Probiogen – intelligent biopharma solutions

Probiogen is a renowned Contract Development and Manufacturing Organization (CDMO) and technology provider, mainly focusing on cell line engineering, process development and GMP manufacturing of biopharmaceuticals.

Probiogen – intelligent biopharma solutions


Probiogen offers various innovative technologies for optimized biopharmaceutical manufacturing and analysis, including fee-for-service-based services covering the entire drug development value chain (from cell line development up to GMP manufacturing). Probiogen’s services include cell line engineering (including media optimization), upstream and downstream process development, GMP and non-GMP manufacturing, analytical services (including sophisticated Cell-Based Bioassays), etc… Depending on the requirements of the protein (i.e. therapeutic proteins/antibodies) the production host has to be chosen carefully. Mammalian cells are the main host of choice because their posttranslational modifications such as glycosylation and sialylation have the biggest impact on the protein’s pharmacokinetics and efficiency. Furthermore, several vaccine viruses (e.g. human influenza virus) are produced in eggs or in primary chicken fibroblast. Probiogen’s avian cell lines AGE1.CR and AGE1.CR.pIX allow scalable chemically defined vaccine manufacturing to overcome limitations of egg-based production and to increase industrial flexibility. Additionally, Probiogen has in-depth experience with a range of biosimilar: Bevacizumab, Infliximab, Trastuzumab, Trastuzumab (GlymaxX ADCC enhanced), Ethanercept, Follicle-stimulating hormone (FSH), Interferon beta 1a, Alpha 1-antitrypsin, etc…

Probiogen is a biotech company founded in 1994 and headquartered in Berlin (Germany). Management Team is composed by Wieland Wolf, Volker Sandig, Rene Brecht and Gabriele Schneider. Probiogen has a highly skilled staff (70 employees) and 3,600 sqm of laboratory and office space. Its GMP unit is based on disposable bioreactor technology and all of its services and technologies are embedded in a total quality management system to assure compliance with international ISO and GMP standards (EMA/FDA). Thus, Probiogen is a partner of choice for biopharma companies seeking high quality cell line development and manufacturing capabilities.

More about Probiogen :

Probiogen – Contract Development and Manufacturing Organization – CDMO

Probiogen – Contract Development Manufacturing Organization – GMP manufacturing – media optimization – glycosylation – sialylation – pharmacokinetics – primary chicken fibroblast – AGE1.CR – AGE1.CR.pIX – Bevacizumab – Infliximab – Trastuzumab – Trastuzumab – GlymaxX ADCC enhanced – Ethanercept – Follicle-stimulating hormone – FSH – Interferon beta 1a – Alpha 1-antitrypsin – Wieland Wolf – Volker Sandig – Rene Brecht – Gabriele Schneider – CDMO