Novotech Welcomes New Investment From GIC, Temasek, and Existing Investor TPG to Accelerate Global Growth

Novotech Welcomes New Investment From GIC, Temasek, and Existing Investor TPG to Accelerate Global Growth




Novotech Welcomes New Investment From GIC, Temasek, and Existing Investor TPG to Accelerate Global Growth

SYDNEY–(BUSINESS WIRE)–#GIC–Novotech, a globally recognized full-service biotech specialist clinical research organization (CRO), announced today that affiliates of GIC and Temasek have signed binding agreements to acquire a significant stake in the company, with the additional capital earmarked to accelerate its global growth. Existing investor TPG will also reinvest through its TPG Asia fund.


Novotech, headquartered in Singapore with a global presence across more than 30 offices, is one of the world’s leading full-service clinical CROs, providing biotech and small- to mid-sized pharmaceutical companies with an accelerated path to market. Today, the company has a global footprint across the Asia-Pacific region, North America and Europe, and partnerships with more than 5,000 trial sites. Novotech has a leading position in the most innovative areas of clinical research such as cell and gene therapies, radiopharmaceuticals and mRNA trials.

The reinvestment by TPG Asia and investment from GIC and Temasek will allow Novotech to pursue further organic growth and transformative M&A opportunities. This is part of Novotech’s ambition to become the first truly global biotech-focused CRO.

Novotech Chief Executive Officer John Moller welcomed the new investment and said the company was uniquely positioned to continue its growth in the Asia Pacific region, where demand for clinical trials is forecasted to grow at 15% a year, in addition to focused expansion in the US and Europe.

“Novotech is already on its way to be a major global player in the CRO space, with 3,000 employees and experience across more than 6,000 clinical projects,” Dr. Moller said. “We are excited by the new support of GIC and Temasek, and the continued support of TPG, as we continue to scale the business while maintaining our high-quality standards.

We have a commanding presence in the Asia Pacific region – which is only growing in popularity for global trials as the trend towards outsourcing continues, particularly among biotechs – and have made significant gains in the US and Europe through acquisitions. This investment will ensure we can continue our record of winning a growing share of larger, multi-region trials, particularly ones with a center of gravity in Asia, and it will also enable us to pursue larger, transformation acquisitions as our industry inevitably consolidates.”

Joel Thickins, Co-Head of TPG Asia and Co-Managing Partner of TPG Capital Asia, said: “Novotech’s growth and performance has been outstanding over the years, and we are delighted to remain involved for the next stage of its global expansion. Since our investment in 2017, Novotech has grown from a 300-person organization operating predominantly in Australia and New Zealand and some parts of Asia, to now a 3,000-person organization with a global presence. TPG has a long history of partnering with management teams to deliver long-term value creation, and by re-investing through TPG Asia, we are excited to continue the journey with Novotech to build something that is truly unique.”

TPG Asia has a strong track record investing in healthcare across Asia-Pacific through its platform-building strategy and regional presence. Other select healthcare investments include iNova, Manipal Hospitals, One Healthcare Asia, Pathology Asia and United Family Healthcare.

Vincent Wong, Co-Head of Healthcare, TPG Capital Asia, added: “Delivering high-quality healthcare relies on building great companies achieved through long-term commitment, and this transaction follows TPG’s playbook of doubling down on winners while further demonstrating TPG’s thematic investment approach and deep expertise in healthcare. Together with our history of partnering with Novotech, and TPG’s deep healthcare ecosystem that has been further strengthened with the recent establishment of a regional leadership model for healthcare investments across TPG Asia, we are well positioned to support Novotech in its multi-decade success story.”

Choo Yong Cheen, Chief Investment Officer of Private Equity at GIC, commented: “Novotech’s proven track record of delivering high-quality outcomes for its biopharma customers has taken them beyond APAC to global markets. We are pleased to support Novotech alongside TPG with our long-term capital and global network in this next phase of growth. We look forward to working with the management team and our partners in driving sustained growth by investing in organic initiatives and M&A.”

Terms of the transaction were not disclosed.

About Novotech

Novotech is a globally recognized full-service clinical research organization (CRO) and scientific advisory company trusted by biotech and small- to mid-sized pharmaceutical companies to guide drug development at every phase. With a global footprint that includes 30+ offices across the Asia-Pacific region, North America, and Europe and partnerships with 5,000+ trial sites, Novotech provides clients an accelerated path to bring life-changing therapies to market by providing access to key clinical trial destinations and diverse patient populations. Through its client-centric service model, Novotech seamlessly integrates people, processes, and technologies to deliver customized solutions that accelerate the path to market for life-changing therapies. By adopting a true partnership approach, Novotech shares a steadfast commitment to client success, empowering innovation, and advancing healthcare worldwide. Recipient of numerous industry accolades, including the Frost & Sullivan CRO Company of the Year award for 19 consecutive years, Novotech is recognized for its excellence in clinical trial execution and innovation. Its deep therapeutic and regulatory expertise, combined with local market insights, ensures streamlined clinical trials, optimized data analytics, and accelerated patient recruitment strategies. Together with clients, Novotech transforms scientific advancements into therapies that improve global health outcomes, embodying a mission of driving innovation and delivering impactful results.

About TPG

TPG is a leading global alternative asset management firm, founded in San Francisco in 1992, with $246 billion of assets under management and investment and operational teams around the world. TPG invests across a broadly diversified set of strategies, including private equity, impact, credit, real estate, and market solutions, and our unique strategy is driven by collaboration, innovation, and inclusion. Our teams combine deep product and sector experience with broad capabilities and expertise to develop differentiated insights and add value for our fund investors, portfolio companies, management teams, and communities.

About GIC

GIC is a leading global investment firm established in 1981 to secure Singapore’s financial future. As the manager of Singapore’s foreign reserves, we take a long-term, disciplined approach to investing, and are uniquely positioned across a wide range of asset classes and active strategies globally. These include equities, fixed income, real estate, private equity, venture capital, and infrastructure. Our long-term approach, multi-asset capabilities, and global connectivity enable us to be an investor of choice. We seek to add meaningful value to our investments. Headquartered in Singapore, we have a global talent force of over 2,300 people in 11 key financial cities and have investments in over 40 countries.

For more information, please visit gic.com.sg or follow us on LinkedIn.

About Temasek

Temasek is a global investment company headquartered in Singapore, with a net portfolio value of S$389 billion (US$288b, €267b, £228b, RMB2.08t) as at 31 March 2024. Marking its unlisted assets to market would provide S$31 billion (US$23b, €21b, £18b, RMB166b) of value uplift and bring its mark to market net portfolio value to S$420 billion (US$311b, €289b, £247b, RMB2.25t).

Temasek’s Purpose “So Every Generation Prospers” guides it to make a difference for today’s and future generations.

Operating on commercial principles, Temasek seeks to deliver sustainable returns over the long term.

It has 13 offices in 9 countries around the world: Beijing, Hanoi, Mumbai, Shanghai, Shenzhen, and Singapore in Asia; and Brussels, London, Mexico City, New York, Paris, San Francisco, and Washington, DC outside Asia.

Contacts

For media inquiries:
Novotech
Toyna Chin

(USA) +1 415 364 8135

mediacontact@novotech-cro.com

TPG
Katelin Stevenson

TPGAsia@brunswickgroup.com

GIC
Mah Lay Choon

Head of Corporate Communications

+65 6889 6841

mahlaychoon@gic.com.sg

Toh Chuan Ting

Assistant Vice President, Corporate Communications

+65 8309 1038

tohchuanting@gic.com.sg

Temasek
Kelvin Ng

Director, Public Affairs

Tel: +65 6828 6939

kelvinng@temasek.com.sg

Rebekah Seow

Associate, Public Affairs

Tel: +65 6828 2500

rebekahseow@temasek.com.sg

Clinical Data Presented at ACC 2025 Shows Sensydia CPS™ Provides Accurate Assessment of Mean Pulmonary Artery Pressure Non-Invasively

Clinical Data Presented at ACC 2025 Shows Sensydia CPS™ Provides Accurate Assessment of Mean Pulmonary Artery Pressure Non-Invasively




Clinical Data Presented at ACC 2025 Shows Sensydia CPS™ Provides Accurate Assessment of Mean Pulmonary Artery Pressure Non-Invasively

— Non-invasive platform offers potential to transform heart failure care —




— CPS on display for physicians in Sensydia booth #8029 at the American College of Cardiology (ACC) Annual Scientific Session & Expo —

CHICAGO–(BUSINESS WIRE)–Sensydia, a clinical-stage non-invasive cardiac assessment company, announced today that University of Minnesota investigators presented positive clinical findings from a recent study evaluating the company’s AI-powered, non-invasive Cardiac Performance System (CPS™) in a poster presentation at the American College of Cardiology (ACC) 2025 Annual Scientific Session & Expo at the McCormick Place Convention Center in Chicago, IL.

Sensydia’s CPS uses heart sound analysis to enable earlier detection and more effective therapy guidance for patients suffering from heart failure and pulmonary hypertension. To obtain these measurements today, patients must undergo echocardiography and invasive right heart catheterization, which are resource intensive, restricted to medical facilities, and only provide snapshot data. In contrast, CPS measurements are fast, safe, may be repeated as frequently as needed, and can be performed essentially anywhere with minimal training.

Poster information:

 

Title:

“Non-Invasive Hemodynamic Monitoring Using AI to Determine Pulmonary Artery Pressures”

Date:

Saturday, March 29, 2025, at 9:30-10:30 am CDT

Location:

Board #55

Key findings

  • The investigator-led study enrolled 50 patients undergoing routine right heart catheterization (RHC), with CPS successfully measuring mean pulmonary artery pressure (mPAP) in 40 subjects.
  • CPS demonstrated its ability to identify patients with elevated mPAP (>35mmHg and >30mmHg) with strong diagnostic accuracy, achieving an AUC of 0.80 and 0.77, respectively.
  • No complications or adverse reactions were reported, and patients tolerated the non-invasive CPS measurement well.

Significance of These Findings

For clinicians and healthcare providers, these findings underscore the potential of CPS to serve as a reliable alternative to invasive RHC. CPS could provide critical, real-time insights into hemodynamics in the clinic or the patient’s home, reducing the need for hospital-based monitoring while potentially improving patient outcomes and streamlining heart failure management.

“CPS offers a fast, non-invasive, and accurate tool to assess hemodynamics that could transform heart failure care,” said Tamas Alexy, MD, PhD of the University of Minnesota. “The ability to track changes in pulmonary artery pressure (PAP) with CPS can empower clinicians to make more informed and timely treatment decisions for patients with heart failure.”

ACC.25 attendees are invited to visit booth 8029 to explore CPS’s role in improving heart failure management and see a demonstration of CPS technology.

Please note: CPS is under development and not yet FDA-approved.

About Sensydia

Sensydia is developing the Cardiac Performance System (CPS™), a non-invasive platform that provides real-time measurements of critical cardiac function. CPS is designed to deliver rapid, safe, and accurate assessments to improve outcomes for patients with heart failure and pulmonary hypertension. The company received FDA 510(k) clearance for non-invasive measurement of ejection fraction using first-generation hardware in 2018. Learn more at sensydia.com.

Contacts

Media:
Kathryn Morris, BrightPoint

kathryn@brightpointny.com
914-204-6412

Quantum-Si to Participate in DNAnexus Webinar on Large Scale Proteomics in Multi-Omics Research

Quantum-Si to Participate in DNAnexus Webinar on Large Scale Proteomics in Multi-Omics Research




Quantum-Si to Participate in DNAnexus Webinar on Large Scale Proteomics in Multi-Omics Research

Validate multi-omics findings at the single-molecule level with Next-Gen Protein Sequencing™

BRANFORD, Conn.–(BUSINESS WIRE)–Quantum-Si Incorporated (Nasdaq: QSI) (“Quantum-Si,” “QSI” or the “Company”), The Protein Sequencing Company, announces participation in an upcoming DNAnexus webinar focused on the role of proteomics in multi-omics research. This discussion will explore how the integration of proteomics data with other omics datasets is driving new discoveries in disease research, including cancer.


When: March 25, 2025, at 8 a.m. PT/11 a.m. ET

Attendees will learn about:

  • The growing impact of proteomics in multi-omics analysis
  • Applications for cancer and other disease research
  • Technologies and strategies for large-scale discovery and data analysis
  • Tools for orthogonal validation of proteins of interest

WHO: Featured speakers include:

  • Meredith Carpenter, PhD, Head of Scientific Affairs, Quantum-Si
  • Cindy Lawley, PhD, Sr. Director, Population Health Proteomic Sciences, Olink, Thermo Fisher Scientific
  • Theresa Wohlever, Sr. Bioinformatics Scientist, DNAnexus

WHERE: Virtual event – registration required.

HOW: To register, please complete the registration form. A confirmation email will be sent upon registration.

About Quantum-Si Incorporated

Quantum-Si, The Protein Sequencing Company, is focused on revolutionizing the growing field of proteomics. The Company’s Platinum® line of instruments enables Next-Gen Protein Sequencing that advances proteomic research, drug discovery, and diagnostics beyond what has been possible with existing proteomic tools. Learn more at quantum-si.com or follow us on LinkedIn or X.

Contacts

Investor Contact
Jeff Keyes

Chief Financial Officer

ir@quantum-si.com

Media Contact
Katherine Atkinson

SVP, Commercial Marketing

media@quantum-si.com

US Patent Office Grants Closed Loop Medicine Key Patents for Cardiometabolic Capabilities in GLP-1 and Direct Oral Anti-Coagulants (DOAC) Therapies

US Patent Office Grants Closed Loop Medicine Key Patents for Cardiometabolic Capabilities in GLP-1 and Direct Oral Anti-Coagulants (DOAC) Therapies




US Patent Office Grants Closed Loop Medicine Key Patents for Cardiometabolic Capabilities in GLP-1 and Direct Oral Anti-Coagulants (DOAC) Therapies

LONDON–(BUSINESS WIRE)–Closed Loop Medicine Ltd., a leader in AI-enabled precision medicines, today announced the expansion of its US patent portfolio. Strengthening its cardiometabolic treatment portfolio, the Company now has patents covering advancements in GLP-1 therapies for obesity and diabetes, and direct oral anticoagulants (DOACs) for cardiovascular health.


Closed Loop Medicine holds over 65 filings across 16 patent families, marking a significant milestone in its mission to deliver precision medicine at scale. The Company continues to expand its strong intellectual property foundation to safeguard the scalability of its innovations in personalized dosing, novel drug forms and drug-digital combination therapies.

In the rapidly-established GLP-1 market, Closed Loop Medicine has recognized the potential in delivering personalized solutions that address both the unpredictability of weight loss and the adverse effects that may otherwise limit patient adherence to weight management programs. The Company’s IP covers dose optimization according to patient-specific factors such as degree of calorie restriction or exercise, providing an opportunity for the development of personalized co-therapies enhancing existing GLP-1 medicines.

The latest patent granted by the US Patent Office extends Closed Loop Medicine’s cardiometabolic capabilities into DOAC therapy, enabling more personalized and effective anticoagulation treatment. This patent supports AI-powered precision dosing for patients requiring DOACs, improving safety and efficacy in stroke prevention and other cardiovascular conditions.

Dr Hakim Yadi, CEO and co-Founder of Closed Loop Medicine, says: “Establishing a strong and differentiated patent portfolio is central to our leadership in AI-enabled personalized medicine. These patents reinforce our ability to deliver smarter, AI-enabled pharmacometric dosing solutions. Not only to improve clinical outcomes and optimize treatment for cardiometabolic diseases with novel drug forms, but also software enhancements of existing drugs, the latter receiving timely support with the FDA’s recent Prescription Drug Use-Related Software PDURS guidance”

To learn more about Closed Loop Medicine and its mission to deliver precision care for all, please visit: www.closedloopmedicine.com

Contacts

Media contact:
Zyme Communications

Lily Jeffery

Email: lily.jeffery@zymecommunications.com

Merz Aesthetics Sponsors Symposium Highlighting Market Trends With a Portfolio Approach at the 2025 Aesthetic and Anti-aging Medicine World Congress (AMWC)

Merz Aesthetics Sponsors Symposium Highlighting Market Trends With a Portfolio Approach at the 2025 Aesthetic and Anti-aging Medicine World Congress (AMWC)




Merz Aesthetics Sponsors Symposium Highlighting Market Trends With a Portfolio Approach at the 2025 Aesthetic and Anti-aging Medicine World Congress (AMWC)

FRANKFURT AM MAIN, Germany–(BUSINESS WIRE)–Merz Aesthetics, the world’s largest dedicated medical aesthetics business, is set to unveil new data on its product portfolio and offer insights into the latest trends in the industry at the 2025 Aesthetic and Anti-Aging Medicine World Congress held in Monaco, France.


“Thanks to the scientific profile of our products, our portfolio continues to meet evolving expectations of physicians,” said Dr. Kerstin Olsson, Head of Medical Affairs in EMEA, “from routine procedures to cutting-edge treatments, we’re redefining innovation in the aesthetics industry”.

“We recognize that beauty is personal and unique to everyone. We are dedicated to understanding the needs of health care professionals and their patients,” said Gonzalo Mibelli, President, EMEA, Merz Aesthetics. “We look forward to sharing our latest data and vision for the future of medical aesthetics”.

Merz Aesthetics’ programming includes a sponsored symposium on March 28 from 14:00 – 16:00, The Evolution of Aesthetics: Foundations, Trends and Future, moderated by Dr. Mariana Muniz, featuring commentary from Dr. Martina Kerscher, Dr. Kate Goldie, Dr. Jani van Loghem, Dr. Nabil Fakih and Dr. Jonathan Kadouch. During the session, the group of experts will highlight emerging trends in medical aesthetics and demonstrate how solutions are tailored for personalized treatments.

In addition to the symposium, Merz Aesthetics is presenting six talks under the umbrella of MAX Merz Aesthetics Exchange, which are taking place at the booth P1, Level 1:

  • The Science of Connection: Using Synchrony to Improve Patient Communication; Joshua Bernstein, Neuroconsultant; Thursday, March 27; 13:15
  • Unlock your Social Media: Insights from a leading expert; Dr. Emi Arpa; Thursday, March 27; 13:45
  • Enhancing Lips: Tailored techniques based on age & gender; Dr. Awat Hassan; Thursday, March 27; 16:15
  • Mastering the Patient Journey; Vanessa Bird, Business Expert; Friday, March 28; 10:45
  • Radiesse: Unlock the Secret to a youthful-looking & smoother Décolleté; Dr. Rosalia Luketina; Friday, March 28; 13:15
  • Radiesse – Biostimulatory Scaffold in Regenerative Aesthetics – Nonclinical research; Dr. Ewelina Kaczuba; Dr. Yoana Dimitrova; Saturday, March 29; 10:45

Twenty e-posters will be available for viewing on-site throughout the congress and displayed on the virtual e-poster platform with detailed abstracts. They include:

  • Efficacy and Safety of IncobotulinumtoxinA in the treatment of Upper Facial Lines: Findings from two phase III randomized, double-blind, placebo-controlled studies – Tatjana Pavicic MD, Michael Gold MD, Martina Kerscher MD, Vladimir Sudimac MD, Petra Weissenberger MD, John Joseph MD
  • Long-term Durability of IncobotulinumtoxinA Treatment in the Upper Face as Reported by Global Aesthetic Improvement Scale – Michael H. Gold, MD; Andy Curry, PhD; Ivanti Galloway; Z. Paul Lorenc M.D., F.A.C.S.
  • Lifting and Structural Enhancement of Dermal Fillers with Cohesive Polydensified Matrix® Technology – Pia Vestweber, PhD; Yoana Dimitrova, MSc; Kay Marquardt, PhD; Thomas Hengl, PhD
  • Long-Term Skin Improvement through Combined MFU-V and CaHA Treatments – Tingsong Lim, MD; Meng Jun Ho, MD
  • The Cohesive Polydensified Matrix Hyaluronic Acid (CPM-HA) Gels Demonstrate Biomimetic Tissue Plane Adaptation: An Integrative Analysis of Physiochemical Properties – Gabriela Casabona, MD; Radovan Vukicevic, PhD; Angela Prager, PhD; Mimi R. Borrelli, MBBS, PhD, MSc

About Merz Aesthetics

Merz Aesthetics is a medical aesthetics business with a long history of empowering health care professionals, patients and employees to live every day with confidence. We aim to help people around the world look, feel and live like the best versions of themselves — however they define it. Clinically proven, its product portfolio includes injectables, devices and skin care treatments designed to meet each patient’s needs with high standards of safety and efficacy. Being family owned for more than 115 years, Merz Aesthetics is known for building unique connections with customers who feel like family. Merz Aesthetics’ global headquarters is in Raleigh, N.C., USA, with a commercial presence in 90 countries worldwide. It is also a part of Merz Group, which was founded in 1908 and is based in Frankfurt, Germany. Learn more at merzaesthetics.com.

Copyright © 2025 Merz Aesthetics GmbH. All rights reserved. MERZ, MERZ AESTHETICS and the MERZ logo are registered trademarks of Merz Pharma GmbH & Co. KGaA.

Contacts

Media Contact
Diana Trojanus – EMEA Communications – Merz Aesthetics GmbH – Eckenheimer Landstraße 100, 60318 Frankfurt am Main, Germany, Media@merz.com

World TB Day 2025: AHF Mobilizes to End TB

World TB Day 2025: AHF Mobilizes to End TB




World TB Day 2025: AHF Mobilizes to End TB

LOS ANGELES–(BUSINESS WIRE)–#TB–This World Tuberculosis (TB) Day, observed on March 24, AIDS Healthcare Foundation (AHF) teams worldwide join government and civil society partners in calling for more substantial political commitments, increased funding, and expanded access to TB services. AHF teams’ World TB Day events will call for action and help raise awareness about TB – the world’s deadliest infectious disease, the leading cause of death for people living with HIV, and a major cause of death related to antimicrobial resistance.

“Ending TB is not a question of whether or not it is possible—it is a matter of commitment. We have the tools, the knowledge, and the ability to stop this disease, but progress will only happen if governments prioritize TB as a global health emergency,” said AHF Chief of Global Advocacy and Policy Terri Ford. “We must invest in stronger healthcare systems, ensure equitable access to treatment, and break the barriers of stigma and neglect that have allowed TB to persist for far too long. This World TB Day, we reaffirm that the fight against TB is not over, and we call on world leaders to act with urgency and accountability. Lives depend on it.”

TB claimed 1.25 million lives in 2023, according to the World Health Organization. While global TB incidence has declined, progress is too slow to meet international targets. An estimated nearly 11 million people fell ill with TB in 2023, with more than 80% of cases and deaths occurring in low- and middle-income countries. At least $22 billion is needed annually for TB prevention and treatment, yet global funding remains significantly short of this goal. Multidrug-resistant tuberculosis remains a public health crisis, with only about two in five people with drug-resistant TB receiving treatment in 2023.

AHF focuses on HIV/TB co-infection care in its clinics and has long prioritized TB prevention, screening, and treatment as part of its global healthcare programs. AHF also advocates for policy changes to make TB drugs and diagnostics more accessible and affordable and engages communities and governments to commit to more vigorous TB control efforts.

AIDS Healthcare Foundation (AHF) is a global non-profit organization providing cutting-edge medicine and advocacy to over 2.3 million people in 48 countries worldwide in Africa, the Americas, the Asia/Pacific Region, and Europe. We are currently the largest non-profit provider of HIV/AIDS medical care in the world. To learn more about AHF, please visit our website: www.aidshealth.org, find us on Facebook: www.facebook.com/aidshealth and follow us on Twitter: @aidshealthcare and Instagram: @aidshealthcare.

Contacts

US MEDIA CONTACT:

Ged Kenslea, Senior Director, Communications, AHF

+1 323 308 1833 work +1.323.791.5526 mobile

gedk@aidshealth.org

Denys Nazarov, Director of Global Policy and Communications, AHF

+1 323.308.1829

denys.nazarov@aidshealth.org

California University of Science and Medicine Celebrates Match Day for 2025 MD Graduates

California University of Science and Medicine Celebrates Match Day for 2025 MD Graduates




California University of Science and Medicine Celebrates Match Day for 2025 MD Graduates

COLTON, Calif.–(BUSINESS WIRE)–California University of Science and Medicine (CUSM) today announced that the 2025 MD graduating class received residency placements as part of the national Match Day event. Sixty-six percent of CUSM Doctor of Medicine (MD) grads will perform their residency in southern California; twenty-eight percent will remain in the Inland Empire. Match Day is the culmination of the National Resident Matching Program, in which all graduating MDs seek residency positions in their chosen specialty. At the same time, across the country (9 a.m. Pacific Time, Friday, March 21, 2025), graduating medical students learn where they will spend the next three to seven years of their lives.




“Match Day is probably the most emotional day in the medical school journey,” said Paul Lyons, MD, CUSM Dean and President. “After years of commitment and challenges, the door to the next chapter is opened. I am thrilled that so many of our talented students will remain in our region and many will serve as residents in our partner hospitals.”

Twenty-six of the 2025 MD graduates will perform their residencies at CUSM partner hospitals including Riverside Community Hospital, Riverside University Health System, Eisenhower Medical Center, and Arrowhead Regional Medical Center, CUSM’s primary teaching partner. CUSM clinical training partners support medical students with critical teaching rotations and clerkship opportunities during their four-year medical school program. Additionally, physicians from these institutions serve as university faculty for CUSM students.

CUSM invited the graduating MD students and their families to the CUSM campus to celebrate with their colleagues, a tradition kept by most medical school programs.

“Our mission to educate compassionate healthcare providers comes to fruition on each and every Match Day. It is a privilege to contribute to the journey of these dedicated students and to share their joy on this momentous day,” added Dr. Lyons.

CUSM graduates achieved placements in competitive programs nationally and across California. Additionally, residencies were secured in the most competitive disciplines, including Anesthesiology, Neurosurgery, ENT, Radiology, Vascular Surgery, Orthopedic surgery, Ophthalmology, and Dermatology.

CUSM Match Day 2025 Breakdown:

  • Ninety-seven percent match rate
  • Thirty-six performing residencies in the Inland Empire
  • One hundred performing residencies in California
  • Top specialties include Internal Medicine, Emergency Medicine, Family Medicine, Psychiatry, and Neurology

About California University of Science and Medicine

California University of Science and Medicine (CUSM) is dedicated to advancing the art and science of medicine through medical education, research, and compassionate healthcare delivery in an inclusive environment. The university provides medical education and community resources designed to inspire, motivate, and empower students to become excellent and caring physicians, scientists, and leaders. CUSM is a not-for-profit health sciences university established in 2015 through a private-public partnership with Arrowhead Regional Medical Center as its teaching hospital, the County of San Bernardino, the City of Colton, and Prime Healthcare Foundation.

Learn more at www.cusm.edu.

Note to editors:

Photo Credit: Grant Terzkis

Video available upon request

Contacts

California University of Science and Medicine

Contact: Cynthia Baker

(909) 498-0610

Cynthia.baker@cusm.edu

Dentalcorp Reports Fourth Quarter and Full Year 2024 Results, Declares Inaugural Dividend

Dentalcorp Reports Fourth Quarter and Full Year 2024 Results, Declares Inaugural Dividend




Dentalcorp Reports Fourth Quarter and Full Year 2024 Results, Declares Inaugural Dividend

Revenue growth and margin expansion combine to drive robust Adjusted EBITDA and Adjusted Free Cash Flow per share growth

Fourth Quarter 2024 Highlights


  • Revenue of $397.5 million, an increase of 9.7% from the fourth quarter of 2023, with Same Practice Revenue Growth (“SPRG”)1 of 2.7%.
  • Adjusted EBITDA1 of $73.9 million, an increase of 12.3% compared to the same period in 2023; Adjusted EBITDA Margin1 of 18.6%, an increase of 40 basis points over the same period in 2023.
  • Adjusted Free Cash Flow1 and Adjusted Free Cash Flow per Share1 of $39.3 million and $0.20, an increase of 15.9% and 11.1%, respectively, over the same period in 2023; Adjusted Net Income1 of $27.4 million.
  • Net debt / PF Adjusted EBITDA after rent Ratio1 of 3.8x, a decrease of 0.6x compared to the same period in 2023.
  • Acquired 12 new practice locations which are expected to generate $10.3 million in PF Adjusted EBITDA after rent1 at 7.2x, expanding Dentalcorp’s national footprint to 561 locations.

Full Year 2024 Highlights

  • Revenue of $1,545.1 million, an 8.4% increase over the previous year, with SPRG1 of 2.3%.
  • Adjusted EBITDA1 of $285.2 million, representing a 9.8% increase over the prior year; Adjusted EBITDA Margin1 of 18.5%, an increase of 30 basis points over the prior year.
  • Adjusted Free Cash Flow1 and Adjusted Free Cash Flow per Share1 of $151.8 million and $0.79, an increase of 19.3% and 16.2%, respectively, over the prior year.
  • Acquired 30 new practice locations, expected to generate $21.4 million in PF Adjusted EBITDA after rent1, expanding our operational footprint to 561 dental practices by year’s end and reinforcing our position as the partner of choice.
  • Completed the year with substantial liquidity of $432.5 million, comprised of cash on hand and available undrawn debt capacity.

Full Year 2025 Outlook

  • Revenue for the year is estimated to increase by 10.0% to 11.0% over fiscal 2024 (to between $1,699.6M and $1,715.1M), and SPRG1 for the year is expected to be 3.0% to 5.0%.
  • Adjusted EBITDA Margin1 is estimated to increase by 20+ basis points over 2024 levels to approximately 18.7% and Adjusted EBITDA1 is estimated to increase to between $317.8M and $320.7M.
  • Expect to complete acquisitions representing PF Adjusted EBITDA after rent1 of $25 million+.
  • Pre-Tax Adjusted Free Cash Flow per Share1 to grow by 15%+.

First Quarter 2025 Outlook

  • Revenue and SPRG1 for the first quarter of 2025 are estimated to increase by 8.0% to 9.0% (to between $402.2M and $405.9M) and 3.0% to 5.0%, respectively, over the first quarter of 2024.
  • Adjusted EBITDA Margin1 for the first quarter of 2025 is estimated to increase by 20 basis points from the first quarter of 2024 and Adjusted EBITDA1 is estimated to increase to between $74.4M and $75.1M.
  • Expect to complete acquisitions representing PF Adjusted EBITDA after rent1 of $8 million+.

(¹) Non-IFRS financial measure, non-IFRS ratio, or supplementary financial measure. For comprehensive definitions and quantitative reconciliations, please refer to the “Non-IFRS and Other Financial Measures” section within this news release.

TORONTO–(BUSINESS WIRE)–dentalcorp Holdings Ltd. (“Dentalcorp” or the “Company”) (TSX: DNTL), Canada’s largest and one of North America’s fastest growing networks of dental practices, today announced its financial and operating results for the fourth quarter and full year ended December 31, 2024. All financial figures are in Canadian dollars unless otherwise indicated.

“Our teams across the country delivered another year of exceptional results, with fourth quarter revenue and Adjusted EBITDA growth of approximately 10% and 12%, respectively, over the fourth quarter of 2023. Full year revenue and Adjusted EBITDA grew by approximately 8% and 10%, respectively, over the prior year. We continued to realize operating leverage across the business, with fourth quarter Adjusted EBITDA Margin expanding 40 basis points over the fourth quarter of 2023 to 18.6%, translating to full year 2024 Adjusted EBITDA Margin of 18.5%, exceeding our expectations,” said Graham Rosenberg, CEO and Chairman of Dentalcorp.

“We generated $151.8 million in Adjusted Free Cash Flow in 2024, translating to full year Adjusted Free Cash Flow per Share growth of 16%, in line with expectations,” Rosenberg continued. “This led to continued deleveraging, with our Net Debt / PF Adjusted EBITDA after rent Ratio decreasing to 3.8x, a reduction of 0.6x from the fourth quarter of 2023.”

“During 2024, we acquired 30 new practices that are expected to generate $21.4 million in PF Adjusted EBITDA after rent, at an average multiple of 7.0x, exceeding our expectations,” Nate Tchaplia, President and Chief Financial Officer said.

“With regards to the federal government’s Canadian Dental Care Plan (“CDCP”), we have treated over 80,000 CDCP patients with over 90% of our practices currently accepting CDCP patients. During the fourth quarter of 2024, SPRG was impacted by the deferral of appointments in the 19-64 age cohort as they awaited their official start date under the program,” Tchaplia continued.

“We are looking forward to a strong 2025, where we expect to see SPRG of 3.0% to 5.0%, an accelerated pace of M&A with acquisitions representing $25 million+ of PF Adjusted EBITDA after rent, Pre-tax Adjusted Free Cash flow per Share growth of 15%+, and another year of Adjusted EBITDA Margin expansion of 20+ basis points,” Rosenberg concluded.

Inaugural Dividend:

As part of the Company’s long-term strategy to maximize shareholder value, the Company’s Board of Directors (the “Board”) has authorized a dividend of $0.025 per Subordinate Voting Share and Multiple Voting Share, payable on April 22, 2025 to shareholders of record at the close of business on April 4, 2025.

“Our robust free cash flow enables us to maintain a strong M&A program and return capital to shareholders, all while deleveraging. This approach is consistent with our overall strategy of maximizing value for all of our shareholders, including those in our nationwide network of 10,000+ dentists, health care professionals, and support staff throughout the country,” said Rosenberg.

It is the intention of the Board to review the amount of the dividend on a quarterly basis. Future declarations will be dependent on, among other things, the prevailing business environment, the Company’s financial and operating results and financial condition, the need for funds to finance ongoing operations or growth initiatives, and other business conditions which the Corporation’s Board of Directors considers relevant.

Consolidated Financial Results

 

Three months ended

December 31,

 

Year ended

December 31,

 

2024

 

2023

 

2024

 

2023

 

$

 

$

 

$

 

$

 

(expressed in millions of dollars)

 

(expressed in millions of dollars)

Revenue

397.5

 

362.2

 

1,545.1

 

1,425.7

Cost of revenue

197.8

 

182.3

 

772.4

 

716.3

Gross profit

199.7

 

179.9

 

772.7

 

709.4

Selling, general and administrative expenses

130.1

 

117.9

 

502.7

 

474.4

Depreciation and amortization

51.0

 

50.7

 

204.7

 

203.1

Share-based compensation

2.8

 

5.1

 

12.6

 

12.1

Foreign exchange (gain) loss

(0.4)

 

0.3

 

(0.7)

 

0.3

Net finance costs

23.0

 

23.2

 

92.4

 

93.1

Change in fair value of financial instruments at

fair value through profit or loss

5.3

 

23.6

 

24.8

 

5.6

Other losses

8.2

 

2.2

 

10.9

 

23.3

Loss before income taxes

(20.3)

 

(43.1)

 

(74.7)

 

(102.5)

Income tax recovery

(7.2)

 

(7.9)

 

(15.3)

 

(16.9)

Net loss and comprehensive loss

(13.1)

 

(35.2)

 

(59.4)

 

(85.6)

Other Metrics

Adjusted EBITDA(a)

73.9

 

65.8

 

285.2

 

259.7

Adjusted net income(a)

27.4

 

0.1

 

81.5

 

66.3

Adjusted free cash flow(a)

39.3

 

33.9

 

151.8

 

127.2

(a) Non-IFRS financial measure, non-IFRS ratio or supplementary financial measure. See the “Non-IFRS and Other Financial Measures and Ratios” section of this release for definitions and quantitative reconciliations.

Conference Call Notification

The Company will hold a conference call to provide a business update on Friday, March 21, 2025, at 8:30 a.m. ET. A question-and-answer session will follow the business update.

LIVE CONFERENCE DETAILS

DATE:

  Friday, March 21, 2025

TIME:

  8:30 a.m. ET

WEBCAST:

  https://events.q4inc.com/attendee/111342934

DIAL-IN NUMBERS:

  1 (888) 660-6396 or 1 (929) 203-0889

CONFERENCE ID:

  9097710

REPLAY:

  Available for two weeks after the call

DIAL-IN NUMBERS:

  1 (800) 770-2030 or 1 (647) 362-9199

CONFERENCE ID:

  9097710

Non-IFRS and Other Financial Measures and Ratios

As appropriate, we supplement our results of operations determined in accordance with IFRS with certain non-IFRS and other financial measures and ratios that we believe are useful to investors, lenders and others in assessing our performance and highlighting trends in our core business that may not otherwise be apparent when relying solely on IFRS measures. Our management also uses non-IFRS measures for purposes of comparing to prior periods; preparing annual operating budgets; developing future projections and earnings growth prospects; measuring the profitability of ongoing operations; analyzing our financial condition, business performance and trends, including the operating performance of the business after taking into consideration the acquisitions of dental practices; and determining components of employee compensation. As such, these measures are provided as additional information to complement IFRS measures by providing further understanding of our results of operations from management’s perspective, including how we evaluate our financial performance and how we manage our capital structure. We also believe that securities analysts, investors and other interested parties frequently use these non-IFRS and other financial measures and ratios and industry metrics in the evaluation of issuers. These non-IFRS and other financial measures and ratios are not recognized measures under IFRS and do not have a standardized meaning prescribed by IFRS and may include or exclude certain items as compared to similar IFRS measures and may not be comparable to similarly-titled measures reported by other companies. Accordingly, these measures should not be considered in isolation nor as a substitute for analysis of our financial information reported under IFRS. For further information on non-IFRS and other financial measures and ratios, including the most directly comparable IFRS measures, composition of the measures, a description of how we use these measures, an explanation of how these measures are useful to investors and applicable reconciliations, refer to the “Non-IFRS and Other Financial Measures”, “Non-IFRS Financial Measures”, “Non-IFRS Ratios” and “Certain Supplementary Financial Measures” sections of management’s discussion and analysis of operations for the three months and year ended December 31, 2024, which is available on the Company’s profile on SEDAR+ at www.sedarplus.ca.

EBITDA

“EBITDA” means, for the applicable period, net loss and comprehensive loss plus (a) net finance costs, (b) income tax recovery, and (c) depreciation and amortization. Management does not use EBITDA as a financial performance metric, but we present EBITDA to assist investors in understanding the mathematical development of Adjusted EBITDA and Same Practice EBITDA Growth. The most comparable IFRS measure to EBITDA is Net loss and comprehensive loss, for which a reconciliation is provided below.

 

Three months ended

December 31,

 

Year ended

December 31,

 

2024

 

2023

 

2024

 

2023

 

$

 

$

 

$

 

$

 

(expressed in millions of dollars)

 

(expressed in millions of dollars)

Net loss and comprehensive loss

(13.1)

 

(35.2)

 

(59.4)

 

(85.6)

Adjustments:

 

 

 

 

 

 

 

Net finance costs

23.0

 

23.2

 

92.4

 

93.1

Income tax recovery

(7.2)

 

(7.9)

 

(15.3)

 

(16.9)

Depreciation and amortization

51.0

 

50.7

 

204.7

 

203.1

EBITDA

53.7

 

30.8

 

222.4

 

193.7

Adjusted EBITDA

“Adjusted EBITDA” is calculated by adding to EBITDA certain expenses, costs, charges or benefits incurred in such period which in management’s view are either not indicative of underlying business performance or impact the ability to assess the operating performance of our business, including: (a) net impact of unrealized foreign exchange gains or losses on non-cash balances and share of associate losses; (b) share-based compensation; (c) external acquisition expenses; (d) change in fair value of financial instruments at fair value through profit of loss; (e) strategic review costs; (f) other corporate costs; (g) loss on disposal of dental practices; (h) loss on disposal and impairment of property and equipment and intangible assets; (i) loss on settlement of other receivables; (j) impairment of right-of-use assets; (k) post-employment benefits; and (l) short-term benefits. Adjusted EBITDA is a supplemental measure used by management and other users of our financial statements to assess the financial performance of our business without regard to the effects of interest, depreciation and amortization costs, expenses that are not considered reflective of underlying business performance, and other expenses that are expected to be one-time or non-recurring. We use Adjusted EBITDA to facilitate a comparison of our operating performance on a consistent basis from period to period and to provide for a more complete understanding of factors and trends affecting our business. The most comparable IFRS measure to Adjusted EBITDA is Net loss and comprehensive loss.

Adjusted EBITDA Margin

“Adjusted EBITDA Margin” means Adjusted EBITDA divided by revenue. We use Adjusted EBITDA Margin to facilitate a comparison of our operating performance on a consistent basis from period to period and to provide for a more complete understanding of factors and trends affecting our business.

 

Three months ended

December 31,

 

Year ended

December 31,

 

2024

 

2023

 

2024

 

2023

 

$

 

$

 

$

 

$

 

(expressed in millions of dollars)

 

(expressed in millions of dollars)

EBITDA

53.7

 

30.8

 

222.4

 

193.7

Add:

 

 

 

 

 

 

 

Net impact of unrealized foreign exchange gains or losses on non-cash balances and share of associate losses(a)

 

 

 

0.1

Share-based compensation

2.8

 

5.1

 

12.6

 

12.1

External acquisition expenses(b)

1.2

 

0.8

 

4.3

 

4.3

Change in fair value of financial instruments at fair value through profit or loss

5.3

 

23.6

 

24.8

 

5.6

Strategic review costs(c)

 

0.1

 

 

6.4

Other corporate costs(d)

2.7

 

1.9

 

7.4

 

13.0

Loss on disposal of dental practices(e)

8.0

 

 

10.3

 

21.0

Loss on disposal and impairment of property and equipment and intangible assets(f)

0.2

 

2.2

 

0.6

 

2.2

Post-employment benefits(g)

 

 

2.3

 

Short-term benefits(h)

 

 

0.5

 

Loss on settlement of other receivables(i)

 

0.9

 

 

0.9

Impairment of right-of-use assets(j)

 

0.4

 

 

0.4

Adjusted EBITDA

73.9

 

65.8

 

285.2

 

259.7

Adjusted EBITDA Margin

18.6 %

 

18.2 %

 

18.5 %

 

18.2 %

(a) Represents the sum of (i) unrealized foreign exchange gains or losses on non-cash balances and (ii) share of associate losses.
(b) Represents professional fees and other expenses paid to third parties that are incurred in connection with individual practice acquisitions and are not related to the underlying business operations of the Company.
(c) Represents costs related to the strategic review process and other costs incurred by the Company to evaluate strategic alternatives to unlock shareholder value.
(d) Represents costs associated with the implementation of new corporate technology systems, the undertaking of vendor consolidations, termination benefits and restructuring activities, and professional fees related to the settlement of the management loan program and issuance of preferred shares, executive search arrangements, other non-recurring capital market initiatives and the implementation of the CDCP. Also included are costs associated with the purchase of profit rights held by Associate dentists in the cash flows of our dental practices and losses of dental practices that were disposed of during the period.
(e) Represents the loss on disposal of dental practices that were disposed of during the three months and years ended December 31, 2024 and 2023.
(f) Represents the loss on disposal and impairment of property and equipment and intangible assets which primarily occurred upon the closure of certain dental practice locations and the subsequent disposal of leasehold improvements and equipment that could not be transferred to other dental practices.
(g) Represents post-employment benefits provided to the Company’s former President.
(h) Represents short-term benefits paid to the CEO during the year ended December 31, 2024 in contemplation of the CEO continuing to facilitate the leadership changes announced in June 2024 (see “Company Overview – Recent Company Developments”) and developing a long-term plan to assist the Board in driving sustained value for the Company’s practices, patients and shareholders.
(i) Associated with the MLP, the Company provided a deemed interest benefit to the MLP Managers on the MLP Loans. Income taxes on the deemed interest benefit are paid by the Company on behalf of the MLP Managers and are then repayable by the MLP Managers to the Company. On the restructuring of certain of the MLP Loans during the year ended December 31, 2023, $0.9 million of the cumulative deemed interest benefit owing by certain of the MLP Managers were settled and a loss of $0.9 million was included in employment expenses in selling, general and administrative expenses in the consolidated statements of loss and comprehensive loss.
(j) Represents impairment of right-of-use assets recognized during the three months and year ended December 31, 2023.

Adjusted Free Cash Flow

“Adjusted free cash flow” is calculated by adding or subtracting from cash flow from operating activities: (a) external acquisition expenses; (b) strategic review costs; (c) other corporate costs; (d) post-employment benefits; (e) short-term benefits; (f) repayment of principal on leases; (g) maintenance capital expenditure; and (h) changes in working capital. We use Adjusted free cash flow to facilitate a comparison of our operating performance on a consistent basis from period to period, to provide for a more complete understanding of factors and trends affecting our business, and to determine components of employee compensation. The most comparable IFRS measure to Adjusted free cash flow is cash flow from operating activities, for which a reconciliation is provided below.

Adjusted free cash flow per Share

“Adjusted free cash flow per Share” means Adjusted free cash flow divided by the total number of Shares on a fully diluted basis. Adjusted free cash flow per Share is utilized to determine components of employee compensation.

Pre-tax Adjusted Free Cash Flow

“Pre-tax Adjusted free cash flow” in respect of a period means Adjusted free cash flow less cash income tax (recovery) expense. We use Pre-tax Adjusted free cash flow to facilitate a comparison of our operating performance on a consistent basis from period to period, to provide for a more complete understanding of factors and trends affecting our business, and to determine components of employee compensation. The most comparable IFRS measure to Pre-tax Adjusted free cash flow is cash flow from operating activities.

Pre-tax Adjusted Free Cash Flow per Share

“Pre-tax Adjusted free cash flow per Share” means Pre-tax Adjusted free cash flow, divided by the total number of Shares on a fully diluted basis. Pre-tax Adjusted free cash flow per Share is utilized to determine components of employee compensation.

 

Three months ended

December 31,

 

Year ended

December 31,

 

2024

 

2023

 

2024

 

2023

 

$

 

$

 

$

 

$

 

(expressed in millions of dollars)

 

(expressed in millions of dollars)

Cash flow from operating activities

44.5

 

38.7

 

194.2

 

153.4

Adjustments:

 

 

 

 

 

 

 

External acquisition expenses(a)

1.2

 

0.8

 

4.3

 

4.3

Strategic review costs(b)

 

0.1

 

 

6.4

Other corporate costs(c)

2.7

 

1.9

 

7.4

 

13.0

Post-employment benefits(d)

 

 

2.3

 

Short-term benefits(e)

 

 

0.5

 

 

48.4

 

41.5

 

208.7

 

177.1

Deduct:

 

 

 

 

 

 

 

Repayment of principal on leases

(7.0)

 

(6.6)

 

(26.8)

 

(26.0)

Maintenance capital expenditure(f)

(5.4)

 

(2.9)

 

(18.1)

 

(14.4)

Changes in working capital(g)

3.3

 

1.9

 

(12.0)

 

(9.5)

Adjusted free cash flow

39.3

 

33.9

 

151.8

 

127.2

(a) Represents professional fees and other expenses paid to third parties that are incurred in connection with individual practice acquisitions and are not related to the underlying business operations of the Company.
(b) Represents costs related to the strategic review process and other costs incurred by the Company to evaluate strategic alternatives to unlock shareholder value.
(c) Represents costs associated with the implementation of new corporate technology systems, the undertaking of vendor consolidations, termination benefits and restructuring activities, and professional fees related to the settlement of the management loan program and issuance of preferred shares, executive search arrangements, other non-recurring capital market initiatives and the implementation of the CDCP. Also included are costs associated with the purchase of profit rights held by Associate dentists in the cash flows of our dental practices and losses of dental practices that were disposed of during the period.
(d) Represents post-employment benefits provided to the Company’s former President.
(e) Represents short-term benefits paid to the CEO during the year ended December 31, 2024 in contemplation of the CEO continuing to facilitate the leadership changes announced in June 2024 (see “Company Overview – Recent Company Developments”) and developing a long-term plan to assist the Board in driving sustained value for the Company’s practices, patients and shareholders.
(f) Represents capital expenditures for general maintenance and safety compliance of dental practices for the period.
(g) Represents the change in non-cash working capital items for the period.

Adjusted Net Income

“Adjusted net income” is calculated by adding to Net loss and comprehensive loss certain expenses, costs, charges or benefits incurred in such period which in management’s view are either not indicative of underlying business performance or impact the ability to assess the operating performance of our business, including: (a) amortization of intangible assets; (b) share-based compensation; (c) change in fair value of contingent consideration; (d) external acquisition expenses; (e) strategic review costs; (f) other corporate costs; (g) loss on disposal of dental practices; (h) change in fair value of preferred shares; (i) loss on disposal and impairment of property and equipment and intangible assets; (j) loss on settlement of other receivables; (k) impairment of right-of-use assets; (l) loss on modification of borrowings; (m) post-employment benefits; (n) short-term benefits; (o) change in fair value of other financial liability; and (p) the tax impact of the above. We use Adjusted net income to facilitate a comparison of our operating performance on a consistent basis from period to period and to provide for a more complete understanding of factors and trends affecting our business. The most comparable IFRS measure to Adjusted net income is Net loss and comprehensive loss, for which a reconciliation is provided below.

 

Three months ended

December 31,

 

Year ended

December 31,

 

2024

 

2023

 

2024

 

2023

 

$

 

$

 

$

 

$

 

(expressed in millions of dollars)

 

(expressed in millions of dollars)

Net loss and comprehensive loss

(13.1)

 

(35.2)

 

(59.4)

 

(85.6)

Adjustments:

 

 

 

 

 

 

 

Amortization of intangible assets

29.4

 

26.5

 

110.8

 

104.3

Share-based compensation

2.8

 

5.1

 

12.6

 

12.1

Change in fair value of contingent consideration(a)

(1.2)

 

(0.1)

 

3.8

 

0.8

Change in fair value of other financial liability(b)

3.0

 

 

3.0

 

Change in fair value of preferred shares(c)

(0.2)

 

1.1

 

(1.6)

 

6.9

External acquisition expenses(d)

1.2

 

0.8

 

4.3

 

4.3

Strategic review costs(e)

 

0.1

 

 

6.4

Other corporate costs(f)

2.7

 

1.9

 

7.4

 

13.0

Loss on disposal of dental practices(g)

8.0

 

 

10.3

 

21.0

Loss on disposal and impairment of property and equipment and intangible assets(h)

0.2

 

2.2

 

0.6

 

2.2

Loss on modification of borrowings(i)

 

 

2.3

 

Post-employment benefits(j)

 

 

2.3

 

Short-term benefits(k)

 

 

0.5

 

Loss on settlement of other receivables(l)

 

0.9

 

 

0.9

Impairment of right-of-use assets(m)

 

0.4

 

 

0.4

 

32.8

 

3.7

 

96.9

 

86.7

Tax impact of the above

(5.4)

 

(3.6)

 

(15.4)

 

(20.4)

Adjusted net income

27.4

 

0.1

 

81.5

 

66.3

Contacts

For investor inquiries, please contact:

Investor Relations
Nick Xiang

Vice President, Corporate Finance

nick.xiang@dentalcorp.ca
(416) 558-8338 x 866

Media
Sebastien Bouchard

Vice President, Corporate Communications

sebastien.bouchard@dentalcorp.ca
(437) 216-0733

Read full story here

Johnson & Johnson Increases U.S. Investment to More than $55 Billion Over the Next Four Years

Johnson & Johnson Increases U.S. Investment to More than $55 Billion Over the Next Four Years




Johnson & Johnson Increases U.S. Investment to More than $55 Billion Over the Next Four Years

Investment builds on almost 140-year legacy of improving and saving lives and supporting American jobs


Includes four planned new manufacturing facilities, with ground-breaking today in North Carolina on $2 billion+ facility

Total Company U.S. economic impact estimated to be more than $100 billion per year

NEW BRUNSWICK, N.J.–(BUSINESS WIRE)–Today, Johnson & Johnson (NYSE: JNJ) (the “Company”), healthcare’s leading, most comprehensive innovation powerhouse, announced manufacturing, research and development, and technology investments of more than $55 billion in the United States over the next four years. This represents a 25% increase in investment compared to the previous four years and builds upon the Company’s already elevated U.S. investment levels resulting from the passage of the 2017 Tax Cuts & Jobs Act.

“Today’s announcements accelerate our nearly 140-year legacy as an American innovation engine tackling the world’s toughest healthcare challenges,” said Joaquin Duato, Chairman and Chief Executive Officer, Johnson & Johnson. “Our increased U.S. investment begins with the ground-breaking of a high-tech facility in North Carolina that will not only add U.S.-based jobs but manufacture cutting edge medicines to treat patients in America and around the world.”

$55 Billion Investment Supports American Innovation & Manufacturing

In addition to the facility in Wilson, North Carolina, the Company’s increased investment in the U.S. over the next four years includes:

  • Three new advanced manufacturing facilities and the expansion of several existing sites across the Company’s Innovative Medicine and MedTech businesses that will create high-paying, high-technology jobs. The Company will share further information on these sites once available.
  • Significant investments in extensive R&D infrastructure aimed at developing lifesaving and life-changing treatments in areas such as oncology, neuroscience, immunology, cardiovascular disease, and robotic surgery.
  • Increased technology investments to help make drug discovery and development faster, support workforce training and enhance our business operations.
  • With its increased investment over the next four years, the Company’s U.S. economic impact will build upon its already estimated more than $100 billion per year.1

Groundbreaking Today in North Carolina Kickstarts U.S. Investment

The North Carolina investment creates jobs starting today in Wilson, North Carolina, where the Company is officially breaking ground on its new, 500,000 square foot, state-of-the-art biologics manufacturing facility.

The North Carolina facility will:

  • Expand our capacity to manufacture next-generation medicines for people living with cancer, immune-mediated and neurological diseases in America and around the world.
  • Support approximately 5,000 jobs during construction and create over 500 positions in North Carolina.
  • Create a $3 billion impact across the state in the first 10 years of operations.

Johnson & Johnson has more manufacturing facilities in the U.S. than in any other country and is a leading investor in American innovation and R&D. With a focus on pharmaceuticals and medical technology, the Company stands alone in its ability to impact the full spectrum of disease. From cardiology to cancer, mental health to vision, cell therapies to robotics, the depth and breadth of Johnson & Johnson’s expertise and capabilities is unique. No company can match Johnson & Johnson’s ability to deliver best-in-class solutions for patients at every step of their journeys.

About Johnson & Johnson:

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at www.jnj.com.

Cautions Concerning Forward-Looking Statements

This press release contains “forward-looking statements” as defined in the Private Securities Litigation Reform Act of 1995. The reader is cautioned not to rely on these forward-looking statements. These statements are based on current expectations of future events. If underlying assumptions prove inaccurate or known or unknown risks or uncertainties materialize, actual results could vary materially from the expectations and projections of Johnson & Johnson. Risks and uncertainties include, but are not limited to: challenges and uncertainties inherent in product research and development, including the uncertainty of clinical success and of obtaining regulatory approvals; uncertainty of commercial success; manufacturing difficulties and delays; competition, including technological advances, new products and patents attained by competitors; challenges to patents; product efficacy or safety concerns resulting in product recalls or regulatory actions; changes in behavior and spending patterns of purchasers of health care products and services; changes to applicable laws and regulations, including global health care reforms; and trends toward health care cost containment. A further list and descriptions of these risks, uncertainties and other factors can be found in Johnson & Johnson’s most recent Annual Report on Form 10-K, including in the sections captioned “Cautionary Note Regarding Forward-Looking Statements” and “Item 1A. Risk Factors,” and in Johnson & Johnson’s subsequent Quarterly Reports on Form 10-Q and other filings with the Securities and Exchange Commission. Copies of these filings are available online at www.sec.gov, www.jnj.com or on request from Johnson & Johnson. Johnson & Johnson does not undertake to update any forward-looking statement as a result of new information or future events or developments.

1 Estimated impact as calculated by an external economic analysis.

Contacts

Media contact:
media-relations@its.jnj.com

Investor contact:

investor-relations@its.jnj.com

Enigma Biomedical USA, Inc. Announces Candidate Selection of Novel 4R Tau PET Imaging Biomarkers

Enigma Biomedical USA, Inc. Announces Candidate Selection of Novel 4R Tau PET Imaging Biomarkers




Enigma Biomedical USA, Inc. Announces Candidate Selection of Novel 4R Tau PET Imaging Biomarkers

KNOXVILLE, Tenn.–(BUSINESS WIRE)–Enigma Biomedical USA, Inc. (EB USA) today announced that it has selected two (2) four-repeat tau (4R Tau) protein PET imaging biomarkers to advance into Phase 1 (Ph1) studies. Previously, EB USA executed an Exclusive License and Option Agreement (License) with AbbVie for the development and potential commercialization of AbbVie’s next-generation F18 PET imaging biomarkers to assess the presence of 4R Tau in subjects with suspected neurodegenerative disease. These imaging biomarkers hold great promise as important new tools in advancing understanding of a range of neurodegenerative diseases in which the misfolded 4R Tau protein is implicated, including the tauopathies Progressive Supranuclear Palsy (PSP) and Corticobasal Degeneration.


Preclinical evaluations successfully identified two candidates to advance to Ph1 studies. These studies will examine several parameters, including safety, dosimetry, biomarker dynamic uptake and washout as well as determination of the optimal time for imaging. The studies are projected to commence in 3Q25.

“We are delighted that we have progressed this program to the clinical stage,” said Rick Hiatt, President and CEO of EB USA. “EB USA is committed to enabling the acceleration of promising technologies to advance the fight against debilitating neurodegenerative diseases. In this, we will build on demonstrated successes with the best-in-class neuroimaging biomarkers MK-6240 (Cerveau Technologies, sold to Lantheus Medical Imaging in 2023) and NAV-4694 (in development by Meilleur Technologies Inc., sold to Lantheus in 2024.) We believe our 4R Tau PET imaging biomarkers from AbbVie have unique properties and will prove useful in developing therapeutic agents in neurodegenerative disease. Our goal is to expand the availability of this novel investigational imaging technology to the broader scientific community.”

Hartmuth Kolb, Ph.D., Chief Science Officer of EB USA, states: “EB USA is excited to take the next steps in this important development process. The Ph1 studies are designed to measure an array of candidate characteristics in addition to safety and dosimetry, including metabolite formation and the dynamics of tracer uptake, retention and clearance. A final candidate for future development will be chosen based on increased uptake in PSP patients relative to that of healthy controls, the extent of off-target and non-specific binding as well as dynamic range, sensitivity and kinetics. We look forward to the first administration of these candidate biomarkers later this year.”

About Enigma Biomedical USA, Inc.

Enigma Biomedical USA, Inc.’s vision is to be the premier provider of imaging biomarkers for neurological pathologies, associated information technology, and related tools to accelerate the development, approval, and adoption of effective therapies to treat neurodegenerative diseases. EB USA’s neuroimaging biomarkers provide Pharma and Academic researchers with best-in-class tools for enabling Disease-Modifying Therapy development with the highest possible precision and accuracy.

Contacts

Enigma Biomedical USA, Inc.  

Rick Hiatt, 617-906-2715