.5%). E-Com sales surged almost everywhere in Q4, accumulating to a 6.2% improvement year-on-year, or 7.3% excluding Disapo. Beyond the online pure player segment Parfumdreams / Niche Beauty (+17.5%), Central Eastern Europe (+13.8%) and France (+11.0%) showed the biggest growth rates. Consistently tight cost management supported profitability in the fourth quarter; however, the gross margin was impacted by changing consumer behavior including higher price sensitivity, ongoing promotional competition and lower supplier bonuses. Reported EBITDA went down 15.1% to 129.8 million euros, corresponding to an EBITDA margin of 13.2% (PY: 15.9%). Adj. EBITDA decreased by 11.4% to 134.3 million euros, resulting in a margin of 13.7% (PY: 15.8%). Net leverage stood at 2.9x as of 30 September 2025 (30 September 2024: 2.8x), or 2.1x before IFRS16. Targeted investments in growth initiatives and operational efficiency To support its growth ambitions in a further evolving and rebalancing market environment, the Group continues to invest in strategic initiatives – including in IT capabilities, supply chain excellence and harmonized processes and systems across the entire organization to achieve a higher degree of standardization and operational efficiency. Moreover, the company evaluates and tests the use of artificial intelligence in different areas such as marketing or the user experience in the online shop. Sander van der Laan: “We firmly believe in ‘Let it Bloom’ as the right strategy for us and omnichannel as the winning model for beauty retail. As we set our eyes on profitable growth, we continue to invest in the initiatives that will drive our business and efficiency – such as IT, E-Com and expansion.” Potential expansion beyond continental Europe The DOUGLAS Group is considering to expand beyond continental Europe and currently evaluates a market entry in the Middle East. With their thriving retail landscapes, rapidly developing economies, and a customer base with strong purchasing power, the GCC countries are predestined for the DOUGLAS Group’s premium beauty offering. A final decision will be made in the course of 2026. Milestones across several strategic initiatives In line with its commitment to the stationary shopping experience, the DOUGLAS Group continues to develop its store network: It has opened 35 new own stores (net) between July and September 2025, including the first flagship store in Tallinn, Estonia, and a new DOUGLAS store in the Swiss capital Bern. 36 existing own stores were refurbished (including relocations). In total, the company has refurbished 139 existing own stores (including relocations) and opened 74 new own stores (net) in 2024/25, elevating the number of stores as of 30 September 2025 to 1,959 (including franchise). The Group has also achieved milestones in a number of further strategic initiatives: It has introduced three new exclusive brands (NEST, Iräye, Drybar) in Q4 and launched a new brand campaign platform to drive consistent and coherent communication across all 22 omnichannel countries. Furthermore, it has made good progress in the rollout of its OWAC (“One Warehouse, All Channels”) supply chain model and getting fulfilment ready for future growth: The fifth OWAC warehouse near Warsaw, Poland, has commenced operations in August, enhancing service quality, delivery times and the customer experience. The OWAC currently handles all B2C orders and store deliveries in Poland and will serve six additional countries in the future. In Italy, OWAC operations transitioned to a modern and highly automated new warehouse: The move, while temporarily affecting the service rate during ramp-up, is expected to lead to significantly reduced logistics expenses. Finally, the company has recently signed a contract for its sixth OWAC warehouse in the Netherlands for the BENE region. Guidance for financial year 2025/26 and mid-term targets In light of the economic and market conditions leading to high price sensitivity among consumers, the DOUGLAS Group has provided its guidance for the financial year 2025/26 and expects sales between 4.65 and 4.80 billion euros, an adj. EBITDA margin of around 16.5%, and a net leverage between 2.5x and 3.0x as of 30 September 2026. As key components to deliver on the latter, the company anticipates positive developments in average net working capital – expected below 4% of LTM sales – and capex (excl. leases), which are expected to be around 150 million euros. Reflecting the focus on profitable growth, the Group also provided its mid-term targets for the next three years and expects to annually increase sales in the low- to mid-single-digits, sustain a stable adj. EBITDA margin, and reduce the net leverage to a range of 2.0x to 2.5x. The company anticipates to be in a position to consider paying a dividend at a net leverage of 2.0x to 2.5x. Van der Laan: “Thanks to our dedicated employees, loyal customers and the strong relationships with our business partners, we have weathered a challenging year. Our markets evolve in a difficult environment, and we are well positioned to continue growing due to our effective omnichannel model and outstanding retail brands. We rely on our strengths and the strategic course we have set.” Solid start into 2025/26 – trading statement on 19 January The DOUGLAS Group has achieved a solid start into the new financial year 2025/26 and will provide more info on the performance in the first quarter in a trading statement on 19 January 2026.
Overview Financial Results (Q4 2024/25)
Overview Financial Results FY 2024/25
Segment Overview: DACHNL (Austria, Belgium, Germany, Switzerland, The Netherlands), France (France, Monaco), SE / Southern Europe (Andorra, Croatia, Italy, Portugal, Slovenia, Spain), CEE / Central Eastern Europe (Bulgaria, Czech Republic, Estonia, Hungary, Latvia, Lithuania, Poland, Romania, Slovakia), PD/NB (Parfumdreams, Niche Beauty) X-Channel refers to cross-channel services, e.g. Click & Collect Express.
About the DOUGLAS Group The DOUGLAS Group, with its commercial brands DOUGLAS, NOCIBÉ, Parfumdreams and Niche Beauty, is the number one omnichannel premium beauty destination in Europe. The DOUGLAS Group is inspiring customers to live their own kind of beauty by offering a unique assortment online and in around 1,960 stores. With unparalleled size and access to customers, the DOUGLAS Group is the partner of choice for brands and offers a premium range of selective and exclusive brands as well as own corporate brands. The assortment includes fragrances, color cosmetics, skin care, hair care, accessories as well as beauty services. Strengthening its successful omnichannel positioning while consistently developing superior customer experience is at the heart of the DOUGLAS Group strategy “Let it Bloom”. The winning business model is underpinned by the Group’s omnichannel proposition, leading brands, and data capabilities. In the financial year 2024/25, the DOUGLAS Group generated sales of 4.58 billion euros and employed more than 19,900 people across Europe. The DOUGLAS Group (Douglas AG) is listed at the Frankfurt Stock Exchange. For further information please visit the DOUGLAS Group Website. Press Contact Peter Wübben Investor Contact Dafne Sanac
18.12.2025 CET/CEST Dissemination of a Corporate News, transmitted by EQS News – a service of EQS Group. The EQS Distribution Services include Regulatory Announcements, Financial/Corporate News and Press Releases. |
| Language: | English |
| Company: | Douglas AG |
| Luise-Rainer-Strasse 7-11 | |
| 40235 Düsseldorf | |
| Germany | |
| ISIN: | DE000BEAU1Y4 |
| WKN: | BEAU1Y |
| Indices: | SDAX |
| Listed: | Regulated Market in Frankfurt (Prime Standard); Regulated Unofficial Market in Berlin, Dusseldorf, Hamburg, Hanover, Munich, Stuttgart, Tradegate Exchange |
| EQS News ID: | 2247752 |
| End of News | EQS News Service |
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2247752 18.12.2025 CET/CEST

