BioAge Raises $90M to Treat Aging and Age-related Diseases

BioAge Raises $90M to Treat Aging and Age-related Diseases




BioAge Raises $90M to Treat Aging and Age-related Diseases

Proceeds will support advancement of the company’s pipeline and proprietary platform for identifying and developing therapies to treat diseases of aging

Company announces Chief Medical Officer as it prepares to enter clinic in 2021 with lead Phase 2-ready therapeutic compounds

RICHMOND, Calif., Dec. 03, 2020 (GLOBE NEWSWIRE) — BioAge Labs, Inc., a biotechnology company developing medicines to treat aging and aging-related diseases, today announced that it has raised $90 million in an oversubscribed Series C financing. The raise was co-led by Andreessen Horowitz and serial entrepreneur, Elad Gil, and included new investors Kaiser Foundation Hospitals, AARP Foundation (through the RockCreek Impact Fund) and Phi-X Capital, the fund of genomics entrepreneur Mostafa Ronaghi, among others. Current investors including Caffeinated Capital, Redpoint Ventures, PEAR Ventures, AME Cloud Ventures, Felicis Ventures, and others also participated.

“These additional funds will support advancement of our systems biology and data-driven platform to map the key pathways that drive human aging and our pipeline of medicines that target these pathways to reverse or eradicate diseases and extend healthspan,” said Kristen Fortney, PhD, co-founder and chief executive officer. “We look forward to advancing our first platform-derived therapies, BGE-117 and BGE-175 into clinical trials in the first half of 2021.”

“BioAge is at the forefront of understanding scientific drivers of aging with its unique and cutting-edge systems biology platform. We believe their approach has the potential to unlock the underlying pathologies of many diseases, such as Alzheimer’s, cardiovascular disease, and frailty, that disproportionately affect older populations,” said Vijay Pande, PhD, general partner at Andreessen Horowitz.

“Drugs that target aging have potential to treat several morbid diseases and improve the lives of older adults. BioAge has built a proprietary engine to analyze molecular signatures in aging populations, and to advance data-driven hypotheses to identify existing clinical-stage drugs that are ready for Phase 2 efficacy trials in age-related diseases. I’m excited to work with them as they scale their platform and develop multiple therapies to improve the health of older individuals,” said Elad Gil, PhD, entrepreneur and investor.

Proceeds from the financing will be used to build and develop a diversified portfolio of therapies that increase healthspan and lifespan, augment BioAge’s artificial intelligence (AI)-driven approach to map the molecular pathways that impact human longevity, and further expand capabilities to test drug candidates in predictive models of human diseases of aging.

Separately, the company announced that Paul Rubin, M.D. will lead its clinical development efforts as chief medical officer. Dr. Rubin, a veteran biopharmaceutical drug developer, brings extensive experience from early discovery, late stage development and ultimate drug approvals across a wide variety of therapeutic areas in global geographies. In former roles heading development at Sepracor, GSK and Abbott, Dr. Rubin has been responsible for the clinical development and approval of more than ten products. Prior to BioAge, he was most recently executive vice president, Research and Development for MiRagen and held a similar role at Xoma, two biotechnology companies. Dr. Rubin earned his M.D. at Rush Medical College, Chicago.

Dr. Rubin commented, “I am thrilled to be leading the BioAge clinical development team at this exciting time. Our platform provides a unique opportunity to identify targets relevant to the aging process and diseases associated with this process. Diseases common to older patients are often ignored despite their direct association with morbidity, mortality and decreased quality of life. The first two drugs from our pipeline are ready to begin Phase 2 trials in indications targeting serious conditions in elderly populations that presently have no good therapeutic options. A key aspect of our strategy is to initiate efficient human clinical trials that will demonstrate that our drugs can address age-related deficiencies in acute conditions, which may expedite approval and serve as a gateway to the treatment of chronic diseases, resulting in healthy aging.”

About the BioAge Platform

The BioAge platform identifies key drug targets that will impact aging. The company’s proprietary human aging cohorts have blood samples collected up to 45 years ago, with participant -omics data that is tied to extensive medical follow-up records including detailed future healthspan, lifespan and disease outcomes. BioAge has built a systems biology and AI platform that leverages these rich datasets to identify the molecular drivers of age-related pathology. BioAge’s pipeline of therapies targeting these key pathways will address the significant unmet medical needs of an aging population.

About BioAge

BioAge is a privately-held biotechnology company developing proprietary drugs to treat aging and aging- related diseases. Since its founding in 2015, the Company has raised $127 million in venture capital funding to back its AI-driven approach to map the molecular pathways that impact human longevity. BioAge’s mission is to develop a pipeline of therapeutic assets that increase healthspan and lifespan. For additional information about BioAge, visit the company’s website at www.bioagelabs.com.

Source: BioAge Labs, Inc.

Contact Information:

BioAge | peng@bioagelabs.com

Media | swheeler@wheelhouselsa.com

Pandion Therapeutics Appoints Katina Dorton to its Board of Directors

Pandion Therapeutics Appoints Katina Dorton to its Board of Directors




Pandion Therapeutics Appoints Katina Dorton to its Board of Directors

WATERTOWN, Mass., Dec. 03, 2020 (GLOBE NEWSWIRE) — Pandion Therapeutics, Inc. (Nasdaq: PAND), a clinical-stage biotechnology company developing novel therapeutics designed to address the unmet needs of patients living with autoimmune diseases, today announced the appointment of Katina Dorton, J.D., M.B.A., to Pandion’s board of directors and as chair of the audit committee. Ms. Dorton assumes the position of chair of the audit committee from Christopher Fuglesang, Ph.D., J.D., who will continue to serve as a member of the board and audit committee. Mitchell Mutz, Ph.D., resigned from the Company’s board on December 2, 2020.

“Ms. Dorton brings to Pandion over two decades of financial expertise, leading a multitude of financial transactions for companies in the life sciences industry. We look forward to her contributions to the growth and value creation for Pandion as a newly public company,” said Rahul Kakkar, M.D., Chief Executive Officer of Pandion Therapeutics. “We also sincerely thank Mitchell for his guidance as we brought Pandion from an idea through its first-in-human clinical trial and wish him the best in his future endeavors.”

“Pandion has the potential to bring about the next generation in autoimmune treatments with a unique focus on activating the body’s natural immune control nodes. I am excited to be a part of the team, particularly as we look to the Phase 1a results for the Company’s lead program, PT101, in early 2021,” commented Katina Dorton.

Ms. Dorton currently serves on the board of directors for Fulcrum Therapeutics (Nasdaq: FULC) and US Ecology (Nasdaq: ECOL). She most recently served as Chief Financial Officer of Repare Therapeutics, a synthetic lethality and DNA repair-focused oncology company. Prior to Repare, Ms. Dorton served as Chief Financial Officer of AVROBIO, a lentiviral gene therapy company. Earlier in her career, she served as a managing director in investment banking for Morgan Stanley and Needham & Company and as an associate attorney at Sullivan & Cromwell. Ms. Dorton received her J.D. from the University of Virginia School of Law, her M.B.A. from George Washington University and her B.A. from Duke University.

About Pandion Therapeutics
Pandion Therapeutics is developing novel therapeutics designed to address the unmet needs of patients living with autoimmune diseases. Pandion’s TALON (Therapeutic Autoimmune reguLatOry proteiN) drug design and discovery platform enables the company to create a pipeline of product candidates using immunomodulatory effector modules, with the ability to also combine an effector module with a tissue-targeted tether module in a bifunctional format. Pandion’s lead product candidate PT101, a combination of an interleukin-2 mutein effector module with a protein backbone, is designed to selectively expand regulatory T cells systemically, without activating proinflammatory cells, such as conventional T cells and natural killer cells, is currently in a Phase 1a clinical trial. Pandion is continuing to develop and expand its library of effector and tether modules as part of its earlier-stage research and discovery pipeline. For more information, please visit www.pandiontx.com.

Forward-Looking Statements
This press release contains “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995 that involve substantial risks and uncertainties. All statements, other than statements of historical facts, contained in this press release, including statements regarding the Company’s strategy and clinical development plans, timelines and prospects, are forward-looking statements. The words “anticipate,” “believe,” “continue,” “could,” “estimate,” “expect,” “intend,” “may,” “plan,” “potential,” “predict,” “project,” “should,” “target,” “will,” “would” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Any forward-looking statements are based on management’s current expectations of future events and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in, or implied by, such forward-looking statements. These risks and uncertainties include, but are not limited to, risks associated with Pandion’s ability to obtain and maintain necessary approvals from the FDA and other regulatory authorities; initiate preclinical studies and clinical trials of PT101 and its other product candidates; advance PT101 and its other product candidates in preclinical research and clinical trials; replicate in clinical trials positive results found in preclinical studies; advance the development of its product candidates under the timelines it anticipates in current and future clinical trials; obtain, maintain or protect intellectual property rights related to its product candidates; manage expenses; and raise the substantial additional capital needed to achieve its business objectives. For a discussion of other risks and uncertainties, and other important factors, any of which could cause the Company’s actual results to differ from those contained in the forward-looking statements, see the “Risk Factors” section, as well as discussions of potential risks, uncertainties and other important factors, in the Company’s most recent filings with the Securities and Exchange Commission. In addition, the forward-looking statements included in this press release represent the Company’s views as of the date hereof and should not be relied upon as representing the Company’s views as of any date subsequent to the date hereof. The Company anticipates that subsequent events and developments will cause the Company’s views to change. However, while the Company may elect to update these forward-looking statements at some point in the future, the Company specifically disclaims any obligation to do so.

Contacts

Media:
Kathryn Morris
The Yates Network
914-204-6412
kathryn@theyatesnetwork.com

Investors:
Michelle Avery
Pandion Therapeutics
857-273-0444
investors@pandiontx.com

PolyPid to Host Key Opinion Leader Call Discussing D-PLEX₁₀₀ and the Prevention of Surgical Site Infections

PolyPid to Host Key Opinion Leader Call Discussing D-PLEX₁₀₀ and the Prevention of Surgical Site Infections




PolyPid to Host Key Opinion Leader Call Discussing D-PLEX₁₀₀ and the Prevention of Surgical Site Infections

PETAH TIKVA, Israel, Dec. 03, 2020 (GLOBE NEWSWIRE) — PolyPid Ltd. (Nasdaq: PYPD), a Phase 3 clinical-stage biopharmaceutical company focused on developing targeted, locally administered, and prolonged-release therapeutics using its proprietary PLEX technology, today announced that it will host a key opinion leader (KOL) call on D-PLEX100 for the prevention of surgical site infections on Tuesday, December 15, 2020, at 8:00 am Eastern Time.

The call will feature presentations by KOLs Hartzell V. Schaff, MD, Mayo Clinic, Anthony J. Senagore, MD, Formerly of UTMB at Galveston, and Oded Zmora, MD, Shamir Medical Center, Israel, who will discuss the burden and challenges related to surgical site infections (SSIs) post colorectal and cardiovascular surgeries and the opportunity for D-PLEX100 to change the current status quo for the better. Dr. Schaff, Dr. Senagore, and Dr. Zmora will be available to answer questions following the formal presentations.

PolyPid’s management team will also discuss its developmental plans for D-PLEX100.

To register for the call, please register here.

Dr. Schaff is the Stuart W. Harrington Professor of Surgery and a consultant in the Division of Cardiovascular Surgery at Mayo Clinic, Rochester, Minnesota. He is a member of major international societies, including the American Association for Thoracic Surgery (2012-2013 President). He has authored or co-authored 784 papers, 94 book chapters, edited or written nine textbooks, and delivered over 500 lectures. He has served or is serving on the editorial boards of 11 journals, including Circulation and the Journal of Thoracic and Cardiovascular Surgery, where he is currently the Associate Editor. Dr. Schaff received his medical degree and training at the University of Oklahoma School of Medicine, where he also completed an NIH Research Fellowship. His surgical training was completed at Johns Hopkins Hospital.

Anthony J. Senagore, MD, is a colorectal surgeon with a long track record of academic surgery practice. He now serves as the Chief Strategy Officer for Genetesis in Mason, Ohio, and consults several healthcare startup companies. He has served as Professor of Surgery at several prestigious academic medical centers, including UTMB (University of Texas Medical Branch) at Galveston, Central Michigan University, College of Medicine, the University of Southern California, Keck School of Medicine, Cleveland Clinic Foundation, and Spectrum Health/Michigan State University. He has served as Chair of the Colorectal Surgery Residency Review Committee for the ACGME, President of the Board of Colon and Rectal Surgery, and he is a Past President of the ASCRS and Midwest Surgical Association. He also served on the Relative Value Update Committee for 16 years and as Chair of the Practicing Physicians Advisory Committee for the Centers for Medicaid Services. He has significant experience in revenue cycle and capacity management for healthcare. In addition, during his career, he was involved in the development of many innovations in laparoscopic colorectal surgery and the field of enhanced recovery.

Dr. Senagore earned his medical degree from Michigan State University (MSU), East Lansing, MI. He completed his residency in General Surgery at the Butterworth Hospital/MSU program. Dr. Senagore then completed a research fellowship and colon and rectal surgery residency at Ferguson Hospital on the Grand Rapids and East Lansing campuses of MSU. He continued his education and later received his Master of Science degree in physiology from MSU and a Master of Business Administration from the University of Phoenix, San Francisco, CA campus. He has edited five textbooks in colon and rectal surgery, authored over 230 peer-reviewed publications and 25 textbook chapters.

Oded Zmora, MD is a Colon and Rectal Surgeon and Chair of the Department of Surgery, Shamir Medical Center, Israel. He is also an associate professor of surgery at the Tel Aviv University School of Medicine. Dr. Zmora’s education and training include residency in general surgery at the Sheba Medical Center in Israel and the Mount Sinai Medical Center in New York, followed by two years of clinical and research fellowships at the Cleveland Clinic, Florida. Dr. Zmora is a past president of the Israel Society of Colon and Rectal Surgeons, immediate past chair of the S-ECCO (Surgeons’ European Crohn and Colitis Organization), and past co-editor of Techniques in Coloproctology. His main research interests focus on colorectal surgery, including surgical infectious complications, prevention of colorectal cancer metastases, treatment of perineal fistulas, and clinical research in colon and rectal surgery.

About D-PLEX100

PolyPid’s lead product candidate, D-PLEX100, is a novel drug product candidate designed to provide local prolonged and controlled anti-bacterial activity directly at the surgical site to prevent SSIs. Following the administration of D-PLEX100 into the surgical site, the PLEX technology enables a prolonged and constant release of the broad-spectrum antibiotic doxycycline, resulting in high local concentration of the drug for a period of four weeks for the prevention of SSIs, with additional potential to treat antibiotic-resistant bacteria at the surgical site. D-PLEX100 has received Breakthrough Therapy Designation from the FDA for the prevention of surgical site infections (SSIs) in patients undergoing elective colorectal surgery. D-PLEX100 has also received two Qualified Infectious Disease Product (QIDP) designations as well as two Fast Track designations for the prevention of post-abdominal surgery incisional infection and for the prevention of sternal wound infection post-cardiac surgery.

About PolyPid

PolyPid is a Phase 3 clinical-stage biopharmaceutical company focused on developing targeted, locally administered and prolonged-release therapeutics using its proprietary PLEX (Polymer-Lipid Encapsulation matriX) technology. PolyPid’s product candidates are designed to address diseases with high unmet medical needs by pairing PLEX with drugs to deliver them directly to precise sites in the body at predetermined release rates and over durations ranging from several days to several months. PolyPid’s lead product candidate, D-PLEX100, is in Phase 3 clinical trials for the prevention of sternal SSIs and abdominal SSIs. PolyPid’s technology and products are based on the inventions and the professional leadership of Dr. Noam Emanuel, the Founder and the Chief Scientific Officer of the company.

For additional company information, visit www.polypid.com.

Forward-looking Statements

This press release contains forward-looking statements within the meaning of the “safe harbor” provisions of the Private Securities Litigation Reform Act of 1995 and other Federal securities laws. Words such as “expects,” “anticipates,” “intends,” “plans,” “believes,” “seeks,” “estimates” and similar expressions or variations of such words are intended to identify forward-looking statements. For example, PolyPid is using forward-looking statements in this press release when it discusses its development and commercial plans for D-PLEX100 and Phase 3 trials of D-PLEX100. Because such statements deal with future events and are based on PolyPid’s current expectations, they are subject to various risks and uncertainties. Actual results, performance or achievements of PolyPid could differ materially from those described in or implied by the statements in this press release. The forward-looking statements contained or implied in this press release are subject to other risks and uncertainties, including those discussed under the heading “Risk Factors” in PolyPid’s final prospectus dated June 25, 2020, filed pursuant to Rule 424(b)(4) with the Securities and Exchange Commission (“SEC”), and in any subsequent filings with the SEC. Except as otherwise required by law, PolyPid undertakes no obligation to publicly release any revisions to these forward-looking statements to reflect events or circumstances after the date hereof or to reflect the occurrence of unanticipated events. References and links to websites have been provided as a convenience, and the information contained on such websites is not incorporated by reference into this press release. PolyPid is not responsible for the contents of third-party websites.

CONTACT: Company contact:

PolyPid, Ltd. 
Dikla Czaczkes Akselbrad
EVP & CFO
Tel: +972-747195700 
ir@polypid.com

Investors contact:

Bob Yedid
LifeSci Advisors
646-597-6989
bob@lifesciadvisors.com

FDA Clears Rezolute’s IND Application for RZ402

FDA Clears Rezolute’s IND Application for RZ402




FDA Clears Rezolute’s IND Application for RZ402

RZ402 is an orally available plasma kallikrein inhibitor in development for the treatment of diabetic macular edema

REDWOOD CITY, Calif., Dec. 03, 2020 (GLOBE NEWSWIRE) — Rezolute, Inc. (Nasdaq:RZLT), focused on advancing therapies for rare, metabolic and life-threatening diseases, announced today that the U.S. Food and Drug Administration (FDA) has cleared an Investigational New Drug (IND) application for RZ402, an orally available plasma kallikrein inhibitor, which is in development for the treatment of diabetic macular edema (DME). The Company expects to initiate a Phase 1 first-in-human clinical study with RZ402 in the first quarter of 2021.

RZ402, by inhibiting the formation of kallikrein, blocks the pro-inflammatory, pro-coagulant, and fluid-leakage cascade which is triggered by up-activation of the contact activation system in the setting of DME and other vascular-mediated diseases. As a result, it has been shown to reduce retinal inflammation and retinal vascular leakage of DME by more than 80% in both preventative and treatment models in rodents. Preclinical studies have also shown an excellent safety profile for RZ402 in both single- and repeat-dose settings at a range of doses. These data, taken together with oral bioavailability and exposure-time profile in canines and non-human primates showing target concentrations are achieved at clinically relevant oral doses, demonstrate the potential of RZ402 as a once-daily oral treatment option for DME.

Brian Roberts, M.D., Rezolute’s head of research and clinical development, commented, “The positive data we have collected from our animal studies highlight RZ402’s potential to address a glaring unmet need in the treatment of diabetic macular edema. Although the emergence of the anti-VEGF therapies has resulted in significant progress in the management of DME, a high percentage of patients do not adequately respond and/or do not tolerate this class of therapies. They have the obvious shortcoming of requiring frequent, burdensome intravitreal injections directly into the eye, often leading to delayed initiation or otherwise sub-optimal administration frequency. As a result, real-world vision outcomes also tend to be suboptimal. Based on animal studies demonstrating safety and efficacy at clinically relevant target exposures achieved with oral administration, we believe that once-daily oral administration of RZ402 has the potential to address these shortcomings. The submission and successful clearance of this IND is a key step towards evaluating RZ402’s potential as an oral therapy for DME, and we are looking forward to the upcoming initiation of clinical studies in the first quarter of next year.”

About Diabetic Macular Edema
Diabetic retinopathy (DR) affects approximately one third of adults with diabetes and can put patients at risk for vision loss. Consistently high blood sugar levels can cause DR, which is characterized by damage to the blood vessels in the eye and fluid leakage into the retina. Diabetic macular edema (DME) is a vision-threatening severe complication of DR marked by progressive vision loss and the potential for blindness. The accumulation of fluid leads to swelling and retinal thickening in the area of the macula, the part of the retina responsible for sharp, straight-ahead vision. The current standard of care for DME are the anti-VEGF therapies, which require repeated injections into the eye over long periods of time in order to preserve vision, and have an inadequate effectiveness and/or safety profile in a significant portion of patients. Compliance with these regimens can be difficult for patients, which in addition to inadequate responsiveness in a high percentage of patients, leads to overall undertreatment and suboptimal vision outcomes in the DME patient population.

About Rezolute, Inc.
Rezolute is advancing targeted therapies for rare, metabolic, and life-threatening diseases. Its lead clinical asset, RZ358, is in Phase 2b development as a potential treatment for congenital HI, a rare pediatric endocrine disorder. Its pipeline also includes RZ402, an IND-ready orally available plasma kallikrein inhibitor which is staged to transition into clinical development for the treatment of diabetic macular edema. For more information, visit www.rezolutebio.com or follow us on Twitter.

Forward-Looking Statements
This release, like many written and oral communications presented by Rezolute, Inc. and our authorized officers, may contain certain forward-looking statements regarding our prospective performance and strategies within the meaning of Section 27A of the Securities Act and Section 21E of the Securities Exchange Act of 1934, as amended. We intend such forward-looking statements to be covered by the safe harbor provisions for forward-looking statements contained in the Private Securities Litigation Reform Act of 1995, and are including this statement for purposes of said safe harbor provisions. Forward-looking statements, which are based on certain assumptions and describe future plans, strategies, and expectations of the Company, are generally identified by use of words such as “anticipate,” “believe,” “estimate,” “expect,” “intend,” “plan,” “project,” “seek,” “strive,” “try,” or future or conditional verbs such as “could,” “may,” “should,” “will,” “would,” or similar expressions. Our ability to predict results or the actual effects of our plans or strategies is inherently uncertain. Accordingly, actual results may differ materially from anticipated results. Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of this release. Except as required by applicable law or regulation, Rezolute undertakes no obligation to update these forward-looking statements to reflect events or circumstances that occur after the date on which such statements were made.

Media Contact
Amy Jobe, Ph.D.
LifeSci Communications
+1 315 879 8192
ajobe@lifescicomms.com

Investor Contact
Corey Davis, Ph.D.
LifeSci Advisors
+1 212 915 2577
cdavis@lifesciadvisors.com

Enlivex Reports Positive Interim Results From Phase II Clinical Trial Evaluating Allocetra in Severe and Critical COVID-19 Patients

Enlivex Reports Positive Interim Results From Phase II Clinical Trial Evaluating Allocetra in Severe and Critical COVID-19 Patients




Enlivex Reports Positive Interim Results From Phase II Clinical Trial Evaluating Allocetra in Severe and Critical COVID-19 Patients

Nes Ziona, Israel, Dec. 03, 2020 (GLOBE NEWSWIRE) — Enlivex Therapeutics Ltd. (Nasdaq: ENLV, the “Company”), a clinical-stage immunotherapy company, today reported positive interim results of an investigator-initiated Phase II clinical trial evaluating AllocetraTM in severe and critical COVID-19 patients.

The interim clinical results relate to eight COVID-19 patients who were treated with AllocetraTM in the Phase II clinical trial , six of whom were in severe condition and two of whom were in critical condition. Key results and conclusions from both the ongoing Phase II clinical trial, as well as a previously-reported investigator-initiated Phase Ib study include: 

  • Seven out of seven (100%) patients treated through November 26, 2020 had complete recovery from their respective severe/critical condition and were discharged from the hospital, after an average of 4.7 days following AllocetraTM administration.
  • Taken together with previously-treated patients in the concluded Phase Ib study, twelve out of twelve patients (100%) through November 26, 2020 had complete recovery from their respective severe/critical condition and were discharged from the hospital, after an average of 5.5 days following AllocetraTM administration.
  • The eighth treated patient in the Phase II study (and 13th treated patient overall), who enrolled in the Phase II study in critical condition on November 27, 2020, has experienced a clinical improvement following treatment with AllocetraTM and is classified as moderate/severe condition on the date of this press release. The patient remains hospitalized six days after treatment (results from patients enrolled in the prior Phase Ib investigator-initiated study showed an average of nine days to hospital discharge following AllocetraTM administration to critical patients).
  • AllocetraTM treatment has been well tolerated with no treatment-related serious adverse events. 

Data from both the previously-reported investigator-initiated Phase Ib study and the ongoing investigator-initiated Phase II COVID-19 trials are shown below:

Clinical Trial # Patients enrolled Disease Severity Clinical Outcome Hospitalization
Post Administration of AllocetraTM
Recovered Mortality Discharged Duration
(days, avg.)
Phase Ib Patients
Phase Ib 3 Severe 3/3 (100%) 0/3 (0%) 3/3 (100%) 5
Phase Ib 2 Critical 2/2 (100%) 0/2 (0%) 2/2 (100%) 9
Total 5   5/5 (100%) 0/5 (0%) 5/5 (100%) 6.6
Phase II, Patients Enrolled Through November 26, 2020
Phase II 6 Severe 6/6 (100%) 0/6 (0%) 6/6 (100%) 4.5
Phase II 1 Critical 1/1 (100%) 0/1 (0%) 1/1 (100%) 6
Total 7   7/7 (100%) 0/1 (0%) 7/7 (100%) 4.7
Summary of Phase Ib + Phase II Patients Enrolled Through November 26, 2020
Total 12   12/12 (100%) 0/12 (0%) 12/12 (100%) 5.5
Phase II, Patients Enrolled After November 26, 2020
Phase II 1 Critical Patient enrolled Nov 27, 2020. Following treatment, clinical status improved from Critical to Severe/Moderate. Patient is currently hospitalized. Results from Phase Ib study showed an average of nine days to hospital discharge following AllocetraTM administration to critical patients

  
Prof. Vernon van Heerden, Head of the Critical Care Medicine Unit at Hadassah Hospital in Israel and the lead investigator of both the prior Phase Ib and the current Phase II COVID-19 clinical trials stated, “Thirteen COVID-19 patients have been treated to date with AllocetraTM. The Phase II patients that have been discharged from the hospital are currently healthy. We believe that these compelling preliminary results have demonstrated safety and an indication of efficacy of AllocetraTM in these complicated patients, highlighting the potential of Enlivex’s product candidate to benefit severe and critical COVID-19 patients as well as others suffering from cytokine storms and organ dysfunctions across various clinical indications.”

Prof. Dror Mevorach, M.D., Chief Scientific and Medical Officer of Enlivex, added, “We believe the results from the COVID-19 clinical trials of AllocetraTM represent a unique opportunity for Enlivex in this COVID-19 patient population, and suggest that AllocetraTM may have utility as a safe and efficacious treatment for resolving states of organ failures across different life-threatening, high mortality clinical indications with high unmet medical needs.”

Oren Hershkovitz, Ph.D., CEO of Enlivex commented, “We are pleased with the interim results of this COVID-19 Phase II clinical trial. We believe that AllocetraTM, if approved, could potentially cover the void that currently exists in treatments for severe or critical COVID-19 patients. The upcoming anticipated regulatory approval of various COVID-19 vaccines is a game-changer in the fight against the pandemic, yet with various surveys demonstrating 33% of the U.S. population unwilling to get vaccinated, and studies showing that vaccines are not 100% effective, our commercial model estimates continued demand for the treatment of severe or critical COVID-19 patients for years to come.”

ABOUT THE ALLOCETRA COVID-19 PHASE II CLINICAL TRIAL
The COVID-19 study is a multi-center investigator-initiated, Phase II clinical trial. The trial is expected to recruit up to twenty-four COVID-19 patients in severe or critical condition, as defined by the U.S. National Institute of Health (NIH), and is designed to assess AllocetraTM in combination with standard of care treatment. Safety, tolerability, cytokine profile and efficacy parameters are planned to be evaluated. Up to twenty-four patients are expected to be recruited, subject to each patient’s eligibility and signing of an informed consent to participate and receive treatment. Eligibility criteria include an existing illness with at least one of (a) radiographic infiltrates by imaging (chest x-ray, CT scan, etc.), or (b) Sp/O2 ratio lower or equal to 94% on room air, or (c) requiring supplemental oxygen (low flow or high flow), with a P/F ratio of below 350 but higher than 150. Exclusion criteria include (a) pregnancy, lactation and childbearing potential woman who are not willing to use acceptable contraceptives measures for the entire study duration, (b) illness combined with other organ failure requiring organ support other than a respirator, including Stage 4 severe chronic kidney disease or requiring dialysis (i.e. estimated glomerular filtration rate (eGFR) < 30), (c) intubated patients (due to inability to sign an informed consent), (d) patients with malignant tumor, other serious systemic diseases and psychosis, (e) patients who are participating in other clinical trials or treated with any experimental agents that may contradict this trial, (f) co-infection of HIV or tuberculosis, (g) known immunocompromised state or medications known to be immunosuppressive, and (h) patients with P/F ratio or S/F ratio of <150 or a change in status of eligibility manifested by a rapid decline of P/F ratio between eligibility status and actual drug delivery.

ABOUT ENLIVEX
Enlivex is a clinical stage immunotherapy company, developing an allogeneic drug pipeline for immune system rebalancing. Immune system rebalancing is critical for the treatment of life-threatening immune and inflammatory conditions which involve hyper-expression of cytokines (Cytokine Release Syndrome) and for which there are no approved treatments (unmet medical needs) such as sepsis and COVID-19, as well as solid tumors’ immune-checkpoint rebalancing.  For more information, visit http://www.enlivex.com.

Safe Harbor Statement:  This press release contains forward-looking statements, which may be identified by words such as “expects,” “plans,” “projects,” “will,” “may,” “anticipates,” “believes,” “should,” “would”, “could,” “intends,” “estimates,” “suggests,” “has the potential to” and other words of similar meaning, including statements regarding expected cash balances, market opportunities for the results of current clinical studies and preclinical experiments, the effectiveness of, and market opportunities for, ALLOCETRATM programs. All such forward-looking statements are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995.  Investors are cautioned that forward-looking statements involve risks and uncertainties that may affect Enlivex’s business and prospects, including the risks that Enlivex may not succeed in generating any revenues or developing any commercial products; that the products in development may fail, may not achieve the expected results or effectiveness and/or may not generate data that would support the approval or marketing of these products for the indications being studied or for other indications; that ongoing studies may not continue to show substantial or any activity; and other risks and uncertainties that may cause results to differ materially from those set forth in the forward-looking statements. The results of clinical trials in humans may produce results that differ significantly from the results of clinical and other trials in animals. The results of early-stage trials may differ significantly from the results of more developed, later-stage trials. The development of any products using the ALLOCETRATM product line could also be affected by a number of other factors, including unexpected safety, efficacy or manufacturing issues, additional time requirements for data analyses and decision making, the impact of pharmaceutical industry regulation, the impact of competitive products and pricing and the impact of patents and other proprietary rights held by competitors and other third parties.  In addition to the risk factors described above, investors should consider the economic, competitive, governmental, technological and other factors discussed in Enlivex’s filings with the Securities and Exchange Commission, including in the Company’s most recent Annual Report on Form 20-F filed with the Securities and Exchange Commission.  The forward-looking statements contained in this press release speak only as of the date the statements were made, and we do not undertake any obligation to update forward-looking statements, except as required under applicable law.

ENLIVEX CONTACT
Shachar Shlosberger, CFO
Enlivex Therapeutics, Ltd.
shachar@enlivexpharm.com

INVESTOR RELATIONS CONTACT
Eric Ribner
LifeSci Advisors
eric@lifesciadvisors.com

Progenity, Inc. Prices $75.0 Million Convertible Senior Notes Offering

Progenity, Inc. Prices $75.0 Million Convertible Senior Notes Offering




Progenity, Inc. Prices $75.0 Million Convertible Senior Notes Offering

SAN DIEGO, Dec. 02, 2020 (GLOBE NEWSWIRE) — Progenity, Inc. (NASDAQ: PROG) today announced the pricing of its offering of $75.0 million aggregate principal amount of 7.25% convertible senior notes due 2025 (the “notes”) in a private offering to qualified institutional buyers pursuant to Rule 144A under the Securities Act of 1933, as amended (the “Securities Act”). The issuance and sale of the notes are scheduled to settle on December 7, 2020, subject to customary closing conditions. Progenity also granted the initial purchaser of the notes an option to purchase, for settlement within a period of 13 days from, and including, the date notes are first issued, up to an additional $15.0 million principal amount of notes.

The notes will be senior, unsecured obligations of Progenity and will accrue interest at a rate of 7.25% per annum, payable semi-annually in arrears on June 1 and December 1 of each year, beginning on June 1, 2021. The notes will mature on December 1, 2025, unless earlier repurchased, redeemed or converted. At any time from, and including, the date that is 30 calendar days after the initial closing date of this offering and before the close of business on the second scheduled trading day immediately before the maturity date, noteholders may convert their notes at their option into shares of Progenity’s common stock, together, if applicable, with cash in lieu of any fractional share, at the then-applicable conversion rate. In addition, noteholders that convert their notes before December 1, 2022 will, in certain circumstances, be entitled to an additional cash payment representing the present value of any remaining interest payments on the notes through December 1, 2022. The initial conversion rate is 278.0094 shares of common stock per $1,000 principal amount of notes, which represents an initial conversion price of approximately $3.60 per share of common stock. The conversion rate and conversion price will be subject to adjustment upon the occurrence of certain events.

The notes will be redeemable, in whole and not in part, for cash at Progenity’s option at any time on or after December 1, 2023, but only if the last reported sale price per share of Progenity’s common stock exceeds 130% of the conversion price for a specified period of time. The redemption price will be equal to the principal amount of the notes to be redeemed, plus accrued and unpaid interest, if any, to, but excluding, the redemption date.

If a “fundamental change” (as defined in the indenture for the notes) occurs, then noteholders may require Progenity to repurchase their notes for cash. The repurchase price will be equal to the principal amount of the notes to be repurchased, plus accrued and unpaid interest, if any, to, but excluding, the applicable repurchase date.

Progenity estimates that the net proceeds from the offering will be approximately $70.8 million (or approximately $85.0 million if the initial purchaser fully exercise its option to purchase additional notes), after deducting the initial purchaser’s discounts and commissions and estimated offering expenses. Progenity intends to use the net proceeds from the offering, together with the net proceeds from the underwritten public offering of common stock referred to below, to support its operations, to invest in its molecular testing research and development program, to invest in research and development with respect to its precision medicine platform, and for working capital and general corporate purposes.

Certain entities affiliated with Athyrium Capital Management, LP (“Athyrium”), one of Progenity’s affiliates, have agreed to acquire up to $103.5 million in aggregate principal amount of notes, consisting of $25.0 million principal amount of notes to be purchased for cash in the offering and, pursuant to a separate exchange agreement, an additional $78.5 million principal amount of notes to be issued in exchange for the discharge of amounts outstanding under Progenity’s credit and security agreement with a fund managed by Athyrium.

In a separate press release, Progenity also announced today the pricing of its previously announced underwritten public offering of 7,645,259 shares of common stock, at a public offering price of $3.27 per share. The issuance and sale of the common stock are scheduled to settle on December 7, 2020, subject to customary closing conditions. Progenity also granted the underwriters of the common stock offering a 30-day option to purchase up to an additional 1,146,788 shares of common stock. The completion of the offering of the notes is not contingent on the completion of the offering of common stock, and the completion of the offering of common stock is not contingent on the completion of offering of the notes. This press release does not constitute an offer to sell, or the solicitation of an offer to buy, any common stock in the public offering.

The offer and sale of the notes and the shares of common stock issuable upon conversion of the notes have not been, and will not be, registered under the Securities Act or any other securities laws, and the notes and such shares cannot be offered or sold except pursuant to an exemption from, or in a transaction not subject to, the registration requirements of the Securities Act and any other applicable securities laws. This press release does not constitute an offer to sell, or the solicitation of an offer to buy, the notes or the shares of common stock issuable upon conversion of the notes, nor will there be any sale of the notes or such shares, in any state or other jurisdiction in which such offer, sale or solicitation would be unlawful.

About Progenity

Progenity, Inc. is a biotechnology company with an established track record of success in developing and commercializing molecular testing products, as well as innovating in the field of precision medicine. Progenity provides in vitro molecular tests designed to improve lives by providing actionable information that helps guide patients and physicians in making medical decisions during key life stages. The company applies a multi-omics approach, combining genomics, epigenomics, proteomics, and metabolomics to its molecular testing products and to the development of a suite of investigational ingestible devices designed to provide precise diagnostic sampling and drug delivery solutions. Progenity’s vision is to transform healthcare to become more precise and personal by improving diagnoses of disease and improving patient outcomes through localized treatment with targeted therapies.

Forward-Looking Statements

This press release contains “forward-looking statements,” which statements are subject to substantial risks and uncertainties and are based on estimates and assumptions. All statements, other than statements of historical facts included in this press release, including, but not limited to, Progenity’s expectations regarding the consummation of the offerings, the satisfaction of customary closing conditions with respect to the offerings and the anticipated use of the net proceeds are forward-looking statements. In some cases, you can identify forward-looking statements by terms such as “may,” “might,” “will,” “objective,” “intend,” “should,” “could,” “can,” “would,” “expect,” “believe,” “design,” “estimate,” “predict,” “potential,” “develop,” “plan” or the negative of these terms, and similar expressions, or statements regarding intent, belief, or current expectations, are forward looking statements. These statements involve known and unknown risks, uncertainties and other factors that could cause Progenity’s actual results to differ materially from the forward-looking statements expressed or implied in this press release, the uncertainties related to market conditions and the completion of the offerings on the anticipated terms or at all, the uncertainties inherent in the clinical drug development process, such as the regulatory approval process, the timing of regulatory filings, and other matters, including the ongoing COVID-19 pandemic and associated shelter-in-place orders, that could affect sufficiency of existing cash, cash equivalents and short-term investments to fund operations and the availability or commercial potential of Progenity’s products, and those risks described in “Risk Factors” and “Management’s Discussion and Analysis of Financial Condition and Results of Operations” in Progenity’s Quarterly Report on Form 10-Q for the quarter ended September 30, 2020, filed with the SEC on November 11, 2020, and other subsequent documents filed with the SEC. Progenity claim the protection of the Safe Harbor contained in the Private Securities Litigation Reform Act of 1995 for forward-looking statements. Progenity expressly disclaims any obligation to update or alter any statements whether as a result of new information, future events or otherwise, except as required by law.

Contact Information

Investor Contact:
Robert Uhl
Managing Director, Westwicke ICR
ir@progenity.com
(619) 228-5886

Media Contact:
Kate Blom-Lowery
CG Life
kblomlowery@cglife.com
(858) 457-2436

Progenity Announces Pricing of Public Offering of Common Stock

Progenity Announces Pricing of Public Offering of Common Stock




Progenity Announces Pricing of Public Offering of Common Stock

SAN DIEGO, Dec. 02, 2020 (GLOBE NEWSWIRE) — Progenity, Inc. (“Progenity”) (NASDAQ: PROG), a biotechnology company with an established track record of success in developing and commercializing molecular testing products, today announced the pricing of its previously announced underwritten public offering of 7,645,259 shares of its common stock at a public offering price of $3.27 per share. The gross proceeds of the offering, before deducting underwriting discounts and commissions and other offering expenses payable by Progenity, are expected to be approximately $25.0 million. All of the shares are being offered by Progenity. Progenity has granted the underwriters a 30-day option to purchase up to an additional 1,146,788 shares of common stock at the public offering price, less underwriting discounts and commissions. The offering is expected to close on December 7, 2020, subject to the satisfaction of customary closing conditions. Progenity expects to use the net proceeds from the offering to support its operations, to invest in its molecular testing research and development program, to invest in research and development with respect to its precision medicine platform and for working capital and general corporate purposes.

In a separate press release, Progenity also announced today the pricing of its previously announced private offering of $75,000,000 aggregate principal amount of 7.25% convertible senior notes due 2025 (the “notes”), plus up to an additional $15,000,000 aggregate principal amount of notes that the initial purchaser of the notes has the option to purchase from Progenity. The issuance and sale of the notes are scheduled to settle on December 7, 2020, subject to customary closing conditions. The completion of the offering of common stock is not contingent on the completion of the offering of the notes, and the completion of the offering of notes is not contingent on the completion of offering of common stock. This press release does not constitute an offer to sell, or the solicitation of an offer to buy, any notes or any shares of common stock issuable upon conversion of the notes.

Piper Sandler & Co. and Wells Fargo Securities, LLC are acting as joint book-running managers for the offering of common stock. BTIG, LLC is acting as the lead manager for the offering of common stock.

A registration statement relating to the offering of common stock became effective on December 2, 2020. The offering is being made only by means of a prospectus, copies of which may be obtained from Piper Sandler & Co., Attention: Prospectus Department, 800 Nicollet Mall, J12S03, Minneapolis, Minnesota 55402, or by telephone at (800) 747-3924, or by email at prospectus@psc.com; or Wells Fargo Securities, LLC, Attention: Equity Syndicate Department, 500 West 33rd Street, New York, New York, 10001, at (800) 326-5897 or email a request to cmclientsupport@wellsfargo.com.

This press release shall not constitute an offer to sell or the solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

About Progenity

Progenity, Inc. is a biotechnology company with an established track record of success in developing and commercializing molecular testing products, as well as innovating in the field of precision medicine. Progenity provides in vitro molecular tests designed to improve lives by providing actionable information that helps guide patients and physicians in making medical decisions during key life stages. The company applies a multi-omics approach, combining genomics, epigenomics, proteomics, and metabolomics to its molecular testing products and to the development of a suite of investigational ingestible devices designed to provide precise diagnostic sampling and drug delivery solutions. Progenity’s vision is to transform healthcare to become more precise and personal by improving diagnoses of disease and improving patient outcomes through localized treatment with targeted therapies.

Forward Looking Statements

This press release contains “forward-looking statements,” which statements are subject to substantial risks and uncertainties and are based on estimates and assumptions. All statements, other than statements of historical facts included in this press release, including, but not limited to, Progenity’s expectations regarding the consummation of the offerings, the satisfaction of customary closing conditions with respect to the offerings and the anticipated use of the net proceeds are forward-looking statements. In some cases, you can identify forward-looking statements by terms such as “may,” “might,” “will,” “objective,” “intend,” “should,” “could,” “can,” “would,” “expect,” “believe,” “design,” “estimate,” “predict,” “potential,” “develop,” “plan” or the negative of these terms, and similar expressions, or statements regarding intent, belief, or current expectations, are forward looking statements. These statements involve known and unknown risks, uncertainties and other factors that could cause Progenity’s actual results to differ materially from the forward-looking statements expressed or implied in this press release, the uncertainties related to market conditions and the completion of the offerings on the anticipated terms or at all, the uncertainties inherent in the clinical drug development process, such as the regulatory approval process, the timing of regulatory filings, and other matters, including the ongoing COVID-19 pandemic and associated shelter-in-place orders, that could affect sufficiency of existing cash, cash equivalents and short-term investments to fund operations and the availability or commercial potential of Progenity’s products, and those risks described in “Risk Factors” and “Management’s Discussion and Analysis of Financial Condition and Results of Operations” in Progenity’s Quarterly Report on Form 10-Q for the quarter ended September 30, 2020, filed with the SEC on November 11, 2020, and other subsequent documents filed with the SEC. Progenity claim the protection of the Safe Harbor contained in the Private Securities Litigation Reform Act of 1995 for forward-looking statements. Progenity expressly disclaims any obligation to update or alter any statements whether as a result of new information, future events or otherwise, except as required by law.

Investor Contact:
Robert Uhl
Managing Director, Westwicke ICR
ir@progenity.com
(619) 228-5886

Media Contact:
Kate Blom-Lowery
CG Life
media@progenity.com
(619) 743-6294

Codexis Announces Pricing of Public Offering of Common Stock

Codexis Announces Pricing of Public Offering of Common Stock




Codexis Announces Pricing of Public Offering of Common Stock

REDWOOD CITY, Calif., Dec. 02, 2020 (GLOBE NEWSWIRE) — Codexis, Inc. (Nasdaq:CDXS), a leading protein engineering company, today announced the pricing of an underwritten public offering of 4,285,715 shares of its common stock at a public offering price of $17.50 per share. Net proceeds to Codexis from the offering are expected to be approximately $70.2 million after underwriting discounts and commissions and estimated offering expenses. The offering is expected to close on or about December 7, 2020, subject to customary closing conditions. Codexis has granted the underwriters of the offering the right for a period of 30 days to purchase up to an additional 642,857 shares of common stock at the public offering price, less underwriting discounts and commissions.

Jefferies LLC, Cowen and Company, LLC and Stifel, Nicolaus & Company, Incorporated are acting as joint book-running managers for the offering. Craig-Hallum Capital Group LLC and Stephens Inc. are acting as co-managers. The Benchmark Company acted as a financial advisor to Codexis in connection with the offering.

Codexis intends to use the net proceeds from the offering to fund research and development activities and infrastructure, to accelerate development of its performance enzyme products and novel biotherapeutic product candidates as well as any additional products or product candidates that Codexis may develop in the future, and for general corporate purposes, including increasing its working capital and capital expenditures. Codexis may also use a portion of the net proceeds to make investments in, or acquire, complementary businesses, products, services or technologies.

A registration statement relating to these securities has been filed with the U.S. Securities and Exchange Commission (SEC) and became effective on December 6, 2018. The offering is being made only by means of a written prospectus and prospectus supplement that will form a part of the registration statement. A preliminary prospectus supplement and the accompanying prospectus relating to the offering have been filed with the SEC and are available on the SEC’s website at www.sec.gov. A final prospectus supplement and accompanying prospectus will be filed with the SEC. Copies of the final prospectus supplement and the accompanying prospectus relating to the offering may be obtained, when available, by contacting Jefferies LLC, Attention: Equity Syndicate Prospectus Department, 520 Madison Avenue, 2nd Floor, New York, NY 10022, or by email at Prospectus_Department@Jefferies.com, or by telephone at (877) 821-7388; Cowen and Company, LLC, c/o Broadridge Financial Services, 1155 Long Island Avenue, Edgewood, NY 11717, Attention: Prospectus Department, or by telephone at (833) 297-2926, or by email at PostSaleManualRequests@broadridge.com; or Stifel, Nicolaus & Company, Incorporated, Attention: Syndicate, One Montgomery Street, Suite 3700, San Francisco, California 94104, or by telephone at 415-364-2720, or by email at syndprospectus@stifel.com.

This press release shall not constitute an offer to sell or a solicitation of an offer to buy, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful, prior to registration or qualification under the securities laws of any such state or jurisdiction.

About Codexis

Codexis is a leading protein engineering company that applies its proprietary CodeEvolver® technology to develop proteins for a variety of applications, including as biocatalysts for the commercial manufacture of pharmaceuticals, fine chemicals and industrial enzymes, and enzymes as biotherapeutics and for use in molecular diagnostics. Codexis’ proven technology enables improvements in protein performance, meeting customer needs for rapid, cost-effective and sustainable manufacturing in multiple commercial-scale implementations of biocatalytic processes.

Forward-Looking Statements

To the extent that statements contained in this press release are not descriptions of historical facts regarding Codexis, they are forward-looking statements reflecting the current beliefs and expectations of management made pursuant to the safe harbor of the Private Securities Litigation Reform Act of 1995, including Codexis’ expected use of the proceeds of the public offering. Such forward-looking statements involve substantial risks and uncertainties that could cause Codexis’ future results, performance or achievements to differ significantly from those expressed or implied by the forward-looking statements. Such risks and uncertainties include, among others, the uncertainties related to market conditions and the completion of the public offering on the anticipated terms or at all. Codexis undertakes no obligation to update or revise any forward-looking statements. For a further description of the risks and uncertainties that could cause actual results to differ from those expressed in these forward-looking statements, as well as risks relating to Codexis’ business in general, please refer to Codexis’ prospectus supplement to be filed with the SEC, including the documents incorporated by reference therein, which include Codexis’ Annual Report on Form 10-K filed with the SEC on February 28, 2020, Codexis’ Quarterly Report on Form 10-Q filed with the SEC on November 6, 2020, and Codexis’ other periodic reports filed with the SEC.

Investor Relations Contact:
Argot Partners
Stephanie Marks/Natallia Clancy
(212)600-1902
Codexis@argotpartners.com

Kinnate Biopharma Announces Pricing of Initial Public Offering

Kinnate Biopharma Announces Pricing of Initial Public Offering




Kinnate Biopharma Announces Pricing of Initial Public Offering

SAN FRANCISCO and SAN DIEGO, Dec. 02, 2020 (GLOBE NEWSWIRE) — Kinnate Biopharma Inc. (Nasdaq: KNTE) (“Kinnate”), a biopharmaceutical company focused on the discovery and development of small molecule kinase inhibitors for difficult-to-treat, genomically defined cancers, today announced the pricing of its initial public offering of 12,000,000 shares of its common stock at a price to the public of $20.00 per share. All of the shares of common stock are being offered by Kinnate. The gross proceeds from the offering, before deducting underwriting discounts and commissions and other offering expenses payable by Kinnate, are expected to be $240.0 million, excluding any exercise of the underwriters’ option to purchase additional shares. Kinnate’s common stock is expected to begin trading on the Nasdaq Global Select Market on December 3, 2020 under the symbol “KNTE”. The offering is expected to close on December 7, 2020, subject to the satisfaction of customary closing conditions. In addition, Kinnate has granted the underwriters a 30-day option to purchase up to an additional 1,800,000 shares of its common stock at the initial public offering price, less the underwriting discounts and commissions.

Goldman Sachs & Co. LLC, SVB Leerink LLC and Piper Sandler & Co. are acting as joint book-running managers for the offering. Wedbush PacGrow is acting as lead manager for the offering.

Registration statements relating to the offering have been filed with the Securities and Exchange Commission and became effective on December 2, 2020. The offering is made only by means of a prospectus, copies of which may be obtained, when available, from: Goldman Sachs & Co. LLC, Attention: Prospectus Department, 200 West Street, New York, NY 10282, by telephone at (866) 471-2526, or by email at Prospectus-ny@ny.email.gs.com; SVB Leerink LLC, Attention: Syndicate Department, One Federal Street, 37th Floor, Boston, MA 02110, by telephone at (800) 808-7525, ext. 6132, or by email at syndicate@svbleerink.com; or Piper Sandler & Co., 800 Nicollet Mall, J12S03, Minneapolis, MN 55402, Attn: Prospectus Department, by telephone at (800) 747-3924, or by email at prospectus@psc.com.

This press release does not constitute an offer to sell or a solicitation of an offer to buy these securities, nor will there be any sale of these securities in any state or jurisdiction in which such offer, solicitation, or sale would be unlawful before registration or qualification under the securities laws of that state or jurisdiction.

About Kinnate Biopharma Inc.

Kinnate Biopharma is focused on the discovery and development of small molecule kinase inhibitors for difficult-to-treat, genomically defined cancers. Kinnate’s mission is to expand the reach of targeted therapeutics by developing products for underserved populations. Kinnate utilizes its deep expertise in structure-based drug discovery, translational research, and patient-driven precision medicine, which we refer to as the Kinnate Discovery Engine, to develop targeted therapies. Based in San Francisco and San Diego, California, the Kinnate team is composed of drug discovery experts supported by a distinguished group of scientific advisors.

For more information, please contact:

Investors:
investors@kinnate.com 

Media:
Colin Sanford
colin@bioscribe.com

Blood Sugar Premier Market Research: Review On Zenith Labs Supplement Fix Irregular Sugar Levels?

Blood Sugar Premier Market Research: Review On Zenith Labs Supplement Fix Irregular Sugar Levels?




Blood Sugar Premier Market Research: Review On Zenith Labs Supplement Fix Irregular Sugar Levels?

Blood Sugar Premier Zenith Labs Supplement Market Research & Reviews – Does Ingredients Really Work To Fix Irregular Sugar Levels? Must Read Customer Complaints Before You Try.

Delaware, CO, Dec. 02, 2020 (GLOBE NEWSWIRE) — Blood Sugar Premier Supplement Reviews: Groundbreaking new report gives critical information every customer needs to know as one gets older many of the body’s processes begin to decline – one of them is the regulation of blood sugar levels. This problem has been a frequent one for individuals aged at least 45 years old and above. For individuals looking for an effective way to support their blood glucose levels to the normal range, the Blood Sugar Premier supplement may be a solution to look at.

According to the official site, this advanced blood sugar support formula integrates just the different natural ingredients to tackle the root cause of irregular blood sugar levels. Increased blood sugar can take a toll not only on one’s physical health but, on their mental health too; causing effects such as headaches and tiredness, mood swings, stress and depression, vision and nerve problems, just to mention a few.

However, people suffering from this condition worry about their loved ones too. This condition can put a burden on their family – whether it’s through worry, having to prepare special meals, or the racking up of medical bills at the hospital.

The Blood Sugar Premier site claims that this super sugar support formula addresses the root cause of blood sugar problems; ensuring that the disease is cured and the symptoms are permanently alleviated with no risks of rebounds.  Plus, one doesn’t have to adopt exercise routines or stick to strict diets.

Why Blood Sugar Premier?

Unlike mainstream drugs, the Blood Sugar Premier is natural, safe, and non-toxic. Utilizing herbs, the supplement naturally works to restore the normal bodily metabolic mechanisms that guarantee controlled blood sugar levels. In fact, some ingredients used in this supplement can even grow in a backyard.

The Blood Sugar Premier formula follows the principles of the Old Testament of natural health, practiced to date in traditional Chinese medicine. Over 360 different natural herbs have been tested to discover their health benefits.

These include ginseng, sesame, honeysuckle, ginger, asparagus, peony, and ephedra. It is thanks to these writings that we know some of the key benefits that come with consuming such ingredients. For example, ginseng aids in weight loss (that may be caused by unregulated blood sugars and diabetes), improving brain health, and soothing inflammation.

Sesame improves overall skin health, memory functions, and even, reduces the risks of heart disease. The Blood Sugar Premier supplement is formulated based on these principles – combining the key ingredients in just the right proportions. In fact, western medication has stemmed from these same writings. For example, the plant willow bark used in the manufacture of aspirin was listed in these writings.

Learn more about the facility and supplement safety on its official website

Ingredients of the Blood Sugar Premier Supplement

The Blood Sugar Premier supplement comes with several naturally ingredients that help to power its effects.

Berberine

If one comes across the Chinese Goldthread plant, they will think it’s just another one of those beautiful flowers in the wild. However, it is more than just a buttercup-like flower. This flower delivers incredible blood sugar controlling functions. From the Chinese Goldthread plant, a popular extract known as Berberine is derived. 

Berberine has been used in several supplements thanks to its powerful healing properties. In this case, it helps to tackle two deadly blood sugar traps. The first one is inflamed cells. When proteins and lipids become too active in the body, this results in inflammation of the cells.

Inflamed cells mean that metabolism will not happen effectively thus, leading to unbalanced sugar levels. This is where Berberine jumps in. This extract helps to protect cells against inflammation and reverses the effects of those that have been damaged to ensure effective metabolism and control of blood sugar levels.

Furthermore, Berberine inhibits the absorption of glucose in the cellswhich ultimately helps to prevent inflammation as well. The second deadly blood sugar trap Berberine helps to eliminate is the fat deposits that strangle the pancreas. The primary function of thepancreas is to keep the blood sugar levels healthy.

When fats squeeze and crush the pancreas, this affects its functions thus, affecting blood sugar levels. Berberine helps to break down these fat deposits whilst preventing new deposits from forming. So the main functions of Berberine in the Blood Sugar Premier Supplement are to support a healthy inflammatory response and to break down the fat deposits around the pancreas.

Additionally, Berberine is known to promote heart health, circulation, and to fight cardiac dysfunction.Whist the Blood sugar Premier supplement derives its Berberine from the Chinese Goldthread plant, there are plenty of other sources locally where one can find Berberine. These include California poppy, yellowroot, and Amur Cork tree.

Curcumin

To amplify Berberine, the Blood sugar Premier supplement is paired with two other ingredients. One of them is Curcumin. Curcumin is derived from Turmeric root. This natural extract helps to support the body’s natural balance of insulin sensitivity and insulin resistance.

In fact, people who naturally integrate foods containing Curcumin such as turmeric in their diet are known to enjoy lower blood sugar levels and low levels of pancreas hijacking fats and lipids.Furthermore, similar to Berberine, Curcumin supports a natural and healthy inflammatory response.

Curcumin also protects muscles and bone health for people with blood sugar imbalance and prevents unwanted aches and pain. One must know that Curcumin may not work on its own – especially for people with existing blood sugar problems.

This is because thelivercontains an enzyme known as UGT. UGT particularly breaks down Curcumin before it becomes effective in the body. That is why it is important to pair it with other elements such as Piperine.

Piperine

Piperine is the second element to be paired with Berberine. Whilst it boasts its own unique functions, it helps to amplify the functions of Berberine and Curcumin. Piperine is extracted from black pepper. Its main function is to break down the enzyme UGT in the liver which blocks the functions of Curcumin.

Yet, Piperine also boasts its blood sugar balancing properties. Piperine helps to accentuate insulin sensitivity thus, allowing the body to naturally regulate blood sugar levels. Furthermore, Piperine is a natural fat loss booster. If one is struggling with increased weight gain, it comesin quite handy. So whilst improving insulin and lipid sensitivity; allows one to return to the ideal and healthier body weight.

Check out the official website to understand more about the science behind the ingredients

What Is The Recommended Dosage And Side Effects of Blood Sugar Premier?

A single bottle of the Blood Sugar Premier supplement contains 60 capsules and typically lasts for 30 days. As a recommended daily dosage, take 2 capsules of the supplement with a large meal. Most users like to take the capsules in the morning with breakfast so they can enjoy the full effects throughout the day.

Why Buy the Blood Sugar Premier Supplement

The Blood Sugar Premier supplement is recommended for use with pre-diabetics and people who suffer from diabetes. The pre-diabetic condition represents the stage to whereon experiences increased levels of unregulated blood sugars.

This puts them at risk of developing type II diabetes if the condition is not handled well. Using the Blood Sugar Premier supplement prevents this condition from transitioning to type II diabetes. Yet, just because one has already developed type II diabetes, it doesn’t mean that this supplement is not ideal for them.

According to the Blood Sugar Premier official site, using the supplement comes with these key results:

  • Blood sugar control
  • Treatment of type II diabetes
  • Clearing fat lipids and lowers weight
  • Enhancing metabolism and prevents inflammation
  • Boosting the functions of the pancreas to enhance insulin secretion
  • Relieving stress, mood swings, and depression
  • Energizing the body
  • Improving cardiac function and health

Check out Blood Sugar Premier Supplement reviews from real life customers: Click Here To Verify

Blood Sugar Premier Pricing

At the moment, the Blood Sugar Premier supplement can be purchased at a discounted price depending on how many bottles one wants. For a single bottle, they will pay $49 instead of $79; allowing them to save up to $30 and $19.95 on shipping. A single bottle will last a month.

If one wants to invest in three months’ worth of supply, which equals 3 bottles, it will cost them only $39 per bottle; allowing them to save more on the bottles and receive free shipping. However, for the best value, one can opt for the six month supply. This package gets them six bottles at only $33 each. This means that they will save up to $276 and save an extra $19.95 on shipping. 

Furthermore, each purchase comes with a risk-free 100% 180-day money back guarantee. So, within 6 months of purchasing the supplements, if no results are seen, one can ask for a full refund at no additional cost.

Check out the current Blood Sugar Premier pricing

Blood Sugar Premier Reviews – Final Verdict

All the Blood Sugar Premier Zenith Labs Supplement integrates is just the natural combination of the three powerful herbs to help reverse symptoms and counter the root cause of high blood sugar. It’s worth giving it a try – after all, it comes with a risk free money back guarantee.

Is the Blood Sugar Premier supplement FDA approved? Check out the official website to find out

Media Contact: support@zenithlabs.com


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