• Significant clinical and regulatory progress across entire pipeline

BV100:

• Initiated global registrational Phase 3 (RIV-TARGET) in HABP/VABP¹ program – US FDA green lights IND
• Phase 2b (RIV-CARE) to be conducted via Wellcome-funded trial network ADVANCE-ID
• First participants dosed in Phase 1 in China, preparing onboarding of China into RIV-TARGET
• BV100 patent granted in China, adding to BV100’s patent coverage in over 25 countries including the US and Europe

Alpibectir:

• Our partner GSK reported first patient first visit for Phase 2b/c trial in pulmonary TB
• Phase 2a results published in New England Journal of Medicine
• Received EMA Orphan Designation

Corporate:

• BV500: Entered global research collaboration with Shionogi for broad-spectrum non-tuberculous mycobacteria
• Successful IPO funding operations into 2028 with BV100 Phase 3 read-out by the end of 2027
• Conference call on March 18, 2026 at 2.00 pm CET (9.00 am EST)

BioVersys AG (SIX: BIOV), a multi-asset, clinical stage biopharmaceutical company focusing on research and development of novel antibacterial products for serious life-threatening infections caused by multi-drug resistant (MDR) bacteria, announced today its audited financial results and corporate highlights for the full year 2025, as well as the publication of its 2025 Annual Report.

Dr. Marc Gitzinger, Chief Executive Officer of BioVersys: “Our successful IPO in early 2025 provided us with the funding to progress our entire pipeline of novel antibacterial drugs, including our two lead assets BV100 and alpibectir. 2025 has been a year of substantial clinical and regulatory progress. We initiated a global Phase 3 program for BV100 in HABP/VABP^[1] caused by carbapenem resistant Acinetobacter baumanni (CRAB), and entered into strategic partnerships with Shionogi for BV500 in non-tuberculous mycobacteria (NTM) infection, and with the ADVANCE-ID clinical trial network for the BV100 Phase 2b (RIV-CARE) study. These agreements validate our rich pipeline and extend our cash runway well beyond the BV100 Phase 3 read-out. In 2025, we also saw significant progress in policy change and reimbursement reforms for novel antibiotics, particularly in Europe, and we believe that BioVersys is ideally positioned to benefit from these long-awaited changes. 2026 has started very strongly with the publication of pre-clinical and clinical data on BV100 and alpibectir in prestigious journals, as well as the US FDA’s acceptance of the BV100 Phase 3 IND. As we continue to advance our pipeline, I would like to thank our shareholders, stakeholders and colleagues for supporting us in developing the next generation antibiotics.”

Pipeline Highlights

BV100:

In 2025, the company’s lead candidate BV100 initiated its planned global Phase 3 registrational trial (RIV-TARGET) in HABP/VABP caused by carbapenem resistant Acinetobacter baumannii (CRAB) and received US FDA green light for its IND. The study aims to enroll approximately 300 HABP/VABP patients with suspected or confirmed CRAB infections. Patients will be randomized 1:1 to receive either [1] BV100 combined with low dose polymyxin B or [2] Colistin combined with high-dose ampicillin-sulbactam, with both arms allowing meropenem as background in case of polymicrobial infections. The primary efficacy endpoint is defined as 28-day all-cause mortality (ACM) in the CRABC microbiological modified intention-to-treat (CRABC m-MITT) population. Secondary efficacy endpoints will include clinical cure status at the test of cure (ToC) in CRABC m-MITT, ventilator free days, time spent in intensive care unit (ICU) and time in hospital. As part of the study protocol, data safety monitoring boards (DSMB)^[2] will be convened at regular intervals to review trial progress.

In parallel to the Phase 3 pivotal trial, an open-label Phase 2b differentiation trial (RIV-CARE) will be initiated in H1 2026, comparing BV100 with BAT in multiple geographies. The Phase 2b trial aims to provide real world evidence of clinical practices in settings with very high drug resistance levels. Interim analysis is planned for end of 2026. In November 2025, BioVersys announced that the ADVANCE-ID clinical trial network will support and collaborate with BioVersys in conducting the Phase 2b study. This support has been made possible thanks to the generous contribution of Wellcome who strengthened the ADVANCE-ID network with SGD 22 million (c. USD 17m or CHF 14m).

A Phase 1 safety study in China was also initiated in 2025 prior to enrolling Chinese patients in the global Phase 3 study program in H2 2026. The Chinese Patent Office granted crucial IP protection to BV100, adding to BV100’s patent coverage in over 25 countries including the US, Europe and the UK.

Alpibectir:

In March 2025, BioVersys announced first patient first visit (FPFV) in part 1 of the alpibectir-ethionamide (AlpE) Phase 2 clinical trial in pulmonary tuberculosis (TB) in combination with 1^st line tuberculosis drugs. This part 1 of the study delivered top line data showed that alpibectir is generally safe and well tolerated warranting progression into part 2 of the study. Part 2 of the study is a Phase 2b in which AlpE is given for 2 months in combination with first-line TB drugs, followed by 18 weeks of Rifampicin and Isoniazid treatment. FPFV for the Phase 2b was reported in March 2026.

Alongside the development in pulmonary TB, BioVersys has also submitted a Phase 2 trial for AlpE in meningeal TB to regulatory authorities. FPFV is expected in H1 2026.

In August 2025, BioVersys received European Medicine Agency Orphan Designation for alpibectir combined with ethionamide for the treatment of tuberculosis. This Designation provides key incentives, including reduced fees, research and clinical protocol support, and 10-year EU market exclusivity, and follows alpibectir ethionamide receiving US FDA Orphan Drug Designation in 2023.

Alpibectir is being developed in strategic partnership with GSK, who leads clinical development in Tuberculosis Pneumonia while BioVersys leads development in Tuberculosis Meningitis. Both partners share equal economics.

BV500:

In July 2025, BioVersys entered a global research collaboration with Shionogi for its broad-spectrum non-tuberculous mycobacteria (NTM) program BV500.

The collaboration provides a research and exclusive license option agreement with Shionogi to jointly develop novel ansamycin leads from BioVersys’ BV500 program into clinical candidates. Under the terms of the agreement, BioVersys is eligible to receive upfront and near-term research payments of CHF 5.0 million and, upon exercise of the license option, regulatory and sales milestones of up to CHF 479 million as well as royalties on future sales.

2025 Financial Highlights

For the year ended 31 December 2025, BioVersys recognized revenues of CHF 0.8 million (2024: nil) related to the Research Collaboration Agreement entered with Shionogi in July 2025 as well as CHF 2.5 million in other operating income made of research tax credits, grants and subsidies (2024: CHF 1.2 million) leading to a total operating income of CHF 3.3 million (2024: CHF 1.2 million).

As a result of BioVersys pipeline progressing through the stages of development, operating expenses were CHF 23.2 million in 2025 compared to CHF 19.9 million in 2024 and leading to an operating loss of CHF 20 million (2024: CHF 18.7m) for the financial year 2025. Operating expenses in 2025 included CHF 16.5 million in R&D expenses, representing approximately 71% of operating expenses for the year (2024: 64.9%).

The net loss in 2025 amounted to CHF 21.8 million (2024: Net loss of CHF 18.7 million). 

The net cash used in operating activities in 2025 was CHF 22.0 million (2024: CHF 16.1 million). 

The company raised approximately CHF 76.7 million as part of its February 2025 Initial Public Offering. The cash and cash equivalents position increased to CHF 82.5 million as of December 31, 2025 (December 31, 2024: CHF 26.6 million).

Total shareholders’ equity stood at CHF 59.8 million as of December 31, 2025 (December 31, 2024: CHF 10.7 million).

As of December 31, 2025, the company employed 33 FTE (full-time equivalents) (end 2024: 27). About 75% of the employees are employed in R&D-related functions.

Key Figures as of December 31, 2025

Initial Public Offering in Q1 2025

On the back of the promising advancement of the company’s pipeline and the related positive clinical data generated, BioVersys successfully completed its IPO on the SIX Swiss Exchange on February 7, 2025. 

Hernan Levett, CFO of BioVersys, comments: “In February 2025, we successfully completed an IPO on the Swiss Stock Exchange, which added proceeds of CHF 76.7 million, providing the necessary capital to advance our pipeline through key development milestones. Later in the year, we entered into a research collaboration agreement with Shionogi and added the partnership with ADVANCE-ID financially supported by Wellcome. These partnerships further strengthen our financial position and  are of strategic importance to our pipeline. The accomplishments of 2025 are a testament to the robust clinical data and the strong team at BioVersys demonstrating potential to bring game-changing anti-infectives to market.”

Outlook 
Following the initiation of the BV100 global Phase 3 registrational study in 2025, BioVersys plans to initiate the recruitment of patients based on regulatory green lights (e.g. US FDA IND) and the completion of the ongoing Phase 1 study in China, respectively. The study remains on track to report top-line data by the end of 2027, with DSMB reviews planned in H2 2026 and H1 2027. The Phase 2b for BV100 being conducted by the ADVANCE-ID network is expected to initiate recruiting patients in H1 2026 with a planned interim analysis expected to take place by end of this year.

For alpibectir, BioVersys’ partner GSK is pursuing the Phase 2 program in pulmonary TB, expecting last patient last visit by end of 2026, while BioVersys is on track to initiate the Phase 2 in meningeal TB in H1 2026.

For BV200 and BV500, BioVersys expects to generate additional pre-clinical data in the course of 2026. In addition, the BioVersys team will continue to engage with industry alliances and will be working with global regulatory and political leaders towards a sustainable policy framework ensuring adequate reimbursement and access mechanisms for novel antibiotics.

Financial Outlook 2026

For the full year 2026, the company expects total operating loss to be in the range of CHF 40.0 to CHF 45.0 million.

Full Year 2025 Documents

This press release, the Annual Report 2025 as well as the webcast presentation are available under the investors section of www.bioversys.com.

Full Year 2025 Conference Call & Audio Webcast

BioVersys will host a conference call and webcast at 2.00 pm CET (9.00 am EST) to discuss the financial results, provide an update on the company’s performance, outline its strategic outlook, and share insights into BioVersys’ therapeutic pipeline.

Event details for Investors, Media and Interested Parties:

• Conference Call Registration: Link (Participants will receive dial-in details upon registration)

Financial calendar

The scheduled events for BioVersys are also available on the investor section of the company’s website.

About BioVersys

BioVersys AG is a multi-asset, clinical stage biopharmaceutical company focused on identifying, developing and commercializing novel antibacterial products for serious life-threatening infections caused by multi-drug resistant (“MDR”) bacteria. Derived from the company’s two internal technology platforms (TRIC and Ansamycin Chemistry), candidates are designed and developed to overcome resistance mechanisms, block virulence production and directly affect the pathogenesis of harmful bacteria towards the identification of new treatment options in the antimicrobial and microbiome fields. This enables BioVersys to address the high unmet medical need for new treatments against life-threatening resistant bacterial infections and bacteria-exacerbated chronic inflammatory microbiome disorders. The company’s most advanced research and development programs address nosocomial infections of Acinetobacter baumannii (BV100, Phase 3), and tuberculosis (alpibectir, Phase 2, in collaboration with GlaxoSmithKline (GSK) and a consortium of the University of Lille, France). BioVersys is located in the biotech hub of Basel, Switzerland.

BioVersys contact 
Hernan Levett, CFO, Tel. +41 61 633 22 50; Mail: hernan.levett@bioversys.com
For media: media@bioversys.com Website: www.bioversys.com

Disclaimer

This communication expressly or implicitly contains certain forward-looking statements, such as “believe”, “assume”, “expect”, “forecast”, “project”, “may”, “could”, “might”, “will” or similar expressions concerning BioVersys and its business, including with respect to the progress, timing and completion of research, development and clinical studies for product candidates. Such statements involve certain known and unknown risks, uncertainties and other factors, which could cause the actual results, financial condition, performance or achievements of BioVersys to be materially different from any future results, performance or achievements expressed or implied by such forward-looking statements. BioVersys is providing this communication as of this date and does not undertake to update any forward-looking statements contained herein as a result of new information, future events or otherwise.

^[1] HABP: Hospital-Acquired Bacterial Pneumonia; VABP: Ventilator-Associated Bacterial Pneumonia.

^[2] The DSMB review is the periodic evaluation of unblinded or partially unblinded clinical trial data by an independent committee of experts to determine whether the study should continue, be modified, or be stopped based on safety, efficacy, or futility considerations.

 ​​​​​FULL-YEAR 2025 KEY FINANCIALS

Basel, 17 March 2026: Medartis Holding AG (MED:SW), a leading orthopaedic company specialising in head and extremity surgery, today reported total sales of CHF 269.3 million for the full year 2025, representing growth of 24.2% at constant exchange rates (CER). Organically, sales rose 15.7% (2024: 11.7%). EMEA was the principal growth driver, advancing by 18.0% and gaining further market share. The strong topline growth enabled Medartis to meet its initial EBITDA margin guidance despite adverse currency effects and US customs tariffs.

Matthias Schupp, CEO of Medartis, comments on the result: “2025 was a transformative year for Medartis and we achieved our goals by increasing organic sales by 15.7% and maintaining our core EBITDA margin at 18.4% despite significant currency and customs burdens. The acquisition of KeriMedical and NeoOrtho establishes the Medartis Group with three distinctive brands and a multi-tier strategy, expanding our addressable market significantly. We have also strengthened our leadership team, restructured our distribution channels in the United States and Japan, and positioned the company for accelerated growth as part of our head-to-toe strategy.”

Acquisitions add over CHF 800 million to addressable market, with further upside

Medartis completed two acquisitions during 2025. The KeriMedical partnership, which commenced in 2020, reached completion in July following FDA approval for the flagship TOUCH prosthesis. Medartis now holds 100% ownership of KeriMedical, strengthening the company’s position in arthroplasty and marking its entry into this segment. Separately, Medartis acquired a 51% controlling stake in NeoOrtho, a fast-growing value player in the Brazilian orthopaedic market. The acquisition enables a multi-tier pricing strategy and expands the company’s presence in Latin America. It represents a strategic entry into the estimated CHF 450 million value market segment in the region, which currently accounts for approximately three-quarters of the total market.

Together, these transactions expand Medartis’ addressable market by more than CHF 800 million, based on current market estimates in the segments where the company is active; the long-term potential is estimated to be considerably larger as these segments continue to grow and the company expands its geographical reach. Beyond portfolio expansion, they form part of a broader organisational evolution as Medartis transitions from a centralised, Swiss precision-oriented structure to a more decentralised, multi-brand model. This shift is designed to enable the company to compete more effectively across diverse global markets with differing customer needs and competitive dynamics.

With the publication of today’s results, Medartis also announced that it has entered an agreement to acquire CADskills, a Belgium-based specialist in personalised implant solutions and titanium printing, two fast-evolving areas in extremity and head (CMF) surgery. The acquisition reinforces Medartis’ strategic focus on more complex clinical applications with custom-made implants — including replacement of the jaw joint^[2], implants designed to sit directly on the bone surface for patients with significant bone loss^[3], and facial contouring solutions^[4]. CADskills holds certification to manufacture class III medical devices — the highest regulatory classification for implants. The company has also developed deep expertise in titanium 3D printing and operates a highly integrated model encompassing design, manufacturing and packaging. These printing capabilities are transferable to other regions in the future, supporting Medartis’ broader geographic expansion.

In addition, the acquisition expands Medartis’ upper extremity replacement offerings through the Carpitech™ family, which includes carpal bone arthoplasties, further consolidating Medartis’ position as a market leader in small bone replacement in the hand.

CADskills was founded by Prof. Dr mult. Dr Maurice Mommaerts, whose work and research in patient-specific implant design and additive manufacturing has contributed to advancing the field. Following the integration in the Medartis Group, Mr Mommaerts will provide scientific and clinical expertise to support continuity during the expansion phase. The transaction is structured as an upfront payment complemented by sales-based earnout components. Both parties have agreed not to disclose exact financial details. Closing of the transaction remains subject to the fulfilment of certain conditions, including a successful Foreign Direct Investment (FDI) screening in Belgium.

PERFORMANCE BY REGION AND PRODUCT CATEGORY

In the EMEA region, core sales rose substantially from CHF 122.8 million in 2024 to CHF 155.4 million in 2025, reflecting growth of 28.5% at constant exchange rates. The acquired KeriMedical business contributed CHF 14.1 million to the topline since its consolidation in July 2025. Organically, sales rose 18.0% (CER). The UK and Spain were the primary contributors to the 18.0% growth. In Germany, the company’s largest market in Europe, results were solid despite some impact from the transition to the new hybrid DRG reimbursement system^[5] for lower extremities. This performance enabled the company to capture additional market share in the region, driven by the expansion of its elbow portfolio, KeriMedical product sales, and greater territorial coverage thanks to a strengthened sales team. The KeriMedical business, currently distributed directly in three markets, accounted for one quarter of regional growth.

The 2025 EMEA performance surpassed expectations. Medartis secured a significant tender in Saudi Arabia and established market access in Malta and the Baltic countries. In Switzerland, the company introduced its new Hand 2 portfolio, strengthened its presence in the French-speaking region, and benefitted from a substantial CMF contract with the region’s largest university clinic.

Fundamental changes completed in the US

Medartis’ core US business achieved organic growth of 13.4% at constant exchange rates. Despite a weakening US Dollar, which reduced reported sales by over 6%-points, sales exceeded the CHF 50 million threshold for the first time in the company’s history. The declining contract manufacturing business from the former NSI contributed CHF 1.8 million in sales to total sales, down from CHF 5.2 million in 2024.

Growth moderated in H2 primarily due to the strategic sales channel optimisation, during which the company replaced approximately half of its 57 distribution partners to achieve greater brand and product exclusivity in operating theatres. Following the optimisation, the company now operates with 65 distribution partners. Mid-year, the company terminated its relationship with its largest distribution partner in Florida, accounting for nearly 10% of US sales, to address fundamental issues that would have constrained future growth in the region. The affected territories were refilled rapidly and coverage was expanded through five new distributors across Florida, with complete integration expected within 12 months from the onset of the transition. The company also appointed a new regional sales manager for the Southeast region Orlando and Tampa, positioning itself to capitalise on its first US training centre in Orlando, scheduled to open in Q4. Florida represents a strategically important market for TOUCH, given the population density and age demographics in this retirement state. Excluding the unexpected change in Florida, full-year growth would have reached 18%.

Concurrent with these developments, the company launched the Avenger radial head prosthesis and prepared for the commercial rollout of TOUCH in 2026, with initial cases performed by key opinion leaders (KOL) and product registration completed in first-mover centres. The registration process through a value analysis committee (VAC) averages up to four months. To support this important launch, Medartis recruited 10 specialists – comprising field experts and education specialists –and established a train-the-trainer programme designed to train more than 300 surgeons with hands-on support in 2026.

A strategic portfolio review resulted in streamlining efforts, including the discontinuation of former NSI products, allowing Medartis to concentrate more resources on upper extremities. The year marked an important transition for the region, with FDA approvals, sales channel optimisation, portfolio streamlining, and leadership changes positioning the company for sustained growth. Management anticipates that TOUCH will serve as a catalyst for business expansion and broaden the surgeon base.

Sales in the APAC region increased from CHF 31.1 million in 2024 to CHF 33.4 million in 2025, representing growth of 14.0% (CER) and strong currency headwind. Excluding a minor acquisition effect from KeriMedical sales in the region, organic sales growth reached 13.3% (CER). The Asia Pacific region returned to double-digit growth after two years of challenging market conditions. With the adverse pricing impact ceasing in mid-2025 and fuelled by distal radius growth in excess of 9%, Medartis’ Australian business achieved solid performance. Following the first full year of TOUCH product sales, reimbursement approval remains pending. The clinician feedback for TOUCH is positive and the clinical appetite for the basal thumb prostheses remains high. Medartis anticipates a reimbursement decision in H1, which is expected to establish pricing for CMC1^[6] arthroplasty on the ‘Prescribed List’ and stimulate patient flow. The Japanese business recorded growth in excess of 50% as the transition to direct distribution for the upper extremity portfolio progressed. New surgeon acquisition and customer conversion from the former local distributor continued to advance, albeit at a slower pace than initially anticipated. The company’s CMF distributor in Japan exceeded planned targets for the Modus product line, whilst APAC distributors delivered single-digit growth, slightly below internal projections.

Latin America recorded a turnaround following the regional sales decline in the prior year. Core regional sales in 2025 advanced by 57.1% (CER) to reach CHF 26.8 million. The acquired NeoOrto business contributed CHF 8.3 million to the topline since its consolidation in May 2025. Organically, sales rose 10.4% (CER). In Mexico, sales grew in the double-digit range, where the company completed a successful reorganisation, transitioning to a direct sales model in Mexico City under the new leadership, which is demonstrating early potential. Distributor sales grew robustly. The Brazilian business stabilised, with a notable improvement in the strategically important CMF segment. Medartis defined a new price positioning for the market and sharpened its commercial focus on the principal urban areas. Through the “Cold Fusion” programme, Medartis is merging the back-office and support functions of Medartis LATAM and NeoOrtho in Curitiba.

The consolidation is expected to generate operational synergies from 2027 onwards and provide the scale required to support regional growth. The new production facility progressed according to plan and is set to be inaugurated at the end of March 2026. Beyond this integration, Medartis is preparing market entries with both brands in Colombia, Argentina, and Chile during 2026 and 2027. The Latin America strategy is intended to serve as a template for entering other value markets in the future.

FINANCIAL PERFORMANCE

This media release and other investor and financial press communications include Alternative Performance Measures (APMs), which exclude one-time effects and M&A-related intangible asset amortisation to provide a clearer view of the company’s underlying operating performance. Medartis management uses these metrics to assess Medartis’ financial and operational performance, providing a complementary perspective to standard financial figures as defined by IFRS. To derive the core result for 2025, the following items were excluded from the reported IFRS figures.

• Under ‘non-core business,’ the negative gross profit contribution of CHF 1.3 million from the US contract manufacturing business and the NeoOrtho hip business were excluded from the core results. The former is scheduled for phase-out in the near term, while the latter was divested in H2.

• Transaction costs of CHF 0.6 million, recorded in general and administrative expenses, relate to the NeoOrtho and KeriMedical acquisitions. The transition of the Swiss pension fund from an insurance-based model to a collective foundation required adjustments to asset and liability recognition under IAS 19, resulting in additional past service costs of CHF 6.6 million. These were classified under ‘others’ and affected both COGS and OPEX. A further CHF 3.0 million was recorded for product write-offs and a legal settlement following the strategic portfolio review and discontinuation of former NSI products.

• The largest adjustment to the reported IFRS figures related to post ‘M&A effects’, comprising: the amortisation of inventory step-up to fair value of CHF 8.8 million; a revaluation of the historical 49% investment in KeriMedical of CHF 14.5 million; and a release of CHF 8.6 million in contingent consideration liabilities related to the final NSI earn-out payment. The M&A effects together with some smaller items had a positive impact of CHF 13.6 million on reported EBITDA.

The following commentary compares the core results for 2025 with those of the prior-year period on a like-for-like basis.

In 2025, core gross profit declined by 1.8PP from 82.8% to 81.0%. The gross margin decline reflected unanticipated US tariff-related costs (0.9 PP), foreign exchange headwinds (0.6 PP) and costs associated with capacity expansion across all four manufacturing sites ahead of anticipated demand growth. Manufacturing efficiency improvements provided a partial offset. The premium KeriMedical product portfolio had an accretive effect on the gross margin, whereas the NeoOrtho value business was dilutive owing to lower average selling prices relative to the premium range.

Core operating expenses (OPEX) increased at a slower rate than revenue. With OPEX of CHF 194.6 million, the OPEX-to-sales ratio decreased from 73.8% in the prior year to 73.1% in 2025, reflecting disciplined cost management despite continued investment in growth initiatives. Ahead of the FDA approval, the company build-up of the support organisation for the TOUCH rollout in the US and Australia. Excluding the aforementioned non-core elements, and before taxes, D&A and interest, core EBITDA rose from CHF 41.7 million to CHF 48.8 million. The corresponding EBITDA margin declined from 19.0% to 18.4%. This is mainly a result of the lower gross profit margin. The core EBIT margin decreased by 0.2PP to 9.2%, though it improved by 1.2PP on a constant currency basis.

The core net result declined from CHF 11.4 million in 2024 to CHF 6.1 million in 2025. This was primarily attributable to the factors outlined above and a lower finance result. In 2025, interest expense on the convertible bond amounted to CHF 3.5 million, with a further CHF 3.3 million in accretion expenses. The higher year-on-year charges reflect the first full-year impact of the convertible bond, which was issued in April 2024 and therefore only affected approximately nine months of the prior-year period (2024 interest expense: CHF 2.5 million). In addition, FX losses of CHF 5.3 million were recorded, mainly related to the depreciation of the US dollar and the Australian dollar. Core income tax expenses of CHF 5.2 million were recorded in 2025, compared to an exceptional income tax credit of CHF 1.0 million in 2024.

Operating cash flow increased by CHF 2.7 million to CHF 34.8 million, and free cash flow reached CHF 9.3 million, reflecting CHF 14.4 million in additional capital expenditure compared with the prior year as the company invested heavily in new production machinery in its facilities in the Warsaw, US, Archamps, Besançon, Curitiba and Basel. M&A-related cash outflows totalled CHF 120.8 million, comprising the equity investment in NeoOrtho and the cash consideration as well as the first of three earn-out payments for KeriMedical. At year-end, the company’s cash position stood at CHF 33.0 million (PY: CHF 138.7 million). For further information on the company’s financial performance, please refer to the financial section of the 2025 Annual Report, available on the company’s website.

NEW BOARD MEMBER PROPOSED

At the upcoming Annual General Meeting on 23 April 2026, shareholders will be asked to elect Yang Xu to the Board of Directors. Ms Xu currently serves as Chief Financial Officer of JDE Peets. Prior to this role, she held the position of CFO at the Straumann Group. She will succeed Jennifer Dean, who has served as a member of the Board and the Finance and Audit Committee since 2024. Ms Dean has decided not to stand for re-election. The Board thanks her for her contributions.

FULL-YEAR 2026 OUTLOOK

(barring any unforeseen circumstances)

Medartis expects to strengthen its market position in the US in 2026, supported by the continued rollout of KeriMedical’s TOUCH prosthesis, alongside continued progress in Japan and further expansion across Latin America. As the number of surgeons trained on TOUCH in the US increases progressively, regional sales growth is anticipated to be stronger in the second half of the year than in the first. Based on its assumptions, the company expects organic growth in core sales^[7] 16% – 18% over the full-year.

The company also expects a core EBITDA margin in the high teens (at CER), reflecting planned investments in growth initiatives and ongoing TOUCH rollout in the US and Australia.

Medartis to Host Full-Year 2025 Results Conference with Q&A

Medartis will present its full-year 2025 results today at 10:30 a.m. CET at its headquarters in Basel.
CEO Matthias Schupp and CFO Peter Hackel will host the event. The conference will be held in English. The presentation materials, Annual Report and a recording of the event are available on the Medartis website (https://medartis.com/en/investors#reports).

If you cannot attend in person, use the webcast link to register and follow the slide presentation and submit questions in writing or via the webcast interface.

IMPORTANT DATES AND UPCOMING INVESTOR EVENTS

Legend: Events highlighted in italic are broadcasted online

Your contact:

Medartis Corporate Communications

Fabian Hildbrand, Head of Corporate Communications, investor.relations@medartis.com

Andreas Richter, Corporate Communications Manager, corporate.communication@medartis.com

+41 61 633 37 36 / +41 61 633 37 34

About Medartis

Founded in 1997 and headquartered in Basel, Switzerland, the Medartis Group is one of the world’s leading manufacturers and providers of medical devices for surgical fixation of bone fractures and joint replacement for upper and lower extremities as well as for the craniomaxillofacial region. The Group has manufacturing sites in Switzerland, the United States, Brazil, and France. Medartis employs approx. 1,400 individuals across 12 countries, with products offered in over 60 countries globally. Medartis is committed to providing surgeons and operating theatre personnel with the most innovative implants and instruments as well as best-in-class service. For more information, please visit www.medartis.com.

Disclaimer

This communication does not constitute an offer or invitation to subscribe for or purchase any securities of Medartis Holding AG. This publication may contain certain forward-looking statements and assessments or intentions concerning the company and its business. Such statements involve certain risks, uncertainties and other factors which could cause the actual results, financial condition, performance or achievements of the company to be materially different from those expressed or implied by such statements. Readers should therefore not place reliance on these statements, particularly in connection with any contract or investment decision. The company disclaims any obligation to update these forward-looking statements, assessments or intentions. Furthermore, neither the company nor any of its directors, officers, employees, agents, counsel or advisers nor any other person makes any representation or warranty, express or implied, as to the accuracy or completeness of the information contained herein or of the views given or implied, and accordingly no reliance should be placed thereon.

^[1],2 This report and accompanying financial documents include alternative performance measures (APMs), referred to as “core” figures, which provide additional insight into Medartis’ underlying performance. Core figures exclude certain one-time, non-recurring and extraordinary items or items related to M&A. The NSI contract manufacturing business and NeoOrtho’s hip business (divested in H2 2025) contributed CHF 3.2 million to total revenue and were classified as non-core. For a detailed overview of all non-core events in the Income Statement, please refer to APM section of the Annual Report. Organic growth is calculated using fixed exchange rates (CER). To ensure fair comparison, it includes the acquired business’s sales in the baseline figures from the date Medartis assumed control.

^[2] Temporomandibular joint replacement, TMJR Parametro™

^[3] Subperiosteal implants, AMSJI^®™ = Additively Manufactured Subperiosteal Jaw Implant

^[4] Facial contouring

^[5] DRG = Diagnosis-Related Group. Reimbursement is calculated by applying a indication specific multiplier to a standardised base rate.

^[6] Thumb osteoarthritis (CMC = carpometacarpal joint arthritis)

^[7] “Organic growth” denotes the increase in sales at constant exchange rates (CER), excluding the sales from acquired or sold businesses (i.e. NeoOrtho, KeriMedical) in the baseline. NSI’s contract manufacturing business and divested NeoOrtho hip business were non-core activities.