• Guidance for 2024 confirmed with full-year 2024 revenue and adjusted EBITDA targets on track, despite challenging market conditions
• Robust growth of Just – Evotec Biologics driven by roll out of projects together with Sandoz and progress of discovery partnerships 
• Successful extensions & expansions with BMS and Novo Nordisk; new collaboration with Pfizer to advance cutting-edge therapeutic solutions
• Priority reset on track to deliver annualised adj. EBITDA improvement of over € 40 m and strategic review initiated

Hamburg, Germany, 06 November 2024:
Evotec SE (Frankfurt Stock Exchange: EVT, SDAX/TecDAX, ISIN: DE0005664809; NASDAQ: EVO) today announced its financial results and corporate updates for the third quarter of 2024, highlighting strategic progress across key partnerships and operations.

Dr Christian Wojczewski, Chief Executive Officer of Evotec, said: “We continue to deliver on the successful execution of our Priority Reset and have achieved significant progress across key initiatives. New and extended partnerships clearly underscore Evotec’s enduring leadership in R&D and precision medicine. Building on this exceptionally strong foundation, we are now laying the groundwork for an accelerated transformation program that will pave the way for long-term profitable growth. While the challenging market environment has impacted near-term results, we are seeing strong momentum across strategic priorities and look forward to reporting back on our progress in early 2025.”
 

Challenging market conditions weigh on Shared R&D, while Just – Evotec Biologics delivers strong growth

• Group revenues decreased by (1)% to € 575.7 m (9M 2023: € 580.1 m)
• Total Shared R&D revenues decreased by (12)% to € 447.1 m (9M 2023: € 506.1 m, due to a challenging market environment
• Evotec’s Just – Evotec Biologics segment saw impressive growth, with revenues rising by 74% year-over-year, contributing €128.7 m (9M 2023: € 74.1 m) to the overall topline
• Adjusted Group EBITDA totalled € (6.0) m (9M 2023: € 50.2 m) driven by a mismatch between revenues and cost base in the Shared R&D segment as well as costs related to the expansion of operations of Just – Evotec Biologics
• Core business activities in Shared R&D as well as Just – Evotec Biologics reached break-even
   

Transformation Process on track with significant savings realised

• Priority Reset is set to yield an annualised adjusted EBITDA improvement of over € 40 m, starting H2 2024
• Successful implementation of measures to improve liquidity
• One-off costs related to Priority Reset measures recognised at € 62.3 m as of Q3, lower than initial provision of € 68.5 m on 30 June 2024
• Strategic Review process initiated to examine status quo and deliver performance and productivity improvements as part of transformation for long-term profitable growth

New and expanded partnerships

• Extension and expansion of tech partnership with Sandoz for development and commercial manufacturing of biosimilars
• Extension of collaboration with Bristol Myers Squibb (“BMS”) based on targeted protein degradation into indications outside of oncology, triggering programme-based payment of US$ 50 m to fund further research
• Further progress made in strategic neuroscience collaboration with Bristol Myers Squibb, payments of US$ 25 m received
• Strong progress in strategic protein degradation partnership with Bristol Myers Squibb, resulted in reception of performance-based and programme-based payments of in total US$ 75 m
• New technology development partnership with Novo Nordisk to support next-generation cell therapies
• New multi-year master research collaboration and option and license agreement with Pfizer, initially focusing on early discovery research for metabolic and infectious diseases
• Collaboration with X-Chem to access DNA-encoded library (“DEL”) to expand hit-finding options

Operational milestone achieved

• Opening of cutting-edge biologics facility J.POD in Toulouse, France (EU) on 20 September 2024 marks significant expansion of European production capabilities and strengthens position in the biologics market.

Business Outlook for full-year 2024

• Group revenues¹⁾ expected in the range of € 790 – 820 m (2023: € 781.4 m).
• R&D expenditures are expected in a range of € 50 – 60 m (2023: € 64.8 m).
• Adjusted Group EBITDA¹⁾ is expected to reach € 15 – 35 m (2023: € 66.4 m).

¹⁾ Guidance including future non-core activities 

More detailed information and financial tables are available in the half-year report published on the Evotec website under the following link: https://www.evotec.com/en/investor-relations/financial-publications

Webcast/Conference Call

The Company plans to hold a conference call to discuss the results as well as provide an update on its performance. The conference call will be held in English.

Webcast details

Date:  Wednesday, 06 November 2024

Time:  2.00 pm CET (01.00 pm BT, 08.00 am ET)

To join the audio webcast and to access the presentation slides, please register via this link.

The on-demand version of the webcast will be available on our website: www.evotec.com/en/investor-relations/financial-publications.

Conference call details

To join via phone, please pre-register via this link.

You will then receive a confirmation email with dedicated dial-in details such as telephone number, access code and PIN to access the call.

A simultaneous slide presentation for participants dialling in via phone is available under this link.

About Evotec SE
Evotec is a life science company with a unique business model that delivers on its mission to discover and develop highly effective therapeutics and make them available to the patients. The Company’s multimodality platform comprises a unique combination of innovative technologies, data and science for the discovery, development, and production of first-in-class and best-in-class pharmaceutical products. Evotec provides high value pipeline co-creating partnerships and solutions to all Top 20 Pharma and over 800 biotechnology companies, academic institutions, as well as other healthcare stakeholders. Evotec has strategic activities in a broad range of currently underserved therapeutic areas, including e.g. neurology, oncology, as well as metabolic and infectious diseases. Within these areas of expertise, Evotec aims to create the world-leading co-owned pipeline for innovative therapeutics and has to-date established a portfolio of more than 200 proprietary and co-owned R&D projects from early discovery to clinical development. Evotec operates globally with more than 5,000 highly qualified people. The Company’s sites in Europe and the USA offer highly synergistic technologies and services and operate as complementary clusters of excellence. For additional information please go to www.evotec.com and follow us on X/Twitter @Evotec and LinkedIn.

Forward-looking-statements
This announcement contains forward-looking statements concerning future events, including the proposed offering and listing of Evotec’s securities. Words such as “anticipate,” “believe,” “could,” “estimate,” “expect,” “intend,” “may,” “might,” “plan,” “potential,” “should,” “target,” “would” and variations of such words and similar expressions are intended to identify forward-looking statements. Such statements include comments regarding Evotec’s expectations for revenues, Group EBITDA and unpartnered R&D expenses. These forward-looking statements are based on the information available to, and the expectations and assumptions deemed reasonable by Evotec at the time these statements were made. No assurance can be given that such expectations will prove to have been correct. These statements involve known and unknown risks and are based upon a number of assumptions and estimates, which are inherently subject to significant uncertainties and contingencies, many of which are beyond the control of Evotec. Evotec expressly disclaims any obligations or undertaking to release publicly any updates or revisions to any forward-looking statements contained herein to reflect any change in Evotec’s expectations with respect thereto or any change in events, conditions or circumstances on which any statement is based.

For further information, please contact:

Investor Relations

Volker Braun
EVP Head of Global Investor Relations & ESG
volker.braun@evotec.com

Media

Susanne Kreuter
VP Head of Strategic Marketing
susanne.kreuter@evotec.com

PharmaSGP Holding SE: Peter Gerckens succeeds Natalie Weigand as Chief Executive Officer

Gräfelfing, November 05, 2024 – Peter Gerckens, who has been a member of the Management Board of PharmaSGP Holding SE as Chief Commercial Officer (CCO) since July 1, 2024, will take over the position of Chief Executive Officer (CEO) of the company on January 1, 2025. This was decided by the Supervisory Board today. Peter Gerckens succeeds Natalie Weigand in this position. She informed the Supervisory Board today that she has decided not to extend her contract, which expires at the end of the year. However, Natalie Weigand will remain associated with the company in an advisory role after her departure.

*    *    *
 

Contact

PharmaSGP Holding SE
Claudius Krause | Jakob Hafer (cometis AG)
Lochhamer Schlag 1
82166 Gräfelfing | Germany
Phone: +49 611 205855-0
E-Mail: ir@pharmasgp.com

CEO change at PharmaSGP Holding SE: Peter Gerckens succeeds Natalie Weigand as of January 1, 2025

Gräfelfing, November 05, 2024 – German OTC pharmaceutical company PharmaSGP Holding SE is announcing a change in the position of Chief Executive Officer (CEO). After more than seven years as CEO, Natalie Weigand informed the Supervisory Board today that, due to personal reasons, she will not be renewing her contract with PharmaSGP, which expires at the end of the year. Peter Gerckens, who has been a member of the Management Board of PharmaSGP Holding SE as Chief Commercial Officer (CCO) since July 1, 2024, will succeed Ms. Weigand as CEO on January 1, 2025. Peter Gerckens has already been able to familiarize himself extensively with PharmaSGP since July 2024 and will continue to drive PharmaSGP’s successful growth course as CEO. The internal succession plan ensures a smooth and rapid transition process. In addition, there is continuity in the PharmaSGP Management Board team with Michael Rudolf as longstanding Chief Financial Officer (CFO). Natalie Weigand will also remain active for the company in an advisory position.

Natalie Weigand, CEO of PharmaSGP, on her upcoming exit: “After careful consideration, I have decided not to extend my contract with PharmaSGP after almost ten years with the company, including more than seven years as CEO. I would like to thank all my colleagues for the successful time we shared and wish each and every one of them all the best. I will remain associated with the company in an advisory position in the future and look forward to accompanying the ongoing success story of PharmaSGP from this new perspective.”

Dr. Clemens Fischer, Chairman of the Supervisory Board: “On behalf of the entire Supervisory Board and the entire company, we would like to thank Ms. Weigand for her outstanding contribution to the successful development of PharmaSGP in recent years. Under her leadership, PharmaSGP has regularly achieved new revenue and earnings records. We wish Ms. Weigand all the best for the future and are delighted that she will continue to support the company in an advisory role. At the same time, we are very happy that we have been able to find an internal successor in Peter Gerckens. Mr. Gerckens knows the business model, the market and the growth opportunities inside out and is therefore, in our view, the ideal person to successfully lead PharmaSGP in the future.”

Peter Gerckens, CCO of PharmaSGP: “It is impressive what Natalie Weigand has built up as CEO together with Michael Rudolf and the entire PharmaSGP team in recent years. Since joining PharmaSGP in July of this year, I have been able to get to know the company very well and I am impressed by the commitment and passion of our entire team. I would like to thank them for their trust and am now looking forward to continuing PharmaSGP success story in my new role.”

CONTACT

cometis AG 
Claudius Krause | Jakob Hafer
Phone: +49-611-2058550 
Email: ir@pharmasgp.com

ABOUT PHARMASGP HOLDING SE

PharmaSGP is a leading consumer health company with a diversified portfolio of over-the-counter (OTC) pharmaceuticals and other healthcare products that are marketed with a focus on the pharmacy distribution channel. These products are mostly based on natural active pharmaceutical ingredients with documented efficacy and few known side effects. 

The Company’s core brands cover chronic indications, including rheumatic pain, nerve pain and other age-related ailments. In Germany, PharmaSGP is the market leader for systemic chemical-free pain remedies with its brand families RubaXX® for rheumatic pain and Restaxil® for neuralgic pain. Furthermore, PharmaSGP also offers leading products against sexual weakness and vertigo symptoms. Since introducing the first product from the current product portfolio in 2012, PharmaSGP has successfully established its business model in other European countries, including Austria, Italy, Belgium, Spain and France. In September 2021, the product portfolio was expanded by the brands Baldriparan®, Formigran®, Spalt® and Kamol®, thus also strengthening or developing the indications pain and sleep disorder. The sales territory was expanded to include Switzerland and Eastern Europe. In 2023, PharmaSGP generated revenues of €101.1 million at an adjusted EBITDA margin of 33.7%. 

In order to further expand its competitive position, PharmaSGP plans to increase the number of indications covered by PharmaSGP’s product offering, increase PharmaSGP’s European footprint, and accelerate its growth strategy especially by capitalizing on selected M&A opportunities. 

Hamburg, 05 November 2024:
Evotec SE (Frankfurt Stock Exchange: EVT, SDAX/TecDAX, ISIN: DE0005664809; NASDAQ: EVO) has announced the sale of its chemical API manufacturing site, Evotec DS GmbH, located in Halle/Westphalia, to Monacum Partners GmbH – a Munich based Private Equity firm. This transaction forms part of Evotec’s “Priority Reset” initiative launched in April 2024, which aims to foster profitable growth by refining the company’s operational footprint and focusing on its primary growth sectors and core competencies.

Evotec DS in Halle/Westphalia is a specialized CDMO (Contract Development and Manufacturing Organization) with a strong foundation in chemical APIs, intermediates, and building blocks, which provides an end-to-end service portfolio, encompassing development to commercial-scale manufacturing.

The transaction presents an opportunity for Evotec DS to achieve its growth ambitions under new ownership. Under the agreement, all business operations and the entire workforce at Evotec DS will transition to Monacum Partners and continue business as DAPIN GmbH (Deutsche API & Intermediates). Financial terms of the transaction were not disclosed.

About Evotec SE
Evotec is a life science company with a unique business model that delivers on its mission to discover and develop highly effective therapeutics and make them available to the patients. The Company’s multimodality platform comprises a unique combination of innovative technologies, data and science for the discovery, development, and production of first-in-class and best-in-class pharmaceutical products. Evotec provides high value pipeline co-creating partnerships and solutions to all Top 20 Pharma and over 800 biotechnology companies, academic institutions, as well as other healthcare stakeholders. Evotec has strategic activities in a broad range of currently underserved therapeutic areas, including e.g. neurology, oncology, as well as metabolic and infectious diseases. Within these areas of expertise, Evotec aims to create the world-leading co-owned pipeline for innovative therapeutics and has to-date established a portfolio of more than 200 proprietary and co-owned R&D projects from early discovery to clinical development. Evotec operates globally with more than 5,000 highly qualified people. The Company’s sites in Europe and the USA offer highly synergistic technologies and services and operate as complementary clusters of excellence. For additional information please go to www.evotec.com and follow us on X/Twitter @Evotec and LinkedIn.

About Monacum Partners
Monacum Partners is a Munich based private equity firm, focused on repositioning of European headquartered businesses. The core of Monacum Partners strategy, is acquiring underperforming companies with significant operational improvement potential and support them through proven turnaround playbooks, implemented by Monacum Partners’ highly experienced operational team. For additional information please go to www.monacumpartners.com.
 

Forward-looking statements
This announcement contains forward-looking statements concerning future events, including the proposed offering and listing of Evotec’s securities. Words such as “anticipate,” “believe,” “could,” “estimate,” “expect,” “intend,” “may,” “might,” “plan,” “potential,” “should,” “target,” “would” and variations of such words and similar expressions are intended to identify forward-looking statements. Such statements include comments regarding Evotec’s expectations for revenues, Group EBITDA and unpartnered R&D expenses. These forward-looking statements are based on the information available to, and the expectations and assumptions deemed reasonable by Evotec at the time these statements were made. No assurance can be given that such expectations will prove to have been correct. These statements involve known and unknown risks and are based upon a number of assumptions and estimates, which are inherently subject to significant uncertainties and contingencies, many of which are beyond the control of Evotec. Evotec expressly disclaims any obligations or undertaking to release publicly any updates or revisions to any forward-looking statements contained herein to reflect any change in Evotec’s expectations with respect thereto or any change in events, conditions or circumstances on which any statement is based.

For further information, please contact:

Investor Relations

Volker Braun
EVP Head of Global Investor Relations & ESG
Volker.Braun@evotec.com

Media

Susanne Kreuter
VP Head of Strategic Marketing
Susanne.Kreuter@evotec.com

Ad hoc announcement pursuant to Art. 53 LR

Allschwil, Switzerland, 4 November 2024

Spexis expects SIX to delist shares of Spexis on the SIX exchange imminently.

Spexis AG (SIX: SPEX), a clinical-stage biopharmaceutical company focused on macrocycle therapeutics for rare diseases and oncology, today announced that it expects the Swiss SIX exchange to delist the shares of Spexis imminently.

Relevant background to the above is provided as follows: 

1. As reported by the Company on 22 July 2024 and made effective by SIX on 30 July, 2024, trading in the Company’s shares on the SIX exchange were suspended due to the Company’s inability to publish audited 2023 and half-year (through June 30, 2024) financial results, for the reasons reported in the referenced 22 July 2024 report.
    
2. Furthermore, according to the SIX Listing Rules (“LR”), Art. 58 para. 1 point 4, if trading has been suspended for a continuous three-month period, and the reasons for the suspension continue to exist, the SIX Regulatory Board may cancel the listing of securities.
    
3. No annual report 2023 in accordance with Art. 49 LR and no interim (semi-annual) report 2024 in accordance with Art. 50 LR have been published yet. Additionally, as of today, 4 November 2024, trading in shares of Spexis Ltd have been suspended for a continuous three-month period and the reasons for the suspension continue to exist.
    
4. Accordingly, suspension of trading in the shares of Spexis Ltd according to Art. 57 LR will continue until the public announcement of the delisting by SER, which is expected imminently. 

Jeff Wager MD, Chair & CEO of Spexis, commented on this development as follows, “While of course delisting from SIX will be a materially negative event, it is not wholly unexpected and does not deter us from continuing to pursue options that will enable the Company to emerge from our moratorium status.  The Company has the right to appeal any forthcoming decision by SIX to delist its shares, and while the probability is low that Spexis will pursue such an appeal, we will reserve deciding upon such an option pending evolution of ongoing discussions with prospective investors.  However, in any event of permanent delisting, our plan is to nonetheless pursue solutions to its moratorium status as a private company.”

About Spexis

Spexis (SIX: SPEX) is a clinical-stage biopharmaceutical company based in Allschwil, Switzerland, focused on macrocycle therapeutics for rare diseases and oncology. For further information please visit: www.spexisbio.com.
 

For further information please contact:

Disclaimer

This press release contains forward-looking statements which are based on current assumptions and forecasts of Spexis management. Known and unknown risks, uncertainties, and other factors could lead to material differences between the forward-looking statements made here and the actual development, in particular Spexis’ results, financial situation, and performance. Readers are cautioned not to put undue reliance on forward-looking statements, which speak only of the date of this communication. Spexis disclaims any intention or obligation to update and revise any forward-looking statements, whether as a result of new information, future events or otherwise.

Berlin and Würzburg, Germany, November 4, 2024 – Pentixapharm, a biopharmaceutical company developing innovative first-in-class radiopharmaceuticals, welcomes the recent announcement by the U.S. Centers for Medicare & Medicaid Services (CMS) to implement separate payments for specialized diagnostic radiopharmaceuticals used in the hospital outpatient setting, extending beyond the transitional pass-through payment period. This significant policy shift could have a direct impact on future reimbursement streams for Pentixapharm’s Ga68-PentixaFor, a diagnostic radiopharmaceutical for which Pentixapharm intends to start a U.S. centric phase III clinical trial next year. The pivotal clinical trial could lead to a U.S. market authorization in primary aldosteronism (PA), one of the major causes of secondary hypertension, as early as 2028.

The CMS pass-through payment period is a temporary reimbursement mechanism under the Hospital Outpatient Prospective Payment System (OPPS). Lasting up to three years, this period provides additional payments for newly introduced medical devices, drugs, and biologicals, encouraging hospitals to adopt cutting-edge technologies by covering their costs beyond standard rates. However, under previous policies, after the pass-through period ended, products would typically revert to standard OPPS payment bundles. With this new policy announcement, CMS has changed this approach, allowing for separate payments beyond the pass-through period for qualifying high-cost diagnostics.

This decision by CMS is highly significant given the size and impact of the Medicare and Medicaid systems, which together insure more than 140 million Americans. As the primary healthcare payer for older adults and individuals with disabilities, CMS’s reimbursement policies shape access to medical innovations across the country. The new rule, effective in 2025, also has the potential to set a market precedent that may influence private insurers to follow CMS’s lead in reimbursing innovative diagnostic tools, further expanding the accessibility of these advanced diagnostics. By providing consistent reimbursement for diagnostic radiopharmaceuticals that exceed a per-day cost threshold of US$630, CMS encourages other insurers to consider similar reimbursement strategies.

The separate payment rule will most likely apply to Pentixapharm’s lead diagnostic compound, Ga68-PentixaFor, following its anticipated approval and the expiration of its pass-through status. Ga68-PentixaFor is a novel tracer for positron emission tomography (PET) imaging used to detect aldosterone-hypersecreting adenomas in patients diagnosed with primary Aldosteronism (PA). With rising prevalence rates for PA, now exceeding 20% in some populations with resistant hypertension, the need for accessible and precise diagnostics is greater than ever.

About Pentixapharm

Pentixapharm is a clinical-stage biotech company discovering and developing novel targeted radiopharmaceuticals with its offices in Berlin and Würzburg, Germany. It is committed to developing CXCR4 ligand-based first-in-class radiopharmaceutical approaches with a clear commercial pathway for diagnostic and therapeutic programs in a number of hematological and solid cancers, as well as cardiovascular, endocrine and inflammatory diseases.

PentixaFor (Gallium (⁶⁸Ga) boclatixafortide) is an innovative PET tracer that specifically targets the chemokine-4 receptor (CXCR4), with broad applications in oncological, cardiovascular, and inflammatory diseases. Particularly in hypertension, PentixaFor has the potential to significantly improve patient management by identifying the presence of hormone-secreting adenomas through non-invasive and broadly available PET/CT imaging.

Apart from PentixaFor, the clinical pipeline also encompasses PentixaTher, an Yttrium-90 or Lutetium-177 based therapeutic against non-Hodgkin lymphomas (NHL). Clinical studies for both compounds have already commenced in Europe, including a dose-finding study for PentixaTher and a Phase III registration study for PentixaFor in marginal zone lymphoma. Recently, the EMA granted PRIME status to PentixaFor in the indication PA.

For more information, please contact:

Pentixapharm Holding AG
Phillip Eckert, Investor Relations
ir@pentixapharm.com
Tel. +49 30 94893232
www.pentixapharm.com

• MEDICLIN increases consolidated sales for 9M 2024 by 2.0% to EUR 558.2 million
• Group EBIT of EUR 34.5 million higher than in the same period of the
  previous year (9M 2023: EUR 29.4 million)
• Occupancy rate up on previous year at 86.0 (9M 2023: 84,4%)
• Hospital reform expected at the turn of the year
• The Executive Board confirms the forecast for the year

Offenburg, 04 November 2024: In the first nine months of 2024, MEDICLIN Aktiengesellschaft (MEDICLIN) generated consolidated sales of EUR 558.2 million. This is EUR 11.1 million or 2.0% more than in the first nine months of 2023. The consolidated operating result improved by EUR 5.1 million to EUR 34.4 million compared to the same period of the previous year. A positive business performance in the third quarter and a stable capacity utilisation rate of 86.0% (9M 2023: 84.4%) allow the Executive Board to confirm the annual forecast. For the current financial year, a decline in sales at the upper end of the forecast of -2.0% to 0.0% is expected. The consolidated operating result is now also expected to be at the upper end of the range of EUR 33.0 million to EUR 39.0 million last specified in the first half of the year.

Sales and earnings performance of the segments

In the post-acute segment, sales increased by 7.2% to EUR 361.2 million (9M 2023: EUR 337.0 million). At EUR 38.0 million, the segment operating result was EUR 2.9 million higher than in the same period of the previous year (9M 2023: EUR 35.1 million). The cost of materials ratio rose by 0.3 percentage points to 20.4% (9M 2023: 20.1%). At EUR 73.8 million, the absolute cost of materials was 9.1% higher than in the previous year (9M 2023: EUR 67.6 million). Personnel expenses increased by EUR 8.1 million or 4.5% to EUR 187.4 million compared to the first half of the previous year. The personnel expenses ratio fell to 51.9% (9M 2023: 53.2%).

The acute segment reported a decline in segment sales of EUR 16.3 million or 8.5%. The segment operating result totalled EUR -3.8 million after EUR -5.4 million in the third quarter of 2023. The cost of materials fell by 12.8% to EUR 50.0 million (9M 2023: EUR 57.3 million). The cost of materials ratio fell slightly to 28.5 % (9M 2023: 29.9%). Personnel expenses totalled EUR 106.1 million and were therefore 8.6% lower than in the first nine months of 2023 (9M 2023: EUR 116.1 million). The personnel expenses ratio remained almost unchanged at 60.4% after 60.5% in the same period of the previous year.

Sales in the Other Activities segment totalled EUR 21.5 million was 17.5% higher than the previous year’s figure, i.e. EUR 3.2 million. The nursing care business division contributed EUR 17.5 million to this figure, which corresponds to an increase of 11.3% compared to the previous year (9M 2023: EUR 15.8 million). At EUR 0.3 million, the segment operating result was up on the previous year’s result of EUR

-0.3 million.

Outlook – positive business performance in the third quarter of 2024

“As in previous years, the third quarter is once again the strongest of the current year. Group sales increased by EUR 7.9 million year-on-year to EUR 190.2 million. Profitability for the quarter was also positive with an EBIT margin of 11.8%. We are in a good financial position and confirm the annual forecasts for sales and consolidated operating profit at the upper end in each case due to the positive business develop-ment”, reports Tino Fritz, CFO of MEDICLIN.

Hospital reform expected at the turn of the year

“The hospital reform expected at the turn of the year has not taken rehabilitation into account. We are convinced that the elimination of hospital beds in the acute sector will not lead to fewer, but to more and earlier rehabilitation services. With MEDICLIN HOME, DIRECT and CAMPUS, we set out early on to face up to the developments in the healthcare market and take advantage of the opportunities offered by the outpati-ent and digitalisation of rehabilitation,” says Dr Joachim Ramming, CEO of MEDICLIN.

Thomas Piefke, COO of MEDICLIN, adds: “On 11 October, we opened outpatient orthopaedic rehabilitation at the Staufenburg Klinik in Durbach – as part of the MEDICLIN DIRECT range of services. With the expansion of this service, we are supplementing the existing services for rehabilitation in the areas of cancer, diabetes and obesity and are thus responding to the increasing demand for outpatient orthopaedic therapies. We are thus successfully driving forward outpatientisation at MEDICLIN and consistently implementing our strategy.”

The interim report as at 30 September 2024 is available from today at www.mediclin.de in German and English.

For further information:

MEDICLIN Aktiengesellschaft
Okenstrasse 27
77652 Offenburg

Investor Relations
Ender Gülcan
Phone: 0781/488-326
ender.guelcan@mediclin.de

Public Relations
Dr Janina Lossen
Phone: 0781/488-180
janina.lossen@mediclin.de

www.mediclin.de

About MEDICLIN Aktiengesellschaft (Ticker: MED; WKN: 659 510)
MEDICLIN includes 32 clinics, six care facilities and ten medical care centers. The Group has around 8,300 beds/care places and employs around 10,000 people. In a strong network, MEDICLIN offers the patient integrative care from the first visit to the doctor through the operation and subsequent rehabilitation to outpatient aftercare. Doctors, therapists and nurses work together in a carefully coordinated manner. MEDICLIN designs the care and support of people in need of care according to their individual needs and personal needs.

MEDICLIN ─ a company of the Asklepios Group

 CureVac to Present at the 12th International mRNA Health Conference
 

TÜBINGEN, Germany/BOSTON, USA – November 4, 2024 – CureVac N.V. (Nasdaq: CVAC) (“CureVac”), a global biopharmaceutical company developing a new class of transformative medicines based on messenger ribonucleic acid (“mRNA”), today announced that new and updated data will be shared in two oral presentations and four posters at the 12^th International mRNA Health Conference, taking place in Boston, Massachusetts, November 12-14, 2024.

More detailed preliminary safety, tolerability and immunogenicity data from the dose escalation part of CureVac’s ongoing Phase 1 CVGBM cancer vaccine study in patients with resected glioblastoma will be shared in an oral presentation. Initial data from this study was presented last month at the European Society for Medical Oncology (ESMO) Congress demonstrating that treatment with CVGBM monotherapy successfully induced cancer antigen-specific T-cell responses in 77% of evaluable patients, of which 84% of immune responses were generated de novo by the vaccine. Expanded data from the dose escalation portion of the study will also be shared at the upcoming Society for Immunotherapy of Cancer (SITC) 39^th Annual Meeting later this week.

A second oral presentation will cover CureVac’s approach to developing optimized LNP delivery, while posters shared at the meeting will provide additional data on how CureVac optimizes its mRNA platform with different approaches as well as highlighting new targets for future development programs. The data to be shared will demonstrate the potential of CureVac’s mRNA platform in technology optimization, oncology, and infectious disease, driving future innovation in the mRNA space.

“With our recent corporate realignment and increased focus on research and innovation to develop meaningful mRNA medicines in different therapeutic areas, CureVac is more committed than ever to extending the horizons of mRNA. We are pleased to be presenting the recently announced promising clinical data from our glioblastoma mRNA vaccine program as well as results from our ongoing research in lipid nanoparticle delivery technology, oncology and infectious diseases,” said Dr. Myriam Mendila, Chief Scientific Officer at CureVac. “These presentations demonstrate the evolution of our long-standing commitment to apply mRNA technology in service to patients across a diverse spectrum of disease areas.”

Details on the two oral presentations are below: 

Title: Development of multiepitope mRNA vaccines – first results of Phase I human study in Glioblastoma patients
Session type: Oral Presentation
Date: Thursday, November 14
Time: 1:44 p.m. EST
Presenting Author: Regina Heidenreich, Ph.D., Senior Director Oncology Preclinical Development, CureVac SE

Title:  Development and optimization of lipid nanoparticles for delivery of mRNA vaccines
Session type: Oral Presentation
Date: Thursday, November 14
Time: 9:38 a.m. EST
Presenting Author: Paula Muresan, Ph.D., Research Scientist, CureVac SE

For more information on the conference and program, please visit the website: https://www.mrna-conference.com/

About CureVac

CureVac (Nasdaq: CVAC) is a pioneering multinational biotech company founded in 2000 to advance the field of messenger RNA (mRNA) technology for application in human medicine. In more than two decades of developing, optimizing, and manufacturing this versatile biological molecule for medical purposes, CureVac has introduced and refined key underlying technologies that were essential to the production of mRNA vaccines against COVID-19, and is currently laying the groundwork for application of mRNA in new therapeutic areas of major unmet need. CureVac is leveraging mRNA technology, combined with advanced omics and computational tools, to design and develop off-the-shelf and personalized cancer vaccine product candidates. It also develops programs in prophylactic vaccines and in treatments that enable the human body to produce its own therapeutic proteins. Headquartered in Tübingen, Germany, CureVac also operates sites in the Netherlands, Belgium, Switzerland, and the U.S. Further information can be found at www.curevac.com.

CureVac Media and Investor Relations Contact

Dr. Sarah Fakih, Vice President Corporate Communications and Investor Relations
CureVac, Tübingen, Germany
T: +49 7071 9883-1298
M: +49 160 90 496949
sarah.fakih@curevac.com

Forward-Looking Statements of CureVac

This press release contains statements that constitute “forward looking statements” as that term is defined in the United States Private Securities Litigation Reform Act of 1995, including statements that express the opinions, expectations, beliefs, plans, objectives, assumptions or projections of CureVac N.V. and/or its wholly owned subsidiaries CureVac SE, CureVac Manufacturing GmbH, CureVac Inc., CureVac Swiss AG, CureVac Corporate Services GmbH, CureVac Belgium SA and CureVac Netherlands B.V. (the “company”) regarding future events or future results, in contrast with statements that reflect historical facts. Examples include discussion of the potential efficacy of the company’s vaccine and treatment candidates and the company’s strategies, financing plans, cash runway expectations, growth opportunities and market growth. In some cases, you can identify such forward-looking statements by terminology such as “anticipate,” “intend,” “believe,” “estimate,” “plan,” “seek,” “project,” “expect,” “may,” “will,” “would,” “could,” “potential,” “intend,” or “should,” the negative of these terms or similar expressions. Forward-looking statements are based on management’s current beliefs and assumptions and on information currently available to the company. However, these forward-looking statements are not a guarantee of the company’s performance, and you should not place undue reliance on such statements. Forward-looking statements are subject to many risks, uncertainties and other variable circumstances, including negative worldwide economic conditions and ongoing instability and volatility in the worldwide financial markets, ability to obtain funding, ability to conduct current and future preclinical studies and clinical trials, the timing, expense and uncertainty of regulatory approval, reliance on third parties and collaboration partners, ability to commercialize products, ability to manufacture any products, possible changes in current and proposed legislation, regulations and governmental policies, pressures from increasing competition and consolidation in the company’s industry, the effects of the COVID-19 pandemic on the company’s business and results of operations, ability to manage growth, reliance on key personnel, reliance on intellectual property protection, ability to provide for patient safety, fluctuations of operating results due to the effect of exchange rates, delays in litigation proceedings, different judicial outcomes or other factors. Such risks and uncertainties may cause the statements to be inaccurate and readers are cautioned not to place undue reliance on such statements. Many of these risks are outside of the company’s control and could cause its actual results to differ materially from those it thought would occur. The forward-looking statements included in this press release are made only as of the date hereof. The company does not undertake, and specifically declines, any obligation to update any such statements or to publicly announce the results of any revisions to any such statements to reflect future events or developments, except as required by law.

For further information, please reference the company’s reports and documents filed with the U.S. Securities and Exchange Commission (the “SEC”). You may get these documents by visiting EDGAR on the SEC website at www.sec.gov.

CureVac Strengthens Leadership Team with Appointment of Seasoned Industry Executive Axel Sven Malkomes as Chief Financial Officer
 

• Experienced CFO and investment banker with 30-year track record will help drive CureVac’s transformation
   

TÜBINGEN, Germany/BOSTON, USA – November 4, 2024 – CureVac N.V. (Nasdaq: CVAC) (“CureVac”), a global biopharmaceutical company developing a new class of transformative medicines based on messenger ribonucleic acid (“mRNA”), today announced the appointment of Axel Sven Malkomes as Chief Financial Officer, effective November 11, 2024.

Mr. Malkomes joins CureVac at a pivotal moment as the company enters a new chapter of growth and innovation, bringing over three decades of senior corporate and investment banking experience within the biotech and pharmaceutical industries.

“Axel’s appointment corresponds with a significant milestone in CureVac’s evolution,” said Dr. Alexander Zehnder, Chief Executive Officer of CureVac. “As we embark on an exciting new phase of corporate development, his extensive expertise and proven leadership in the life sciences sector will be instrumental. Axel will play a key role in advancing our strategic initiatives, strengthening our financial foundation, and enhancing shareholder value. We are thrilled to welcome him to our leadership team.”

“I am honored to join CureVac at such a transformative time in the company’s journey,” said Axel Malkomes. “With its pioneering mRNA technology and the momentum from the recent deal with GSK, CureVac is well-positioned to make significant advancements in developing innovative medicines. I look forward to leveraging my experience in financial management and corporate growth to support CureVac’s mission and contribute to its future success.”

Mr. Malkomes most recently served as CFO at Cardior Pharmaceuticals GmbH, a private clinical-stage biopharmaceutical company pioneering the discovery and development of non-coding RNA-based therapeutics designed to address the root causes of heart disease. During his tenure, he played a crucial role in strategically and financially preparing the company for capital markets, co-leading significant financing rounds, and supported potential M&A and partnering transactions, culminating in the successful acquisition of Cardior by Novo Nordisk in 2024.

Before Cardior, Mr. Malkomes was CFO and Chief Business Officer at Medigene AG, a publicly listed cell therapy company. There, he was instrumental in strategically and financially reshaping the company, significantly extending its cash runway and expanding its portfolio of strategic collaborations.

His extensive experience also includes senior healthcare investment banking roles at Barclays and Société Générale, as well as co-heading European healthcare investments at 3i Group plc, a UK-listed private equity firm with over $20 billion in assets under management. Earlier in his career, he held senior operational and corporate leadership positions at Merck KGaA.

Mr. Malkomes began his career in investment banking with institutions such as Dresdner Bank, Donaldson Lufkin Jenrette (which later became Credit Suisse), and Lehman Brothers, focusing on corporate finance, M&A, equity capital markets, and private equity transactions in the healthcare and life sciences sectors.

Since 2022, he has been a member of the Board of Directors of Cellectis SA, a cell and gene editing company listed on NASDAQ and Euronext, where he chairs the audit committee.

Mr. Malkomes holds a degree in business administration from Otto-Friedrich University in Bamberg, Germany, and has completed executive management programs at INSEAD, Kellogg School of Management at Northwestern University, and the Hong Kong University of Science and Technology.

About CureVac

CureVac (Nasdaq: CVAC) is a pioneering multinational biotech company founded in 2000 to advance the field of messenger RNA (mRNA) technology for application in human medicine. In more than two decades of developing, optimizing, and manufacturing this versatile biological molecule for medical purposes, CureVac has introduced and refined key underlying technologies that were essential to the production of mRNA vaccines against COVID-19, and is currently laying the groundwork for application of mRNA in new therapeutic areas of major unmet need. CureVac is leveraging mRNA technology, combined with advanced omics and computational tools, to design and develop off-the-shelf and personalized cancer vaccine product candidates. It also develops programs in prophylactic vaccines and in treatments that enable the human body to produce its own therapeutic proteins. Headquartered in Tübingen, Germany, CureVac also operates sites in the Netherlands, Belgium, Switzerland, and the U.S. Further information can be found at www.curevac.com.

CureVac Media and Investor Relations Contact

Dr. Sarah Fakih, Vice President Corporate Communications and Investor Relations
CureVac, Tübingen, Germany
T: +49 7071 9883-1298
M: +49 160 90 496949
sarah.fakih@curevac.com

Forward-Looking Statements of CureVac

This press release contains statements that constitute “forward looking statements” as that term is defined in the United States Private Securities Litigation Reform Act of 1995, including statements that express the opinions, expectations, beliefs, plans, objectives, assumptions or projections of CureVac N.V. and/or its wholly owned subsidiaries CureVac SE, CureVac Manufacturing GmbH, CureVac Inc., CureVac Swiss AG, CureVac Corporate Services GmbH, CureVac Belgium SA and CureVac Netherlands B.V. (the “company”) regarding future events or future results, in contrast with statements that reflect historical facts. Examples include discussion of the potential efficacy of the company’s vaccine and treatment candidates and the company’s strategies, financing plans, cash runway expectations, growth opportunities and market growth. In some cases, you can identify such forward-looking statements by terminology such as “anticipate,” “intend,” “believe,” “estimate,” “plan,” “seek,” “project,” “expect,” “may,” “will,” “would,” “could,” “potential,” “intend,” or “should,” the negative of these terms or similar expressions. Forward-looking statements are based on management’s current beliefs and assumptions and on information currently available to the company. However, these forward-looking statements are not a guarantee of the company’s performance, and you should not place undue reliance on such statements. Forward-looking statements are subject to many risks, uncertainties and other variable circumstances, including negative worldwide economic conditions and ongoing instability and volatility in the worldwide financial markets, ability to obtain funding, ability to conduct current and future preclinical studies and clinical trials, the timing, expense and uncertainty of regulatory approval, reliance on third parties and collaboration partners, ability to commercialize products, ability to manufacture any products, possible changes in current and proposed legislation, regulations and governmental policies, pressures from increasing competition and consolidation in the company’s industry, the effects of the COVID-19 pandemic on the company’s business and results of operations, ability to manage growth, reliance on key personnel, reliance on intellectual property protection, ability to provide for patient safety, fluctuations of operating results due to the effect of exchange rates, delays in litigation proceedings, different judicial outcomes or other factors. Such risks and uncertainties may cause the statements to be inaccurate and readers are cautioned not to place undue reliance on such statements. Many of these risks are outside of the company’s control and could cause its actual results to differ materially from those it thought would occur. The forward-looking statements included in this press release are made only as of the date hereof. The company does not undertake, and specifically declines, any obligation to update any such statements or to publicly announce the results of any revisions to any such statements to reflect future events or developments, except as required by law.

For further information, please reference the company’s reports and documents filed with the U.S. Securities and Exchange Commission (the “SEC”). You may get these documents by visiting EDGAR on the SEC website at www.sec.gov.

Classification of NuWays AG to CS MEDICA A/S

Revolutionizing alternative medicine; Initiate with BUY

CS MEDICA, a Danish Med-Tech company founded in 2011, is at the forefront of developing CBD-infused medical devices that offer safe, effective alternatives for autoimmune and stress-related conditions like arthritis, psoriasis, pain and hair loss. The company utilizes CBD’s proven anti-inflammatory and antioxidative properties in >10 products, classified as medical devices or cosmetics and backed by clinical trials. With regulatory approval in major markets such as the EU, U.K. and the U.S., CS MEDICA has established itself as a key player in the rapidly growing alternative medicine space.

CS MEDICA’s capital-light business model focuses on R&D and distribution while outsourcing manufacturing to partners in Europe. This allows the company to scale efficiently while minimizing operational risks. As one of only few CBD-infused medical device company registered for sale in pharmacies, CS MEDICA occupies a unique position at the intersection of the pharmaceutical and cosmetics markets, offering clinically proven products with fewer side effects at competitive price points.

CS MEDICA’s hybrid product formulations, which combine R&D, clinical evidence, compliance, and the benefits of CBD, a natural ingredient, set the company apart from competition. Its flagship line, CANNASEN ®, includes highly effective treatments for pain, skin disorders, and hair loss, with superior bioavailability when applied topically.

Strong growth prospects: Global demand for alternative treatments is booming, with the alternative medicine market projected to grow at a 15.7% CAGR until 2031. CS MEDICA is well-positioned to benefit from this trend. Especially non-European markets such as MENA and APAC offer high growth potentials once the regulatory hurdles have been overcome and social acceptance increased. The company’s private/white-label segment (~ 2/3 of order intake), offers a steady revenue stream, while its CANNASEN® brand continues to expand, contributing to rapid top-line growth.

The market’s strong growth prospects coupled with CS MEDICA’s unique positioning should allow the company to strongly grow its top-line to DKK 108m by FY 2027/28e, implying a 61% CAGR (vs FY 2023/24e). At the same time, thanks to the resulting operating leverage, the EBITDA margin should turn positive, reaching 25%.

We initiate the coverage with a BUY rating and a EUR 2.30 PT based on a SOTP valuation.

You can download the research here: http://www.more-ir.de/d/31171.pdf

For additional information visit our website: www.nuways-ag.com/research

Contact for questions:
NuWays AG – Equity Research
Web: www.nuways-ag.com
Email: research@nuways-ag.com
LinkedIn: https://www.linkedin.com/company/nuwaysag
Adresse: Mittelweg 16-17, 20148 Hamburg, Germany
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Diese Meldung ist keine Anlageberatung oder Aufforderung zum Abschluss bestimmter Börsengeschäfte.
Offenlegung möglicher Interessenskonflikte nach § 85 WpHG beim oben analysierten Unternehmen befinden sich in der vollständigen Analyse.
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