Not for release, publication or distribution, directly or indirectly, in or intothe United States of America, Australia, Canada or Japan or any otherjurisdiction in which such release, publication or distribution would be unlawful. The important notes at the end of this announcement need to be observed.

• Consistent implementation of Cantourage’s European growth strategy
• Positioning as a premium partner in Poland’s medical cannabis market
• Additional products for the Polish market currently in the registration process

Berlin, 4 November 2025 – Cantourage Group SE continues to expand its activities in the European medical cannabis market and is launching the “Gelato 33” strain from Canadian cultivator LOT420 in Poland for the first time. Following the successful introduction of the strain MAC 1 at the end of 2024, Cantourage’s collaboration with Polish wholesaler PharmaVitae continues to expand.

The Polish market experienced a temporary slowdown at the end of 2024 following regulatory changes – particularly restrictions on online prescriptions. However, market observers expect demand to recover significantly over the course of 2025 and reach new record levels in 2026.

Together with PharmaVitae, Cantourage is preparing for this anticipated growth. The two partners aim to at least double sales next year – from around 500 kilograms in 2025 to over one tonne of cannabis flowers in 2026. In addition to the now available Gelato 33 and MAC 1 varieties, four other products that are already in high demand in Germany are currently undergoing the approval process for the Polish market.

“Poland is increasingly becoming one of the most exciting European markets,” says Philip Schetter, CEO of Cantourage. “Together with PharmaVitae, we are building on an extremely successful first year. The strong demand shows that our commitment to quality resonates internationally.”

Malgożata Leman-Borsuk, CEO of PharmaVitae, adds: “Our partnership with Cantourage has proven to be extraordinarily successful from the start. With Gelato 33, we are expanding our portfolio with another strain that has great potential in Poland.”

The Canadian cultivator LOT420 is also pleased to see its products becoming available in yet another country: “At LOT420 we strive to provide patients with the best quality cannabis, being able to expand our products into a new country is always a great honor. We hope that our Gelato 33 cultivar will be well received by Poland’s medical patients and become a staple within the medical cannabis community,” says Stefan Macdonald, CEO of LOT420.

In light of the ongoing discussion about potential regulatory changes in its home market Germany, Cantourage is increasingly focusing on diversifying across Europe. At the same time, the company remains confident that Germany will continue to be its most important market. The current market developments in Poland, in particular, demonstrate that demand for high-quality and safe medical cannabis products continues to grow – regardless of the distribution channel.

About Cantourage
Cantourage is a leading European producer and distributor of cannabis flowers and cannabis-based medicinal preparations and drugs. The Berlin-based company was founded in 2019 by industry pioneers Norman Ruchholtz, Dr. Florian Holzapfel and Patrick Hoffmann. With an experienced management team and its “Fast Track Access” platform, Cantourage enables producers from around the world to become part of the growing European medical cannabis market faster, easier and more cost-effectively by processing and distributing their cannabis raw materials and extracts. In this context, Cantourage ensures compliance with the highest European pharmaceutical quality standards at all times. The company offers pharmaceutical-grade products in all relevant market segments: dried flower, extracts, dronabinol and cannabidiol. Cantourage was listed on the Frankfurt Stock Exchange on 11 November 2022 – ISIN: DE000A3DSV01.

Further information: www.cantourage.com

About PharmaVitae
PharmaVitae is a privately owner Polish company founded in 2011 that specializes in the import and distribution of Rx and OTC pharmaceuticals, medical devices and cosmetics. The company supplies pharmacies, doctors, hospitals, clinics and drugstores throughout Poland and reported annual salesof PLN 80 million in 2023. PharmaVitae ensures efficient and reliable distribution with its modern, WDL-certified warehouse that meets all GDP requirements and can accommodate up to 2,000 pallets.

Further information: www.pharmavitae.com.pl

Investor Relations contact at Cantourage

Manuel Taverne
taverne@cantourage.com

This announcement does not constitute a public offer or an advertisement for a public offer to sell securities, in particular not within the meaning of Regulation (EU) 2017/1129 (Prospectus Regulation).

Abivax Announces Patient-Reported Outcomes Data from the Phase 3 ABTECT Induction Trials of Obefazimod, Demonstrating Significant Improvements in Quality of Life for Patients with Moderate-to-Severely Active Ulcerative Colitis

• Improvements across all patient reported outcomes (PROs) were observed from baseline to Week 8 in all PRO instruments utilized in the ABTECT induction trials evaluating bowel urgency, sleep interruption, fatigue, quality of life, and work productivity for both 50mg and 25mg once-daily obefazimod. 
• At week 8 in the ABTECT 1 & 2 trials, 37% of patients taking once daily 50mg obefazimod reported no bowel urgency (BU) compared to 18.1% of patients in the placebo group (18.9, p<0.0001[1]), with improvements in BU observed as early as week two
• 47.6% of patients on 50mg obefazimod reported no nocturnal bowel movements (NBM) at week 8 compared to 24.7% in the placebo group (23.1, p<0.0001¹)
• In the 50 mg group 17.1% of patients reported fatigue remission as measured with the Fatigue Numerical Rating Scale (NRS) at week 8, compared to 7.7% in the placebo group ( 9.5, p=0.0001¹)
• Detailed data across PROs, including data for both 25mg and 50mg groups, to be submitted for presentation at upcoming medical meetings

PARIS, France – November 3, 2025 – 10:05 PM CET – Abivax SA (Euronext Paris: FR0012333284 – ABVX / Nasdaq: ABVX) (“Abivax” or the “Company”), a clinical-stage biotechnology company focused on developing therapeutics that harness the body’s natural regulatory mechanisms to stabilize the immune response in patients with chronic inflammatory diseases, today announced patient-reported outcomes (PRO) from its Phase 3 ABTECT 8-week induction trials evaluating obefazimod in adult patients with moderate-to-severely active ulcerative colitis (UC). In addition to the trials’ clinical efficacy endpoints, PRO instruments are important in determining how patients perceived changes in their symptoms, quality of life, and activities of daily living.

“Ulcerative colitis can be a devastating condition that affects every aspect of a person’s daily life, including their ability to work, socialize, and maintain their emotional well-being,” said Marla Dubinsky, MD[2], Professor of Pediatrics and Medicine, Chief, Division of Pediatric Gastroenterology and Nutrition, Co-Director, Susan and Leonard Feinstein IBD Clinical Center, Mount Sinai Kravis Children’s Hospital, Icahn School of Medicine Mount Sinai New York. “For these patients, improvement isn’t just about controlling inflammation, it’s about regaining a sense of normalcy. That’s why measures of quality of life are so important when evaluating potential new therapies so that we also capture the outcomes that truly matter to patients, and bowel urgency is one of these key factors. The consistency of improvements across all PRO instruments utilized in this program underscores the meaningful benefit obefazimod provided to patients’ daily experience and supports the positive Phase 3 efficacy results observed at week 8. Together, these results highlight obefazimod’s potential to meaningfully advance care for patients with UC.”

PRO instruments evaluated in the ABTECT trials include:

• Bowel urgency
• Nocturnal bowel movement
• Fatigue numerical rating scale (NRS)
• Fatigue and ability to function (FACIT-F)
• Inflammatory bowel disease questionnaire (IBDQ)
• Overall quality of life (EQ-5D-5L)
• Workplace productivity (WPAI Domains)

Detailed analysis of these PROs will be submitted for presentation at an upcoming medical conference. 

Marc de Garidel, MBA, Chief Executive Officer of Abivax, commented, “The data shared today further support obefazimod’s potential as a meaningful treatment option for patients with ulcerative colitis (UC). Our development efforts, guided by the recognized need for more effective and tolerable long-term therapies, are focused on advancing treatments that can significantly improve patients’ quality of life. Taken together with the previously reported positive ABTECT 8-week induction trial results, we are one step closer to realizing this goal. We will be submitting more detailed aspects of this dataset for presentation at an upcoming medical meeting and look forward to sharing results from our 44-week maintenance trial in the second quarter of 2026.”

About Abivax

Abivax is a clinical-stage biotechnology company focused on developing therapeutics that harness the body’s natural regulatory mechanisms to stabilize the immune response in patients with chronic inflammatory diseases. Based in France and the United States, Abivax’s lead drug candidate, obefazimod (ABX464), is in Phase 3 clinical trials for the treatment of moderately to severely active ulcerative colitis.

Contact:

Patrick Malloy
SVP, Investor Relations
Abivax SA
patrick.malloy@abivax.com
+1 847 987 4878

FORWARD-LOOKING STATEMENTS

This press release contains forward-looking statements, forecasts and estimates, including those relating to the Company’s business. Words such as “anticipate,” “expect,” “potential” and variations of such words and similar expressions are intended to identify forward-looking statements. These forward-looking statements include statements concerning the Company’s anticipated timing for data readouts of its ABTECT induction and maintenance clinical trials and the potential therapeutic benefit of obefazimod. Although Abivax’s management believes that the expectations reflected in such forward-looking statements are reasonable, investors are cautioned that forward-looking information and statements are subject to various risks, contingencies and uncertainties, many of which are difficult to predict and generally beyond the control of Abivax, that could cause actual results and developments to differ materially from those expressed in, or implied or projected by, the forward-looking information and statements. A description of these risks, contingencies and uncertainties can be found in the documents filed by the Company with the French Autorité des Marchés Financiers pursuant to its legal obligations including its universal registration document (Document d’Enregistrement Universel) and in its Annual Report on Form 20-F filed with the U.S. Securities and Exchange Commission on March 24, 2025 under the caption “Risk Factors.” These risks, contingencies and uncertainties include, among other things, the uncertainties inherent in research and development, future clinical data and analysis, decisions by regulatory authorities, such as the FDA or the EMA, regarding whether and when to approve any drug candidate, as well as their decisions regarding labelling and other matters that could affect the availability or commercial potential of such product candidates, and the availability of funding sufficient for the Company’s foreseeable and unforeseeable operating expenses and capital expenditure requirements. Special consideration should be given to the potential hurdles of clinical and pharmaceutical development, including further assessment by the Company and regulatory agencies and IRBs/ethics committees following the assessment of preclinical, pharmacokinetic, carcinogenicity, toxicity, CMC and clinical data. Furthermore, these forward-looking statements, forecasts and estimates are made only as of the date of this press release. Readers are cautioned not to place undue reliance on these forward-looking statements. Abivax disclaims any obligation to update these forward-looking statements, forecasts or estimates to reflect any subsequent changes that the Company becomes aware of, except as required by law. Information about pharmaceutical products (including products currently in development) that is included in this press release is not intended to constitute an advertisement. This press release is for information purposes only, and the information contained herein does not constitute either an offer to sell or the solicitation of an offer to purchase or subscribe for securities of the Company in any jurisdiction. Similarly, it does not give and should not be treated as giving investment advice. It has no connection with the investment objectives, financial situation or specific needs of any recipient. It should not be regarded by recipients as a substitute for exercise of their own judgment. All opinions expressed herein are subject to change without notice. The distribution of this document may be restricted by law in certain jurisdictions. Persons into whose possession this document comes are required to inform themselves about and to observe any such restrictions.  

[1] ABTECT-1&2 pooled analysis; all p-values are nominal.  Endpoints are secondary and not alpha controlled.

[2] Marla Dubinsky, MD is a paid consultant for Abivax.

Press release 

Thomas Meier becomes new CEO of Medios AG

Berlin, November 3, 2025 – The Supervisory Board of Medios AG has appointed Thomas Meier as a member of the Executive Board with effect from February 1, 2026, and designated him the new Chief Executive Officer (CEO) of the Company. He succeeds Matthias Gaertner, who will remain in office until December 31, 2025.

Thomas Meier has been CEO of the Swiss CDMO (Contract Development and Manufacturing Organization) company Bachem Holding AG, which is also listed on the stock exchange, since 2020. Prior to this, he was Chief Operations Officer on the Executive Board of Bachem and worked as Head of Manufacturing at Peninsula Laboratories in San Carlos, California, USA, from 2001 to 2004. Thomas Meier will play a key role in driving the further growth of the Medios Group.

Dr. Yann Samson, Chairman of the Supervisory Board of Medios AG: “With Thomas Meier, we are gaining an internationally experienced leader with a strong track record of capital-efficient, profitable growth. We warmly welcome him and are convinced that his entrepreneurial spirit, expertise and leadership will contribute significantly to achieving our ambitious goals and sustainably increasing value for shareholders, partners, and customers. At the same time, on behalf of the entire Supervisory Board, I would like to express my sincere thanks to Matthias Gaertner for his outstanding work and great commitment over the past ten years. He has had a decisive influence on the growth and success of Medios.”

Thomas Meier: “I am very much looking forward to the task of leading Medios into its next phase of development. Together with my colleagues on the Executive Board and the entire Medios team, I will continue to consistently develop the successful strategy and sustainably expand Medios’ position in the European Specialty Pharma market.”
 

Important dates for Medios in the 2025 financial year

——————-

About Medios AG

Medios is a leading provider of Specialty Pharma in Europe. With locations in Germany, the Netherlands, Belgium and Spain, the Company supports key partners in the supply chain with innovative solutions and intelligent services. Medios has focused on pioneering individualized medicine to make the most innovative therapies available to everyone together with pharmacies, specialist practices and pharmaceutical companies.

Medios AG is Germany’s first listed specialty pharmaceutical Company. The shares (ISIN: DE000A1MMCC8) are listed on the regulated market of the Frankfurt Stock Exchange (Prime Standard) and are included in the SDAX selection index.

www.medios.group 

More information on the topic of individualized medicine: https://app.medios.group/en/individualizedmedicine
 

Contact

Claudia Nickolaus

Head of Investor & Public Relations, ESG Communications

Medios AG

Heidestraße 9 | 10557 Berlin

T +49 30 232 566 800

ir@medios.group

www.medios.group

PRESS RELEASE

Heidelberg Pharma to Present New Clinical Data of Lead ADC Candidate HDP-101 at the World ADC Congress 2025 and to Host Webinar

• Objective responses and promising anti-tumor activity observed in several patients across multiple cohorts in the ongoing Phase I/IIa clinical trial
• Data reinforces the therapeutic potential and safety profile of HDP-101 in relapsed or refractory multiple myeloma.
• R&D Webinar to be hosted on 11 November 2025 at 05:00 pm CET (08:00 am PST)

Ladenburg, Germany, 3 November 2025 – Heidelberg Pharma AG (FSE: HPHA), a clinical-stage developer of innovative Antibody Drug Conjugates (ADCs), today announced the presentation of new clinical data from its ongoing Phase I/IIa clinical study evaluating its lead Amanitin-based ADC candidate, HDP-101 (INN: pamlectabart tismanitin), at the 16^th Annual World ADC Congress, taking place in San Diego, California, from 3 to 6 November 2025.

HDP-101 (INN: pamlectabart tismanitin) is an anti-BCMA antibody-drug conjugate being investigated for the treatment of relapsed or refractory multiple myeloma, a bone marrow cancer with a high unmet medical need. Phase I of the ongoing study is a dose-escalation trial designed to determine the optimal and safe dose level of HDP-101 in preparation for subsequent Phase II clinical evaluation.

Professor Andreas Pahl, Chief Executive Officer of Heidelberg Pharma, will present an update from patient cohort 8 including efficacy data of the open-label, multicenter Phase I/IIa study evaluating HDP-101 in patients with relapsed or refractory multiple myeloma.

Details of the presentation at 16^th Annual World ADC Congress:

Presentation title: From Bench to Breakthrough: The Evolution of Amanitin ADCs – Insights from HDP-101 Phase I/II & the Future of Payload Differentiation

R&D Webinar to take place with Key Opinion Leader

Following the World ADC Congress, Heidelberg Pharma will host an R&D webinar on 11 November 2025 at 05:00 pm CET (11:00 am EST; 08:00 am PST), for investors, analysts, and media.

The R&D webinar will feature presentations by the Heidelberg Pharma management team, alongside Key Opinion Leader (KOL) Professor Marc-Steffen Raab, Head of the Myeloma Center at the University Hospital Heidelberg and clinical investigator of the study.

Webinar participants will have the opportunity to submit questions in advance of the webinar or ask questions live during the event.

For further information on the R&D webinar, or to register your attendance, please use the link below:

https://us06web.zoom.us/webinar/register/WN_AG_mESPaT-aSsm8_O2DllA

A recording of the R&D webinar will be accessible via the press & investor section of the Company website after the event.

About Heidelberg Pharma

Heidelberg Pharma is a biopharmaceutical company working on a new treatment approach in oncology and developing novel drugs based on its ADC technologies for the targeted and highly effective treatment of cancer. ADCs are antibody-drug conjugates that combine the specificity of antibodies with the efficacy of toxins to fight cancer. Selected antibodies are loaded with cytotoxic compounds, the so-called payloads, that are transported into diseased cells. Inside the cells, the toxins then unleash their effect and kill the diseased cells.

Heidelberg Pharma is the first company to use the compound Amanitin from the green death cap mushroom in cancer therapy. The biological mechanism of action of the toxin represents a new therapeutic modality and is used as a compound in the Amanitin-based ADC technology, the so-called ATAC technology.

The lead candidate HDP-101 is a BCMA ATAC in clinical development for multiple myeloma. A second ATAC candidate, HDP-102, has recently started clinical development in Non-Hodgkin Lymphoma and is currently on a temporary hold. HDP-103 against metastatic castration-resistant prostate cancer and HDP-104 targeting gastrointestinal tumors such as colorectal cancer have completed preclinical development. Heidelberg Pharma is open for partnering.

The company is based in Ladenburg, Germany, and is listed on the Frankfurt Stock Exchange: ISIN DE000A11QVV0 / WKN A11QVV / Symbol HPHA. More information is available at www.heidelberg-pharma.com

ATAC^® is a registered trademark of Heidelberg Pharma Research GmbH.

This communication contains certain forward-looking statements relating to the Company’s business, which can be identified by the use of forward-looking terminology such as “estimates”, “believes”, “expects”, “may”, “will”, “should”, “future”, “potential” or similar expressions or by a general discussion of the Company’s strategy, plans or intentions. Such forward-looking statements involve known and unknown risks, uncertainties and other factors, which may cause our actual results of operations, financial condition, performance, achievements, or industry results, to be materially different from any future results, performance or achievements expressed or implied by such forward-looking statements. Given these uncertainties, prospective investors and partners are cautioned not to place undue reliance on such forward-looking statements. We disclaim any obligation to update any such forward-looking statements to reflect future events or developments.

Ad hoc announcement pursuant to Art. 53 LR

Fribourg, 3 November 2025

AEVIS VICTORIA SA (AEVS.SW) – Continued revenue growth in the third quarter of 2025

Consolidated growth of 18.2%, driven by the Healthcare and Hospitality divisions. Adjusted organic growth of 2.6%.

AEVIS VICTORIA SA (AEVIS) achieved consolidated gross revenue of CHF 899.2 million in the first nine months of 2025, compared to CHF 761.0 million in the same period of 2024, representing total growth of 18.2%. Net revenue amounted to CHF 789.9 million (3Q2024: CHF 668.6 million), up 18.1%, including adjusted organic growth of 1.5%.

Healthcare: sustained growth and successful integration of new entities
With its 21 hospitals and its outpatient centers, Swiss Medical Network generated gross revenue of CHF 722.6 million (3Q2024: CHF 594.9 million), up 21.5%. Adjusted organic growth reached 3.3%, supported by the expansion of the outpatient network and the full integration of Spital Zofingen, CentroMedico in Ticino, and several medical practices in German-speaking Switzerland. Swiss Medical Network is continuing its expansion in integrated care, with the extension of the integrated care model to a third region, Aare Netz – the first in German-speaking Switzerland – on 1 January 2026.

Viva Health: Attractive premiums in all cantons within the integrated care regions
VIVA Health, the alternative basic insurance product developed in collaboration with insurer Visana, is entering its third year with the lowest premiums on the market in most categories and cantons. Viva is available in the Jura Arc, Ticino, and Zofingen/Aarau regions.

Hospitality: positive momentum maintained
MRH Switzerland AG, the group’s hotel division managed by Michel Reybier Hospitality, generated gross revenue of CHF 157.4 million (3Q2024: CHF 151.6 million), up 3.8%. Organic growth was supported by excellent performance across all establishments. The winter season, starting on 12 December 2025, looks promising, as Switzerland continues to strengthen its appeal as a travel destination. The hotel portfolio has remained unchanged at eleven properties.

Real Estate: strong contribution driven by apartment sales in Zermatt
The Real Estate division, represented by Swiss Hotel Properties SA, recorded revenue of CHF 36.1 million (3Q2024: CHF 24.0 million), up 50.5%. This increase was mainly due to the sale of apartments in Zermatt, around one-third of which have already been sold. The remaining units will be marketed by the end of the winter season (1Q2026), further supporting the division’s revenue in the next quarter.

Strategic options under review
AEVIS VICTORIA is currently exploring various strategic options for its subsidiaries, particularly Swiss Medical Network and Infracore, to support their long-term development. Swiss Medical Network aims to cover all regions where it operates with its integrated care offering and with Viva, the alternative basic insurance product developed with Visana. In this context, AEVIS plans to welcome new strategic shareholders and intends to reduce its participation in Swiss Medical Network in order to strengthen the independence of the Swiss integrated care group. In parallel, Infracore is exploring various opportunities to open up its capital base, potentially including a listing, to meet the growing demand for sale-and-leaseback solutions in the public and private hospital market in Switzerland.

For further information:
AEVIS VICTORIA SA Media and Investor Relations: c/o Dynamics Group, Zurich
Philippe R. Blangey, prb@dynamicsgroup.ch, +41 (0) 43 268 32 35 or +41 (0) 79 785 46 32
Séverine Van der Schueren, svanderschueren@aevis.com, +41 (0) 79 635 04 10

AEVIS VICTORIA SA – Investing for a better life
AEVIS VICTORIA SA invests in healthcare, hospitality & lifestyle and infrastructure. AEVIS′s main shareholdings are Swiss Medical Network Holding SA (76.3%, directly and indirectly), the only Swiss private network of hospitals present in the country’s three main language regions, MRH Switzerland AG, a luxury hotel group managing eleven hotels in Switzerland and abroad, Infracore SA (30%, directly and indirectly), a real estate company dedicated to healthcare-related infrastructure, Swiss Hotel Properties SA, a hospitality real estate division, and NESCENS SA, a brand dedicated to better aging. AEVIS is listed on the Swiss Reporting Standard of the SIX Swiss Exchange (AEVS.SW).
www.aevis.com.

STRATEC REPORTS SUPPLY CHAIN-RELATED PRODUCTION DELAYS, ADJUSTMENT TO 2025 SALES GUIDANCE AND PRELIMINARY RESULTS FOR 9M/2025

Birkenfeld, October 30, 2025

STRATEC SE, Birkenfeld, Germany (Frankfurt: SBS; Prime Standard, SDAX), expects to witness temporary interruptions to the supply of input materials for some of its system lines in the fourth quarter of 2025. In particular, in connection with trade policy tensions a supply chain interruption has arisen in recent weeks for a specific type of magnet with impurities relating to export-restricted rare earths (0.1% share of affected production batch). Against this backdrop, delivery backlogs already arose for system deliveries in the third quarter of 2025. Following close communication with its suppliers, STRATEC now no longer expects to receive sufficient quantities of input materials to make up for these delivery backlogs or for the production volumes originally planned for the fourth quarter of 2025. Furthermore, global tariff conflicts are leading to greater fluctuations in customers’ order behavior and to associated inventory optimization measures. These particularly affect the Service Parts and Consumables business.

In view of these factors, the Board of Management has decided to adjust its sales guidance for the 2025 financial year. STRATEC now expects its consolidated sales at constant currency to approximately match the previous year’s figure (previously: “consolidated sales at constant currency to show growth in a low to medium single-digit percentage range”). Despite the lower sales base hereby forecast and negative currency items, STRATEC nevertheless expects to achieve the lower end of the forecast corridor of around 10.0% to 12.0% for its adjusted EBIT margin. This expected intra-year rise in profitability in the fourth quarter of 2025 is attributable to benefits of scale, efficiency measures, and higher earnings contributions from the realization of high-margin development sales.

Based on preliminary figures and despite the delivery backlogs that have already arisen, in the first nine months of 2025 STRATEC was able to increase its consolidated sales at constant currency year-on-year by 2.5% to € 175.6 million (9M/2024: € 173.0 million). The adjusted EBIT margin for the first nine months is expected to amount to 7.3% (9M/2024: 8.8%).

STRATEC will publish its definitive results and its Quarterly Statement for the first nine months of 2025 as planned on November 7, 2025.

FURTHER INFORMATION IS AVAILABLE FROM:
STRATEC SE
Jan Keppeler, CFA | Investor Relations, Sustainability & Corporate Communications
Tel: +49 7082 7916-6515
ir@stratec.com
www.stratec.com

Not for release, publication or distribution, directly or indirectly, in or intothe United States of America, Australia, Canada or Japan or any otherjurisdiction in which such release, publication or distribution would be unlawful. The important notes at the end of this announcement need to be observed.

• Revenue up 148% to EUR 75 million in the first nine months of 2025
• On track to become a European player – market liberalization in other European countries offers opportunities
• Outlook – Focus on further growth and geographic diversification

Berlin, 30 October 2025 – Cantourage Group SE continued its positive business development in the third quarter of 2025 and consolidated its position as one of the leading players in the European medical cannabis market, despite a challenging regulatory environment in Germany.

In the third quarter of 2025, Cantourage generated revenue of around EUR 20.1 million (comparable period 2024: EUR 13.2 million). This resulted in total group revenue of around EUR 74.9 million at the end of the third quarter (comparable period 2024: EUR 30.2 million). EBITDA of roughly EUR 3.9 million (comparable period in 2024: EUR 2.1 million) at the end of Q3 2025 underscores the strong operating performance and high scalability of the business model.

Robust development in Germany

In Germany, Cantourage recorded a robust development in both the cannabis flower and pharmaceutical ingredient business. Cantourage was able to further consolidate its position and successfully meet the demand for high-quality medical cannabis products.

“Germany remains a challenging market in a difficult regulatory and economic environment. Despite the current positive development, we are monitoring the broader conditions with due attention,” says Philip Schetter, CEO of Cantourage Group SE.

Growth in international markets

Cantourage is also continuing its growth trajectory outside Germany: positive momentum is continuing in the UK, while business is being expanded in a strategic approach in Poland. At the same time, Cantourage is preparing to enter other European growth markets such as Spain and Italy in order to benefit from the opening of these markets at an early stage.

Innovation and digitalization

Cantourage is continuing to develop its telemedicine offering in Germany in anticipation of regulatory changes, so that patients will continue to have the best possible and safe access to medical cannabis in the future. At the same time, the company is working on the development of new, innovative product formats that are designed to better meet the needs of patients.

Outlook

Against the backdrop of its operational performance to date in 2025, Cantourage is confident about the fourth quarter and the full year 2025. The company considers itself well positioned to achieve further growth in existing and new markets, but remains attentive to potential market changes. Note:

All figures are preliminary, unaudited, and unconsolidated.

About Cantourage
Cantourage is a leading European producer and distributor of cannabis flowers and cannabis-based medicinal preparations and drugs. The Berlin-based company was founded in 2019 by industry pioneers Norman Ruchholtz, Dr. Florian Holzapfel and Patrick Hoffmann. With an experienced management team and its “Fast Track Access” platform, Cantourage enables producers from around the world to become part of the growing European medical cannabis market faster, easier and more cost-effectively by processing and distributing their cannabis raw materials and extracts. In this context, Cantourage ensures compliance with the highest European pharmaceutical quality standards at all times. The company offers pharmaceutical-grade products in all relevant market segments: dried flower, extracts, dronabinol and cannabidiol. Cantourage was listed on the Frankfurt Stock Exchange on 11 November 2022 and is listed under – ISIN: DE000A3DSV01. 

Further information: www.cantourage.com

Investor Relations contact at Cantourage

Manuel Taverne
taverne@cantourage.com

This announcement does not constitute a public offer or an advertisement for a public offer to sell securities, in particular not within the meaning of Regulation (EU) 2017/1129 (Prospectus Regulation).

News Release

Notice of the Revised Forecast of Consolidated Financials for FY2025 (IFRS)

OSAKA, Japan, October 30, 2025 – Takeda (TSE:4502/NYSE:TAK) today announced the revised forecast of the full year consolidated financials for the fiscal year ending March 31, 2026 (FY2025), as below.

Takeda’s fiscal year 2025 first half results are consistent with our expectations for core business progress in this year of transition to a new phase focusing on new product launches. Our updated full-year outlook reflects impairment charges associated with strategic pipeline decisions taken in Q2, as well as transactional FX.

1. Revised Forecast for Full Year Consolidated Financials for the Fiscal Year Ending March 31, 2026

(millions JPY)

^* Announced on May 8, 2025.

(millions JPY)

^* Announced on May 8, 2025.

(Note) For the definition of Core financial measures, please refer to the “Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations” in the Financial Appendix attached to the Earnings Report.

2. Reasons for Revision

Takeda expects FY2025 revenue to be JPY 4,500.0 billion, a decrease of JPY 30.0 billion, or 0.7%, from the original forecast, mainly reflecting a revised forecast for ENTYVIO and a steeper than anticipated decline in VYVANSE sales in the U.S. due to generic erosion. These factors are partially offset by favorable overall changes in the assumptions of foreign exchange rates.

The Core Revenue forecast has been revised in the same way as the Revenue forecast.

Operating Profit is expected to decrease by JPY 75.0 billion, or 15.8%, from the original forecast to JPY 400.0 billion, primarily due to an unfavorable product mix as a result of lower revenue from high margin products, headwinds from transactional foreign exchange rates for certain products, and an increased forecast of impairment losses on intangible assets associated with products. These factors are expected to be partially offset by additional cost savings within R&D, including from pipeline prioritization and the enterprise-wide efficiency program, with such savings anticipated to broadly materialize as reductions in operating expenses.

Core Operating Profit is expected to be JPY 1,130.0 billion, a decrease of JPY 10.0 billion, or 0.9%.

Net Profit for the Year (attributable to owners of the Company) is expected to be JPY 153.0 billion, a decrease of JPY 75.0 billion, or 32.9%, from the original forecast. Profit Before Tax is expected to decrease by JPY 64.0 billion, or 20.8%, to JPY 243.0 billion, primarily due to the decrease in Operating Profit, while net finance expenses are expected to decrease by JPY 11.0 billion, or 6.6%, to JPY 156.0 billion. While Profit Before Tax is expected to decrease, the tax expense is anticipated to remain at a similar level to the original forecast due to an increase of non-deductible expenses mainly from impairments as well as derecognition of deferred tax assets, resulting in an assumed effective tax rate of approximately 37%.

Reported EPS is expected to be JPY 97.14, a decrease of JPY 47.66, or 32.9%, and Core EPS is expected to be JPY 479, a decrease of JPY 6, or 1.2%.

3. Management Guidance for the Fiscal Year Ending March 31, 2026

Takeda uses change in Core Revenue, Core Operating Profit and Core EPS at Constant Exchange Rate (CER) basis as its Management Guidance. The full year management guidance for the fiscal year ending March 31, 2026 (FY2025) has been revised from the management guidance announced on May 8, 2025.

CER % Change

About Takeda

Takeda is focused on creating better health for people and a brighter future for the world. We aim to discover and deliver life-transforming treatments in our core therapeutic and business areas, including gastrointestinal and inflammation, rare diseases, plasma-derived therapies, oncology, neuroscience and vaccines. Together with our partners, we aim to improve the patient experience and advance a new frontier of treatment options through our dynamic and diverse pipeline. As a leading values-based, R&D-driven biopharmaceutical company headquartered in Japan, we are guided by our commitment to patients, our people and the planet. Our employees in approximately 80 countries and regions are driven by our purpose and are grounded in the values that have defined us for more than two centuries. For more information, visit www.takeda.com.

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Important Notice

For the purposes of this notice, “press release” means this document, any oral presentation, any question and answer session and any written or oral material discussed or distributed by Takeda Pharmaceutical Company Limited (“Takeda”) regarding this press release. This press release (including any oral briefing and any question-and-answer in connection with it) is not intended to, and does not constitute, represent or form part of any offer, invitation or solicitation of any offer to purchase, otherwise acquire, subscribe for, exchange, sell or otherwise dispose of, any securities or the solicitation of any vote or approval in any jurisdiction. No shares or other securities are being offered to the public by means of this press release. No offering of securities shall be made in the United States except pursuant to registration under the U.S. Securities Act of 1933, as amended, or an exemption therefrom. This press release is being given (together with any further information which may be provided to the recipient) on the condition that it is for use by the recipient for information purposes only (and not for the evaluation of any investment, acquisition, disposal or any other transaction). Any failure to comply with these restrictions may constitute a violation of applicable securities laws.

The companies in which Takeda directly and indirectly owns investments are separate entities. In this press release, “Takeda” is sometimes used for convenience where references are made to Takeda and its subsidiaries in general. Likewise, the words “we”, “us” and “our” are also used to refer to subsidiaries in general or to those who work for them. These expressions are also used where no useful purpose is served by identifying the particular company or companies.

The product names appearing in this document are trademarks or registered trademarks owned by Takeda, or their respective owners.

Forward-Looking Statements

This press release and any materials distributed in connection with this press release may contain forward-looking statements, beliefs or opinions regarding Takeda’s future business, future position and results of operations, including estimates, forecasts, targets and plans for Takeda. Without limitation, forward-looking statements often include words such as “targets”, “plans”, “believes”, “hopes”, “continues”, “expects”, “aims”, “intends”, “ensures”, “will”, “may”, “should”, “would”, “could”, “anticipates”, “estimates”, “projects”, “forecasts”, “outlook” or similar expressions or the negative thereof. These forward-looking statements are based on assumptions about many important factors, including the following, which could cause actual results to differ materially from those expressed or implied by the forward-looking statements: the economic circumstances surrounding Takeda’s global business, including general economic conditions in Japan and the United States and with respect to international trade relations; competitive pressures and developments; changes to applicable laws and regulations, including tax, tariff and other trade-related rules; challenges inherent in new product development, including uncertainty of clinical success and decisions of regulatory authorities and the timing thereof; uncertainty of commercial success for new and existing products; manufacturing difficulties or delays; fluctuations in interest and currency exchange rates; claims or concerns regarding the safety or efficacy of marketed products or product candidates; the impact of health crises, like the novel coronavirus pandemic; the success of our environmental sustainability efforts, in enabling us to reduce our greenhouse gas emissions or meet our other environmental goals; the extent to which our efforts to increase efficiency, productivity or cost-savings, such as the integration of digital technologies, including artificial intelligence, in our business or other initiatives to restructure our operations will lead to the expected benefits; and other factors identified in Takeda’s most recent Annual Report on Form 20-F and Takeda’s other reports filed with the U.S. Securities and Exchange Commission, available on Takeda’s website at: https://www.takeda.com/investors/sec-filings-and-security-reports/or at www.sec.gov.Takeda does not undertake to update any of the forward-looking statements contained in this press release or any other forward-looking statements it may make, except as required by law or stock exchange rule. Past performance is not an indicator of future results and the results or statements of Takeda in this press release may not be indicative of, and are not an estimate, forecast, guarantee or projection of Takeda’s future results.

Financial Information and Non-IFRS Measures

Takeda’s financial statements are prepared in accordance with International Financial Reporting Standards (“IFRS”).

This press release and materials distributed in connection with this press release include certain financial measures not presented in accordance with IFRS, such as Core Revenue, Core Operating Profit, Core Net Profit for the year attributable to owners of the Company, Core EPS, Constant Exchange Rate (“CER”) change, Net Debt, Adjusted Net Debt, EBITDA, Adjusted EBITDA, Free Cash Flow and Adjusted Free Cash Flow. Takeda’s management evaluates results and makes operating and investment decisions using both IFRS and non-IFRS measures included in this press release. These non-IFRS measures exclude certain income, cost and cash flow items which are included in, or are calculated differently from, the most closely comparable measures presented in accordance with IFRS. Takeda’s non-IFRS measures are not prepared in accordance with IFRS and such non-IFRS measures should be considered a supplement to, and not a substitute for, measures prepared in accordance with IFRS (which we sometimes refer to as “reported” measures). Investors are encouraged to review the definitions and reconciliations of non-IFRS measures to their most directly comparable IFRS measures, which are in the Financial Appendix appearing at the end of our FY2025 H1 investor presentation (available at www.takeda.com/investors).

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Press Release // October 30, 2025
 

Formycon invites to Conference Call on 2025 Nine-Month Results and announces Participation in Investor Conferences in the 4th Quarter of 2025
 

Planegg-Martinsried, Germany – Formycon AG (FSB: FYB, Prime Standard, „Formycon“) plans to publish its Nine-Month Results 2025 on November 13, 2025. The Management Board will discuss the company’s development, key financial figures, and provide an outlook for the course of 2025. The conference call, which will be broadcast live on the internet, will take place on Thursday, November 13, 2025, at 3:00 PM (CET) in English.

To participate in the conference call, please register at:
https://webcast.meetyoo.de/reg/KYTa1G3ju56X

After registration, participants will receive a confirmation email with individual dial-in data.

The presentation and audio broadcast can be accessed via the following webcast link:
https://www.webcast-eqs.com/formycon-2025-q3

After a brief presentation, the Management Board will be available for analysts’ questions. The conference call will be recorded and can subsequently be accessed via the Formycon website at: https://www.formycon.com/en/investor-relations/publications/

Formycon in Dialogue

Representatives of the Management Board will participate in the following national and international investor conferences in the fourth quarter of 2025:

October 30, 2025
ODDO BHF Autumn Round Table
Dr. Stefan Glombitza (CEO)
Frankfurt, Germany

November 17 – 20, 2025
Jefferies Global Healthcare Conference
Enno Spillner (CFO)
London, UK

November 24 – 26, 2025
Deutsche Börse Equity Forum
Enno Spillner (CFO)
Frankfurt, Germany

December 9, 2025
mwb Research Roundtable
Dr. Stefan Glombitza (CEO), Enno Spillner (CFO),
Nicola Mikulcik (CBO), Dr. Andreas Seidl (CSO)
virtual

Preview on 2026:

January 12 – 15, 2026
J.P. Morgan 44^th Annual Healthcare Conference
Dr. Stefan Glombitza (CEO), Enno Spillner (CFO), Nicola Mikulcik (CBO)
San Francisco, USA
 

Please find our current events at:
https://www.formycon.com/en/investors/financial-calendar/

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About Formycon:
Formycon AG (FSE: FYB) is a leading, independent developer of high-quality biosimilars, follow-on products of biopharmaceutical medicines. The company focuses on therapies in ophthalmology, immunology, immuno-oncology and other key disease areas, covering almost the entire value chain from technical development through clinical trials to approval by the regulatory authorities. For commercialization of its biosimilars, Formycon relies on strong, well-trusted and long-term partnerships worldwide. With FYB201/ranibizumab and FYB202/ustekinumab, Formycon already has two biosimilars on the market. Another biosimilar, FYB203/aflibercept, has been approved by the FDA, EMA, and MHRA. Four pipeline candidates are currently in development. With its biosimilars, Formycon is making an important contribution to providing as many patients as possible with access to highly effective and affordable medicines.

Formycon AG is headquartered in Munich, listed in the Prime Standard of the Frankfurt Stock Exchange: FYB / ISIN: DE000A1EWVY8 / WKN: A1EWVY and is part of the SDAX selection index. Further information can be found at: https://www.formycon.com/

About Biosimilars:
Since their introduction in the 1980s, biopharmaceutical drugs have revolutionized the treatment of serious and chronic diseases. By 2032, many of these drugs will lose their patent protection – including 45 blockbusters with an estimated total annual global turnover of more than 200 billion US dollars. Biosimilars are successor products to biopharmaceutical drugs for which market exclusivity has expired. They are approved in highly regulated markets such as the EU, the USA, Canada, Japan and Australia in accordance with strict regulatory procedures. Biosimilars create competition and thus give more patients access to biopharmaceutical therapies. At the same time, they reduce costs for healthcare systems. Global sales of biosimilars currently amount to around 21 billion US dollars. Analysts assume that sales could rise to over 74 billion US dollars by 2030.

Contact:
Sabrina Müller
Director Investor Relations & Corporate Communications
Formycon AG
Fraunhoferstr. 15
82152 Planegg-Martinsried
Germany

Tel.: +49 (0) 89 – 86 46 67 149
Fax: + 49 (0) 89 – 86 46 67 110
Mail: Sabrina.Mueller@formycon.com

Disclaimer:
This press release may contain forward-looking statements and information which are based on Formycon’s current expectations and certain assumptions. Various known and unknown risks, uncertainties and other factors could lead to material differences between the actual future results, financial situation, performance of the company, development of the products and the estimates given here. Such known and unknown risks and uncertainties comprise, among others, the research and development, the regulatory approval process, the timing of the actions of regulatory bodies and other governmental authorities, clinical results, changes in laws and regulations, product quality, patient safety, patent litigation, contractual risks and dependencies from third parties. With respect to pipeline products, Formycon AG does not provide any representation, warranties or any other guarantees that the products will receive the necessary regulatory approvals or that they will prove to be commercially exploitable and/or successful. Formycon AG assumes no obligation to update these forward-looking statements or to correct them in case of developments which differ from those anticipated. This document neither constitutes an offer to sell nor a solicitation of an offer to buy or subscribe for securities of Formycon AG. No public offering of securities of Formycon AG will be made nor is a public offering intended. This document and the information contained therein may not be distributed in or into the United States of America, Canada, Australia, Japan or any other jurisdictions, in which such offer or such solicitation would be prohibited. This document does not constitute an offer for the sale of securities in the United States.