Concept Life Sciences Presents New Data Advancing Neuroinflammation and Neurodegeneration Research at Neuroscience 2025

Concept Life Sciences Presents New Data Advancing Neuroinflammation and Neurodegeneration Research at Neuroscience 2025




Concept Life Sciences Presents New Data Advancing Neuroinflammation and Neurodegeneration Research at Neuroscience 2025

Three posters highlight advances in inflammasome inhibition, astrocyte neurotoxicity, and myelination models supporting translational drug discovery

CHAPEL-EN-LE-FRITH, United Kingdom, Nov. 20, 2025 (GLOBE NEWSWIRE) — Concept Life Sciences, a leading contract research organization (CRO) serving the global life sciences and pharma industry, today announces that it presented three new research posters at Neuroscience 2025, the annual meeting of the Society for Neuroscience (SfN), held in San Diego, California on 15-19 November. The studies demonstrate Concept Life Sciences’ expanding expertise in neuroinflammation, neurodegeneration, and translational cell models that enhance the predictivity of early drug discovery.

Advancing translational neuroscience and drug discovery

The three posters showcase how Concept Life Sciences applies physiologically relevant in-vitro and ex-vivo systems to model key mechanisms underlying neurodegenerative and neuroinflammatory diseases:

1. Development of a Drug Screening Cascade to Identify Novel Potent and Selective NLRP3 Inhibitors

This study establishes a validated, multi-stage phenotypic screening cascade for discovering next-generation NLRP3 inflammasome inhibitors. Using human THP-1 cells, primary human macrophages, human iPSC-derived microglia, and organotypic brain slices, the workflow delivers integrated mechanistic and functional readouts to enhance translatability in early drug discovery.

The poster can be accessed [here].

2. In-Vitro Models of OPC Maturation and Myelination for Drug Discovery

This study introduces in-vitro assays that enable robust quantification of oligodendrocyte precursor cell (OPC) proliferation, differentiation, and myelin formation. By combining High-Content and 3D Imaging with gene expression analysis and metabolite quantification, Concept Life Sciences established reproducible assays that capture the molecular and functional hallmarks of OPC maturation and myelination. These models provide a translational platform to evaluate compounds that may enhance remyelination in disorders such as multiple sclerosis, Alzheimer’s disease, and ischemic stroke.

The poster can be accessed [here].

3. Leveraging iPSC-Derived Astrocytes to Accelerate the Discovery of Novel Drugs Targeting Neuroinflammation

Concept Life Sciences validated human iPSC-derived astrocytes as a reproducible model of reactive neurotoxic astrocytes, establishing a high-value assay for evaluating compounds that modulate neuroinflammatory pathways.

The poster can be accessed [here].

Dr. Elise Malavasi, Neuroscience Associate Director at Concept Life Sciences, commented:

“Our work, presented at Neuroscience 2025, highlighted how our integrated biology platforms enable a deeper understanding of neuroinflammatory and neurodegenerative mechanisms. By combining advanced human cell systems, primary cell-based assays, and 3D models, we provide our partners with translational tools that de-risk discovery and accelerate progress toward clinical impact.”

New white paper: Building a complete picture of inflammasome activity

Ahead of its presentations at Neuroscience 2025, Concept Life Sciences launched a new white paper entitled “Advancing Inflammasome Drug Discovery: Building a Complete Picture of Inflammasome Activity for Therapeutic Success.”

The paper highlights the inflammasome as a high-value therapeutic target with the potential for intervention across a wide range of inflammatory, metabolic, neurodegenerative and autoimmune diseases. It also focuses on the importance of using a suite of physiologically relevant assays across multiple inflammasome types and cell models to generate more disease-relevant and predictive data for drug discovery. Concept Life Sciences’ integrated assay portfolio supports a comprehensive understanding of inflammasome modulation — helping discovery teams make faster, more confident candidate selections and thereby accelerating drug discovery in the inflammation and immunology space.

The white paper can be accessed here.

About Concept Life Sciences

Concept Life Sciences is a leading contract research organisation (CRO) serving the global life sciences industry. For over 25 years, Concept Life Sciences, and its heritage companies, have provided consultative, and collaborative, drug discovery and development services. Our approach, supported by passionate scientists and world-leading capabilities, enables us to overcome complex scientific challenges across a broad range of therapeutic areas, improving success rates for translating innovations into viable therapeutics. To date, Concept Life Sciences has successfully helped 29 candidates advance to the clinic.

The company offers sophisticated translational biology services coupled with exceptional end-to-end chemistry capabilities offering concept to clinic solutions. Across modalities, including small molecules, biologics, peptides, and cell & gene therapies, Concept Life Sciences seamlessly integrates capabilities and provides bespoke solutions to address drug discovery challenges.

Collectively, the company’s high-quality services across the drug discovery and development pathway have helped its customers advance their drugs from concept to clinic in as little as 32 months, well ahead of the industry average of 60 months.

Driven by a passion for science, Concept Life Sciences has around 230 employees, with over 70% holding PhDs. The company operates from state-of-the-art UK facilities, headquartered near Manchester, with additional specialist operations in Edinburgh, Dundee, and Sandwich.

Visit us at www.conceptlifesciences.com and follow us on LinkedIn.

Media contacts

Concept Life Sciences
Clare Whitewoods – Marketing Director
Clare.Whitewoods@conceptlifesciences.com

Scius Communications
Katja Stout
+44 778 943 5990
katja@sciuscommunications.com 
Daniel Gooch
+44 7747 875479
daniel@sciuscommunications.com 

IMU Biosciences Appoints Dr. Carlos Paya as Non-Executive Director, Strengthening its Board of Directors

IMU Biosciences Appoints Dr. Carlos Paya as Non-Executive Director, Strengthening its Board of Directors




IMU Biosciences Appoints Dr. Carlos Paya as Non-Executive Director, Strengthening its Board of Directors

PRESS RELEASE

London, UK, 20 November 2025 — IMU Biosciences (or “the Company”), a biotechnology company decoding the immune system to drive next generation health outcomes, today announced the appointment of Dr. Carlos Paya as Non-Executive Director.

Carlos has a distinguished track record of leadership spanning academic medicine and the biopharmaceutical industry, with deep expertise in drug development and commercial strategy across early-stage start-ups to large-cap pharmaceutical companies.

Carlos currently serves as Chairman of Vaxcyte and Highlight Therapeutics and is a Venture Partner at Abingworth, and YSIOS Capital. Previously, he was Chairman of Fluidigm Standard Biotools, a Board Member of Mallinckrodt Pharmaceuticals, President, Board Member and Chief Executive Officer of Immune Design Corp, President of Elan Pharmaceuticals and Vice President of Eli Lilly and Company, where he led discovery research and late-stage clinical development. He holds a CEI, Executive Business Education from the University of Chicago Booth School of Business and an MD and PhD degrees from Universidad Complutense de Madrid. He was a Professor of Medicine, Immunology and Laboratory Medicine at the Mayo Clinic, Rochester, MN.

Dr John Baker, Chief Executive Officer at IMU Biosciences, said: “Carlos has deep biopharma and life science tools expertise, including drug discovery, development and commercialisation. His insights and strategic perspectives will be instrumental as we advance the application of our proprietary immune profiling platform across diagnostics, drug development and personalised medicine. I am delighted to welcome him to the Board of Directors and look forward to working with him as we enter our next phase of growth.”

Dr Carlos Paya, Non-Executive Director at IMU Biosciences, added: “IMU’s ability to translate complex immune data into clinically actionable insights represents a transformative advancement in the understanding, diagnosis and treatment of immune-related diseases. By harnessing the world’s largest immune dataset, IMU is creating a new paradigm in immunology with the potential to significantly improve patient outcomes. I am delighted to be joining the Board of Directors and look forward to leveraging my industry and academic experience to support IMU’s continued growth.”

About IMU Biosciences

IMU’s goal is to revolutionise the way immune-related diseases are understood, diagnosed and treated. It is pioneering advanced immune profiling and AI analytics to decode the human immune system and its relationship to disease.

Starting with a simple blood sample and building immune profiles which extend from the molecular to the population level, IMU has created the world’s largest and highest-resolution immune dataset. This novel platform applies proprietary immune analysis and machine learning to decode immune variation and its disease association at an unprecedented depth and scale.

By mapping the immune system of individuals at the molecular, cellular and system level and aggregating immune profiles from tens of thousands of people, IMU translates this into population-level insights, unlocking an unparalleled understanding of immune-driven health and disease. These clinically actionable insights are enabling IMU to uncover new immune mechanisms and deliver precision approaches for diagnosing, monitoring and treating disease, prescribing the safest and most pertinent medicines and enabling the development of next generation therapies.
  
The Company was built by a team of immune specialists and technologists based on a decade of research at King’s College London and the Francis Crick Institute.


-ENDS-

Contacts:
 
John Baker, CEO, IMU Biosciences
media@imubiosciences.com                                              

ICR Healthcare
Tel: +44 (0) 20 3709 5700
Jessica Hodgson/Stephanie Cuthbert/Jonathan Edwards
IMUBiosciences@ICRHealthcare.com

Burning Rock Reports Third Quarter 2025 Financial Results

Burning Rock Reports Third Quarter 2025 Financial Results




Burning Rock Reports Third Quarter 2025 Financial Results

GUANGZHOU, China, Nov. 20, 2025 (GLOBE NEWSWIRE) — Burning Rock Biotech Limited (NASDAQ: BNR, the “Company” or “Burning Rock”), a company focused on the application of next generation sequencing (NGS) technology in the field of precision oncology, today reported financial results for the three months ended September 30, 2025.

Recent Business Updates

  • Therapy Selection
    • Presented study results at the Cell Reports Medicine on esophageal squamous cell carcinoma in September 2025. “Integrating ctDNA with clinical response evaluation improves residual disease detection post-neoadjuvant chemoradiotherapy to support organsparing strategies and that postoperative ctDNA stratifies recurrence risk beyond pathological response to inform adjuvant immunotherapy decisions”.
  • Early Detection
    • PROMISE study test results presented at The Innovation in September 2025. “The PROMISE study was conducted to investigate the feasibility of a multi-omics integration strategy in multi-cancer detection blood tests across nine types of cancers in head and neck (excluding nasopharynx), esophagus, lung, stomach, liver, biliary tract, pancreas, colorectum, and ovary……Compared to the methylation-based classifier, the multimodal classifier combining methylation and protein features, exhibited an improved sensitivity of 75.1% (95% 75 confidence interval [CI], 69.3%–80.3%) at the same specificity of 98.8% with the accuracy of top predicted origin (TPO1) of 73.1% (95% CI, 66.2%–79.2%)”.
  • Pharma Services
    • The OncoGuide™ OncoScreen™ Plus CDx System based on OncoScreen™ Plus to be used as a companion diagnostic for AstraZeneca’s capivasertib has received Manufacturing and Marketing Approval from Japan’s Ministry of Health, Labour and Welfare (MHLW) in September, 2025.

Third Quarter 2025 Financial Results

Total revenues were RMB131.6 million (US$18.5 million) for the three months ended September 30, 2025, representing a 2.3% increase from RMB128.6 million for the same period in 2024.

  • Revenue generated from in-hospital business was RMB52.8 million (US$7.4 million) for the three months ended September 30, 2025, representing a 17.1% decrease from RMB63.8 million for the same period in 2024, driven by a decrease in sales volume.
  • Revenue generated from central laboratory business was RMB36.8 million (US$5.2 million) for the three months ended September 30, 2025, representing a 7.9% decrease from RMB40.0 million for the same period in 2024, primarily attributable to a decrease in the number of tests, as we continued our transition towards in-hospital testing.
  • Revenue generated from pharma research and development services was RMB42.0 million (US$5.9 million) for the three months ended September 30, 2025, representing a 68.6% increase from RMB24.9 million for the same period in 2024, primarily attributable to an increased development and testing services performed for our pharma customers.

Cost of revenues was RMB32.8 million (US$4.6 million) for the three months ended September 30, 2025, representing an 10.9% decrease from RMB36.8 million for the same period in 2024.

Gross profit was RMB98.8 million (US$13.9 million) for the three months ended September 30, 2025, representing a 7.6% increase from RMB91.8 million for the same period in 2024. Gross margin was 75.1% for the three months ended September 30, 2025, compared to 71.4% for the same period in 2024. By channel, gross margin of central laboratory business and in-hospital business were 81.8% and 71.8% for the three months ended September 30, 2025, compared to 83.2% and 73.0% during the same period in 2024, primarily due to the cost reduction caused by the rent subsidy for the headquarter building in the third quarter of 2024; gross margin of pharma research and development services was 73.4% for the three months ended September 30, 2025, compared to 48.2% during the same period of 2024, primarily due to the significant increase in revenue from high-margin companion diagnostic (CDx) projects.

Non-GAAP gross profit, which excludes depreciation and amortization expenses, was RMB100.9 million (US$14.2million) for the three months ended September 30, 2025, representing a 3.2% increase from RMB97.8 million for the same period in 2024. Non-GAAP gross margin was 76.7% for the three months ended September 30, 2025, compared to 76.0% for the same period in 2024.

Operating expenses were RMB115.0 million (US$16.2 million) for the three months ended September 30, 2025, representing a 11.9% decrease from RMB130.4 million for the same period in 2024. The decrease was primarily driven by decreases in amortized expense on share-based compensation, budget control measures and headcount reduction to improve the Company’s operating efficiency.

  • Research and development expenses were RMB41.5 million (US$5.8 million) for the three months ended September 30, 2025, representing a 15.6% decrease from RMB49.2 million for the same period in 2024, primarily due to (i) a decrease in the expenditure for research projects; (iii) a decrease in amortized expense on share-based compensation; and (iv) a decrease in amortized expenses for office building decoration.
  • Selling and marketing expenses were RMB41.8 million (US$5.9 million) for the three months ended September 30, 2025, representing a 13.6% decrease from RMB48.4 million for the same period in 2024, primarily due to (i) a decrease in staff cost resulted from the reorganization of the sales department and improvement in operating efficiency; (ii) a decrease in amortized expense on share-based compensation; and (iii) a decrease in amortized expenses for office building decoration.
  • General and administrative expenses were RMB31.7 million (US$4.5 million) for the three months ended September 30, 2025, representing a 3.6% decrease from RMB32.9 million for the same period in 2024, primarily due to (i) a decrease in the general and administrative personnel’s staff cost; (ii) a decrease in amortized expense on share-based compensation; and partially offset by (i) an increase in impairment expenses for accounts receivables and contract assets; (iii) an increase in operating lease.

Net loss was RMB16.8 million (US$2.4 million) for the three months ended September 30, 2025, compared to RMB35.7 million for the same period in 2024.

Cash, cash equivalents and restricted cash were RMB467.0 million (US$65.6 million) as of September 30, 2025.

About Burning Rock

Burning Rock Biotech Limited (NASDAQ: BNR), whose mission is to guard life via science, focuses on the application of next generation sequencing (NGS) technology in the field of precision oncology. Its business consists of i) NGS-based therapy selection testing for late-stage cancer patients, and ii) cancer early detection, which has moved beyond proof-of-concept R&D into the clinical validation stage.

For more information about Burning Rock, please visit: ir.brbiotech.com.

Safe Harbor Statement

This press release contains forward-looking statements. These statements constitute “forward-looking” statements within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended, and as defined in the U.S. Private Securities Litigation Reform Act of 1995. These forward-looking statements can be identified by terminology such as “will,” “expects,” “anticipates,” “future,” “intends,” “plans,” “believes,” “estimates,” “target,” “confident” and similar statements. Burning Rock may also make written or oral forward-looking statements in its periodic reports to the SEC, in its annual report to shareholders, in press releases and other written materials and in oral statements made by its officers, directors or employees to third parties. Statements that are not historical facts, including statements about Burning Rock’s beliefs and expectations, are forward-looking statements. Such statements are based upon management’s current expectations and current market and operating conditions, and relate to events that involve known or unknown risks, uncertainties and other factors, all of which are difficult to predict and many of which are beyond Burning Rock’s control. Forward-looking statements involve risks, uncertainties and other factors that could cause actual results to differ materially from those contained in any such statements. All information provided in this press release is as of the date of this press release, and Burning Rock does not undertake any obligation to update any forward-looking statement as a result of new information, future events or otherwise, except as required under applicable law.

Non-GAAP Measures

In evaluating the business, the Company considers and uses non-GAAP measures, such as non-GAAP gross profit and non-GAAP gross margin, as supplemental measures to review and assess operating performance. The presentation of these non-GAAP financial measures is not intended to be considered in isolation or as a substitute for the financial information prepared and presented in accordance with accounting principles generally accepted in the United States of America (“U.S. GAAP”). The company defines non-GAAP gross profit as gross profit excluding depreciation and amortization. The company defines non-GAAP gross margin as gross margin excluding depreciation and amortization.

The company presents these non-GAAP financial measures because they are used by management to evaluate operating performance and formulate business plans. The company believe non-GAAP gross profit and non-GAAP gross margin excluding non-cash impact of depreciation and amortization reflect the company’s ongoing business operations in a manner that allows more meaningful period-to-period comparisons.

Contact: IR@brbiotech.com

 
Selected Operating Data
   
  As of
  September 30,
2024
December 31,
2024
March 31,
2025
June 30,
2025
September 30,
2025
In-hospital Channel:          
Pipeline partner hospitals(1) 30 29 30 30 31
Contracted partner hospitals(2) 61 63 63 63 63
Total number of partnerhospitals 69 92 93 93 94

(1) Refers to hospitals that are in the process of establishing in-hospital laboratories, laboratory equipment procurement or installation, staff training or pilot testing using the Company’s products.
(2) Refers to hospitals that have entered into contracts to purchase the Company’s products for use on a recurring basis in their respective in-hospital laboratories the Company helped them establish. Kit revenue is generated from contracted hospitals.
   

Selected Financial Data
                 
    For the three months ended   For the nine months ended
Revenues   September 30,
2024
  September 30,
2025
  September 30,
2024
  September 30,
2025
    (RMB in thousands)   (RMB in thousands)
Central laboratory channel   39,984   36,811   136,371   115,968
In-hospital channel   63,769   52,847   181,028   173,030
Pharma research and development channel   24,891   41,959   72,401   124,255
Total revenues   128,644   131,617   389,800   413,253
                 

    For the three months ended   For the nine months ended
Revenues by location of customer   September 30,
2024
  September 30,
2025
  September 30,
2024
  September 30,
2025
    (RMB in thousands)   (RMB in thousands)
Overseas   25,840   17,214   59,553   79,079
Mainland China   102,804   114,403   330,247   334,174
Total Revenues   128,644   131,617   389,800   413,253
                 

    For the three months ended   For the nine months ended
Gross profit   September 30,
2024
  September 30, 2025   September 30,
2024
  September 30, 2025
    (RMB in thousands)   (RMB in thousands)
Central laboratory channel   33,262   30,126   108,688   98,254
In-hospital channel   46,580   37,925   129,830   128,310
Pharma research and development channel   12,004   30,793   34,460   77,784
Total gross profit   91,846   98,844   272,978   304,348
                 

    For the three months ended   For the nine months ended
Share-based compensation expenses   September 30,
2024
  September 30,
2025
  September 30,
2024
  September 30,
2025
    (RMB in thousands)   (RMB in thousands)
Cost of revenues   289   301   1,349   889
Research and development expenses   3,180   73   27,475   1,603
Selling and marketing expenses   1,917   624   3,657   2,013
General and administrative expenses   4,732   2,831   115,129   6,249
Total share-based compensation expenses   10,118   3,829   147,610   10,754
                 

Burning Rock Biotech Limited
Unaudited Condensed Statements of Comprehensive Loss
(in thousands, except for number of shares and per share data)
   
  For the three months ended
  September 30,
2024
  December 31,
2024
  March 31,
2025
  June 30,
2025
  September 30,
2025
  September 30,
2025
 
  RMB   RMB   RMB   RMB   RMB   US$  
Revenues 128,644   126,022   133,082   148,554   131,617   18,488  
Cost of revenues (36,798 ) (36,600 ) (35,681 ) (40,451 ) (32,773 ) (4,604 )
Gross profit 91,846   89,422   97,401   108,103   98,844   13,884  
Operating expenses:            
Research and development expenses (49,150 ) (52,203 ) (40,389 ) (49,770 ) (41,469 ) (5,825 )
Selling and marketing expenses (48,411 ) (46,730 ) (40,888 ) (38,413 ) (41,808 ) (5,873 )
General and administrative expenses (32,874 ) (37,289 ) (31,303 ) (31,417 ) (31,698 ) (4,453 )
Impairment loss on long-lived assets   (35,127 )        
Total operating expenses (130,435 ) (171,349 ) (112,580 ) (119,600 ) (114,975 ) (16,151 )
Loss from operations (38,589 ) (81,927 ) (15,179 ) (11,497 ) (16,131 ) (2,267 )
Interest income 3,173   1,814   2,581   2,226   1,744   245  
Interest expense         (15 ) (2 )
Other income (expense), net 1   4,353   (652 ) 387   7   1  
Foreign exchange loss, net (129 ) (220 ) (26 ) (574 ) (2,151 ) (302 )
Loss before income tax (35,544 ) (75,980 ) (13,276 ) (9,458 ) (16,546 ) (2,325 )
Income tax expenses (201 ) (5,314 ) (224 ) (244 ) (212 ) (30 )
Net loss (35,745 ) (81,294 ) (13,500 ) (9,702 ) (16,758 ) (2,355 )
Net loss attributable to Burning Rock Biotech Limited’s shareholders (35,745 ) (81,294 ) (13,500 ) (9,702 ) (16,758 ) (2,355 )
Net loss attributable to ordinary shareholders (35,745 ) (81,294 ) (13,500 ) (9,702 ) (16,758 ) (2,355 )
Loss per share for class A and class B ordinary shares:            
Class A ordinary shares – basic and diluted (0.35 ) (0.79 ) (0.13 ) (0.09 ) (0.16 ) (0.02 )
Class B ordinary shares – basic and diluted (0.35 ) (0.79 ) (0.13 ) (0.09 ) (0.16 ) (0.02 )
Weighted average shares outstanding used in loss per share computation:            
Class A ordinary shares – basic and diluted 85,902,670   86,036,286   90,291,658   90,357,970   90,416,619   90,416,619  
Class B ordinary shares – basic and diluted 17,324,848   17,324,848   17,324,848   17,324,848   17,324,848   17,324,848  
Other comprehensive (loss) income, net of tax of nil:            
Foreign currency translation adjustments (4,054 ) 6,009   (72 ) (243 ) (1,724 ) (242 )
Total comprehensive loss (39,799 ) (75,285 ) (13,572 ) (9,945 ) (18,482 ) (2,597 )
Total comprehensive loss attributable to Burning Rock Biotech Limited’s shareholders (39,799 ) (75,285 ) (13,572 ) (9,945 ) (18,482 ) (2,597 )
Burning Rock Biotech Limited
Unaudited Condensed Statements of Comprehensive Loss
(in thousands, except for number of shares and per share data)
   
  For the nine months ended
  September 30,
2024
  September 30,
2025
  September 30,
2025
 
  RMB RMB US$
Revenues 389,800   413,253   58,049  
Cost of revenues (116,822 ) (108,905 ) (15,299 )
Gross profit 272,978   304,348   42,750  
Operating expenses:      
Research and development expenses (180,087 ) (131,628 ) (18,490 )
Selling and marketing expenses (144,174 ) (121,109 ) (17,012 )
General and administrative expenses (224,349 ) (94,418 ) (13,263 )
Total operating expenses (548,610 ) (347,155 ) (48,765 )
Loss from operations (275,632 ) (42,807 ) (6,015 )
Interest income 10,398   6,551   920  
Interest expense   (15 ) (2 )
Other income, net 353   (258 ) (36 )
Foreign exchange gain (loss), net 120   (2,751 ) (386 )
Loss before income tax (264,761 ) (39,280 ) (5,519 )
Income tax expenses (571 ) (680 ) (96 )
Net loss (265,332 ) (39,960 ) (5,615 )
Net loss attributable to Burning Rock Biotech Limited’s shareholders (265,332 ) (39,960 ) (5,615 )
Net loss attributable to ordinary shareholders (265,332 ) (39,960 ) (5,615 )
Loss per share for class A and class B ordinary shares:      
Class A ordinary shares – basic and diluted (2.58 ) (0.37 ) (0.05 )
Class B ordinary shares – basic and diluted (2.58 ) (0.37 ) (0.05 )
Weighted average shares outstanding used in loss per share computation:      
Class A ordinary shares – basic and diluted 85,467,131   90,332,672   90,332,672  
Class B ordinary shares – basic and diluted 17,324,848   17,324,848   17,324,848  
Other comprehensive loss, net of tax of nil:      
Foreign currency translation adjustments (2,524 ) (2,039 ) (286 )
Total comprehensive loss (267,856 ) (41,999 ) (5,901 )
Total comprehensive loss attributable to Burning Rock Biotech Limited’s shareholders (267,856 ) (41,999 ) (5,901 )
Burning Rock Biotech Limited

Unaudited Condensed Consolidated Balance Sheets

(In thousands)

   
  As of
  December 31,
2024
  September 30,
2025
  September 30,
2025
  RMB   RMB   US$
ASSETS          
Current assets:          
Cash and cash equivalents 519,849   463,994   65,177
Restricted cash 2,313   2,985   419
Accounts receivable, net 152,013   183,841   25,824
Contract assets, net 13,855   13,049   1,833
Inventories, net 62,625   54,469   7,651
Prepayments and other current assets, net 25,963   20,985   2,950
Total current assets 776,618   739,323   103,854
Non-current assets:          
Property and equipment, net 47,152   33,755   4,742
Operating right-of-use assets 53,188   32,281   4,534
Intangible assets, net 421   316   44
Other non-current assets 7,926   6,493   912
Total non-current assets 108,687   72,845   10,232
TOTAL ASSETS 885,305   812,168   114,086
Burning Rock Biotech Limited

Unaudited Condensed Consolidated Balance Sheets (Continued)

(in thousands)

   
  As of
  December 31,
2024
  September 30,
2025
  September 30,
2025
 
  RMB RMB US$
LIABILITIES AND SHAREHOLDERS’ EQUITY      
Current liabilities:      
Accounts payable 33,747   34,277   4,815  
Deferred revenue 117,895   106,448   14,953  
Accrued liabilities and other current liabilities 89,498   76,992   10,816  
Customer deposits 592   592   83  
Short-term borrowings   200   28  
Current portion of operating lease liabilities 24,567   16,603   2,332  
Total current liabilities 266,299   235,112   33,027  
Non-current liabilities:      
Long-term borrowings   1,800   253  
Non-current portion of operating lease liabilities 27,754   14,577   2,048  
Other non-current liabilities 10,425   11,102   1,559  
Total non-current liabilities 38,179   27,479   3,860  
TOTAL LIABILITIES 304,478   262,591   36,887  
Shareholders’ equity:      
Class A ordinary shares 124   120   17  
Class B ordinary shares 21   21   3  
Additional paid-in capital 5,002,255   5,006,937   703,320  
Treasury stock (63,264 ) (57,193 ) (8,034 )
Accumulated deficits (4,200,261 ) (4,240,221 ) (595,620 )
Accumulated other comprehensive loss (158,048 ) (160,087 ) (22,487 )
Total shareholders’ equity 580,827   549,577   77,199  
TOTAL LIABILITIES AND SHAREHOLDERS’ EQUITY 885,305   812,168   114,086  
Burning Rock Biotech Limited

Unaudited Condensed Statements of Cash Flows

(in thousands)

   
  For the three months ended
  September
30,2024
  September
30,2025
  September 30,
2025
 
  RMB RMB US$
Net cash used in operating activities (30,278 ) 16,394   2,303  
Net cash used in investing activities (987 ) (2,747 ) (386 )
Net cash generated from financing activities 2      
Effect of exchange rate on cash, cash equivalents and restricted cash (3,537 ) (1,692 ) (237 )
Net decrease in cash, cash equivalents and restricted cash (34,800 ) 11,955   1,680  
Cash, cash equivalents and restricted cash at the beginning of period 533,047   455,024   63,916  
Cash, cash equivalents and restricted cash at the end of period 498,247   466,979   65,596  
       

  For the nine months ended
  September
30,2024
  September
30,2025
  September
30,2025
 
  RMB RMB US$
Net cash used in operating activities (111,323 ) (51,482 ) (7,232 )
Net cash used in investing activities (3,600 ) (4,071 ) (572 )
Net cash generated from financing activities 2   2,000   281  
Effect of exchange rate on cash, cash equivalents and restricted cash (2,048 ) (1,630 ) (229 )
Net decrease in cash, cash equivalents and restricted cash (116,969 ) (55,183 ) (7,752 )
Cash, cash equivalents and restricted cash at the beginning of period 615,216   522,162   73,348  
Cash, cash equivalents and restricted cash at the end of period 498,247   466,979   65,596  
     

Burning Rock Biotech Limited

Reconciliations of GAAP and Non-GAAP Results

     
  For the three months ended
  September 30,
2024
  December 31,
2024
  March 31,
2025
  June 30,
2025
  September 30,
2025
 
  (RMB in thousands)
Gross profit:    
Central laboratory channel 33,262   33,153   32,191   35,937   30,126  
In-hospital channel 46,580   29,563   43,895   46,490   37,925  
Pharma research and development channel 12,004   26,706   21,315   25,676   30,793  
Total gross profit 91,846   89,422   97,401   108,103   98,844  
Add: depreciation and amortization:          
Central laboratory channel 1,277   1,010   562   456   231  
In-hospital channel 798   623   290   389   372  
Pharma research and development channel 3,846   2,534   2,412   1,528   1,491  
Total depreciation and amortization included in cost of revenues 5,921   4,167   3,264   2,373   2,094  
Non-GAAP gross profit:          
Central laboratory channel 34,539   34,163   32,753   36,393   30,357  
In-hospital channel 47,378   30,186   44,185   46,879   38,297  
Pharma research and development channel 15,850   29,240   23,727   27,204   32,284  
Total non-GAAP gross profit 97,767   93,589   100,665   110,476   100,938  
Non-GAAP gross margin:          
Central laboratory channel 86.4%   87.0%   85.5%   89.1%   82.5%  
In-hospital channel 74.3%   69.5%   76.6%   75.0%   72.5%  
Pharma research and development channel 63.7%   67.6%   64.0%   60.2%   76.9%  
Total non-GAAP gross margin 76.0%   74.3%   75.6%   74.4%   76.7%  

Scientific Industries Announces Third Quarter 2025 Results And Launch of VIVID’s New AI-Powered Feature

Scientific Industries Announces Third Quarter 2025 Results And Launch of VIVID’s New AI-Powered Feature




Scientific Industries Announces Third Quarter 2025 Results And Launch of VIVID’s New AI-Powered Feature

TORBAL DIVISION SALES UP 15% YTD
LAUNCH OF VIVID’S FIRST AI-POWERED FEATURE
SECOND GENERATION VIVID-ONE LAUNCH SCHEDULED FOR Q1 CY26

Investor Call to be held Thursday, November 20th at 11:00 a.m. Eastern Time

BOHEMIA, N.Y., Nov. 19, 2025 (GLOBE NEWSWIRE) — Scientific Industries, Inc. (OTCQB: SCND), a leading developer of digitally simplified bioprocessing solutions and vision-based pill counters, today reported financial results for the three and nine months ended September 30, 2025, and announced the launch of a new AI-enabled feature for its VIVID WORKSTATION.

Business Highlights:

  • Launched an innovative prescription label documentation and verification feature for the VIVID WORKSTATION, harnessing AI technology
  • Achieved a 27% year-over-year sales increase for VIVID products
  • Torbal Division sales up 15% year-over-year
  • DOTS MPS Platform augmented with single use nanoparticles for baffled flasks.

2025 Third Quarter Financial Overview:

  • Net revenues totaled $1.4 million versus $1.3 million in the prior year period
    • Genie Division sold on August 7, 2025
  • Gross profit was $0.6 million, compared to $0.7 million in the prior year period
  • Gross margin was 45.5%, compared to 51.0% in the prior year period
  • Cash, cash equivalents and investments were $8.3 million as of September 30, 2025

Management Discussion

Helena Santos, Chief Executive Officer of Scientific Industries, stated: “The divestiture of our Genie brand portfolio has sharpened our focus on our high-growth segments, including our pill counting business. With the introduction of AI-driven capabilities in the VIVID WORKSTATION, we are redefining innovation in pharmacy automation. This upgrade not only strengthens compliance and accountability but also delivers significant cost efficiencies for our customers. Our unwavering commitment to continuous improvement—across hardware, firmware, and software—ensures that VIVID pill counters remain at the forefront of automated pill counting solutions.”

“Our relentless focus on innovation – spanning hardware, firmware, and software—keeps VIVID pill counters at the forefront of automated pill counting solutions. This commitment not only drives future revenues, but also builds a powerful and enduring platform of value for our customers,” concluded Ms. Santos.

John Moore, Chairman said, “Scientific Bioprocessing continues to innovate with the introduction of the world’s first dissolved oxygen sensor designed for baffled flasks. Nine out of ten pilot testers were surprised to discover that their cultures were severely oxygen-limited, meaning they were not producing their Gene of Interest (GOI) as expected. These insights have led to major new customer wins, seamless workflow integrations, and repeat orders. Breakthrough findings like these—helping scientists improve the reproducibility of their experiments—are emerging with each new component added to the DOTS platform. Customers are already looking forward to the pilot results of our new pH sensor, expected in the first quarter of 2026. In the meantime, customer budgets have been affected by tariffs and reduced government funding for scientific research. We have subsequently experienced delays in customer purchases. Despite these challenges, we remain optimistic about the fourth quarter and 2026 and are excited about the future.” 

2025 Third Quarter and Nine-Month Financial Review

Net revenues for the three months ended September 30, 2025, increased $69,600, or 52.2% to $1,404,000 from $1,334,400 for the three months ended September 30, 2024, primarily due to an increase in revenues from the Torbal Division of the Benchtop Laboratory Equipment Operations. Driven by growing demand for VIVID products. Bioprocessing Systems Operations revenues reflected a $141,700 decrease for the quarter due to overall softness in the market and requirements for products not yet available by the Company.

Net revenues for the nine months ended September 30, 2025, decreased $87,500, or (2.5%) to $3,427,100 from $3,514,600 for the nine months ended September 30, 2024, primarily due to decreased Bioprocessing Systems Operations revenues, reflecting an overall softness in the market. The decrease was partially offset by increased revenues from the Torbal Division, with total revenues increased $356,700, or 15% to $2,737,300 for the nine months ended September 30, 2025 compared to $2,380,600 in the prior year period.

The gross profit margin for the three and nine months ended September 30, 2025 was 45.5% and 39.8%, compared to 51.0% and 44.1%, respectively, for the prior year periods, primarily due to the sale of the Genie Division on August 7, 2025. Additionally, increases in material costs due to tariffs for Torbal OEM products, and lower gross margins for Bioprocessing products due to fixed costs on lower sales.

Operating expenses decreased $84,800 and $439,600, to $2,160,900 and $6,797,700, respectively in the three-month and nine-month periods ended September 30, 2025, compared to $2,245,700 and $7,237,300, respectively in the same period in 2024, primarily as a result of decreased expenses resulting from reduced costs by the Bioprocessing Systems Operations.

The Company reflected Total Other Income, Net of $5,526,900 and $5,582,300 for the three and nine months ended September 30, 2025, respectively compared to $78,500 and $169,000, respectively, due to a gain on sale of $5,263,400 from the Genie Division sale on August 7, 2025 to Ohaus Corporation’s affiliate, Troemner, LLC.

As a result, the Company posted net income of $3,994,400, and $692,200 or $0.34 and $0.06 earnings per share for the three and nine month periods ended September 30, 2025, respectively, compared to net losses of $1,180,100 and $4,515,400 or $(0.11) and $(0.43) loss per share for the three and nine month periods ended September 30, 2024, respectively.

Conference Call Details

Scientific Industries will conduct a conference call to discuss financial results for the third quarter of 2025 on Thursday, November 20, 2025, at 11:00 A.M. ET. Interested parties can access the conference call by dialing (844) 481-2706 or (412) 317-0662 (international). A webcast of the call will be available on the Company’s Investor Relations page at https://www.scientificindustries.com/investor-relations/ or at https://app.webinar.net/85AGrAdVN1d.

A replay of the call will be available through November 27, 2025, at (855) 669-9658 or (412) 317-0088 (international), replay access code: 4098504, or for 30 days at https://www.scientificindustries.com/investor-relations/.

About Scientific Industries, Inc.

Scientific Industries (OTCQB: SCND) designs, manufactures, and markets bioprocessing systems under the product name DOTS, and vision-based pill counters under the VIVID brand in addition to weighing instruments. Scientific Industries’ products are generally used in laboratories of universities, hospitals, pharmaceutical companies, and pharmacies. To learn more visit www.scientificbio.com, www.torbalscales.com, and www.pillcounters.com.

Safe Harbor Statement

Statements made in this press release that relate to future events, performance or financial results of the Company are forward-looking statements which involve uncertainties that could cause actual events, performance or results to materially differ. The Company undertakes no obligation to update any of these statements. Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as to the date hereof. Accordingly, any forward-looking statement should be read in conjunction with the additional information about risks and uncertainties set forth in the Company’s Securities and Exchange Commission reports, including our annual report on Form 10-K.

Company Contact:  
Helena R. Santos or:
CEO and President Joe Dorame
Phone: 631-567-4700 Lytham Partners, LLC
hsantos@scientificindustries.com Phone: (602)889-9700
info@scientificindustries.com SCND@lythampartners.com


—FINANCIAL TABLES FOLLOW—

SCIENTIFIC INDUSTRIES, INC. AND SUBSIDIARIES
CONDENSED CONSOLIDATED BALANCE SHEETS
         
      30-Sep-25       31-Dec-24  
ASSETS     (Unaudited )        
         
Cash and Cash Equivalents   $ 1,162,600     $ 587,900  
Investment Securities     7,131,100       1,985,000  
Other Current Assets     3,595,000       5,714,800  
Intangibles Assets and Goodwill     564,600       861,300  
Other Long Term Assets     2,104,100       2,411,800  
Total Assets   $ 14,557,400     $ 11,560,800  
         
         
LIABILITIES AND SHAREHOLDERS’ EQUITY        
         
Current Liabilities   $ 1,553,500     $ 1,747,000  
Long-Term Liabilities     542,200       694,400  
Shareholders’ Equity     12,461,700       9,119,400  
Total Shareholders’ Equity & Liabilities   $ 14,557,400     $ 11,560,800  

SCIENTIFIC INDUSTRIES, INC. AND SUBSIDIARIES
CONDENSED CONSOLIDATED STATEMENT OF OPERATIONS AND COMPREHENSIVE INCOME (LOSS)
                 
    For the Three Months Ended   For the Three Months Ended   For the Nine Months Ended   For the Nine Months Ended
    30-Sep-25   30-Sep-24   30-Sep-25   30-Sep-24
                 
Revenues   $ 1,404,000     $ 1,334,400     $ 3,427,100     $ 3,514,600  
Gross Profit     638,600       679,900       1,363,000       1,551,500  
Operating Expenses     2,160,900       2,245,700       6,797,700       7,237,300  
Loss From Continuing Operations     (1,522,300 )     (1,565,800 )     (5,434,700 )     (5,685,800 )
Total Other Income, Net     5,526,900       78,500       5,582,300       169,000  
Loss From Continuing Operations Before Income Tax Expense     4,004,600       (1,487,300 )     147,600       (5,516,800 )
Income Tax Expense     15,300             15,300        
Loss From Continuing Operations     3,989,300       (1,487,300 )     132,300       (5,516,800 )
Gain From Discontinued Operations, Net of Tax     5,100       307,200       559,900       1,001,400  
Net Income (Loss)     3,994,400       (1,180,100 )     692,200       (4,515,400 )
Comprehensive Gain (Loss)     (29,800 )     113,600       249,800       69,100  
Total Comprehensive Loss   $ 3,964,600     $ (1,066,500 )   $ 942,000     $ (4,446,300 )
                 
                 
Basic and Diluted income (loss) per common share   $ 0.34     $ (0.11 )   $ 0.06     $ (0.43 )
                 
Weighted average number of outstanding shares (basic):     11,712,567       10,503,599       11,150,939       10,443,029  

FibroBiologics Announces Closing of $4 Million Registered Direct Offering Priced At-the-Market Under Nasdaq Rules

FibroBiologics Announces Closing of $4 Million Registered Direct Offering Priced At-the-Market Under Nasdaq Rules




FibroBiologics Announces Closing of $4 Million Registered Direct Offering Priced At-the-Market Under Nasdaq Rules

HOUSTON, Nov. 19, 2025 (GLOBE NEWSWIRE) — FibroBiologics, Inc. (Nasdaq: FBLG) (“FibroBiologics” or the “Company”), a clinical-stage biotechnology company with 270+ patents issued and pending with a focus on the development of therapeutics and potential cures for chronic diseases using fibroblasts and fibroblast-derived materials, today announced the closing of its previously announced issuance and sale to an existing shareholder of 3,540,000 shares of its common stock and pre-funded warrants to purchase 8,570,203 shares of its common stock at a purchase price of $0.3303 per share or pre-funded warrant (less $0.00001 for each pre-funded warrant), in a registered direct offering priced at-the-market under Nasdaq rules. The pre-funded warrants are exercisable at any time at an exercise price of $0.00001 per share and do not expire.

The purchase price for the shares or prefunded warrants was paid not in cash but with sovereign-issued .9999 fine gold coins valued at $4,069.18 per ounce based on the spot price of gold at the time of signing of the purchase agreement, delivered to the Company’s depository. The Company intends to liquidate the purchase price into United States dollars in the near term.

In addition, in a concurrent private placement, the Company issued and sold unregistered warrants to purchase one share of its common stock for each share of common stock or pre-funded warrant purchased in the registered direct offering, for up to 12,110,203 shares of common stock. The unregistered warrants have an exercise price of $0.3303 per share of common stock, will be exercisable beginning on the effective date of, and subject to, approval by our stockholders of the issuance of the shares of common stock upon exercise of the unregistered warrants (the “Stockholder Approval”) and will expire five years following the date of the Stockholder Approval. The Company has agreed to file a registration statement with the Securities and Exchange Commission (“SEC”) to register the resale of the shares of common stock underlying the unregistered warrants. If at the time of exercise of such warrants there is no effective registration statement registering the shares issuable upon exercise of such warrants, or the prospectus contained therein is not available for the resale of such shares by the warrant holder, then such warrants may also be exercised, in whole or in part, by cashless (net) exercise.

The gross proceeds to the Company from the offering were approximately $4 million, before deducting the offering expenses payable by FibroBiologics. FibroBiologics intends to use the net proceeds from the offering for general corporate purposes, including the satisfaction of debt. In addition, if the holders of the unregistered warrants exercise such warrants in full for cash following the Stockholder Approval, the Company would receive additional gross proceeds of approximately $4.0 million. The Company cannot predict when or if the unregistered warrants will be exercised for cash or exercised at all. It is possible that the unregistered warrants may expire and may never be exercised.

The shares of common stock, pre-funded warrants and shares of common stock issuable upon exercise of the pre-funded warrants offered in the registered direct offering (but not the unregistered warrants issued in the concurrent private placement or the shares issuable upon exercise of such unregistered warrants) was offered pursuant to a shelf registration statement on Form S-3 (File No. 333-284663) previously filed and declared effective by the SEC on February 10, 2025. The offering of the shares of common stock and pre-funded warrants in the registered direct offering was made only by means of a prospectus supplement that forms a part of the registration statement. The final prospectus supplement relating to the securities offered in the registered direct offering was filed by FibroBiologics with the SEC. Copies of the final prospectus supplement relating to the registered direct offering, together with the accompanying prospectus, can be obtained from the SEC’s website at www.sec.gov.

The unregistered warrants issued in the concurrent private placement and the shares issuable upon exercise of such warrants were offered in a private placement under Section 4(a)(2) of the Securities Act of 1933, as amended (the “Act”), and/or Regulation D promulgated thereunder, have not been registered under the Act or applicable state securities laws and may not be offered or sold in the United States absent registration or an applicable exemption from registration requirements.

This press release does not constitute an offer to sell or the solicitation of an offer to buy, nor will there be any sales of these securities in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of such jurisdiction.

Forward-Looking Statements

This communication contains “forward-looking statements” as defined in the Private Securities Litigation Reform Act of 1995. Forward-looking statements include, but are not limited to, the use of proceeds from the registered direct offering and concurrent private placement, the receipt of Stockholder Approval, the exercise of the unregistered warrants and the receipt of proceeds therefrom. These forward-looking statements are based on FibroBiologics’ management’s current expectations, estimates, projections and beliefs, as well as a number of assumptions concerning future events. These forward-looking statements are not guarantees of future performance, conditions or results, and involve a number of known and unknown risks, uncertainties, assumptions and other important factors, many of which are outside FibroBiologics’ management’s control, that could cause actual results to differ materially from the results discussed in the forward-looking statements, including those set forth under the caption “Risk Factors” and elsewhere in FibroBiologics’ annual, quarterly and current reports (i.e., Form 10-K, Form 10-Q and Form 8-K) as filed or furnished with the SEC and any subsequent public filings. Copies are available on the SEC’s website, www.sec.gov. Forward-looking statements speak only as of the date they are made. Readers are cautioned not to put undue reliance on forward-looking statements, and FibroBiologics assumes no obligation and, except as required by law, does not intend to update or revise these forward-looking statements, whether as a result of new information, future events, or otherwise. FibroBiologics gives no assurance that it will achieve its expectations.

About FibroBiologics

Based in Houston, FibroBiologics is a clinical-stage biotechnology company developing a pipeline of treatments and seeking potential cures for chronic diseases using fibroblast cells and fibroblast-derived materials. FibroBiologics holds 270+ US and internationally issued patents/patents pending across various clinical pathways, including wound healing, multiple sclerosis, disc degeneration, psoriasis, orthopedics, human longevity, and cancer. FibroBiologics represents the next generation of medical advancement in cell therapy and tissue regeneration. For more information, visit www.FibroBiologics.com.

General Inquiries:
info@fibrobiologics.com

Investor Relations:
Nic Johnson
Russo Partners
(212) 845-4242
fibrobiologicsIR@russopr.com

Media Contact:
Liz Phillips
Russo Partners
(347) 956-7697
Elizabeth.phillips@russopartnersllc.com

Profusa Announces Third Quarter Business and Financial Highlights

Profusa Announces Third Quarter Business and Financial Highlights




Profusa Announces Third Quarter Business and Financial Highlights

Recapitalization reduced net debt to $14 million as of October 31; achieved key milestones to deliver potential 2026 revenue target

BERKELEY, Calif, Nov. 19, 2025 (GLOBE NEWSWIRE) — Profusa, Inc. (“Profusa” or the “Company”) (Nasdaq: PFSA), a commercial stage digital health company pioneering a next-generation technology platform enabling the continuous monitoring of an individual’s biochemistry, announces financial results for the third quarter ended September 30, 2025, and provides business highlights.

Ben Hwang, Ph.D., Profusa’s Chairman and CEO, said, “It was an extremely busy four months for the team, and we are proud of our achievements in such a short period of time. In the third quarter, we achieved a significant milestone for the company with the completion of our merger with NorthView Acquisition Corporation. We recapitalized our balance sheet, reducing net debt from $34 million to $14 million as of October 31, 2025. Since the closing of the merger on July 11, 2025, we have raised $7 million in gross proceeds through our Equity Line of Credit (“ELOC”) transaction and an additional $2 million in convertible debt.

“We also delivered key operational milestones including the build-out of our manufacturing capabilities; entered several potential distributor and clinical and commercial collaborations; and built a team focused on executing the company’s strategy.

“We now lead Profusa forward as we execute on our plans to potentially achieve $200 to $250 million in revenue by 2030; capitalize on the near-term European and US Lumee oxygen opportunity to deliver 2026 potential revenue of $0.5 to $2 million and $9 to $13 million potential revenue in 2027,” concluded Mr. Hwang.

Third Quarter 2025 Business Highlights:

  • Completed reverse recapitalization with NorthView Acquisition Corporation; Profusa company equity value was $155 million
  • Completed manufacturing build-out and remain on track to begin product shipments and revenue in early 2026
  • Expanded sales footprint with key distributors for Lumee™ Oxygen tissue monitoring platform in Europe, currently covering approximately 35% of the European population
  • Entered into several clinical and commercial collaborations with vascular surgeons of prominent vascular centers

Fred Knechtel, CFO of Profusa, commented, “To deliver value to shareholders and provide the company with adequate capital to achieve near-term revenue goals and define long-term growth strategies, we transformed the company’s balance sheet by raising capital and reducing outstanding indebtedness. We intend to further reduce debt to minimal levels in the next few quarters by exercising flexibility with debt to equity conversions, in addition to evaluating opportunities with the capital markets as they arise.”

Third Quarter 2025 Financial Highlights:

  • Raised $12 million in gross proceeds from convertible PIPE note; $10 million remains available to the Company
  • Raised $7 million in gross proceeds from ELOC as of October 31, 2025; $93 million remains available to the Company
  • Reduced net debt to $16 million in 3Q and $14 million as of October 31, 2025, a $34 million decrease from $48 million last quarter

    o   Repaid and converted $47 million of debt at close of the business combination

    o   Repaid $4 million of the Ascent Note principal balance from ELOC proceeds and conversions

    o   Cash and cash equivalents increased to $4 million

About Profusa

Based in Berkeley, Calif., Profusa is a commercial stage digital health company led by visionary scientific founders, an experienced management team and a world-class board of directors in the development of a new generation of tissue-integrated sensors to detect and continuously transmit actionable, medical-grade data for personal and medical use. With its long-lasting, injectable and affordable biosensors and its intelligent data platform, Profusa aims to provide people with a personalized biochemical signature rooted in data that clinicians can trust and rely on.

“LUMEE”, “PROFUSA” and the PROFUSA logo are registered trademarks of Profusa Inc. in the United States, Canada, European Union, China, Japan, South Korea and Australia.

For more information, visit https://profusa.com.

Special Note Regarding Forward-Looking Statements
Certain statements in this press release (this “Press Release”) may be considered “forward-looking statements” within the meaning of the “safe harbor” provisions of the United States Private Securities Litigation Reform Act of 1995. Forward-looking statements generally relate to future events or future financial or operating performance of Profusa. In some cases, you can identify forward-looking statements by terminology such as “anticipate,” “believe,” “continue,” “could,” “estimate,” “expect,” “forecast,” “future,” “intend,” “may,” “might,” “plan,” “possible,” “potential,” “predict,” “project,” “propose,” “seek,” “should,” “strive,” “will,” or “would” or the negatives of these terms or variations of them or similar terminology. Such forward-looking statements are subject to risks, uncertainties, and other factors which may be beyond the control of Profusa and could cause actual results to differ materially from those expressed or implied by such forward-looking statements. These forward-looking statements are based upon estimates and assumptions that, while considered reasonable by Profusa and its management, are inherently uncertain. Profusa cautions you that these statements are based on a combination of facts and factors currently known and projections of the future, which are inherently uncertain. There are risks and uncertainties described in the definitive proxy/final prospectus relating to the business combination, which has been filed with the SEC, and in other documents filed by Profusa from time to time with the SEC. These filings may identify and address other important risks and uncertainties that could cause actual events and results to differ materially from those contained in the forward-looking statements. Profusa cannot assure you that the forward-looking statements in this communication will prove to be accurate.

Contacts
Investor and Media Contacts
email: info@coreir.com
phone: 1 (212) 655-0924

Apollomics Announces Settlement of Cayman Litigation

Apollomics Announces Settlement of Cayman Litigation




Apollomics Announces Settlement of Cayman Litigation

FOSTER CITY, Calif., Nov. 19, 2025 (GLOBE NEWSWIRE) — Apollomics Inc. (“Apollomics” or the “Company”) (Nasdaq: APLM) announced today entering into a settlement agreement (the “Settlement Agreement” or the “Agreement”) with TWVC Goldlink Partners Investment Limited and TWVC Panglin Group Investment Limited (together, “TWVC”), entities represented by Triwise Capital Management Ltd, in connection with the litigation previously filed in the Grand Court of the Cayman Islands (the “Cayman Litigation”). The Cayman Litigation involved claims by two minority shareholders relating to the requested redemption of preferred shares of the Company before the consummation of the Company’s merger with Maxpro Capital Acquisition Corporation in 2023.

The Settlement Agreement fully resolves all disputes between the Company and TWVC. Under the Agreement, the Company has agreed to pay TWVC a total of US$5 million in cash, to be made in several installments over a period of two years, plus approximately US$879,757.78 in associated legal expenses. As agreed in the Settlement Agreement, TWVC will withdraw all claims against the Company and its affiliates, and the parties are in the process of submitting the Settlement and Settlement Agreement for the court’s approval to conclude the associated litigation proceedings. The original amount of damages claimed by TWVC was approximately US$40 million, as disclosed in the Form 20-F filed in April 2025.

About Apollomics Inc.
Apollomics Inc. is an innovative clinical-stage biopharmaceutical company focused on the discovery and development of oncology therapies with the potential to be combined with other treatment options to harness the immune system and target specific molecular pathways to inhibit cancer. Apollomics’ lead program is vebreltinib (APL-101), a potent, selective c-Met inhibitor for the treatment of non-small cell lung cancer and other advanced tumors with c-Met alterations, which is currently in a Phase 2 multicohort clinical trial in the United States and other countries. For more information, please visit www.apollomicsinc.com.

Cautionary Statement Regarding Forward-Looking Statements
This press release includes statements that constitute “forward-looking statements” within the meaning of the federal securities laws, including Section 27A of the Securities Act of 1933, as amended (the “Securities Act”), and Section 21E of the Securities Exchange Act of 1934, as amended (the “Exchange Act”). All statements, other than statements of present or historical fact included in this press release, regarding Apollomics’ strategy, prospects, plans, objectives and anticipated outcomes from the development and commercialization of vebreltinib, or future proceedings with respect to the Cayman Litigation, are forward-looking statements. When used in this press release, the words “could,” “should,” “will,” “may,” “believe,” “anticipate,” “intend,” “estimate,” “expect,” “seek,” “project,” the negative of such terms and other similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain such identifying words. These forward-looking statements are based on management’s current expectations and assumptions about future events and are based on currently available information as to the outcome and timing of future events. In addition, Apollomics cautions you that the forward-looking statements contained in this press release are subject to unknown risks, uncertainties and other factors, including those risks and uncertainties discussed in the Annual Report on Form 20-F for the year ended December 31, 2024, filed by Apollomics Inc. with the U.S. Securities and Exchange Commission (“SEC”) under the heading “Risk Factors” and the other documents filed, or to be filed, by Apollomics with the SEC. Additional information concerning these and other factors that may impact the operations and projections discussed herein can be found in the reports that Apollomics has filed and will file from time to time with the SEC. Forward-looking statements speak only as of the date made by Apollomics. Apollomics undertakes no obligation to update publicly any of its forward-looking statements to reflect actual results, new information or future events, changes in assumptions or changes in other factors affecting forward-looking statements, except to the extent required by applicable law.

CONTACT: Peter Lin
Peter.lin@apollomicsinc.com 

Extendicare to Expand its Home Health Care Business by Acquiring CBI Home Health for $570 Million in Cash Consideration

Extendicare to Expand its Home Health Care Business by Acquiring CBI Home Health for $570 Million in Cash Consideration




Extendicare to Expand its Home Health Care Business by Acquiring CBI Home Health for $570 Million in Cash Consideration

Extendicare also announces $200 million bought deal private placement equity offering

Not for distribution to U.S. news wire services or dissemination in the United States.

MARKHAM, ONTARIO, Nov. 19, 2025 (GLOBE NEWSWIRE) — Extendicare Inc. (“Extendicare” or the “Company”) (TSX: EXE) announced today that its wholly-owned home health care subsidiary, ParaMed Inc. (“ParaMed” or the “Purchaser”), has entered into a definitive agreement to acquire all of the equity interests of CBI Home Health LP and CBI (GP) 3 Inc. and their respective subsidiaries (collectively, “CBI Home Health”), from CBI Health LP and CBI GP Holdco Inc. (the “Acquisition”). The Acquisition will accelerate Extendicare’s services-focused growth strategy and strengthen its national leadership position.

The acquisition will be completed for a cash purchase price of $570.0 million, subject to customary adjustments, plus approximately $13.6 million in estimated lease liabilities in accordance with IFRS 16 – Leases (“IFRS 16”).

Acquisition Highlights

  • CBI Home Health is a national home health care company, delivering over 10 million hours of care annually across seven provinces, anchored by sizeable Ontario and Alberta operations.  
  • Diversifies ParaMed’s geographic footprint and establishes a sizeable presence in the Alberta market.
  • Enhances ParaMed’s capabilities through innovative care models, including service partnerships with hospitals and specialized community services.
  • Highly complementary to Extendicare’s home health platform, adding scale to ParaMed’s technology platform to drive operating performance and significant IT and other cost synergies.
  • Highly compelling financial profile: 8.4x Adjusted EBITDA multiple after giving effect to the expected post-Acquisition synergies of approximately $7.4 million, resulting in pro forma AFFO per share and earnings per share (fully diluted) accretion of 20% and 15%, respectively (as further described below).1
  • Prudent financing plan resulting in 3.3x Pro forma Total Debt to Adjusted EBITDA as at September 30, 2025.2

In connection with the Acquisition, the Company further announced today that it has entered into an agreement with a syndicate of underwriters co-led by CIBC Capital Markets, as sole bookrunner, and BMO Capital Markets (collectively, the “Underwriters”), pursuant to which the Underwriters have agreed to purchase, on a “bought deal” private placement basis, 10.64 million common shares of Extendicare (the “Offered Shares”) at a price of $18.80 per share (the “Offering Price”), for gross proceeds of approximately $200 million (the “Offering”).

“Home care services play an important role in relieving pressure on the rest of the health care system. The combination of ParaMed and CBI Home Health brings together two outstanding teams to enhance access to community-based care across the country,” said Dr. Michael Guerriere, President and CEO of Extendicare. “This Acquisition accelerates the growth trajectory of our home health care segment, significantly enhancing our presence in Western Canada and adding innovative care models to broaden our service offerings. The deep bench of talent and scale of our combined operations will allow us to support more Canadians to live independently at home, while leveraging our technology platform to drive outstanding customer experience and significant cost synergies to deliver strong value for our customers and shareholders,” added Dr. Guerriere.

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1 Adjusted EBITDA” and AFFO per shareare non-GAAP financial measures. See “Non-GAAP Measures” below. Based on CBI Home Health’s trailing twelve months (TTM) ended July 31, 2025 Adjusted EBITDA of $61.9 million, including adjustments for lease accounting policy alignment adjustments to EBITDA ($5.5 million) and lease liability ($13.6 million) related to facilities leases, net of Extendicare Quality of Earnings (“QoE”) EBITDA adjustments of $3.3 million. Per share amounts calculated based on fully-diluted shares outstanding as at September 30, 2025, including the 10,640,000 common shares of Extendicare to be issued in connection with the Offering (as defined below).
2 “Pro forma total debt to Adjusted EBITDA ratio” is a non-GAAP ratio. See “Non-GAAP Measures” below. Pro forma total debt to Adjusted EBITDA is based on the combined Extendicare and CBI Home Health third quarter 2025 (“Q3-25”) TTM results, including outstanding Extendicare letters of credit.

Acquisition Overview

CBI Home Health is the home health care subsidiary of CBI Health LP. It provides services in seven provinces and delivered over 10 million hours of care in 2024 (average daily volume of approximately 28,000 hours). CBI Home Health’s approximately 8,500 team members provide a comprehensive suite of publicly funded home health care services, including innovative care models such as hospital to home programs, integrated care provided by interdisciplinary teams and specialized community support services, in addition to the more traditional provincially funded home health care services.

CBI Home Health’s standalone financial performance for the twelve months ended July 31, 2025, generated revenue of approximately $477.9 million and Adjusted EBITDA3 of approximately $61.9 million (or approximately 12.9% Adjusted EBITDA margin3). Based on these results, the purchase price of $570.0 million and approximately $13.6 million in estimated lease liabilities in accordance with IFRS 16, represents an estimated purchase price multiple of 9.4x CBI Home Health’s Adjusted EBITDA. Extendicare expects to realize annualized run-rate synergies of approximately $7.4 million related to the integration of IT platforms and other cost synergies over the two-year period following closing of the Acquisition. Including the effect of these synergies, the implied purchase price multiple would be approximately 8.4x of CBI Home Health’s Adjusted EBITDA.

Given the complementary nature of ParaMed’s and CBI Home Health’s operations, Extendicare expects to realize further annualized run-rate synergies of approximately $5.0 to $7.0 million over a longer period of time as the Company deploys enhanced technology solutions to drive productivity gains in areas such as automated scheduling and front-line employee experience once CBI Home Health’s business has been fully integrated.

Closing of the Acquisition is subject to customary closing conditions, including receipt of consents from third parties, including Ontario Health atHome and Assisted Living Alberta, and regulatory approval pursuant to the Competition Act (Canada), and is not conditional on financing or due diligence. The Acquisition is anticipated to close in the first quarter of 2026.

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3 “Adjusted EBITDA” and “Adjusted EBITDA margin is a non-GAAP financial measure and a non-GAAP ratio, respectively. See “Non-GAAP Measures” below. Based on CBI Home Health TTM July 31, 2025 Adjusted EBITDA of $61.9 million, including adjustments for lease accounting policy alignment adjustments to EBITDA ($5.5 million) and lease liability ($13.6 million) related to facilities leases, net of Extendicare QoE EBITDA adjustments of $3.3 million.

Acquisition Financing

The Acquisition will be funded through a fully-committed $264.5 million upsizing to the Company’s existing senior secured credit facility, comprising: a $60.0 million increase to the Company’s existing revolving credit facility; a $204.5 million increase to the Company’s existing delayed draw term facility that will be fully drawn on closing; a new $150.0 million equity bridge facility that will backstop the Offering and will be reduced or cancelled in its entirety upon closing of the Offering; draws on the increased revolving credit facility; and cash on hand. Based on the above, and assuming that the Acquisition closed as at September 30, 2025, it is estimated that Extendicare’s pro forma total debt to Adjusted EBITDA4 as at September 30, 2025 would be 3.3x.

Additionally, the Company intends to use the proceeds from the Offering (net of Underwriters’ fees) of approximately $192 million to partially fund the Acquisition.

The Offered Shares will be offered by way of private placement to “accredited investors” in all provinces of Canada and in the United States on a private placement basis to “qualified institutional buyers” pursuant to Rule 144A under the U.S. Securities Act of 1933, as amended (the “U.S. Securities Act”). Closing of the Offering is expected to occur on or about December 3, 2025, subject to the approval of the Toronto Stock Exchange and customary closing conditions. The closing of the Offering is not conditional on closing of the Acquisition. In the event that the Acquisition does not ultimately close, Extendicare intends to use the net proceeds from the Offering to reduce its outstanding indebtedness, finance future growth opportunities, including acquisitions, and for general corporate purposes.

The Offered Shares have not been and will not be registered under the U.S. Securities Act, or under any state securities laws in the United States, and may not be offered, sold, directly or indirectly, or delivered within the United States except in certain transactions exempt from or not subject to, the registration requirements of the U.S. Securities Act and applicable state securities laws. This press release does not constitute an offer to sell or a solicitation of an offer to buy Offered Shares in the United States or in any other jurisdiction where such offer is or may be unlawful.

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4 Pro forma total debt to Adjusted EBITDA ratio” is a non-GAAP ratio. See “Non-GAAP Measures” below. Pro forma total debt to Adjusted EBITDA is based on the combined Extendicare and CBI Home Health results for TTM Q3-25, including outstanding Extendicare letters of credit.

Conference Call

Extendicare has posted an investor presentation and a pre-recorded management presentation online at www.extendicare.com under the “Investors/Events & Presentations” section.

Advisors

CIBC Capital Markets is acting as financial advisor and Torys LLP is acting as legal advisor to Extendicare in connection with the Acquisition and related financings. Blake, Cassels & Graydon LLP is acting as legal advisor to the Underwriters in connection with the Offering. TD Securities and Houlihan Lokey are acting as financial advisors and Stikeman Elliott LLP is acting as legal advisor to CBI Home Health in connection with the Acquisition. Canadian Imperial Bank of Commerce is acting as lead arranger and administrative agent under Extendicare’s credit facilities and McCarthy Tétrault LLP is acting as legal advisor to Canadian Imperial Bank of Commerce in connection with such credit facilities.

About Extendicare

Extendicare is a leading provider of care and services for seniors across Canada, operating under the Extendicare, ParaMed, Extendicare Assist, and SGP Purchasing Network brands. We are committed to delivering quality care to meet the needs of a growing seniors’ population, inspired by our mission to provide people with the care they need, wherever they call home. We operate a network of 99 long-term care homes (59 owned, 40 under management contracts), deliver approximately 13.5 million hours of home health care services annually, and provide group purchasing services to third parties representing approximately 152,100 beds across Canada. Extendicare proudly employs approximately 28,000 qualified, highly trained and dedicated team members who are passionate about providing high-quality care and services to help people live better.

Non-GAAP Measures

Certain measures used in this press release, such as “Adjusted EBITDA”, “Adjusted EBITDA margin”, “AFFO” and “Pro forma total debt to Adjusted EBITDA”, including any related per share amounts, are not measures recognized under GAAP and do not have standardized meanings prescribed by GAAP. These measures may differ from similar computations as reported by other issuers and, accordingly, may not be comparable to similarly titled measures as reported by such issuers. These measures are not intended to replace earnings (loss) from continuing operations, net earnings (loss), cash flow, or other measures of financial performance and liquidity reported in accordance with GAAP. Such items are presented in this press release because management believes that they are relevant measures of Extendicare’s operating performance and ability to pay cash dividends.

Management uses these measures to exclude the impact of certain items, because it believes doing so provides investors a more effective analysis of underlying operating and financial performance and improves comparability of underlying financial performance between periods. The exclusion of certain items does not imply that they are non-recurring or not useful to investors.

Detailed descriptions of these measures can be found in Extendicare’s Q3 2025 MD&A (refer to “Non-GAAP Measures”), which is available on SEDAR+ at www.sedarplus.ca and on Extendicare’s website at www.extendicare.com, and which is incorporated by reference in this press release.

Please see below for additional information related to certain of the Non-GAAP measures included herein:

Pro forma total debt to Adjusted EBITDA” is a Non-GAAP ratio and is defined as total debt divided by Adjusted EBITDA. Total debt consists of all short-term and long-term credit facilities, mortgages and lease liabilities on the Company’s balance sheet, excluding deferred financing costs.

Reconciliations for certain non-GAAP measures included in this press release are provided below.

The following table provides a reconciliation of pro forma net operating income to Adjusted EBITDA.

  Extendicare Inc.   CBI Home Health LP   Extendicare Inc.  
(unaudited)
(thousands of dollars unless otherwise noted)
Twelve months ending September 30, 2025(1)   Out-of-
period
adjust-
ments(2)
Adjusted twelve months ending September 30, 2025   Pro forma adjust-
ments(3)
  Pro forma adjusted twelve months ending September 30, 2025   Adjusted twelve months ending July 31, 2025(4)   Pro
forma consolidated
Revenue 1,589,938     (15,179 ) 1,574,759     143,569     1,718,329     477,943     2,196,272  
Operating expenses (1,365,014 )   733   (1,364,281 )   (129,429 )   (1,493,710 )   (421,589 )   (1,915,299 )
Net operating income 224,924     (14,445 ) 210,479     14,140     224,619     56,353     280,973  
IFRS 16 adjustment           476     476     5,504     5,980  
Net operating income, IFRS 16 adjusted 224,924     (14,445 ) 210,479     14,616     225,095     61,857     286,952  
Administrative costs (59,063 )     (59,063 )       (59,063 )       (59,063 )
Adjusted EBITDA 165,861     (14,445 ) 151,416     14,616     166,032     61,857     227,889  
Depreciation and amortization (35,168 )     (35,168 )   (3,026 )   (38,194 )   (16,437 )   (54,632 )
Other expense (income) 6,466       6,466     (647 )   5,819     (839 )   4,981  
Share of profit from investment in joint ventures 1,037     (567 ) 470         470         470  
Earnings before net finance costs and income taxes 138,196     (15,012 ) 123,184     10,943     134,127     44,581     178,708  
Interest expense (net of capitalized interest) (18,448 )     (18,448 )   (2,292 )   (20,740 )   (16,870 )   (37,609 )
Interest revenue 5,844       5,844     (1,682 )   4,162     (1,757 )   2,405  
Accretion (944 )     (944 )       (944 )       (944 )
Loss on early redemption of convertible debentures (820 )     (820 )       (820 )       (820 )
Fair value adjustments (2,399 )     (2,399 )       (2,399 )       (2,399 )
Net finance costs (16,767 )     (16,767 )   (3,974 )   (20,741 )   (18,626 )   (39,367 )
Earnings before income taxes 121,429     (15,012 ) 106,417     6,969     113,386     25,955     139,341  
Current income tax expense (35,614 )   3,971   (31,643 )   (2,221 )   (33,864 )   (6,878 )   (40,742 )
Deferred income tax recovery 5,190       5,190         5,190         5,190  
Total income tax expense (30,424 )   3,971   (26,453 )   (2,221 )   (28,674 )   (6,878 )   (35,552 )
Net earnings 91,005     (11,041 ) 79,964     4,748     84,712     19,077     103,789  
Earnings per basic share ($) 1.077     (0.131 ) 0.946     0.056     1.002     0.200     1.091  
Earnings per diluted share ($) 1.062     (0.129 ) 0.933     0.055     0.989     0.198     1.077  
Weighted Average Number of Shares                        
Basic (000’s) 84,524     84,524   84,524     84,524     84,524     95,164     95,164  
Diluted (000’s) 85,688     85,688   85,688     85,688     85,688     96,328     96,328  

The following table provides a reconciliation of pro forma net earnings to FFO and AFFO.

  Extendicare Inc.   CBI Home Health LP   Extendicare Inc.  
(unaudited)
(thousands of dollars unless otherwise noted)
Twelve months ending September 30, 2025(1)   Out-of-
period
adjust-
ments(2)
Adjusted twelve months ending September 30, 2025   Pro forma adjust-
ments(3)
  Pro forma adjusted twelve months ending September 30, 2025   Adjusted twelve months ending July 31, 2025(4)   Pro
forma consolidated
Net earnings 91,005     (11,041 ) 79,964     4,748     84,712     19,077     103,789  
Add (Deduct):                        
Depreciation and amortization 35,168       35,168     3,026     38,194     16,437     54,632  
Depreciation for FFEC (maintenance capex) (7,814 )     (7,814 )   (2,348 )   (10,162 )   (12,136 )   (22,298 )
Depreciation for office leases (3,033 )     (3,033 )       (3,033 )   (4,301 )   (7,334 )
Other expense (income) (6,466 )     (6,466 )   647     (5,819 )       (5,819 )
Loss on early redemption of convertible debentures 820       820         820         820  
Fair value adjustments 2,399       2,399         2,399         2,399  
Current income tax expense (recovery) on other expense (income) and FV adjustments (1,059 )     (1,059 )       (1,059 )       (1,059 )
Deferred income tax recovery (5,190 )     (5,190 )       (5,190 )       (5,190 )
FFO adjustments for joint ventures 2,811       2,811         2,811         2,811  
FFO 108,641     (11,041 ) 97,600     6,073     103,673     19,077     122,750  
Amortization of deferred financing costs 1,499       1,499         1,499     839     2,338  
Accretion costs 944       944         944         944  
Non-cash share-based compensation 393       393         393         393  
Principal portion of government capital funding 1,616       1,616         1,616         1,616  
Additional maintenance capex (9,907 )     (9,907 )       (9,907 )   8,303     (1,604 )
AFFO adjustments for joint ventures (91 )     (91 )       (91 )       (91 )
AFFO 103,095     (11,041 ) 92,054     6,073     98,127     28,219     126,346  
Per Basic Share ($)                        
FFO 1.285     (0.131 ) 1.155     0.072     1.227     0.200     1.290  
AFFO 1.220     (0.131 ) 1.089     0.072     1.161     0.297     1.328  
Per Diluted Share ($)                        
FFO 1.268     (0.129 ) 1.139     0.071     1.210     0.198     1.274  
AFFO 1.203     (0.129 ) 1.074     0.071     1.145     0.293     1.312  

Notes:

(1) Represents the consolidated results of Extendicare for the twelve-month period ended September 30, 2025, as reported.
(2) Represents adjustments to revenue and operating expenses for the twelve-month period ended September 30, 2025, related to out-of-period retroactive funding adjustments and workers’ compensation rebates related to prior periods, net of tax at the current statutory tax rates currently or substantively enacted of 26.5%.
(3) Represents the adjustments to annualize the impact of: (i) the acquisition of the issued and outstanding shares of Closing the Gap Healthcare Group Inc. and certain affiliates (collectively, “Closing the Gap”) from the ultimate shareholders of Closing the Gap (the “CTG Transaction”) which closed on July 1, 2025; and (ii) the acquisition of nine Class C long-term care (“LTC”) homes acquired from the seller and certain of its affiliates that closed on June 1, 2025 and the related loss of management contracts related to these homes, and an additional 21 LTC homes sold on May 1, 2025 by the seller to a third party that were being managed by the Company (collectively, the “LTC Transactions”), as follows:

(i) Additional trailing nine months ended June 30, 2025, of the financial performance of Closing the Gap, including certain adjustments of $0.6 million related to differences in estimates and timing matters identified in the Company’s due diligence and assuming the purchase price was settled with a $55.0 million increase in the Company’s delayed draw term loan bearing interest at an estimated 5.24%, with the remainder funded with cash on hand. Results exclude any impact of the potential earn-out and do not give effect to potential costs savings or operating synergies; 
(ii) Additional eight-month impact of the nine LTC homes acquired on June 1, 2025, and the corresponding loss of the management contracts associated therewith and an additional seven-month impact of the loss of the management contracts for the 21 homes sold as of May 1, 2025. Estimated Revenue, NOI and AFFO derived from the actual results for the nine months ended September 30, 2024 for the nine LTC homes and associated management contracts lost and assuming the purchase price for the nine LTC homes was paid with cash on hand; and
(iii) the impact of the above adjustments, net of tax at the current statutory tax rates currently or substantively enacted of 26.5%.

(4) Reflects the Acquisition for a cash purchase price of $570.0 million, plus the assumption of approximately $13.6 million in estimated lease liabilities under IFRS 16, before customary net working capital and other closing adjustments. Assumes the purchase price is funded with $359.0 million of incremental revolver and delayed draw term loan debt bearing interest at an estimated 4.8%; the net proceeds from the Offering; and cash on hand. Pro forma adjustments are based on the unaudited TTM July 31, 2025 results of CBI Home Health, adjusted for estimated lease accounting adjustments under IFRS 16 of $5.5 million, certain adjustments related to differences in estimates and timing matters identified in the Company’s due diligence QoE of $3.3 million, and additional depreciation and amortization resulting from the preliminary purchase price allocation primarily related to the estimated recognition of customer contract and customer relationship intangible assets. Net earnings are adjusted for tax impacts based on the statutory tax rates currently or substantively enacted of 26.5%. Results exclude any impact of potential costs savings or operating synergies. Per share figures are based on 10,640,000 common shares of Extendicare to be issued in connection with the Offering.

Forward-Looking Statements
Certain statements contained in this press release may be considered “forward-looking information” as defined under applicable securities laws (“forward-looking statements”). Statements other than statements of historical fact contained in this press release may be forward-looking statements, including, without limitation, management’s expectations, intentions and beliefs concerning anticipated future events, results, circumstances, economic performance or expectations with respect to the Company, including, without limitation: statements regarding the Acquisition, the timing of its completion and financial impact therefrom (including anticipated post-Acquisition synergies and the timing of those synergies), the terms of the Offering, the timing of closing thereof and the intended use of proceeds therefrom, and Extendicare’s business operations, business strategy, growth strategy, results of operations and financial condition. Forward-looking statements can often be identified by the expressions “anticipate”, “believe”, “estimate”, “expect”, “intend”, “objective”, “plan”, “project”, “will”, “may”, “should” or other similar expressions or the negative thereof. These forward-looking statements reflect the Company’s current expectations regarding future results, performance or achievements and are based upon information currently available to the Company and on assumptions that the Company believes are reasonable. Actual results and developments may differ materially from results and developments discussed in the forward-looking statements, as they are subject to a number of risks and uncertainties.

Although forward-looking statements are based upon estimates and assumptions that the Company believes are reasonable based upon information currently available, these statements are not representations or guarantees of future results, performance or achievements of the Company and are inherently subject to significant business, economic and competitive uncertainties and contingencies. In addition to the assumptions and other factors referred to specifically in connection with these forward-looking statements, the risks, uncertainties and other factors that could cause the actual results, performance or achievements of the Company to differ materially from those expressed or implied by the forward-looking statements, include, without limitation, those risks, uncertainties and other factors identified in the Company’s regulatory filings with the Canadian securities regulators, including Extendicare’s current annual information form and management’s discussion and analysis, which are available on SEDAR+ at www.sedarplus.ca under the Company’s issuer profile. These risks and uncertainties include the following: the occurrence of a pandemic, epidemic or outbreak of a contagious illness, such as COVID-19; changes in the overall health of the economy and changes in government, both domestic and foreign; the availability and ability of the Company to attract and retain qualified personnel; changes in the health care industry in general and the long-term care industry in particular because of political, legal and economic influences; inflationary pressures and supply chain interruptions, in particular as they impact redevelopment; changes in regulations governing the health care and long-term care industries and the compliance by the Company with such regulations; changes in government funding levels for health care services; the ability of the Company to comply with and renew its government licenses and customer and joint venture agreements; changes in labour relations, employee costs and pay equity; changes in tax laws; resident care and class action litigation, including the Company’s exposure to punitive damage claims, increased insurance costs and other claims; the ability of the Company to maintain and increase resident occupancy levels and business volumes; changes in competition; changes in demographics; changes in interest rates; changes in the financial markets, which may affect the ability of the Company to refinance debt; and the availability and terms of capital to the Company to fund capital expenditures and acquisitions; changes in the anticipated outcome and benefits of proposed or actualized dispositions, acquisitions and development projects, including risks relating to the actual completion of proposed transactions. The forward-looking statements relating to the Acquisition and the benefits expected to be realized therefrom is subject to further risks regarding the possible failure to complete the Acquisition; potential inability of the Company to successfully integrate CBI Home Health’s business upon completion of the Acquisition; the potential failure to realize anticipated benefits from the Acquisition; unexpected costs or liabilities related to the Acquisition; or risks related to information provided by CBI Home Health.

The preceding reference to material factors or assumptions is not exhaustive. All forward-looking statements contained in this press release are qualified in their entirety by this forward-looking disclaimer. Although forward-looking statements contained in this press release are based upon what management believes are reasonable assumptions, there can be no assurance that actual results will be consistent with these forward-looking statements. Accordingly, readers should not place undue reliance on such forward-looking statements and assumptions as management cannot provide assurance that actual results or developments will be realized or, even if substantially realized, that they will have the expected consequences to, or effects on, the Company. The forward-looking statements speak only as of the date of this press release. Except as required by applicable securities laws, the Company assumes no obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise.

Financial outlook and future-oriented financial information contained in this press release about prospective financial performance or financial position is based on assumptions about future events, including economic conditions and proposed courses of action, based on management’s assessment of the relevant information currently available. Readers are cautioned that any such financial outlook and future-oriented financial information contained herein should not be used for purposes other than for which it is disclosed herein. The prospective financial information included in this press release has been prepared by, and is the responsibility of, management and has been approved by management as of the date hereof. The Company and management believe that prospective financial information has been prepared on a reasonable basis, reflecting the best estimates and judgments, and represent, to the best of management’s knowledge and opinion, the Company’s expected course of action. However, because this information is highly subjective, it should not be relied on as necessarily indicative of future results. The preparation of any financial outlook is complex and is not necessarily susceptible to partial analysis or summary description and any attempt to do so could lead to undue emphasis on any particular factor or analysis. Furthermore, investors should not assume that any pro forma financial information included in this press release will be the actual financial position of the Company in the future.

Extendicare contact:
David Bacon, Executive Vice President and Chief Financial Officer
T: (905) 470-4000
E: david.bacon@extendicare.com
www.extendicare.com

FDA Pilots Faster Clarifications to Meeting Minutes

FDA Pilots Faster Clarifications to Meeting Minutes




FDA Pilots Faster Clarifications to Meeting Minutes

Silver Spring, Md., Nov. 19, 2025 (GLOBE NEWSWIRE) — The U.S. Food and Drug Administration today announced a pilot program designed to streamline communications with sponsors following formal meetings. Through the program, sponsors are given a “Meeting Minute Clarification Opportunity” which gives them the opportunity to obtain a quick clarification of a response from a single discipline.

“In this industry, time is a precious commodity. Numerous drug developers have told me that a quick touchpoint or clarification opportunity with the FDA team could spare them months of guesswork,” said FDA Commissioner Marty Makary, M.D., M.P.H. “Our goal is to give sponsors prompt, clear feedback so they can focus on what they do best: delivering more cures and innovative treatments to the American people.” 

Specifically, sponsors will be able to submit a question via email and agency staff will aim to respond within three business days by email. Since the pilot launched in October, the agency has provided several helpful clarifications to sponsors following receipt of FDA meeting minutes. 

The program is being piloted by the FDA’s Office of New Drugs and is part of the agency’s broader initiative to streamline the drug development process and improve agency interactions with sponsors. The agency intends to expand these practices across FDA centers.  

Contact Info

U.S. Food and Drug Administration
FDAPressAlerts@fda.hhs.gov
+1 202-690-6343

Ceribell to Participate in the Piper Sandler 37th Annual Healthcare Conference

Ceribell to Participate in the Piper Sandler 37th Annual Healthcare Conference




Ceribell to Participate in the Piper Sandler 37th Annual Healthcare Conference

SUNNYVALE, Calif., Nov. 19, 2025 (GLOBE NEWSWIRE) — CeriBell, Inc. (Nasdaq: CBLL) (“Ceribell”), a medical technology company focused on transforming the diagnosis and management of patients with serious neurological conditions, today announced that Jane Chao, Ph.D., CEO and Co-founder, will present at the upcoming Piper Sandler 37th Annual Healthcare Conference in New York. The presentation will take place on Wednesday, December 3, 2025, at 6:10 a.m. Pacific Standard Time / 9:10 a.m. Eastern Standard Time. 

Event: Piper Sandler 37th Annual Healthcare Conference
Date: Wednesday, December 3, 2025
Time: 6:10 a.m. PST / 9:10 a.m. EST

A live and archived webcast of the presentation will be available in the “Investor Relations” section of the Ceribell website at https://investors.ceribell.com/

About CeriBell, Inc.
Ceribell is a medical technology company focused on transforming the diagnosis and management of patients with serious neurological conditions. Ceribell has developed the Ceribell System, a novel, point-of-care electroencephalography (“EEG”) platform specifically designed to address the unmet needs of patients in the acute care setting. By combining proprietary, highly portable, and rapidly deployable hardware with sophisticated artificial intelligence (“AI”)-powered algorithms, the Ceribell System enables rapid diagnosis and continuous monitoring of patients with neurological conditions. The Ceribell System is FDA-cleared for detecting suspected seizure activity and currently utilized in intensive care units and emergency rooms across the U.S. Ceribell is headquartered in Sunnyvale, California. For more information, please visit www.ceribell.com or follow the company on LinkedIn.

Investor Contact
Brian Johnston or Laine Morgan
Gilmartin Group
Investors@ceribell.com

Media Contact
Brian Price
Press@ceribell.com