Surgery Partners, Inc. Announces Third Quarter 2025 Earnings Release Date and Conference Call Details

Surgery Partners, Inc. Announces Third Quarter 2025 Earnings Release Date and Conference Call Details




Surgery Partners, Inc. Announces Third Quarter 2025 Earnings Release Date and Conference Call Details

BRENTWOOD, Tenn., Oct. 24, 2025 (GLOBE NEWSWIRE) — Surgery Partners, Inc. (NASDAQ:SGRY) (“Surgery Partners” or the “Company”), a leading short-stay surgical facility owner and operator, announced the Company will release its third quarter 2025 results before the market opens on Monday, November 10, 2025, to be followed by a conference call at 8:30 a.m. (Eastern Time).

You can join the call as follows:

  • Dial in number for live access: 1-877-451-6152 (domestic), 1-201-389-0879 (international)
  • Replay (available 3 hours after the call and available until November 24, 2025): 1-844-512-2921 (domestic), 1-412-317-6671 (international)
  • Passcode for the live call and the replay: 13756022

Interested investors and other parties may also listen to a simultaneous webcast of the conference call by logging onto the Investor Relations section of the Company’s website at www.surgerypartners.com. The replay will also be available on this same website for a limited time following the call.

To learn more about Surgery Partners, please visit the company’s website at www.surgerypartners.com. Surgery Partners uses its website as a channel of distribution of material company information. Financial and other material information regarding Surgery Partners is routinely posted on the Company’s website and is readily accessible. 

About Surgery Partners

Headquartered in Brentwood, Tennessee, Surgery Partners is a leading healthcare services company with a differentiated outpatient delivery model focused on providing high-quality, cost-effective solutions for surgical and related ancillary care in support of both patients and physicians. Founded in 2004, Surgery Partners is one of the largest and fastest growing surgical services businesses in the country, with more than 200 locations in 30 states, including ambulatory surgery centers, surgical hospitals, multi-specialty physician practices and urgent care facilities. For additional information, visit www.surgerypartners.com.

Contact:

Surgery Partners Investor Relations
(615) 234-8940
IR@surgerypartners.com

Prenetics Global Limited Announces Proposed Public Offering

Prenetics Global Limited Announces Proposed Public Offering




Prenetics Global Limited Announces Proposed Public Offering

CHARLOTTE, N.C., Oct. 24, 2025 (GLOBE NEWSWIRE) — Prenetics Global Limited (“Prenetics” or the “Company”), a leading health sciences company, today announced that it has commenced a public offering of shares of its Class A Ordinary Shares (or prefunded warrants in lieu thereof) and common warrants (the “Offering”). The Company will allocate proceeds from the offering toward the global expansion of IM8, driven by its explosive growth, and the strategic accumulation of Bitcoin (BTC) as part of its pioneering dual-pronged health and wealth strategy.

The Offering is subject to market conditions, and there can be no assurance as to whether or when the Offering may be completed, or as to the actual size or terms of the Offering.

Dominari Securities LLC is acting as the sole placement agent for the Offering

This Offering is being made pursuant to an effective shelf registration statement on Form F-3, as amended (No. 333-288824), declared effective by the U.S. Securities and Exchange Commission (the “SEC”) on September 11, 2025. A preliminary prospectus supplement and accompanying shelf prospectus (“Shelf Prospectus”) describing the terms of the Offering will be filed with the SEC and will be available on the SEC’s website located at https://www.sec.gov. Electronic copies of the preliminary prospectus supplement (together with the final prospectus supplement for this Offering, the “Prospectus Supplement”) and the accompanying shelf prospectus may be obtained, when available, by contacting Dominari Securities LLC, Attention: Syndicate Department, 725 5th Ave 23 Floor, New York, NY 10022, by email at info@dominarisecurities.com, or by telephone at (212) 393-4500.

Before investing in this Offering, interested parties should read, in their entirety, the prospectus supplement and the Shelf Prospectus and the other documents that the Company has filed with the SEC pertaining to the Offering and that are incorporated by reference in the Prospectus Supplement and the Shelf Prospectus, which provide more information about the Company and such Offering.

This press release shall not constitute an offer to sell or the solicitation of an offer to buy, nor shall there be any sale of securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

About Prenetics

Prenetics (NASDAQ: PRE) is a leading health sciences company redefining the future of health and longevity through IM8, its flagship consumer brand co-founded with David Beckham and now one of the world’s fastest-growing supplement brands.

As the first consumer health company to establish a Bitcoin Treasury, Prenetics continues to pioneer at the intersection of health innovation and digital assets — purchasing 1 Bitcoin per day, now totaling 272 BTC as of October 24, 2025.

Forward-Looking Statements

This press release contains forward-looking statements. These statements are made under the “safe harbor” provisions of the U.S. Private Securities Litigation Reform Act of 1995. These forward-looking statements can be identified by terminology such as “will,” “expects,” “anticipates,” “future,” “intends,” “plans,” “believes,” “estimates,” and similar statements. Prenetics may also make written or oral forward-looking statements in its periodic reports to the U.S. Securities and Exchange Commission, in its annual report to shareholders, in press releases and other written materials, and in oral statements made by its officers, directors, or employees to third parties. Statements that are not historical facts, including statements about Prenetics’ beliefs and expectations, are forward-looking statements. Forward-looking statements involve inherent risks and uncertainties. A number of factors could cause actual results to differ materially from those contained in any forward-looking statement, including but not limited to the following: the Company’s ability to complete the offering, the Company’s ability to execute its new Bitcoin treasury strategy; the volatility of Bitcoin; the Company’s ability to manage its growth and expansion; the Company’s ability to compete in the highly competitive consumer health market; and other risks and uncertainties. Further information regarding these and other risks is included in Prenetics’ filings with the U.S. Securities and Exchange Commission. All information provided in this press release is as of the date of this press release, and Prenetics does not undertake any obligation to update any forward-looking statement, except as required under applicable law.

Investor Relations Contact:
investors@prenetics.com 
PRE@mzgroup.us 

Angela Cheung
Investor Relations / Corporate Finance 
angela.hm.cheung@prenetics.com 

Surgery Partners, Inc. Announces Third Quarter 2025 Earnings Release Date and Conference Call Details

Surgery Partners, Inc. Announces Third Quarter 2025 Earnings Release Date and Conference Call Details




Surgery Partners, Inc. Announces Third Quarter 2025 Earnings Release Date and Conference Call Details

BRENTWOOD, Tenn., Oct. 24, 2025 (GLOBE NEWSWIRE) — Surgery Partners, Inc. (NASDAQ:SGRY) (“Surgery Partners” or the “Company”), a leading short-stay surgical facility owner and operator, announced the Company will release its third quarter 2025 results before the market opens on Monday, November 10, 2025, to be followed by a conference call at 8:30 a.m. (Eastern Time).

You can join the call as follows:

  • Dial in number for live access: 1-877-451-6152 (domestic), 1-201-389-0879 (international)
  • Replay (available 3 hours after the call and available until November 24, 2025): 1-844-512-2921 (domestic), 1-412-317-6671 (international)
  • Passcode for the live call and the replay: 13756022

Interested investors and other parties may also listen to a simultaneous webcast of the conference call by logging onto the Investor Relations section of the Company’s website at www.surgerypartners.com. The replay will also be available on this same website for a limited time following the call.

To learn more about Surgery Partners, please visit the company’s website at www.surgerypartners.com. Surgery Partners uses its website as a channel of distribution of material company information. Financial and other material information regarding Surgery Partners is routinely posted on the Company’s website and is readily accessible. 

About Surgery Partners

Headquartered in Brentwood, Tennessee, Surgery Partners is a leading healthcare services company with a differentiated outpatient delivery model focused on providing high-quality, cost-effective solutions for surgical and related ancillary care in support of both patients and physicians. Founded in 2004, Surgery Partners is one of the largest and fastest growing surgical services businesses in the country, with more than 200 locations in 30 states, including ambulatory surgery centers, surgical hospitals, multi-specialty physician practices and urgent care facilities. For additional information, visit www.surgerypartners.com.

Contact:

Surgery Partners Investor Relations
(615) 234-8940
IR@surgerypartners.com

Pennant Announces Third Quarter 2025 Earnings Release and Call

Pennant Announces Third Quarter 2025 Earnings Release and Call




Pennant Announces Third Quarter 2025 Earnings Release and Call

EAGLE, Idaho, Oct. 24, 2025 (GLOBE NEWSWIRE) — The Pennant Group, Inc. (NASDAQ: PNTG), the parent company of operating subsidiaries that provide home health, hospice and senior living services, announced today that it expects to issue its third quarter 2025 financial results on Wednesday, November 5, 2025.

Pennant invites current and prospective investors to tune into a live webcast to be held the following day, Thursday, November 6, 2025, at 10:00 a.m. Mountain Time (12:00 p.m. Eastern Time), during which Pennant’s management will discuss its third quarter results.

To listen to the webcast, or to view any financial or other statistical information required by SEC Regulation G, please visit the Investor Relations section of our website at http://investor.pennantgroup.com. The webcast will be recorded and will be available for replay via the website until 5:00 p.m. Mountain Time on November 6, 2026.

About Pennant

The Pennant Group, Inc. is a holding company of independent operating subsidiaries that provide healthcare services through home health and hospice agencies and senior living communities located throughout Alabama, Arizona, California, Colorado, Georgia, Idaho, Montana, Nevada, Oklahoma, Oregon, Tennessee, Texas, Utah, Washington, Wisconsin and Wyoming. Each of these businesses is operated by a separate, independent operating subsidiary that has its own management, employees and assets. More information about Pennant is available at www.pennantgroup.com.

Contact

The Pennant Group, Inc.
(208) 401-1400
ir@pennantservices.com

SOURCE: The Pennant Group, Inc.

Enzon and Viskase Announce Amendment to Merger Agreement

Enzon and Viskase Announce Amendment to Merger Agreement




Enzon and Viskase Announce Amendment to Merger Agreement

Enzon and Viskase stockholders will respectively own 45% and 55% of the combined company

CRANFORD, N.J. and LOMBARD, Ill., Oct. 24, 2025 (GLOBE NEWSWIRE) — Enzon Pharmaceuticals, Inc. (OTCQB: ENZN) (“Enzon” or the “Company”) and Viskase Companies, Inc. (OTC Pink Limited: VKSC) (“Viskase”) today announced that they have entered into an amendment (the “Amendment”) to the previously disclosed Agreement and Plan of Merger (the “Merger Agreement”), pursuant to which Viskase will merge with and into a wholly owned subsidiary of Enzon in an all-stock transaction (the “Merger”). The Amendment was entered into to reflect recent developments in the operations of Viskase during the past several months and its expected operations in the near term.

Pursuant to the terms of the Amendment, the parties agreed, among other things, to:

  • an adjustment to the exchange ratio as calculated under the Merger Agreement for the exchange of each share of common stock, par value $0.01 per share, of Viskase, issued and outstanding immediately prior to the Merger into shares of the common stock, par value $0.01 per share, of Enzon (the “Enzon Common Stock”), such that current Viskase stockholders will own 55% of the combined company following the Merger;
  • an adjustment to the exchange ratio for the exchange of each share of Enzon’s Series C Non-Convertible Redeemable Preferred Stock, par value $0.01 per share (the “Series C Preferred Stock”), for shares of Enzon Common Stock to be based upon the 20-day volume weighted average price of Enzon Common Stock prior to execution of the Amendment (the “20-Day VWAP”);
  • a reduction in the minimum amount of cash that Enzon is required to have at the closing of the Merger;
  • Enzon effecting a 1 for 100 reverse stock split with respect to with respect to all shares of Enzon Common Stock prior to the effective time of the Merger; and
  • an extension to the date on which either party may terminate the Merger Agreement if the Merger has not yet occurred from 11:59 p.m., Eastern Time, on December 31, 2025, to 11:59 p.m., Eastern Time, on March 31, 2026.

In connection with the execution and delivery of the Amendment, Icahn Enterprises Holdings L.P. (“IEH”) and certain of its affiliates entered into an amendment (“Support Agreement Amendment”) to the Support Agreement that was previously entered into between IEH, Enzon and Viskase in connection with the execution of the Merger Agreement (the “Support Agreement”). Pursuant to the terms of the Support Agreement (as amended by the Support Agreement Amendment), IEH agreed to, among other things, (i) deliver or cause the delivery of written consents with respect to all of the issued and outstanding shares of Enzon Common Stock held by IEH and its affiliates approving the Merger and the amendment to Enzon’s certificate of incorporation, and (ii) exchange all of the shares of Series C Preferred Stock held by IEH and its affiliates for Enzon Common Stock prior to the consummation of the Merger, based on the full liquidation preference of such shares of Series C Preferred Stock and the 20-Day VWAP.

Enzon believes that the Merger as revised pursuant to the terms of the Amendment will result in Enzon’s net operating losses and other tax benefits to be maintained and available for use by the combined company following the Merger.

The Amendment was recommended by a special committee of the independent directors of Enzon and was recommended by a special committee of the independent directors of Viskase and, acting upon such recommendations, was, respectively approved by the Boards of Directors of each of Enzon and Viskase.

About Enzon Pharmaceuticals, Inc.

Enzon Pharmaceuticals, Inc., together with its subsidiary, is positioned as a public company acquisition vehicle, that has sought to become an acquisition platform.

About Viskase Companies, Inc.

Viskase Companies, Inc., together with its subsidiaries, is a producer of non-edible cellulosic, fibrous and plastic casings used to prepare and package processed meat products, and provides value-added support services relating to these products, for some of the largest global consumer product companies. Viskase operates nine manufacturing facilities in North America, Europe, South America, and Asia, and, as a result, is able to sell its products in nearly one hundred countries throughout the world.

No Offer or Solicitation

This communication is not intended to be, and shall not constitute, an offer to sell or the solicitation of an offer to buy or sell any securities or a solicitation of any vote or approval, nor shall there be any sale of securities in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such jurisdiction. No offer of securities shall be made except by means of a prospectus meeting the requirements of Section 10 of the Securities Act of 1933, as amended.

Important Information About the Merger and Where to Find It

In connection with the proposed transactions between Enzon and Viskase, Enzon intends to file a registration statement on Form S-4 with the Securities and Exchange Commission (the “SEC”) that will contain a consent solicitation statement and prospectus (the “Registration Statement”). The Registration Statement will include financial information regarding the combined company. This communication is not a substitute for the Registration Statement or any other documents that Enzon may file with the SEC or that Enzon or Viskase may send to their respective stockholders in connection with the transactions contemplated by the Merger Agreement, as amended. BEFORE MAKING ANY VOTING DECISION, ENZON AND VISKASE URGE INVESTORS AND STOCKHOLDERS TO READ THESE MATERIALS CAREFULLY AND IN THEIR ENTIRETY WHEN THEY BECOME AVAILABLE BECAUSE THEY WILL CONTAIN IMPORTANT INFORMATION ABOUT ENZON, THE COMBINED COMPANY, THE MERGER AGREEMENT, AS AMENDED, AND THE TRANSACTIONS CONTEMPLATED THEREBY, INCLUDING THE MERGER, AND RELATED MATTERS.

You may obtain free copies of the Registration Statement and all other documents filed or that will be filed with the SEC regarding the proposed transaction at the website maintained by the SEC at www.sec.gov. Once filed, the Registration Statement will be available free of charge on Enzon’s website at https://www.enzon.com. Investors and stockholders are urged to read the Registration Statement and the other relevant materials when they become available before making any voting or investment decision with respect to the proposed transaction.

Participants in the Solicitation

Each of Enzon and Viskase and each of their respective directors and executive officers and certain of their other members of management and employees may be deemed to be participants in the solicitation of consents or proxies in connection with the Merger Agreement, as amended, and the transactions contemplated thereby, including the Merger. Information about Enzon’s directors and executive officers is included in Enzon’s Amendment No. 1 to the Annual Report on Form 10-K/A for the year ended December 31, 2024, filed with the SEC on April 28, 2025, and Enzon’s definitive proxy statement for its 2024 Annual Meeting of Stockholders, filed with the SEC on August 8, 2024. Additional information regarding these persons and their interests in the transactions contemplated by the Merger Agreement, as amended, as well as information regarding Viskase’s directors and executive officers, will be included in the Registration Statement relating to the Merger Agreement, as amended, and the transactions contemplated thereby, including the Merger, when it is filed with the SEC. These documents can be obtained free of charge from the sources indicated above.

Cautionary Statements Regarding Forward-Looking Statements

Certain statements contained in this filing may be considered forward-looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995, including statements regarding the proposed transaction involving Enzon and Viskase, the ability to consummate the proposed transaction, and the ability to quote the common stock of the combined company on the “OTCQB” tier of the OTC market of the OTC Markets Group, Inc. Forward-looking statements generally include statements that are predictive in nature and depend upon or refer to future events or conditions, and include words such as “may,” “will,” “should,” “would,” “expect,” “anticipate,” “plan,” “likely,” “believe,” “estimate,” “project,” “intend,” and other similar expressions among others. Statements that are not historical facts are forward-looking statements. Forward-looking statements are based on current beliefs and assumptions that are subject to risks and uncertainties and are not guarantees of future performance. Actual results could differ materially from those contained in any forward-looking statement as a result of various factors, including, without limitation: (i) the risk that the conditions to the closing of the proposed transaction are not satisfied, including the failure to obtain the necessary approvals for the proposed transaction; (ii) uncertainties as to the timing of the consummation of the proposed transaction, including timing for satisfaction of the closing conditions, and the ability of each of Enzon and Viskase to consummate the proposed transaction; (iii) the ability of Viskase to timely deliver the financial statements required by the Merger Agreement, as amended; (iv) the possibility that other anticipated benefits of the proposed transaction will not be realized, including without limitation, anticipated revenues, expenses, earnings and other financial results, and growth and expansion of the combined company’s operations, and the anticipated tax treatment of the combination; (v) potential litigation relating to the proposed transaction that could be instituted against Enzon, Viskase or their respective officers or directors; (vi) possible disruptions from the proposed transaction that could harm Enzon’s or Viskase’s respective businesses; (vii) the ability of Viskase to retain, attract and hire key personnel; (viii) potential adverse reactions or changes to relationships with customers, employees, suppliers or other parties resulting from the announcement or completion of the proposed transaction; (ix) potential business uncertainty, including changes to existing business relationships, during the pendency of the proposed transaction that could affect Enzon’s or Viskase’s financial performance; (x) certain restrictions during the pendency of the proposed transaction that may impact Enzon’s or Viskase’s ability to pursue certain business opportunities or strategic transactions; (xi) the exchange ratio and relative ownership levels as of the closing of the transactions contemplated by the Merger Agreement, as amended; (xii) estimates regarding future revenue, expenses, and capital requirements following the closing of the transactions contemplated by the Merger Agreement, as amended; (xiii) legislative, regulatory and economic developments; (xiv) unpredictability and severity of catastrophic events, including, but not limited to, acts of terrorism, trade wars, or outbreak of war or hostilities, as well as management’s response to any of the aforementioned factors; and (xv) such other risks and uncertainties, including those that are set forth in the Registration Statement under the heading “Risk Factors”, in Enzon’s periodic public filings with the SEC, and in Viskase’s annual and quarterly reports posted to Viskase’s website. Enzon and Viskase can give no assurance that the conditions to the proposed transaction will be satisfied. Except as required by applicable law, neither Enzon, nor Viskase undertakes any obligation to revise or update any forward-looking statement, or to make any other forward-looking statements, whether as a result of new information, future events or otherwise.

Contact:
Richard L. Feinstein, CEO and CFO
Email: rlfeinsteincpa@enzon.com

BlossomHill Therapeutics Presents Preliminary Findings from Phase 1/2 SOLARA Trial of BH-30643 in EGFR-mutant NSCLC at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics

BlossomHill Therapeutics Presents Preliminary Findings from Phase 1/2 SOLARA Trial of BH-30643 in EGFR-mutant NSCLC at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics




BlossomHill Therapeutics Presents Preliminary Findings from Phase 1/2 SOLARA Trial of BH-30643 in EGFR-mutant NSCLC at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics

BH-30643, a first-in-class, macrocyclic OMNI-EGFR™ inhibitor, demonstrates preliminary anti-tumor activity across a variety of advanced EGFR-mutant non-small cell lung cancers with complex and difficult-to-treat resistance mutations

SAN DIEGO, Oct. 24, 2025 (GLOBE NEWSWIRE) — BlossomHill Therapeutics, Inc., a privately-held, a clinical-stage biopharmaceutical company focused on the design and development of next-generation medicines for cancer, today presented preliminary findings from the dose escalation portion of the company’s ongoing, first-in-human Phase 1/2 SOLARA trial of BH-30643 in patients with locally advanced or metastatic EGFR-mutant non-small cell lung cancer (NSCLC) at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics. BH-30643 is a first-in-class, macrocyclic, non-covalent, mutant selective OMNI-EGFR™ inhibitor designed for super-potency against a broad spectrum of EGFR mutations, including EGFR classical mutations and atypical mutations (such as PACC mutations and beyond), diverse EGFR resistant mutations (such as C797S and/or T790M), and other types of mutations.

“We are very encouraged by these early dose escalation findings from the ongoing SOLARA trial, which begin to demonstrate the potential of our OMNI-EGFR inhibitor, BH-30643, to overcome the resistance limitations of contemporary EGFR inhibitors,” said Geoff Oxnard, M.D., Chief Medical Officer of BlossomHill Therapeutics. “Current EGFR inhibitors often fall short due to factors such as inadequate potency, targeting only a narrow slice of mutations, or having a vulnerability to resistance mutations which shorten the duration of benefit. By potently inhibiting a broad spectrum of classical, atypical and resistant EGFR mutations, BH-30643 holds the potential to become an important advancement in the treatment of EGFR-mutant NSCLC. Enrollment of both targeted therapy naive and pretreated patients is ongoing into expansion cohorts to further characterize the promising clinical profile of BH-30643.”

As of the cut-off date of August 28, 2025, 39 patients with previously treated EGFR-mutant NSCLC were enrolled into the Phase 1 dose escalation portion of the ongoing SOLARA trial across dose cohorts ranging from 20 mg to 160 mg total daily dose of BH-30643. High plasma exposures were observed, well exceeding target EC90 at candidate doses, and comparing favorably with the exposures seen with contemporary EGFR inhibitors. The poster presentation highlights several case examples showing tumor reductions in heavily pretreated EGFR-mutant NSCLC patients, including those with complex and difficult-to-treat mutations such as C797S + exon 19 deletion, C797S + T790M + exon 19 deletion, G724A + exon 19 deletion, T790M + exon 20 insertion, and exon 20 insertion with brain metastases.

“BH-30643 stands out with its fundamentally novel macrocyclic architecture,” said J. Jean Cui, Ph.D., President and Chief Executive Officer of BlossomHill Therapeutics. “In contrast to many current EGFR inhibitors that repurpose chemical scaffolds from earlier generations, BH-30643 was purpose-built to potently, selectively, and non-covalently target a broad range of EGFR mutations—including those driving resistance to current therapies. We believe this compound represents a significant leap forward in oncology drug design, and we look forward to sharing more findings from the Phase 1/2 SOLARA trial in 2026.”

The poster presentation will be made available on the BlossomHill Therapeutics website at https://bhtherapeutics.com/pipeline/#posters-presentations.

About the Phase 1/2 SOLARA Trial
SOLARA is a global, open label, Phase 1/2 clinical trial designed to assess the safety, tolerability, pharmacokinetics, pharmacodynamics and preliminary anti-tumor activity of BH-30643 in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) bearing EGFR and/or HER2 mutations. The expansion cohorts of the SOLARA trial assess single-agent objective response rate (ORR) of BH-30643 in NSCLC patients with diverse EGFR mutations, including patients with classical and atypical EGFR mutations (whether or not they have received prior EGFR targeted therapy). For additional information on SOLARA, including a list of study sites and how to enroll, please visit at clinicaltrials.gov (NCT06706076).

About BH-30643
BH-30643 is a first-in-class, macrocyclic, non-covalent, mutant selective OMNI-EGFR inhibitor designed for super-potency against a broad spectrum of mutations in the EGFR kinase domain, including EGFR classical mutations and atypical mutations (such as PACC mutations and beyond), diverse EGFR resistant mutations (such as C797S +/- T790M), and other types of mutations. BH-30643 is also designed to spare wild type EGFR and HER2 inhibition (and associated toxicity) through selective targeting of the active conformation of the kinases. BH-30643 is currently being evaluated in the Phase 1/2 SOLARA clinical trial in patients with locally advanced or metastatic NSCLC bearing EGFR and/or HER2 mutations.

About BlossomHill Therapeutics
BlossomHill Therapeutics, Inc. is a privately held, clinical-stage biopharmaceutical company focused on designing and developing next-generation targeted therapies for cancer. Founded and led by industry veterans with a proven track record in oncology drug discovery and development – including multiple FDA-approved therapies – BlossomHill applies cutting-edge science to address key oncogenic drivers and improve patient outcomes in difficult-to-treat cancers. The company’s lead clinical programs include BH-30643, a first-in-class, macrocyclic, non-covalent, mutant selective OMNI-EGFR inhibitor for the treatment of EGFR- or HER2-mutated non-small cell lung cancer (NSCLC), and BH-30236, a macrocyclic CLK inhibitor for the treatment of relapsed or refractory acute myeloid leukemia (AML) or higher-risk myelodysplastic syndrome (HR-MDS), representing a first-in-class opportunity. BlossomHill Therapeutics is headquartered in San Diego, California and is supported by leading life sciences investors, including Cormorant Asset Management, OrbiMed, Vivo Capital and Colt Ventures. For more information, visit bhtherapeutics.com and follow us on LinkedIn and X.

Contacts:

Media:
Ashlea Kosikowski
1AB
ashlea@1abmedia.com

Investors:
Steve Klass
1AB
steve@1abmedia.com

BlossomHill Therapeutics Presents Preliminary Findings from Phase 1/2 SOLARA Trial of BH-30643 in EGFR-mutant NSCLC at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics

BlossomHill Therapeutics Presents Preliminary Findings from Phase 1/2 SOLARA Trial of BH-30643 in EGFR-mutant NSCLC at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics




BlossomHill Therapeutics Presents Preliminary Findings from Phase 1/2 SOLARA Trial of BH-30643 in EGFR-mutant NSCLC at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics

BH-30643, a first-in-class, macrocyclic OMNI-EGFR™ inhibitor, demonstrates preliminary anti-tumor activity across a variety of advanced EGFR-mutant non-small cell lung cancers with complex and difficult-to-treat resistance mutations

SAN DIEGO, Oct. 24, 2025 (GLOBE NEWSWIRE) — BlossomHill Therapeutics, Inc., a privately-held, a clinical-stage biopharmaceutical company focused on the design and development of next-generation medicines for cancer, today presented preliminary findings from the dose escalation portion of the company’s ongoing, first-in-human Phase 1/2 SOLARA trial of BH-30643 in patients with locally advanced or metastatic EGFR-mutant non-small cell lung cancer (NSCLC) at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics. BH-30643 is a first-in-class, macrocyclic, non-covalent, mutant selective OMNI-EGFR™ inhibitor designed for super-potency against a broad spectrum of EGFR mutations, including EGFR classical mutations and atypical mutations (such as PACC mutations and beyond), diverse EGFR resistant mutations (such as C797S and/or T790M), and other types of mutations.

“We are very encouraged by these early dose escalation findings from the ongoing SOLARA trial, which begin to demonstrate the potential of our OMNI-EGFR inhibitor, BH-30643, to overcome the resistance limitations of contemporary EGFR inhibitors,” said Geoff Oxnard, M.D., Chief Medical Officer of BlossomHill Therapeutics. “Current EGFR inhibitors often fall short due to factors such as inadequate potency, targeting only a narrow slice of mutations, or having a vulnerability to resistance mutations which shorten the duration of benefit. By potently inhibiting a broad spectrum of classical, atypical and resistant EGFR mutations, BH-30643 holds the potential to become an important advancement in the treatment of EGFR-mutant NSCLC. Enrollment of both targeted therapy naive and pretreated patients is ongoing into expansion cohorts to further characterize the promising clinical profile of BH-30643.”

As of the cut-off date of August 28, 2025, 39 patients with previously treated EGFR-mutant NSCLC were enrolled into the Phase 1 dose escalation portion of the ongoing SOLARA trial across dose cohorts ranging from 20 mg to 160 mg total daily dose of BH-30643. High plasma exposures were observed, well exceeding target EC90 at candidate doses, and comparing favorably with the exposures seen with contemporary EGFR inhibitors. The poster presentation highlights several case examples showing tumor reductions in heavily pretreated EGFR-mutant NSCLC patients, including those with complex and difficult-to-treat mutations such as C797S + exon 19 deletion, C797S + T790M + exon 19 deletion, G724A + exon 19 deletion, T790M + exon 20 insertion, and exon 20 insertion with brain metastases.

“BH-30643 stands out with its fundamentally novel macrocyclic architecture,” said J. Jean Cui, Ph.D., President and Chief Executive Officer of BlossomHill Therapeutics. “In contrast to many current EGFR inhibitors that repurpose chemical scaffolds from earlier generations, BH-30643 was purpose-built to potently, selectively, and non-covalently target a broad range of EGFR mutations—including those driving resistance to current therapies. We believe this compound represents a significant leap forward in oncology drug design, and we look forward to sharing more findings from the Phase 1/2 SOLARA trial in 2026.”

The poster presentation will be made available on the BlossomHill Therapeutics website at https://bhtherapeutics.com/pipeline/#posters-presentations.

About the Phase 1/2 SOLARA Trial
SOLARA is a global, open label, Phase 1/2 clinical trial designed to assess the safety, tolerability, pharmacokinetics, pharmacodynamics and preliminary anti-tumor activity of BH-30643 in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) bearing EGFR and/or HER2 mutations. The expansion cohorts of the SOLARA trial assess single-agent objective response rate (ORR) of BH-30643 in NSCLC patients with diverse EGFR mutations, including patients with classical and atypical EGFR mutations (whether or not they have received prior EGFR targeted therapy). For additional information on SOLARA, including a list of study sites and how to enroll, please visit at clinicaltrials.gov (NCT06706076).

About BH-30643
BH-30643 is a first-in-class, macrocyclic, non-covalent, mutant selective OMNI-EGFR inhibitor designed for super-potency against a broad spectrum of mutations in the EGFR kinase domain, including EGFR classical mutations and atypical mutations (such as PACC mutations and beyond), diverse EGFR resistant mutations (such as C797S +/- T790M), and other types of mutations. BH-30643 is also designed to spare wild type EGFR and HER2 inhibition (and associated toxicity) through selective targeting of the active conformation of the kinases. BH-30643 is currently being evaluated in the Phase 1/2 SOLARA clinical trial in patients with locally advanced or metastatic NSCLC bearing EGFR and/or HER2 mutations.

About BlossomHill Therapeutics
BlossomHill Therapeutics, Inc. is a privately held, clinical-stage biopharmaceutical company focused on designing and developing next-generation targeted therapies for cancer. Founded and led by industry veterans with a proven track record in oncology drug discovery and development – including multiple FDA-approved therapies – BlossomHill applies cutting-edge science to address key oncogenic drivers and improve patient outcomes in difficult-to-treat cancers. The company’s lead clinical programs include BH-30643, a first-in-class, macrocyclic, non-covalent, mutant selective OMNI-EGFR inhibitor for the treatment of EGFR- or HER2-mutated non-small cell lung cancer (NSCLC), and BH-30236, a macrocyclic CLK inhibitor for the treatment of relapsed or refractory acute myeloid leukemia (AML) or higher-risk myelodysplastic syndrome (HR-MDS), representing a first-in-class opportunity. BlossomHill Therapeutics is headquartered in San Diego, California and is supported by leading life sciences investors, including Cormorant Asset Management, OrbiMed, Vivo Capital and Colt Ventures. For more information, visit bhtherapeutics.com and follow us on LinkedIn and X.

Contacts:

Media:
Ashlea Kosikowski
1AB
ashlea@1abmedia.com

Investors:
Steve Klass
1AB
steve@1abmedia.com

Cogent Biosciences Announces KRAS Poster Presentation at the 2025 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics

Cogent Biosciences Announces KRAS Poster Presentation at the 2025 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics




Cogent Biosciences Announces KRAS Poster Presentation at the 2025 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics

WALTHAM, Mass. and BOULDER, Colo., Oct. 24, 2025 (GLOBE NEWSWIRE) — Cogent Biosciences, Inc. (Nasdaq: COGT), a biotechnology company focused on developing precision therapies for genetically defined diseases, today announced updated preclinical data from the company’s potent and selective pan KRAS(ON) inhibitor in a poster presentation at the 2025 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics taking place in Boston, MA, October 22-26, 2025. 

“We are excited today to share updated data from our pan KRAS(ON) program which demonstrates a potential best-in-class profile for our lead molecule,” said Andrew Robbins, Cogent’s President and Chief Executive Officer. “We look forward to advancing this program with the goal of filing an Investigational New Drug (IND) application to the U.S. Food and Drug Administration (FDA) in 2026.”  

Poster Details
The poster will be accessible on the ‘Posters and Publications’ page of Cogent’s website.

Title: Identification of CGT1263, a Potent KRAS Inhibitor with Selectivity for Mutant KRAS over HRAS and NRAS
Session Date and Time: Poster Session B, Friday, October 24, 2025 – 12:30 p.m. – 4:00 p.m. ET
Poster Number: B024
Abstract Number: B024

Mutations in KRAS are among the most prevalent mutations found in cancer, occurring most often in colorectal cancer, non-small cell lung cancer and pancreatic cancer. The poster presented today describes Cogent’s internally developed KRAS(ON/OFF) inhibitor CGT1263, showing clear selectivity over HRAS and NRAS, with picomolar (pM) activity across a broad panel of KRAS mutant cell lines. In addition, the poster also characterizes CGT1815 (the prodrug of CGT1263), which is designed to optimize human pharmacokinetic performance, supported by pharmacokinetics data from both CGT1815 and CGT1263 across multiple species. Finally, the poster highlights that CGT1815 demonstrates superior efficacy in KRASG12D and KRASG12V tumor growth inhibition studies when compared to RMC-6236.

About Cogent Biosciences, Inc.
Cogent Biosciences is a biotechnology company focused on developing precision therapies for genetically defined diseases. The most advanced clinical program, bezuclastinib, is a selective tyrosine kinase inhibitor that is designed to potently inhibit the KIT D816V mutation as well as other mutations in KIT exon 17. KIT D816V is responsible for driving systemic mastocytosis, a serious disease caused by unchecked proliferation of mast cells. Exon 17 mutations are also found in patients with advanced gastrointestinal stromal tumors (GIST), a type of cancer with strong dependence on oncogenic KIT signaling. The company also has an ongoing Phase 1 study of its novel internally discovered FGFR2/3 inhibitor. In addition, the Cogent Research Team is developing a portfolio of novel targeted therapies to help patients fighting serious, genetically driven diseases targeting mutations in ErbB2, PI3Kα and KRAS. Cogent Biosciences is based in Waltham, MA and Boulder, CO. Visit our website for more information at www.cogentbio.com. Follow Cogent Biosciences on social media: X (formerly known as Twitter) and LinkedIn. Information that may be important to investors will be routinely posted on our website and X.

Forward Looking Statements
This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, including, but not limited to, statements regarding the potential best-in-class profile of the company’s lead molecule in its pan KRAS(ON) program and the goal of filing an IND for this program in 2026. The use of words such as, but not limited to, “anticipate,” “believe,” “continue,” “could,” “estimate,” “expect,” “intend,” “may,” “might,” “plan,” “potential,” “predict,” “project,” “should,” “target,” “will,” or “would” and similar words expressions are intended to identify forward-looking statements. Forward-looking statements are neither historical facts nor assurances of future performance. Instead, they are based on our current beliefs, expectations and assumptions regarding the future of our business, future plans and strategies, our clinical results, the rate of enrollment in our clinical trials and other future conditions. New risks and uncertainties may emerge from time to time, and it is not possible to predict all risks and uncertainties. No representations or warranties (expressed or implied) are made about the accuracy of any such forward-looking statements. We may not actually achieve the forecasts or milestones disclosed in our forward-looking statements, and you should not place undue reliance on our forward-looking statements. Such forward-looking statements are subject to a number of material risks and uncertainties including but not limited to those set forth under the caption “Risk Factors” in Cogent’s most recent Quarterly Report on Form 10-Q filed with the SEC. Any forward-looking statement speaks only as of the date on which it was made. Neither we, nor our affiliates, advisors or representatives, undertake any obligation to publicly update or revise any forward-looking statement, whether as result of new information, future events or otherwise, except as required by law. These forward-looking statements should not be relied upon as representing our views as of any date subsequent to the date hereof. 

Contact:
Christi Waarich
Senior Director, Investor Relations
christi.waarich@cogentbio.com
617-830-1653

Canatu grants license for commercial production of CNT pellicle membranes using CNT100 SEMI reactor

Canatu grants license for commercial production of CNT pellicle membranes using CNT100 SEMI reactor




Canatu grants license for commercial production of CNT pellicle membranes using CNT100 SEMI reactor

VANTAA, Finland, Oct. 24, 2025 (GLOBE NEWSWIRE) — Canatu has granted a commercial production license for the first CNT100 SEMI reactor to Korean semiconductor company FINE SEMITECH CORPORATION (hereinafter “FST”). The license authorizes FST as the licensee to mass-produce CNT pellicle membranes using the CNT100 SEMI reactor, which will be operated by FST. FST will pay Canatu a one-time license fee for the commercial production rights.

The value of the one-time license fee for commercial production of CNT pellicle membranes is classified within the lower half of the “Medium” (1.0- 5.0M€) category under Canatu’s disclosure policy. The related revenue will be recognized in Q4/2025.

The commencement of commercial production will also create two new sources of future revenue streams for Canatu:

  1. Sales of proprietary consumables used in the CNT manufacturing process by Canatu
  2. Royalties payable to Canatu on each CNT pellicle sold by FST to its end customers

The materialization of such future revenue streams is subject to uncertainties, as such revenue streams are inherently dependent on FST and its end customers, and are therefore not fully within Canatu’s control.

Juha Kokkonen, CEO of Canatu, commented: “This marks a significant milestone, bringing our customer closer to high-volume mass production of CNT pellicle membranes. It also validates the maturity of CNT pellicle technology and demonstrates market demand for CNT pellicles.”

The first CNT100 SEMI reactor was shipped to FST in September 2024. In July 2025, Canatu announced that the reactor and associated post-processing equipment had passed the customer approval (Site Acceptance Test, SAT). The mass production license now granted is part of the agreed roadmap toward commercial deployment.

Additional information

Juha Kokkonen, CEO, juha.kokkonen@canatu.com, +358 40 543 0367

Mari Makkonen, VP, IR, Communications & Marketing, mari.makkonen@canatu.com, +358 50 442 2343

Certified adviser

DNB Carnegie Investment Bank AB (publ), tel. +46 (0) 8 588 685 70

About Canatu

Canatu (CANATU, Nasdaq First North, Finland) is a fast-growing deep technology company creating advanced carbon nanotubes (Canatu CNTs), related products, and manufacturing equipment for the semiconductor, automotive, and medical diagnostics industries. Canatu partners with forerunner companies, together transforming products for better tomorrows with nano carbon.

Canatu’s versatile platform technology has broad potential applications. Its current core includes CNT membranes for extreme ultraviolet (EUV) processes in the semiconductor industry, enabling more effective manufacturing of the most advanced chips, as well as film heaters for advanced driver-assistance systems (ADAS) in the automotive industry. Additionally, electrochemical sensors for medical diagnostics are in the development phase. Canatu’s patented CNT reactors and Dry DepositionTM method yield clean and pristine CNTs. The company operates through two business models: selling CNT products directly, as well as selling CNT reactors and licensing the related technology so that customers can produce CNT products under a limited license.

Headquartered in Finland, Canatu also operates in the US, Japan and Taiwan. Founded in 2004 as a spin-off from Aalto University’s Nanomaterials Group, Canatu currently has close to 150 employees representing over 30 nationalities, with nearly 20% holding or pursuing doctorates. Discover more at www.canatu.com and follow us on LinkedIn.

A photo accompanying this announcement is available at https://www.globenewswire.com/NewsRoom/AttachmentNg/3902fe40-82a3-4e92-8e0c-a908e0fbcee9

Canatu grants license for commercial production of CNT pellicle membranes using CNT100 SEMI reactor

Canatu grants license for commercial production of CNT pellicle membranes using CNT100 SEMI reactor




Canatu grants license for commercial production of CNT pellicle membranes using CNT100 SEMI reactor

VANTAA, Finland, Oct. 24, 2025 (GLOBE NEWSWIRE) — Canatu has granted a commercial production license for the first CNT100 SEMI reactor to Korean semiconductor company FINE SEMITECH CORPORATION (hereinafter “FST”). The license authorizes FST as the licensee to mass-produce CNT pellicle membranes using the CNT100 SEMI reactor, which will be operated by FST. FST will pay Canatu a one-time license fee for the commercial production rights.

The value of the one-time license fee for commercial production of CNT pellicle membranes is classified within the lower half of the “Medium” (1.0- 5.0M€) category under Canatu’s disclosure policy. The related revenue will be recognized in Q4/2025.

The commencement of commercial production will also create two new sources of future revenue streams for Canatu:

  1. Sales of proprietary consumables used in the CNT manufacturing process by Canatu
  2. Royalties payable to Canatu on each CNT pellicle sold by FST to its end customers

The materialization of such future revenue streams is subject to uncertainties, as such revenue streams are inherently dependent on FST and its end customers, and are therefore not fully within Canatu’s control.

Juha Kokkonen, CEO of Canatu, commented: “This marks a significant milestone, bringing our customer closer to high-volume mass production of CNT pellicle membranes. It also validates the maturity of CNT pellicle technology and demonstrates market demand for CNT pellicles.”

The first CNT100 SEMI reactor was shipped to FST in September 2024. In July 2025, Canatu announced that the reactor and associated post-processing equipment had passed the customer approval (Site Acceptance Test, SAT). The mass production license now granted is part of the agreed roadmap toward commercial deployment.

Additional information

Juha Kokkonen, CEO, juha.kokkonen@canatu.com, +358 40 543 0367

Mari Makkonen, VP, IR, Communications & Marketing, mari.makkonen@canatu.com, +358 50 442 2343

Certified adviser

DNB Carnegie Investment Bank AB (publ), tel. +46 (0) 8 588 685 70

About Canatu

Canatu (CANATU, Nasdaq First North, Finland) is a fast-growing deep technology company creating advanced carbon nanotubes (Canatu CNTs), related products, and manufacturing equipment for the semiconductor, automotive, and medical diagnostics industries. Canatu partners with forerunner companies, together transforming products for better tomorrows with nano carbon.

Canatu’s versatile platform technology has broad potential applications. Its current core includes CNT membranes for extreme ultraviolet (EUV) processes in the semiconductor industry, enabling more effective manufacturing of the most advanced chips, as well as film heaters for advanced driver-assistance systems (ADAS) in the automotive industry. Additionally, electrochemical sensors for medical diagnostics are in the development phase. Canatu’s patented CNT reactors and Dry DepositionTM method yield clean and pristine CNTs. The company operates through two business models: selling CNT products directly, as well as selling CNT reactors and licensing the related technology so that customers can produce CNT products under a limited license.

Headquartered in Finland, Canatu also operates in the US, Japan and Taiwan. Founded in 2004 as a spin-off from Aalto University’s Nanomaterials Group, Canatu currently has close to 150 employees representing over 30 nationalities, with nearly 20% holding or pursuing doctorates. Discover more at www.canatu.com and follow us on LinkedIn.

A photo accompanying this announcement is available at https://www.globenewswire.com/NewsRoom/AttachmentNg/3902fe40-82a3-4e92-8e0c-a908e0fbcee9