Frauenfeld, 6 November 2025

Press release

DocMorris announces the start of the tender offer period for its Outstanding Convertible Bonds due 2026

After publication of the Offer Notice on 22 October 2025 and the end of the cooling-off period, DocMorris announces the start of the tender offer period for its Outstanding Convertible Bonds due 2026. The Tender Offer price for each of the Outstanding Convertible Bonds due 2026 amounts to CHF 1,035 per bond, corresponding to 103.50% of the par value, plus accrued and unpaid interest.

The tender offer period starts today and is expected to expire on 12 November 2025 at 4:00pm CET. Settlement of the Tender Offer is expected to occur on 17 November 2025. The bonds are listed and traded on SIX Swiss Exchange (ISIN: CH1210198169; SSN: A3K86S).

This press release is not an offer for the repurchase of the Outstanding Convertible Bonds due 2026 but only discloses the most important terms of the planned Tender Offer. The Tender Offer is solely made based on the Tender Offer notice published on 22 October 2025 in accordance with Swiss Tender Offer rules.

Investors and analyst contact
Dr. Daniel Grigat, Head of Investor Relations & Sustainability
Email: ir@docmorris.com, phone: +41 52 560 58 10

Media contact
Torben Bonnke, Director Communications
Email: media@docmorris.com, phone: +49 171 864 888 1

Agenda

DocMorris
The Swiss-based DocMorris AG is a leading company in the fields of online pharmacy, telemedicine and marketplace with strong brands in Germany and other European countries. Deliveries are mainly from the highly automated logistics centre in Heerlen, the Netherlands. TeleClinic is Germany’s largest telemedicine platform, connecting patients with more than 5,000 physicians. DocMorris operates leading marketplaces for health and personal care products in Southern Europe. With its broad range of products and services, DocMorris is pursuing its vision of becoming the leading digital health companion for everyone to manage their health in one click. Around 1,600 employees in Germany, the Netherlands, Spain, France, Portugal and Switzerland generated an external revenue of CHF 1,085 million serving more than10 million active customers in 2024. The shares of DocMorris AG are listed on the SIX Swiss Exchange (securities number 4261528, ISIN CH0042615283, ticker DOCM). For further information, please visit corporate.docmorris.com.

Disclaimer

THE CONTENTS OF THIS ANNOUNCEMENT HAVE BEEN PREPARED BY AND ARE THE SOLE RESPONSIBILITY OF DOCMORRIS AG (THE “COMPANY”) AND DOCMORRIS FINANCE B.V. (THE “ISSUER”). THE INFORMATION CONTAINED IN THIS ANNOUNCEMENT IS FOR BACKGROUND PURPOSES ONLY AND DOES NOT PURPORT TO BE FULL OR COMPLETE. NO RELIANCE MAY BE PLACED BY ANY PERSON FOR ANY PURPOSE ON THE INFORMATION CONTAINED IN THIS ANNOUNCEMENT OR ITS ACCURACY, FAIRNESS OR COMPLETENESS.

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SCHOTT Pharma: Christian Mias to succeed Andreas Reisse as CEO of SCHOTT Pharma

• Andreas Reisse to retire as CEO of SCHOTT Pharma as planned
• Christian Mias, Executive Vice President of SCHOTT’s Electronic Packaging Business Unit, appointed as new CEO of SCHOTT Pharma effective May 1^st, 2026
• Seamless leadership transition ensured

The Supervisory Board of SCHOTT Pharma Management AG has appointed Christian Mias as CEO of SCHOTT Pharma. He will take over from Andreas Reisse, who will retire as planned in April 2026. Reisse will actively support a seamless leadership transition over the coming months to ensure continuity and stability for the company and the entire team.

Christian Mias, born in Iserlohn in 1974, will succeed Andreas Reisse starting May 1^st. As an industrial engineer with a doctoral degree, he looks back on more than 20 years of management experience, including over 18 years within the SCHOTT group. Before joining SCHOTT, he started his career as Commercial Project Manager at Siemens AG. Christian Mias gained significant experience in the pharmaceutical industry when joining SCHOTT Tubing, which produces intermediate products for the pharma sector, including SCHOTT Pharma. Throughout his career at SCHOTT, Christian has held leadership positions across various business units and continents, including roles as Managing Director in Brazil and Chief Operating Officer in the United States. In such roles, he successfully drove profitable growth by optimizing processes, improving productivity, and increasing earnings quality. Since 2016, he has served as Vice President, and since 2018 as Executive Vice President, currently heading the Business Unit Electronic Packing. Across his executive positions, Christian combined strategic foresight with operational discipline to drive the organizations toward consistent growth and strong financial performance.

Peter Goldschmidt, Chairman of the Supervisory Board of SCHOTT Pharma AG & Co. KGaA, said: “We are delighted to welcome Christian Mias as the new CEO of SCHOTT Pharma. His proven success within the SCHOTT Group, combined with strategic expertise and strong execution -demonstrated through integrative, performance-oriented, and participative leadership – makes him an excellent fit to lead SCHOTT Pharma into its next phase of profitable growth.

We are confident that Christian, together with Reinhard Mayer (CFO), will continue to drive profitable growth and further strengthen SCHOTT Pharma’s position as a global leader in pharmaceutical packaging and delivery systems.”

Commenting on his appointment, Christian Mias said: “I am honored to join SCHOTT Pharma at such an exciting time in the company’s journey. SCHOTT Pharma has built an exceptional reputation for innovation, quality, and reliability in the pharmaceutical industry. I look forward to working with the excellent team at SCHOTT Pharma to build upon this strong foundation and drive continued growth while advancing our mission to improve global healthcare. I would also like to thank Andreas Reisse for his outstanding leadership and dedication over the years. His vision and commitment have been instrumental in shaping SCHOTT Pharma’s success. I am looking forward to working together with Reinhard Mayer (CFO) on shaping the future of SCHOTT Pharma.”

Andreas Reisse has been with the SCHOTT Group since 1987 and has led the “Pharmaceutical Systems” division since 2010, which has been listed on the Frankfurt Stock Exchange as SCHOTT Pharma AG & Co. KGaA since 2023. He is now retiring upon reaching the statutory age limit for members of the Executive Board.

“Andreas Reisse has played an indispensable role in developing SCHOTT Pharma into one of the world’s leading companies in pharmaceutical containment solutions and delivery systems. Under his leadership, the company has achieved remarkable growth, delivered industry-leading innovations, and successfully transitioned to a publicly listed company. We thank him for his exceptional contributions and wish him all the best for his well-deserved retirement,” said Peter Goldschmidt.

Andreas Reisse commented: “It has been a privilege to spend so many years at SCHOTT Pharma and within the SCHOTT Group. I am very grateful for the collaboration and trust I have had with all stakeholders and the Supervisory Board. Together with a dedicated management team, we have established SCHOTT Pharma as a key partner in the pharmaceutical industry and achieved significant milestones, such as the successful IPO. As I prepare for retirement, I am confident that the company is well positioned for continued success and innovation. SCHOTT Pharma will be in excellent hands with Christian Mias, whom I have known and appreciated for almost two decades.”

For further news about SCHOTT Pharma, please visit our Media Center.

About SCHOTT Pharma

Human health matters. That is why SCHOTT Pharma designs solutions grounded in science to ensure that medications are safe and easy to use for people around the world. Every minute, more than 25,000 people receive an injection packed in a SCHOTT Pharma product. The portfolio comprises drug containment solutions and delivery systems for injectable drugs ranging from prefillable glass and polymer syringes to cartridges, vials, and ampoules. Every day, a team of around 4,700 people from over 60 nations works at SCHOTT Pharma to contribute to global healthcare. The company is represented in all main pharmaceutical hubs with 17 manufacturing sites in Europe, North and South America, and Asia. With over 1,000 patents and technologies developed in-house and a state-of-the-art R&D center in Switzerland, the company is focused on developing innovations for the future. SCHOTT Pharma AG & Co. KGaA is headquartered in Mainz, Germany and listed on the Frankfurt Stock Exchange as part of the SDAX. It is majority owned by SCHOTT AG, which is owned by the Carl Zeiss Foundation. In light of this spirit, SCHOTT Pharma is committed to sustainable development for society and the environment. Currently, SCHOTT Pharma has over 1,800 customers including the top 30 leading pharma manufacturers for injectable drugs and generated revenue of EUR 957 million in the fiscal year 2024. Further information at www.schott-pharma.com.   

Contact

Katrin Schreyer

Corporate Communications

Tel.: +49 (0) 6131 66-4932

E-Mail: katrin.schreyer@schott.com 

Lea Kaiser

Media Relations

Tel.: +49 (0) 6131 66-2422

E-Mail: lea.kaiser@schott.com 

Tobias Erfurth

Head of Investor Relations

E-Mail: Tobias.Erfurth@schott.com

Jasko Terzic, CFA

Senior Manager Investor Relations

E-Mail: Jasko.Terzic@schott.com

Evotec SE (Frankfurt Stock Exchange: EVT, SDAX/TecDAX, Prime Standard, ISIN: DE0005664809, WKN 566480; NASDAQ: EVO) today announced its business update for 9M 2025, illustrating the ongoing systematic execution of its strategy. In the D&PD segment, the market for early drug discovery services remained soft, while strategic partnerships are on track and Evotec records strong progress in its partnered asset pipeline. JEB continues its strong momentum and reports further accelerating growth in the non-Sandoz / non-DoD business.

After the end of the period, Evotec signed a > US$ 650 m landmark transaction with Sandoz AG (SIX:SDZ/OTCQX:SDZNY) on 04 November. According to the terms of the agreement, Sandoz will acquire 100% of Just – Evotec Biologics EU in Toulouse plus an indefinite technology license to Evotec’s continuous manufacturing platform technology for a payment of approximately US$ 350 m in cash. The agreement includes additional license fees and development revenues including success-based milestones, adding up to more than US$ 300 m in the coming years, replacing existing contractual commitments. In the future, Evotec expects to benefit from royalties on a portfolio of up to ten biosimilars in technical and early development, targeting a net-originator sales market of more than US$ 90 bn.

Dr Christian Wojczewski, Chief Executive Officer of Evotec:

“Evotec remains firmly on track in delivering against its strategic objectives, demonstrating strong execution for future sustainable and profitable growth. Despite a continued softness in the early drug discovery market, we are seeing first signals of improvement in our base business in D&PD. With 11% revenue growth year-over-year, JEB is not only enjoying high demand but also delivering strong results above our expectations. The agreement with Sandoz enables us to sharpen our focus on JEB’s capabilities as a scalable technology provider with an asset-lighter model. The transaction is a testament for our world class continuous manufacturing technology. A core element of our new strategy is to sharpen our offering and reduce complexity while progress in our strategic partnerships continues to build momentum.“
 

Continuing challenges for D&PD; JEB building strong momentum

• Group revenues decrease by (7.1)% to € 535.1 m (9M 2024: € 575.7 m)
• Total D&PD revenues decrease by (12.3)% to € 392.1 m (9M 2024: € 447.1 m), due to soft demand in the early drug discovery service market; quotations are growing in number and value, negative change orders are declining
• JEB revenues increase by 11.3% to € 143.4 m (9M 2024: € 129.3 m), driven by continued strong non-Sandoz / non-Department of Defense (“DoD”) business growth of 105% year over year
• Adjusted Group EBITDA totaled € (16.9) m (9M 2024: € (6.0) m) driven by continued underutilization and a high fixed cost base in the D&PD segment as well as costs related to the ramp-up of the JEB Toulouse facility
• Cost out initiatives ahead of plan, expected to result in a total cost reduction of more than € 60 m in 2025 (2x initial target)
   

Driving growth through strategic priorities

• Significant progress in the strategic protein degradation collaboration with Bristol Myers Squibb (“BMS”) resulted in performance- and program-based payments amounting to US$ 75 m the first half of the year
• In the second quarter, Evotec reported key advancements in its neuroscience collaboration with BMS, resulting in a US$ 20 m research payment to the company
• Two partnered assets entered Phase II clinical trials
   

Events after Period-End

• In a landmark industry transaction, Evotec signs agreement with Sandoz, resulting in payments of potentially over US$ 650 m plus royalties on a portfolio of up to 10 biosimilar molecules
• Progress in the strategic preclinical neuroscience partnership with BMS resulted in a payment of US$25m to support the continued progression of joint programs
• Investigational New Drug (“IND”) submission by partner Dewpoint Therapeutics for novel oncology therapy marks culmination of the partnership, advancing a de novo development candidate from discovery through IND-enabling studies
• Evotec’s collaboration with Esperion leads to the nomination of a preclinical development candidate for the treatment of Primary Sclerosing Cholangitis, a chronic, progressive disease-causing inflammation and sclerosis of the bile ducts leading over time to liver cell damage and can result in fibrosis, cirrhosis, and eventually liver failure
   

Guidance for full-year 2025 confirmed

• Group revenues expected in the range of € 760 – 800 m (2024: € 797.0 m)
• R&D expenditures are expected in a range of € 40 – 50 m (2024: € 50.9 m)
• Adjusted Group EBITDA is expected to reach € 30 – 50 m (2024: € 22.6 m)
   

Outlook 2028

• Group revenues CAGR _2024-2028 targeted to be in a range of 8 – 12%
• Adjusted EBITDA margin 2028 expected to be above 20%

More detailed information and financial tables are available in the interim statement for the first nine months 2025 published on the Evotec website under the following link: https://www.evotec.com/en/investor-relations/financial-publications

Webcast/Conference Call

The Company is going to hold a conference call to discuss the results as well as provide an update on its performance. The conference call will be held in English.

Webcast details

Date:  Wednesday, 05 November 2025

Time:  2.00 pm CET (01.00 pm GMT, 08.00 am EST)

To join the audio webcast and to access the presentation slides, please register via this link.

The on-demand version of the webcast will be available on our website: Financial Publications – Evotec.

Conference call details

To join via phone, please pre-register via this link. You will then receive a confirmation email with dedicated dial-in details such as telephone number, access code and PIN to access the call.

A simultaneous slide presentation for participants dialling in via phone is available

About Evotec SE
Evotec is a life science company that is pioneering the future of drug discovery and development. By integrating breakthrough science with AI-driven innovation and advanced technologies, we accelerate the journey from concept to cure — faster, smarter, and with greater precision.

Our expertise spans small molecules, biologics, cell therapies and associated modalities, supported by proprietary platforms such as Molecular Patient Databases, PanOmics and iPSC-based disease modeling.

With flexible partnering models tailored to our customers’ needs, we work with all Top 20 Pharma companies, over 800 biotechs, academic institutions, and healthcare stakeholders. Our offerings range from standalone services to fully integrated R&D programs and long-term strategic partnerships, combining scientific excellence with operational agility.

Through Just – Evotec Biologics, we redefine biologics development and manufacturing to improve accessibility and affordability.

With a strong portfolio of over 100 proprietary R&D assets, most of them being co-owned, we focus on key therapeutic areas including oncology, cardiovascular and metabolic diseases, neurology, and immunology.

Evotec’s global team of more than 4,800 experts operates from sites in Europe and the U.S., offering complementary technologies and services as synergistic centers of excellence. Learn more at www.evotec.com and follow us on LinkedIn and X/Twitter @Evotec.

Forward-looking statements
This announcement contains forward-looking statements concerning future events, including the proposed offering and listing of Evotec’s securities. Words such as “anticipate,” “believe,” “could,” “estimate,” “expect,” “intend,” “may,” “might,” “plan,” “potential,” “should,” “target,” “would” and variations of such words and similar expressions are intended to identify forward-looking statements. Such statements include comments regarding Evotec’s expectations for revenues, Group EBITDA and unpartnered R&D expenses. These forward-looking statements are based on the information available to, and the expectations and assumptions deemed reasonable by Evotec at the time these statements were made. No assurance can be given that such expectations will prove to have been correct. These statements involve known and unknown risks and are based upon a number of assumptions and estimates, which are inherently subject to significant uncertainties and contingencies, many of which are beyond the control of Evotec. Evotec expressly disclaims any obligations or undertaking to release publicly any updates or revisions to any forward-looking statements contained herein to reflect any change in Evotec’s expectations with respect thereto or any change in events, conditions or circumstances on which any statement is based.

For further information, please contact:

Investor Relations

Volker Braun
EVP Head of Global Investor Relations & ESG
Volker.Braun@evotec.com

Hamburg, Germany, 04 November 2025:
 

Evotec SE (Frankfurt Stock Exchange: EVT, SDAX/TecDAX, Prime Standard, ISIN: DE0005664809, WKN 566480; NASDAQ: EVO), a life science company that is pioneering the future of drug discovery and development, today announced the successful signing of the sale of the Just – Evotec Biologics Toulouse site to Sandoz AG (SIX: SDZ / OTCQX: SDZNY), a global leader in generic and biosimilar medicines.

Under the landmark transaction, Sandoz will acquire 100% of Just – Evotec Biologics EU plus an indefinite technology license to Evotec’s continuous manufacturing platform technology for a payment of approximately US$ 350 m in cash. The agreement includes additional license fees and development revenues including success-based milestones, adding up to more than US$ 300 m in the coming years. In the future, Evotec expects to benefit from royalties on a portfolio of up to ten biosimilars in technical and early development targeting a net originator sales market of more than US$ 90 bn.

With this acquisition, Sandoz will gain access to Evotec’s proprietary platform for integrated development and advanced continuous manufacturing of biologics via an indefinite license.

The contract signature follows the announcement in July of a non-binding term-sheet agreement on 30 July 2025. Both parties aim to close the transaction in Q4 2025 subject to meeting closing conditions including foreign direct investment (FDI) clearance by the French authorities. The transaction will have a significant positive impact on Evotec’s revenue mix, profit margins, and capital efficiency immediately after closing.

Dr Christian Wojczewski, Chief Executive Officer of Evotec, said:

“This is a transformative milestone for Evotec as we further leverage Just – Evotec Biologics’ capabilities and position the company as a scalable technology provider. With our unique offering, we are expanding the scope of addressable partners and shaping a new segment in the biologics manufacturing market in a very capital efficient way. Additionally, with this transaction, Evotec is delivering on its asset lighter strategy, sharpening its focus on its core strengths, and is well on track for sustainable and profitable growth.”

Dr Linda Zuckerman, EVP and Global Head of Just – Evotec Biologics, said:

“Sandoz’s acquisition of Just – Evotec Biologics’ Toulouse site is a powerful endorsement of our pioneering J.POD platform and its potential to revolutionize biologics manufacturing. This strategic transaction empowers Sandoz to leverage our advanced perfusion-based continuous manufacturing technology, progressing our shared mission to expand global access to affordable, high-quality biosimilars. We are proud to see our innovation continue to have a transformative impact for patients around the world.”

After closing of the transaction, Evotec will continue to serve our customers in the U.S. and Europe with capacity for molecular design, upstream, downstream, analytical and formulation development as well as First-In-Human to commercial biologics GMP manufacturing.

Evotec confirms guidance for full-year 2025 and its Outlook 2028

For the current fiscal year, the Company expects revenues in the range of € 760 – 800 m (2024: € 797.0 m);

R&D expenditures are expected in a range of € 40 – 50 m (2024: € 50.8 m);

Adjusted EBITDA¹ is expected to reach € 30 – 50 m (2024: € 22.6 m).

Outlook 2028 remains unchanged with a targeted Group revenue CAGR_2024-2028 in a range of 8 – 12% and an expected adj. EBITDA margin above 20% by 2028.

^{1 Excluding potential costs related to the transformation program in 2025
CAGR: Compound annual growth rate}

About Evotec SE
Evotec is a life science company that is pioneering the future of drug discovery and development. By integrating breakthrough science with AI-driven innovation and advanced technologies, we accelerate the journey from concept to cure — faster, smarter, and with greater precision.

Our expertise spans small molecules, biologics, cell therapies and associated modalities, supported by proprietary platforms such as Molecular Patient Databases, PanOmics and iPSC-based disease modeling.

With flexible partnering models tailored to our customers’ needs, we work with all Top 20 Pharma companies, over 800 biotechs, academic institutions, and healthcare stakeholders. Our offerings range from standalone services to fully integrated R&D programs and long-term strategic partnerships, combining scientific excellence with operational agility.

Through Just – Evotec Biologics, we redefine biologics development and manufacturing to improve accessibility and affordability.

With a strong portfolio of over 100 proprietary R&D assets, most of them being co-owned, we focus on key therapeutic areas including oncology, cardiovascular and metabolic diseases, neurology, and immunology.

Evotec’s global team of more than 4,800 experts operates from sites in Europe and the U.S., offering complementary technologies and services as synergistic centers of excellence. For additional information please go to www.evotec.com and follow us on X/Twitter @Evotec and LinkedIn.

Forward-looking statements
This announcement contains forward-looking statements concerning future events, including the proposed offering and listing of Evotec’s securities. Words such as “anticipate,” “believe,” “could,” “estimate,” “expect,” “intend,” “may,” “might,” “plan,” “potential,” “should,” “target,” “would” and variations of such words and similar expressions are intended to identify forward-looking statements. Such statements include comments regarding Evotec’s expectations for revenues, Group EBITDA and unpartnered R&D expenses. These forward-looking statements are based on the information available to, and the expectations and assumptions deemed reasonable by Evotec at the time these statements were made. No assurance can be given that such expectations will prove to have been correct. These statements involve known and unknown risks and are based upon a number of assumptions and estimates, which are inherently subject to significant uncertainties and contingencies, many of which are beyond the control of Evotec. Evotec expressly disclaims any obligations or undertaking to release publicly any updates or revisions to any forward-looking statements contained herein to reflect any change in Evotec’s expectations with respect thereto or any change in events, conditions or circumstances on which any statement is based.

For further information, please contact:

Investor Relations

Volker Braun
EVP Head of Global Investor Relations & ESG
volker.braun@evotec.com

• Group operating result amounts to EUR 48.9 million (9M 2024: EUR 34.5 million)
• Consolidated group sales amounts to EUR 586.9 million (9M 2024: EUR 558.2 million)
• Overall capacity utilisation stable at 86.8%

For further information:

MEDICLIN Aktiengesellschaft
Okenstraße 27
77652 Offenburg

Investor Relations
Ender Gülcan
Tel.: +49781/488-326
ender.guelcan@mediclin.de

www.mediclin.de

About MEDICLIN Aktiengesellschaft (Ticker: MED; WKN: 659 510)

MEDICLIN ─ a company of the Asklepios Group

Mallia Aesthetics Launches 8T3 Essentials Hair Serum and
8T3 Essentials Lash & Brow Serum

• Mallia launches new web shop with its 8T3 Essentials Line
• 8T3 serums are the first products for stimulating hair growth based on the immunomodulatory mode of action of sCD83
• 8T3 Essentials Hair Serum and 8T3 Essentials Lash & Brow Serum can now be ordered via Mallia’s online shop 8T3.com

Erlangen, Germany, November 04, 2025 – Mallia Aesthetics GmbH, a company focusing on the development and commercialization of cosmetic products to stimulate hair growth, today announced the official market launch of its innovative 8T3 Essentials Hair Serum and 8T3 Essentials Lash & Brow Serum. 8T3 Essentials Serums will be available exclusively via Mallia’s online shop 8T3.com for customers in the EU.

All products in the 8T3 line are hormone-free, dermatologically tested, certified microbiome-friendly, and with excellent tolerability on sensitive skin.

8T3 Essentials Hair Serum supports and enhances hair density and thickness. The product is designed for biweekly application to the scalp using single-dose, preservative-free vials. It will be available in 6-month boxes.

8T3 Essentials Lash & Brow Serum promotes growth and thickness of eyelashes and eyebrows. The serum is sold in vials with an integrated applicator brush and should be used daily for the best results.

The 8T3 Essentials product line is built on the active ingredient MAL-838, a proprietary derivative of the human soluble CD83 protein. Mallia co-founder Prof. Dr. Alexander Steinkasserer and his team have shown that sCD83 possesses immunomodulatory properties, which can stimulate wound healing and new hair growth, and have published these results in a peer-reviewed journal.¹

Dr. Anne Asmuß, Managing Director of Mallia Aesthetics, said: “We are excited to see years of dedicated research and meticulous planning come to fruition as we today introduce our science-driven cosmetics to the market. For the first time, consumers will be able to benefit directly from the mode of action of an sCD83 derivative in the form of hormone-free, scientifically grounded formulations. With 8T3, we offer products that are convenient, safe, and designed for visible results.”

About sCD83

Soluble CD83 (sCD83) is an immunomodulatory protein that is currently being developed for the topical treatment of hair loss (MAL‑856) and stimulation of hair growth (MAL‑838). The soluble CD83 protein was first identified in 2001 by Mallia co-founder Prof. Steinkasserer. It has anti-inflammatory properties via the induction of resolution of inflammation, which promotes wound healing and induces new hair growth.¹ In addition, sCD83 has been shown to activate regulatory T cells (Tregs)², which interact directly with hair follicles and can activate them.³ Furthermore, sCD83 inhibits cell death of hair follicles and directly activates follicular stem cells, as well as keratin production, thereby stimulating new hair growth. This multimodal mode of action distinguishes sCD83 from other topically applied hair growth agents.

Topically applied, sCD83 can directly reach the hair follicles but does not penetrate through the skin and thus does not enter the bloodstream. The effect is localized, which is a major advantage over systemic treatment options, which can cause severe side effects.

About hair loss

Hormone-related hair loss in men and women (androgenetic alopecia, or AGA) is the most common form of hair loss. Worldwide, more than 70% of men and 50% of women post menopause are affected by androgenetic alopecia. Another 147 million people suffer from immune-related, circular hair loss (alopecia areata, or AA^4,5).

Androgenetic alopecia usually progresses gradually and is due to genetic and hormonal factors. In men, it often leads to a receding hairline and baldness on the top of the head, while in women it causes thinning hair in the parting area. Alopecia areata causes circular hair loss on the scalp, face or other parts of the body. It occurs when the immune system erroneously attacks hair follicles, leading to immune-mediated hair loss.

About Mallia

Mallia Innovations GmbH, based in Erlangen, Germany, is the holding company strategically driving the proprietary development and commercialization of biopharmaceutical therapies and cosmetic applications of the immunomodulatory sCD83 protein, targeting hair growth, hair loss and other dermatological indications, including wound healing.

Mallia Therapeutics GmbH focuses on the clinical development of novel therapies for patients suffering from androgenetic alopecia or alopecia areata, among other conditions. MAL-856 is based on the scientifically proven immunomodulatory mode of action of sCD83, which has been investigated for close to 25 years by Mallia Co‑founder Prof. Dr Alexander Steinkasserer.⁶

Mallia Aesthetics GmbH focuses on cosmetic applications for the stimulation of hair growth, which are also based on the scientifically validated sCD83 protein. The Company develops Innovative cosmetic products using MAL-838 that are marketed to specialists and consumers.

To purchase products from the 8T3 Essentials line, please visit our online shop: www.8T3.com

For more information, visit www.mallia.com and follow us on LinkedIn, Instagram, and Facebook.
 

¹ Royzman, D., Peckert-Maier, K., Stich, L., König, C., Wild, A. B., Tauchi, M., … & Steinkasserer, A. (2022). Soluble CD83 improves and accelerates wound healing by the induction of pro-resolving macrophages. Frontiers in Immunology, 13, 1012647. DOI: 10.3389/fimmu.2022.1012647

² Bock, F., Rössner, S., Onderka, J., Lechmann, M., Pallotta, M. T., Fallarino, F., … & Zinser, E. (2013). Topical application of soluble CD83 induces IDO-mediated immune modulation, increases Foxp3+ T cells, and prolongs allogeneic corneal graft survival. The Journal of Immunology, 191(4), 1965-1975. DOI: 10.4049/jimmunol.1201531

³ Ali, N., Zirak, B., Rodriguez, R. S., Pauli, M. L., Truong, H. A., Lai, K., … & Rosenblum, M. D. (2017). Regulatory T cells in skin facilitate epithelial stem cell differentiation. Cell, 169(6), 1119-1129. DOI: 10.1016/j.cell.2017.05.002

⁴ Feinstein, R. P. (2022). Androgenetic alopecia.: https://emedicine.medscape.com/article/1070167-overview

⁵ Mostaghimi, A., Gandhi, K., Done, N., Ray, M., Gao, W., Carley, C., … & Sikirica, V. (2022). All-cause health care resource utilization and costs among adults with alopecia areata: A retrospective claims database study in the United States. Journal of Managed Care & Specialty Pharmacy, 28(4), 426-434: DOI: 10.18553/jmcp.2022.28.4.426

⁶ Lechmann, M., Krooshoop, D. J., Dudziak, D., Kremmer, E., Kuhnt, C., Figdor, C. G., … & Steinkasserer, A. (2001). The extracellular domain of CD83 inhibits dendritic cell–mediated T cell stimulation and binds to a ligand on dendritic cells. The Journal of experimental medicine, 194(12), 1813-1821. DOI: 10.1084/jem.194.12.1813