Biocytogen Announces ADC Innovator Tubulis Has Signed Global Exclusive License Agreement for Single Antibody




Biocytogen Announces ADC Innovator Tubulis Has Signed Global Exclusive License Agreement for Single Antibody

BEIJING–(BUSINESS WIRE)–#ADCTherapeutics–Biocytogen Pharmaceuticals (Beijing) Co., Ltd. (Biocytogen, HKEX: 02315), a global biotechnology company that drives the research and development of novel antibody-based drugs with innovative technologies, today announced that ADC therapeutics developer, Tubulis has exercised an exclusive license for the global development and commercialization of a fully human antibody developed by Biocytogen. The antibody will be applied in a novel ADC candidate proprietary to Tubulis. It is part of a previously signed research collaboration and option agreement to discover and advance antibody components for the development and commercialization of ADC products based on Biocytogen’s antibody discovery engine.

The antibody was generated using Biocytogen’s proprietary RenMice^® platform and features high affinity, low immunogenicity, and favorable developability. Tubulis will apply its proprietary linker and payload technologies to develop innovative ADC therapies based on this antibody, aiming to address areas of high unmet clinical need in cancer treatment.

Dr. Yuelei Shen, President and CEO of Biocytogen, said, “We are very pleased that Tubulis has exercised its option, which reflects the international competitiveness and translational potential of our fully human antibody discovery platform. We look forward to seeing this antibody advance through Tubulis’ powerful ADC development engine and into clinical development to benefit patients around the world.”

Jonas Helma-Smets, PhD, CSO and co-founder of Tubulis, stated: “Our goal is to drive innovation in ADC development and deliver uniquely positioned ADC therapeutics that can improve treatment outcomes to patients with solid tumors. The R&D collaboration with Biocytogen has yielded an antibody candidate that we believe fits well with our ADC technology platforms and that may support us in the development of a novel therapeutic candidate.”

Under the terms of the agreement, Biocytogen will receive an upfront payment and is eligible for certain development, regulatory, and commercial milestone payments, and single-digit royalties on net sales.

About Biocytogen

Biocytogen (HKEX: 02315) is a global biotechnology company that drives the research and development of novel antibody-based drugs with innovative technologies. Founded on gene editing technology, Biocytogen leverages genetically engineered proprietary RenMice^® (RenMab^™/ RenLite^®/ RenNano^®/ RenTCR mimic^™) platforms for fully human monoclonal/bispecific/multispecific antibody discovery, bispecific antibody-drug conjugate discovery, nanobody discovery and TCR mimic antibody discovery, and has established a sub-brand, RenBiologics^™, to explore global partnerships for an off-the-shelf library of >1,000,000 fully human antibody sequences against over 1000 targets for worldwide collaboration. As of June 30, 2025, approximately 280 therapeutic antibody and multiple clinical asset co-development/out-licensing/transfer agreements and over 50 target-nominated RenMice^® licensing projects have been established around the globe, including several partnerships with multinational pharmaceutical companies (MNCs). Biocytogen pioneered the generation of drug target knock-in humanized models for preclinical research, and currently provides a few thousand off-the-shelf animal and cell models under the company’s sub-brand, BioMice™, along with preclinical pharmacology and gene-editing services for clients worldwide. Headquartered in Beijing, Biocytogen has branches in China (Haimen Jiangsu, Shanghai), USA (Boston, San Francisco, San Diego), and Germany (Heidelberg). For more information, please visit https://biocytogen.com.

Contacts

Biocytogen Contacts
Antibody assets and platforms: BD-Licensing@biocytogen.com
Media: pr@bbctg.com.cn

Paysign, Inc. Announces Summary Notice of Pendency and Proposed Settlement of Stockholder Derivative Actions




Paysign, Inc. Announces Summary Notice of Pendency and Proposed Settlement of Stockholder Derivative Actions

HENDERSON, Nev.–(BUSINESS WIRE)–Paysign, Inc. (NASDAQ: PAYS), a leading provider of patient affordability programs, donor compensation solutions, engagement and management platforms and integrated payment processing for the life sciences industries, today posted the following summary notice of pendency and proposed settlement of stockholder derivative actions.

To: All Record Holders and Beneficial Owners of Paysign, Inc. (“Paysign” of the “Company”) Common Stock as of November 25, 2024.

Please read this summary notice carefully and in its entirety and as your rights may be affected by proceedings in the litigation.

YOU ARE HEREBY NOTIFIED that the following stockholder derivative actions (the “Derivative Actions”), are being settled on the terms set forth in a Stipulation and Agreement of Settlement dated November 25, 2024 (the “Stipulation”): (i) the above-captioned consolidated action, titled Toczek v. Newcomer et al, Case No. 2:20-cv-01722-JCM-NJK; (ii) Blanchette v. Paysign, Inc. et al., Case No. 2:23-cv-01632-JCM-BNW (D. Nev.); and (iii) Jeewa v. Newcomer, et al., Case No. 2:23-cv-02129-RFB-EJY (D. Nev.).

The Derivative Actions allege that, inter alia, between March 12, 2019 through September 17, 2020, at least, the Individual Defendants breached their fiduciary duties by issuing and/or causing the Company to issue materially false and misleading statements (including by soliciting a materially false and misleading proxy statement allegedly in violation of Section 14(a) of the Securities Exchange Act of 1934) and by failing to disclose material facts to the public regarding, among other things, that: (1) the Company failed to design, implement, and maintain effective IT general controls, specifically pertaining to user access and the Company’s systems change management; (2) the Company failed to maintain effective disclosure controls and internal controls over its financial reporting; and (3) due to the foregoing, the Company would be forced to delay filing its 2019 10-K and holding its 2019 year-end earnings call. The Derivative Actions also allege that the Individual Defendants breached their fiduciary duties by failing to correct and/or causing the Company to fail to correct these false and misleading statements and omissions of material fact to the investing public, while four of the Individual Defendants engaged in lucrative insider sales, netting combined proceeds of over $5.7 million. The Derivative Actions allege that, as a result of the foregoing, the Company experienced reputational and financial harm. Defendants have denied and continue to deny each and all of the claims and allegations of wrongdoing asserted in the Derivative Actions.

Pursuant to the terms of the Settlement, Paysign agrees to implement and maintain certain corporate governance reforms that are outlined in Exhibit A to the Stipulation (the “Reforms”). The Reforms shall be maintained for five (5) years. Paysign acknowledges and agrees that the filing, pendency, and settlement of the Derivative Actions was the cause of the Company’s decision to adopt, implement, and maintain the Reforms. Paysign also acknowledges and agrees that the Reforms confer substantial benefits to Paysign and its shareholders.

After negotiating the principal terms of the Settlement, counsel for the Parties, with the assistance of the Mediator, negotiated the attorneys’ fees and expenses to be paid to Plaintiffs’ Counsel, subject to Court approval (the “Fee and Expense Amount”). In light of the substantial benefits conferred upon the Company and its stockholders, Defendants’ insurers shall pay to Plaintiffs’ Counsel $607,500.00 for their attorneys’ fees and expenses, subject to Court approval. Defendants also agreed not to object to the request for the Court to approve Service Awards of up to two thousand dollars ($2,000.00) for each of the four Plaintiffs, to be paid from the Fee and Expense Amount.

On November 14, 2025 at 1:00 p.m., a hearing (the “Settlement Hearing”) will be held before the Honorable Richard F. Boulware at the United States District Court for the District of Nevada, Las Vegas Division, 333 Las Vegas Boulevard South, Las Vegas, Nevada 89101, for the purpose of determining whether the Settlement should be approved as fair, reasonable, and adequate and whether the Court should approve the agreed-to Fee and Expense Amount and the Service Awards for Plaintiffs. Because this is not a class action, except as otherwise provided for in the Stipulation with respect to the Plaintiffs, no Current Paysign Stockholder has the right to receive any individual compensation as a result of the Settlement.

This Summary Notice provides a condensed overview of certain provisions of the Stipulation and the full Notice of Pendency and Proposed Settlement of Stockholder Derivative Actions (the “Notice”). It is not a complete statement of the events of the Derivative Actions or the terms set forth in the Stipulation. This summary should be read in conjunction with, and is qualified in its entirety by reference to, the text of the Stipulation. For additional information about the claims asserted in the Derivative Actions, and the terms of the proposed Settlement, you may inspect the full Notice and the Stipulation and its exhibits and other papers at the Clerk’s office in the Court at any time during regular business hours. In addition, copies of the Stipulation and its exhibits and the Notice are available on the Investor Relations page of the Company’s website, www.paysign.com.

The Court may, in its discretion, change the date, time, or format of the Settlement Hearing without further notice to you. If you intend to attend the Settlement Hearing, please consult the Court’s calendar or Investor Relations page of the Company’s website, www.paysign.com, for any change in the date, time, or format of the Settlement Hearing.

Inquiries about the Derivative Actions or the Settlement may be made to: Timothy Brown, The Brown Law Firm, P.C., 767 Third Avenue, Suite 2501, New York, NY 10017, Telephone: (516) 922-5427, Email: tbrown@thebrownlawfirm.net.

You may enter an appearance before the Court, at your own expense, individually or through counsel of your choice. If you want to object at the Settlement Hearing, you must be a Current Paysign Stockholder and you must first comply with the procedures for objecting that are set forth in the Notice. Any objection to any aspect of the Settlement must be filed with the Clerk of the Court and sent to Plaintiffs’ Counsel and Defendants’ Counsel no later than October 24, 2025 (21 days before the Settlement Hearing), in accordance with the procedures set forth in the Stipulation and the Notice. Any Current Paysign Stockholder who fails to object in accordance with such procedures will be bound by the Order and Final Judgment of the Court granting final approval to the Settlement and the releases of claims therein, and shall be deemed to have waived the right to object (including the right to appeal) and forever shall be barred, in this proceeding or in any other proceeding, from raising such objection.

PLEASE DO NOT CALL THE COURT OR DEFENDANTS WITH QUESTIONS ABOUT THE SETTLEMENT.

About Paysign

Paysign, Inc. (NASDAQ: PAYS) operates at the intersection of fintech and healthcare, integrating advanced payment processing and program management with tailored technologies for the plasma, pharmaceutical and life sciences industries. Their breakthrough patient affordability solutions ensure patients receive the financial assistance they need to adhere to prescribed therapies by mitigating the effects of copay accumulators and maximizers. Paysign specializes in blood and plasma donor compensation programs, as well as comprehensive engagement and management platforms optimized for life sciences. Paysign’s proprietary processing architecture supports physical, virtual, mobile and bank-based payments with real-time transaction intelligence, enabling efficient, compliant and scalable program delivery. Through advanced reporting, analytics and in-house 24/7 bilingual customer support, Paysign delivers measurable value, exceptional service and a superior experience for donors, patients, healthcare providers, pharmaceutical manufacturers and program sponsors across their growing fintech healthcare ecosystem. The company is committed to improving efficiencies, reducing costs, streamlining communications, increasing program performance and providing actionable insights to those they serve.

Forward-Looking Statements

Certain statements in this news release may contain forward-looking information within the meaning of Rule 175 under the Securities Act of 1933 and Rule 3b-6 under the Securities Exchange Act of 1934, and are subject to the safe harbor created by those rules. All statements, other than statements of fact, included in this release, including, without limitation, statements regarding potential future plans and objectives of the companies, are forward-looking statements that involve risks and uncertainties. There is no assurance that such statements will prove to be accurate, and actual results and future events could differ materially. Paysign undertakes no obligation to publicly update or revise any statements in this release, whether as a result of new information, future events or otherwise.

Contacts

Investor Relations

ir@paysign.com
888.522.4853

paysign.com/investors

Media Relations

Alicia Ches

888.522.4850

pr@paysign.com

Apimeds Expands ai² Future Labs Program to Include University of San Diego Students in Biotech Business Development




Apimeds Expands ai² Future Labs Program to Include University of San Diego Students in Biotech Business Development

MATAWAN, N.J.–(BUSINESS WIRE)–Apimeds Pharmaceuticals US, Inc. (NYSE American: APUS) (“Apimeds”) today announced the expansion of its ai² Future Labs program by engaging graduate students from the University of San Diego’s Knauss School of Business. The initiative is designed to identify promising pharmaceutical assets critical to improving human health while cultivating the next generation of business leaders for the biopharmaceutical industry.

Future Labs is part of Apimeds’ ai² innovation platform, connecting university students with real-world strategy and business development projects. Through this collaboration, student teams will work closely with Apimeds mentors to identify and evaluate opportunities to advance development projects previously left behind by industry.

“We’re thrilled to welcome University of San Diego students into the Future Labs program,” said Erik Emerson, CEO of Apimeds. “USD represents exactly the type of forward-thinking institution we want to partner with—where students are encouraged to bring fresh perspectives to complex problems. Drug development is challenging, and many therapies with true potential never reach patients. Future Labs is meant to function as both a discovery engine for assets and a training ground for tomorrow’s leaders.”

Students will gain hands-on experience in market analysis, FDA regulations, clinical development requirements, competitive positioning, intellectual property, and commercialization planning—skills that extend far beyond the classroom. Top-performing teams at each participating institution will be eligible for paid internships or consulting opportunities with Apimeds, creating a direct pathway into the industry.

“As a recent graduate of the University of San Diego, I see Future Labs as an incredible way to take what we’ve learned in the classroom and apply it directly to the challenges of the biopharma industry,” said Coben Emerson, Manager, FP&A, Apimeds. “By working hands-on with asset evaluation and strategy, students not only contribute to Apimeds’ pipeline exploration but also gain the kind of practical, career-ready experience that sets us apart as we enter the workforce.”

“Our students will gain invaluable exposure to the business side of the life sciences industry,” said Jaime Alonso Gomez, PhD, professor of strategy, international management and family business at the Knauss School of Business. “Partnering with Apimeds allows us to deliver a one-of-a-kind experience—where academic rigor meets real-world biopharma decision-making.”

The initiative underscores Apimeds’ commitment to fostering innovation, building meaningful industry–academic collaborations, and shaping the next generation of biotech leaders.

About Apimeds Pharmaceuticals

Apimeds Pharmaceuticals (NYSE American: APUS) is a clinical-stage biopharmaceutical company focused on developing non-opioid, biologic-based therapies for pain management. The company’s lead product candidate, Apitox, is in late-stage clinical development for osteoarthritis of the knee. For more information visit www.apimedsus.com. Information on the Apimeds’ website does not constitute a part of and is not incorporated by reference into this press release.

About the Knauss School of Business, University of San Diego

The Knauss School of Business at the University of San Diego is committed to developing socially responsible leaders with a global mindset through values-based education and innovative research. Together, we work to advance sustainable and ethical business solutions that address the world’s greatest challenges.

Forward-Looking Statements

This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Statements contained in this news release that are not statements of historical fact may be deemed to be forward-looking statements. Without limiting the generality of the foregoing, words such as “anticipate”, “believe”, “expect”, “plan” and “will” are intended to identify forward-looking statements. Such forward-looking statements are based on the beliefs of management, as well as assumptions made by, and information currently available to, management. These statements relate only to events as of the date on which the statements are made, and Apimeds undertakes no obligation to publicly update any forward-looking statements, whether as a result of new information, future events or otherwise, except as required by law. All of the forward-looking statements made in this press release are qualified by these cautionary statements, and there can be no assurance that the actual results anticipated by Apimeds will be realized or, even if substantially realized, that they will have the expected consequences to or effects on the company or its business or operations. Readers are cautioned that certain important factors may affect Apimeds’ actual results and could cause such results to differ materially from any forward-looking statements that may be made in this press release. Factors that may affect Apimeds’ results include, but are not limited to, the ability of Apimeds to raise additional capital to finance its operations (whether through public or private equity offerings, debt financings, strategic collaborations or otherwise); risks relating to Apimeds’ ability to advance its product candidate and successfully complete clinical trials; risks relating to its ability to hire and retain qualified personnel; and the additional risk factors described in Apimeds’ filings with the U.S. Securities and Exchange Commission (the “SEC”), including its Annual Report on Form 10-K for the year ended December 31, 2024 as filed with the SEC on April 15, 2025 (as amended on May 2, 2025).

Contacts

Media Contact:
Brian Peters

Apimeds Pharmaceuticals

919-602-6557

Genesee Scientific Acquires Jade Scientific, Expanding Capabilities in Lab Essentials Market




Genesee Scientific Acquires Jade Scientific, Expanding Capabilities in Lab Essentials Market

The acquisition strengthens portfolio, broadens customer reach, and accelerates Genesee’s growth strategy

SAN DIEGO–(BUSINESS WIRE)–#BetterTogether—Genesee Scientific, a leading provider of high-quality, value-driven lab essentials, today announced the acquisition of Jade Scientific, a Michigan-based distributor recognized for its extensive offering of chemicals and consumables to clinical reference, pharma/biotech, and environmental labs nationwide.

This strategic acquisition marks a significant milestone in Genesee’s growth journey. Together, the two companies will expand product offerings, strengthen customer relationships, and reinforce Genesee’s position as a trusted partner for scientists across academia, biotech, and diagnostic labs.

“We are thrilled to welcome Jade Scientific into the Genesee family,” said Dan Monahan, CEO of Genesee Scientific. “Jade has built an exceptional reputation for customer service and quality. Together, we will broaden our ability to deliver essential products to scientists – while staying true to our mission of providing extraordinary value and uncompromising quality.”

Founded in 1995, Jade Scientific has served the scientific community for three decades, earning customer loyalty through strong relationships, deep product expertise, and an unwavering commitment to service.

“Joining forces with Genesee Scientific is an exciting opportunity for Jade, our employees, and our customers,” said Mike Smolin, CEO of Jade Scientific. “We share the same focus on quality, service, and supporting science. With Genesee’s scale and resources, we can deliver even greater value to customers while creating new opportunities for our team.”

The acquisition underscores Genesee’s strategy to accelerate growth through both organic initiatives and strategic partnerships. Customers of both companies will continue to receive the same personalized service they trust, while gaining access to a broader, more cost-efficient portfolio of lab essentials.

About Genesee Scientific

Genesee Scientific is a leading provider of lab essentials, delivering high-quality consumables, equipment, and private-label solutions to researchers in academic institutions, biotechnology, and diagnostic labs. Genesee’s mission is to serve scientists with extraordinary value in the everyday fundamentals of science.

About Jade Scientific

Founded in 1995, Jade Scientific is a trusted distributor of chemicals and consumables, serving clinical reference, pharma/biotech, industrial and environmental labs. With a reputation for reliability and service, Jade has supported scientists nationwide for 30 years.

Contacts

Media Contact
Sarah Kinsella

Head of Marketing, Genesee Scientific

SKinsella@GeneseeSci.com

Personalis Announces Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)




Personalis Announces Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)

FREMONT, Calif.–(BUSINESS WIRE)–Personalis, Inc. (Nasdaq: PSNL), a leader in advanced genomics for precision oncology, today announced that the Compensation Committee of its Board of Directors granted, on September 15, 2025, a non-qualified stock option to purchase an aggregate of 440,000 shares of its common stock to Personalis’ new Senior Vice President, Chief Information Officer under Personalis’ 2020 Inducement Plan.

The 2020 Inducement Plan is used exclusively for the grant of equity awards to individuals who were not previously an employee, or non-employee director, of Personalis, as an inducement material to such individual’s entering into employment with Personalis, pursuant to Rule 5635(c)(4) of the Nasdaq Listing Rules. Personalis is making this announcement as required by Nasdaq rules.

The inducement stock option granted on September 15, 2025 has an exercise price of $5.93 per share, which is equal to the closing price of Personalis’ common stock on the grant date. The inducement stock option vests over four years, with 25% of the shares vesting on the first anniversary of the grant date and 1/36th of the remaining shares vesting monthly thereafter, subject to continued service through each applicable vesting date. The foregoing inducement award is subject to the terms and conditions of Personalis’ 2020 Inducement Plan, and the terms and conditions of the applicable award agreement covering the grant.

About Personalis, Inc.

At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care throughout the patient journey. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time. Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest timepoints, enable the selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development. Personalis is based in Fremont, California. To learn more, visit www.personalis.com and connect with us on LinkedIn and X (Twitter).

Contacts

Investors:
Caroline Corner

investors@personalis.com
415-202-5678

Media:
pr@personalis.com

Thermo Fisher Scientific Expands Neurodegeneration Research Capabilities with Launch of Olink® Target 48 Neurodegeneration Panel




Thermo Fisher Scientific Expands Neurodegeneration Research Capabilities with Launch of Olink® Target 48 Neurodegeneration Panel

Targeted proteomics panel delivers absolute quantification of key and emerging biomarkers in one scalable assay

WALTHAM, Mass.–(BUSINESS WIRE)–Thermo Fisher Scientific Inc., the world leader in serving science, today announced the launch of the Olink® Target 48 Neurodegeneration panel, a high-performance, targeted proteomics immunoassay panel developed to accelerate discoveries in neurodegenerative disease research. With diseases such as Alzheimer’s, multiple sclerosis and Parkinson’s on the rise and clinical pipelines eager for translational biomarkers, researchers face a pressing need for scalable, reproducible and disease-relevant protein measurement. This panel delivers simultaneous measurement of 41 key and emerging proteins for neurodegeneration research with absolute quantification and optimized for plasma measurement from as little as 1µL of sample.

The Target 48 Neurodegeneration panel is the latest addition to Olink’s growing portfolio of multiplex disease panels with absolute quantification readouts. Alongside the Olink® Target 48 Cytokine, Olink® Target 48 Immune Surveillance, and the semi-custom Olink® Flex platform, this solution helps create a powerful ecosystem for proteomics research. When combined, these panels allow researchers to seamlessly analyze a larger library of protein biomarkers that can help provide comprehensive insights into neurodegeneration and inflammation in the body.

An early access user, Charlotte Teunissen, professor in neurochemistry at the Department of Laboratory Medicine at Amsterdam University Medical Center, shared, “The Target 48 Neurodegeneration panel is a critical tool that enables the detection and quantification of key and emerging neurodegenerative disease biomarkers from plasma and cerebrospinal fluid samples. By generating quantitative data, it ensures reproducible results across and within longitudinal studies, moving a step forward towards clinical utilization.”

“Neurological diseases are complex, multifactorial and urgently in need of translational insights especially with non-invasive proteomic biomarkers for longitudinal monitoring,” said Yan Zhang, President of the Proteomic Sciences business at Thermo Fisher Scientific. “The panel, designed in close collaboration with leading clinical researchers, offers absolute quantification of multiplex key biomarkers to monitor disease progression and therapeutic responses to power precision medicine.”

Key benefits of the Olink® Target 48 Neurodegeneration include:

• Targeted depth: 41 protein biomarkers selected for relevance across Alzheimer’s disease, multiple sclerosis, amyotrophic lateral sclerosis, Parkinson’s disease and other neurodegenerative disorders.
• Absolute quantification: Ability to quantify key and emerging biomarkers for neurodegeneration research simultaneously in one panel.
• Minimal sample input: Enables high-throughput studies with precious or biobank samples.
• Scalability and standardization: Compatible with Thermo Fisher’s global network of Olink-equipped labs for reproducibility across sites, critical for multi-center trials and large consortia.
• Proven solution: Uses Olink’s gold-standard Proximity Extension Assay (PEA) technology.

The new panel reinforces Thermo Fisher’s commitment to advancing precision medicine and neurology research, joining the company’s broader suite of tools spanning mass spectrometry, cryo-electron microscopy, and multiplex immunoassays. It builds on recent initiatives such as the UK Biobank proteomics program, the Geisinger Health Study with the Regeneron Genetics Center and cross-platform collaborations with leading biopharma companies.

The Olink® Target 48 Neurodegeneration has been developed with the aim of reducing import barriers such as long lead-times for importing into geographies with blood or plasma-derived import licenses. The Olink® Target 48 Neurodegeneration panel is fully compatible with the Olink® Signature Q100 benchtop system, providing a simplified workflow, minimal instrument maintenance and streamlined quality control, enabling laboratories to accelerate their biomarker research.

To learn more about the Olink® Target 48 Neurodegeneration Panel, please visit our website and register for the webinar on September 17, 2025. This panel and a discussion on neurodegenerative disease research will also be featured at the premier global virtual conference Olink Proteomics World on October 8, 2025.

*For research use only. Not for use in diagnostic procedures.

About Thermo Fisher Scientific

Thermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue over $40 billion. Our Mission is to enable our customers to make the world healthier, cleaner and safer. Whether our customers are accelerating life sciences research, solving complex analytical challenges, increasing productivity in their laboratories, improving patient health through diagnostics or the development and manufacture of life-changing therapies, we are here to support them. For more information, please visit www.thermofisher.com.

Contacts

Media Contact Information: 
Jess King

760-289-8032

Email: jess.king@thermofisher.com

Alex M. Azar II Joins Guardant Health Board of Directors




Alex M. Azar II Joins Guardant Health Board of Directors

PALO ALTO, Calif.–(BUSINESS WIRE)–Guardant Health, Inc. (Nasdaq: GH), a leading precision oncology company, today announced the appointment of Alex M. Azar II to its board of directors, effective immediately. As the 24th Secretary of the U.S. Department of Health and Human Services (HHS), Secretary Azar had oversight and management of agencies critical to all Americans’ health care including the Centers for Medicare and Medicaid Services, the Food and Drug Administration, and the Center for Disease Control and Prevention.

“We’re honored to welcome Secretary Azar to Guardant’s board,” said Helmy Eltoukhy, chairman and co-CEO of Guardant Health. “Secretary Azar has served at the senior-most levels of government as well as the private sector, bringing deep operating experience coupled with a strategic understanding of how policy, innovation and patient access intersect. His perspective will be invaluable as we continue developing new innovations to conquer cancer and working to ensure more patients have access to lifesaving technologies.”

“Guardant pioneered a new category with liquid biopsy and continues to push the boundaries of what is possible as the leading company in the space,” said Secretary Azar. “I look forward to working with the board and leadership team to advance the company’s impact and mission of helping people live longer, healthier lives by catching and managing cancer earlier.”

Prior to his appointment as HHS Secretary, Azar held multiple executive leadership roles including as President of Lilly USA, LLC, the largest affiliate of Eli Lilly and Company, General Counsel of HHS, Deputy Secretary of HHS, and Partner at Wiley Rein LLP. He currently serves as an Adjunct Professor of Business and Distinguished Executive-in-Residence at the University of Miami Patti and Allan Herbert Business School. He also serves as a member of the Board of Trustees at the Aspen Institute, chairman of the board of LifeScience Logistics, a member of the boards of Global Health/MCS, AbsoluteCare, and Interwell Health, and as an advisor at Foresite Capital, a member of the advisory board of Milken Institute’s FasterCures, and a member of the Department of Health Policy Advisory Board at the Stanford University School of Medicine.

About Guardant Health

Guardant Health is a leading precision oncology company focused on guarding wellness and giving every person more time free from cancer. Founded in 2012, Guardant is transforming patient care and accelerating new cancer therapies by providing critical insights into what drives disease through its advanced blood and tissue tests, real-world data and AI analytics. Guardant tests help improve outcomes across all stages of care, including screening to find cancer early, monitoring for recurrence in early-stage cancer, and treatment selection for patients with advanced cancer. For more information, visit guardanthealth.com and follow the company on LinkedIn, X (Twitter) and Facebook.

Forward-Looking Statements

This press release contains forward-looking statements within the meaning of federal securities laws, including statements regarding the potential utilities, values, benefits and advantages of Guardant Health’s liquid biopsy tests or assays, which involve risks and uncertainties that could cause the actual results to differ materially from the anticipated results and expectations expressed in these forward-looking statements. These statements are based on current expectations, forecasts and assumptions, and actual outcomes and results could differ materially from these statements due to a number of factors. These and additional risks and uncertainties that could affect Guardant Health’s financial and operating results and cause actual results to differ materially from those indicated by the forward-looking statements made in this press release include those discussed under the captions “Risk Factors” and “Management’s Discussion and Analysis of Financial Condition and Results of Operation” and elsewhere in its Annual Report on Form 10-K for the year ended December 31, 2024, and any current and periodic reports filed with or furnished to the Securities and Exchange Commission thereafter. The forward-looking statements in this press release are based on information available to Guardant Health as of the date hereof, and Guardant Health disclaims any obligation to update any forward-looking statements provided to reflect any change in its expectations or any change in events, conditions, or circumstances on which any such statement is based, except as required by law. These forward-looking statements should not be relied upon as representing Guardant Health’s views as of any date subsequent to the date of this press release.

Contacts

Investor Contact:
Zarak Khurshid

investors@guardanthealth.com

Media Contact:
Meaghan Smith

press@guardanthealth.com

Atom Therapeutics Enrolls First Patient in Multicenter Global Phase 2 Trial of ABP-745 for Acute Gout Flares




Atom Therapeutics Enrolls First Patient in Multicenter Global Phase 2 Trial of ABP-745 for Acute Gout Flares

ABP-745 is an oral small molecule drug with potential applications, for other inflammatory conditions such as cardiovascular disease

HANGZHOU, China–(BUSINESS WIRE)–Atom Therapeutics, a clinical stage biotechnology company developing best-in-class treatments for inflammatory and metabolic diseases, announced today it has enrolled the first patient in a multi-country Phase 2 trial of ABP-745, a novel anti-inflammatory drug, for treatment of painful acute gout flares.

Trial sites in the US, China and Australia are expected to enroll more than 200 patients in this randomized, double-blind study to evaluate the safety, efficacy and pharmacodynamics of ABP-745 in reducing the pain and swelling associated with an acute gout flare. ABP-745 dosing regimen will be compared with placebo and colchicine, a standard treatment for gout flares.

Dr. William Dongfang Shi, Founder, Chairman and CEO of Atom Therapeutics, commented, “This study follows a Phase 1 trial in the US demonstrating that ABP-745 is safe and well tolerated and represents significant progress in our development of a new anti-inflammatory drug. ABP-745 was designed as a new chemical entity with the intention of improving efficacy without the concern for key interactions with other medications and better safety than colchicine in the treatment of acute gout flares.”

Dr. Shi added, “While the first clinical indication for ABP-745 is for the treatment of acute gout flares, based on its positive inhibitory effects on various inflammatory factors such as IL-1β, TNF-α, IL-6, and IL-18, it will also be developed for other inflammatory conditions including certain types of cardiovascular disease.”

Acute gout flares are characterized by sudden severe pain and swelling of joints, usually in the lower extremities, triggered by a build-up of urate crystals. The formation of urate crystals is caused by an excessive level of uric acid in the blood usually greater than 7 mg/dL which leads to the development of chronic gout. Most acute gout flares occur in the big toe joint and last for up to seven to ten days before pain and swelling subside. In addition to colchicine, nonsteroidal anti-inflammatory drugs and glucocorticoids are used for the treatment for acute gout flares, but these medications can be associated with serious adverse events such as gastrointestinal discomfort, cardiovascular events, kidney injury, and osteoporosis. Another class of medications used in treatment of gout, IL-1β inhibitors, also have serious side effects such as increased risk of infection, immunosuppression, and allergic reactions.

Gout is caused by hyperuricemia and it is one of the most common types of inflammatory arthritis affecting more than 60 million people worldwide. The disease has a large and growing patient population in the U.S., Europe, Asia and Latin America. Gout affects approximately 12 million patients in the U.S., with an average of 6.6 acute gout flares per year. As many gout flares are not reported, the true burden may be higher, and the number of acute gout flares in the U.S. may exceed 80 million per year.

If hyperuricemia is not controlled, the frequency and severity of acute gout flares may further worsen. Acute gout flares seriously affect the quality of life and safety of patients. Recent research reports have shown that acute gout flares are associated with an increased probability of sudden death caused by cardiovascular disease. Gout can also worsen other serious comorbidities including kidney injury.

Atom’s lead product, lingdolinurad (ABP-671), is an oral small molecule URAT1 inhibitor in global multicenter Phase 2b/3 trials for chronic gout. Positive topline results show ABP-671 has achieved its primary endpoint in lowering patients’ uric acid levels and has demonstrated good safety and tolerability, positioning it as a leading candidate for best-in-class treatment of chronic gout. Read the full press release.

About Atom Therapeutics

Atom Therapeutics Co., Ltd (formerly Jiangsu Atom Bioscience and Pharmaceutical Co., Ltd) is a fast-growing innovative clinical stage biotechnology company focused on development of best-in-class small molecule therapeutics for treatment of inflammatory and metabolic diseases. The company’s lead product, lingdolinurad (ABP-671), is in late-stage clinical development for treatment of chronic gout. Another small molecule ABP-745, for anti-inflammatory and autoimmune conditions, is in global Phase 2 clinical trials for acute gout.

For more information, please visit: https://atomthera.us/

Contacts

Media Contact:
Daniel Eramian

Opus Biotech Communications

http://opusbiotech.com/
425-306-8716

Business Development Contact:
Roy J. Wu, MBA

Sr. Vice President, Business Development

Atom Therapeutics

Email: roy.wu@atombp.com

Innate Pharma Announces Its Participation in the 25th Edition of the European Midcap Event




Innate Pharma Announces Its Participation in the 25th Edition of the European Midcap Event

MARSEILLE, France–(BUSINESS WIRE)–#ANKET–Regulatory News:

Innate Pharma SA (Euronext Paris: IPH; Nasdaq: IPHA) (“Innate” or the “Company”) today announced that Frédéric Lombard, Chief financial Officer of the Company, will participate in the 25^th edition of the European Midcap Event being held from September 30 to October 1, 2025 in Paris, France.

The European Midcap Event is a key gathering that brings together institutional investors and listed companies to foster strategic meetings and financing opportunities. This flagship event provides a unique platform to engage with the European financial community.

About Innate Pharma

Innate Pharma S.A. is a global, clinical-stage biotechnology company developing immunotherapies for cancer patients. Its innovative approach aims to harness the innate immune system through three therapeutic approaches: multi-specific NK Cell Engagers via its ANKET^® (Antibody-based NK cell Engager Therapeutics) proprietary platform and Antibody Drug Conjugates (ADC) and monoclonal antibodies (mAbs).

Innate’s portfolio includes several ANKET^® drug candidates to address multiple tumor types as well as IPH4502, a differentiated ADC in development in solid tumors. In addition, anti-KIR3DL2 mAb lacutamab is developed in advanced form of cutaneous T cell lymphomas and peripheral T cell lymphomas, and anti-NKG2A mAb monalizumab is developed with AstraZeneca in non-small cell lung cancer.

Innate Pharma is a trusted partner to biopharmaceutical companies such as Sanofi and AstraZeneca, as well as leading research institutions, to accelerate innovation, research and development for the benefit of patients.

Headquartered in Marseille, France with a US office in Rockville, MD, Innate Pharma is listed on Euronext Paris and Nasdaq in the US.

Learn more about Innate Pharma at www.innate-pharma.com and follow us on LinkedIn and X.

Information about Innate Pharma shares

Disclaimer on forward-looking information and risk factors

This press release contains certain forward-looking statements, including those within the meaning of applicable securities laws, including the Private Securities Litigation Reform Act of 1995. The use of certain words, including “anticipate,” “believe,” “can,” “could,” “estimate,” “expect,” “may,” “might,” “potential,” “intend,” “should,” “will,” or the negative of these and similar expressions, is intended to identify forward-looking statements. Although the Company believes its expectations are based on reasonable assumptions, these forward-looking statements are subject to numerous risks and uncertainties, which could cause actual results to differ materially from those anticipated. These risks and uncertainties include, among other things, the uncertainties inherent in research and development, including related to safety, progression of and results from its ongoing and planned clinical trials and preclinical studies, review and approvals by regulatory authorities of its product candidates, the Company’s reliance on third parties to manufacture its product candidates, the Company’s commercialization efforts and the Company’s continued ability to raise capital to fund its development. For an additional discussion of risks and uncertainties, which could cause the Company’s actual results, financial condition, performance or achievements to differ from those contained in the forward-looking statements, please refer to the Risk Factors (“Facteurs de Risque”) section of the Universal Registration Document filed with the French Financial Markets Authority (“AMF”), which is available on the AMF website http://www.amf-france.org or on Innate Pharma’s website, and public filings and reports filed with the U.S. Securities and Exchange Commission (“SEC”), including the Company’s Annual Report on Form 20-F for the year ended December 31, 2024, and subsequent filings and reports filed with the AMF or SEC, or otherwise made public by the Company. References to the Company’s website and the AMF website are included for information only and the content contained therein, or that can be accessed through them, are not incorporated by reference into, and do not constitute a part of, this press release.

In light of the significant uncertainties in these forward-looking statements, you should not regard these statements as a representation or warranty by the Company or any other person that the Company will achieve its objectives and plans in any specified time frame or at all. The Company undertakes no obligation to publicly update any forward-looking statements, whether as a result of new information, future events or otherwise, except as required by law.

This press release and the information contained herein do not constitute an offer to sell or a solicitation of an offer to buy or subscribe to shares in Innate Pharma in any country.

Contacts

For additional information, please contact:
Innate Pharma
Stéphanie Cornen

stephanie.cornen@innate-pharma.fr

Investor Relations
investors@innate-pharma.fr

Medias
communication@innate-pharma.fr

Curatis: Double-Digit Growth in Core Business and Development Milestone Achieved for C-PTBE-01




Curatis: Double-Digit Growth in Core Business and Development Milestone Achieved for C-PTBE-01

LIESTAL, Switzerland–(BUSINESS WIRE)–Curatis Holding AG (SIX:CURN) reports revenues of CHF 5.2m for H1 2025, a like for like yoy growth of 14% vs 6 months of revenues of Curatis AG in 2024. In addition, Curatis was able to sign a significant partnership with Phoenix Labs, Ireland, adding 4 products that generated approximately CHF 5m of revenues in 2024. The loss for the period amounted to CHF -1.2m, mainly driven by increased development expenses for C-PTBE-01 (corticorelin). Cash flow amounted to CHF -1.0m. As planned, Curatis held a Type B meeting with the US Food and Drug Administration (FDA) on 9 September 2025.

Business development and finances

Product sales in the first half of the year amounted to CHF 5.0m and services revenues to CHF 0.2m. Curatis AG was able to increase the sales of its distribution business from CHF 4.6m (H1 2024) to CHF 5.2m (H1 2025) in the entire 6 months due to strong organic growth of the existing portfolio and new products, which corresponds to a growth of 14%. The loss for the period amounted to CHF -1.2m, driven mainly by significant investments in C-PTBE-01 in preparation for the planned Phase 3 clinical trial.

Curatis has a cash position of CHF 2.0m despite increased development expenses.

For a more detailed discussion of the half-year figures, please refer to the half-year report and the associated management report, which are available on the Curatis website www.curatis.com.

Corticorelin / C-PTBE-01

Curatis’ lead product candidate, C-PTBE-01 (corticorelin), is being developed to treat peritumoral brain edema (PTBE). PTBE occurs in association with many primary and metastatic (secondary) brain tumors, often in connection with metastases caused by lung cancer, breast cancer, melanoma and colorectal cancer. PTBE results in impairment of brain function due to the accumulation of extracellular fluid around the tumor and can cause symptoms such as headaches, vomiting and neurological dysfunction such as paralysis, speech disorders, visual problems and altered mental status. Standard of care treatment for PTBE is the use of corticosteroids which frequently have serious side effects such as severe myopathy, impaired glucose metabolism, muscle wasting, abnormal weight gain, osteoporosis, gastritis, gastrointestinal bleeding, hypertension and personality changes. Additionally, corticosteroids can also counteract certain cancer therapies such as chemotherapy or emerging immunotherapies that rely on adequate T-cell functionality which is impaired by corticosteroids.

Corticorelin (hCRH), a 41 amino acid endogenous polypeptide, has demonstrated preclinically (in vivo) the ability to positively impact the blood-brain barrier after a disruption due to the underlying malignant tumor. In two clinical studies in patients with PTBE, corticorelin, demonstrated the potential to substantially reduce, or in some cases completely replace steroid use, which may reduce or avoid the severe glucocorticoid-related side effects and subsequently improve quality of life. In the US alone, more than 150,000 patients suffer from PTBE. Corticorelin is an investigational drug not approved for therapeutic use in the United States or outside the United States.

Curatis met with the FDA on 9 September 2025 to achieve alignment on the design of a pivotal Phase 3 clinical trial for corticorelin as well as on key non-clinical and manufacturing aspects. The outcome of the meeting was positive. Further details will be published once the minutes of the FDA meeting are available. In Q3 of 2025, Curatis Holding AG began the process of partnering C-PTBE-01 (corticorelin) with global pharmaceutical companies active in oncology.

Outlook

The Curatis Group anticipates growth in its product and service revenues for 2025 compared to 2024. This growth is expected to be primarily driven by new products, notably four recently contracted products from Phoenix Labs in pain management and urology. These products generated approximately CHF 5 million in sales in 2024. Curatis Group’s objective remains to achieve a break even result in 2026 regardless of whether a partner for C-PTBE-01 can be secured. This would be achieved through substantially increased revenues and lower costs compared to 2025.

About Curatis

Curatis Holding AG is a publicly listed company (CURN.SW) specializing in the late stage development and commercialization of drugs for rare diseases and specialty care. Curatis has a sales portfolio of more than 40 products and a pipeline of orphan and specialty drugs. More information can be found on the website www.curatis.com.

Disclaimer:

The information contained in this media release and in any link to our website indicated herein is not for use within any country or jurisdiction or by any persons where such use would constitute a violation of law. If this applies to you, you are not authorized to access or use any such information.

This media release contains “forward-looking statements” that are based on our current expectations, assumptions, estimates and projections about us and our industry. Forward-looking statements include, without limitation, any statement that may predict, forecast, indicate or imply future results, performance or achievements, and may contain the words “may”, “will”, “should”, “continue”, “believe”, “anticipate”, “expect”, “estimate”, “intend”, “project”, “plan”, “will likely continue”, “will likely result”, or words or phrases with similar meaning. Undue reliance should not be placed on such statements because, by their nature, forward-looking statements involve risks and uncertainties, including, without limitation, economic, competitive, governmental and technological factors outside of the control of Curatis Group, that may cause Curatis’ business, strategy or actual results to differ materially from the forward-looking statements (or from past results). For any factors that could cause actual results to differ materially from the forward-looking statements contained in this media release, please see the risk factors included in our listing prospectus in connection with the Business Combination. Curatis Group undertakes no obligation to publicly update or revise any of these forward-looking statements, whether to reflect new information, future events or circumstances or otherwise. It should further be noted that past performance is not a guide to future performance. Persons requiring advice should consult an independent adviser.

The information contained in this media release is not an offer to sell or a solicitation of offers to purchase or subscribe for securities. This media release is not a prospectus within the meaning of the Swiss Financial Services Act nor a prospectus under any other applicable laws.

Some financial information in this media release has been rounded and, as a result, the figures shown as totals in this media release may vary slightly from the exact arithmetic aggregation of the figures that precede them.

Contacts

Patrick Ramsauer

CFO

Phone: +41 61 927 8777

ir@curatis.com