Lonza Upgrades Organic Growth Model and Mid-term Financial Ambitions at Capital Markets Day; Q3 2026 In Line with Expectations

  • With the transformation into a focused, pure-play CDMO1 complete, and operational and financial performance strengthened, Lonza upgrades its Organic Growth Model2 and resulting mid-term financial ambitions.
  • The model entails low-teens (10-13%) organic CER sales growth on average over time, CORE EBITDA growth ahead of sales growth, an upgraded ambition to reach a CORE EBITDA margin in the high thirties in the mid-term, driving ROIC3 up to two to three times WACC4, and an improving FCF conversion5 on average over time.
  • Q3 2026 Qualitative Update: Lonza performed well and in line with expectations across all Business Platforms, and confirms its Full-Year 2026 Outlook, which was upgraded in H1 2026.

Basel, Switzerland, 14 October 2026 – At its Capital Markets Day in Vacaville, California, Lonza reports progress of its One Lonza Strategy to deliver long-term, profitable, above-market growth. In less than two years, Lonza has completed its transformation into a pure-play CDMO, following the exit6 of the Capsules & Health Ingredients business and further divestments. Based on stronger operational and financial performance, successful execution of growth projects and attractive future market opportunities, Lonza upgrades its Organic Growth Model. 

Wolfgang Wienand, CEO, Lonza, commented: “Lonza performed well in Q3 2026 and we continued to successfully execute our One Lonza Strategy. The transformation into a pure-play CDMO has created a stronger, more integrated global organization that is delivering for our customers across all Business Platforms. The power of the Lonza Engine and the improvements we are bringing to the business further strengthen our confidence in our Organic Growth Model and our ability to improve margin faster over time. We continue to significantly grow, expand profit margins and returns, increase cash generation, and allocate capital with discipline. It is this highly differentiated model that will drive sustainable long-term value creation for our customers and their patients, our shareholders and our people at One Lonza.”

Lonza’s Organic Growth Model

As a structural growth compounder, Lonza delivers resilient and repeatable above-market organic sales growth, high and further increasing profit margins and improving cash generation which funds investments into future growth at high returns to deliver sustainable long-term value to its shareholders.

Maturing high-return growth projects, improvements in operational, commercial and CapEx7 performance, and continued discipline in overhead costs are progressing well. Based on this, Lonza upgrades its Organic Growth Model of low-teens organic CER sales growth on average over time with an acceleration of the CORE EBITDA margin expansion, now reaching high thirties in the mid-term. It also expands the model to include a mid-term ROIC ambition of two to three times today’s WACC and an improving FCF conversion on average over time, reflecting its disciplined investment approach and overall greater capital efficiency. Unchanged, organic CapEx  is expected to fluctuate around mid-to-high teens percentage of sales, while Lonza remains committed to a progressive8 dividend distribution, all in line with its Capital Allocation Framework first shared in 2024. 

Q3 2026 qualitative business update

In Q3 2026, Lonza continued to perform well, in line with expectations across all Business Platforms. Lonza reiterates its Full-Year 2026 Outlook, as upgraded after H1 2026, of 11–12% CER sales growth and a CORE EBITDA margin of 33–34%. The company also reiterates its expectation of a negative FX impact of approximately 2% to 3% on 2026 sales growth.

Q3 performance in Capsules & Health Ingredients was also in line with expectations, with Lonza continuing to expect mid-single-digit CER sales growth and further CORE EBITDA margin expansion for Full-Year 2026.

About Vacaville

The Capital Markets Day is being held at Lonza’s Vacaville facility, acquired in 2024 from Roche. It is the company’s largest Integrated Biologics site for the commercial manufacture of complex biologics. During the investor event, management will share insights into Lonza’s Integrated Biologics Business Platform, which combines scientific, technological and manufacturing capabilities in an industry-leading end-to-end9 offering. 

The Capital Markets Day 2026 presentation is available to download here. To join the live webcast on 14 October 2026 at 09:00 PT / 18:00 CEST, please register here. 

Ad hoc: Evotec announces preliminary nine-months 2026 results above market expectations, reaffirming full-year 2026 guidance

Evotec SE / Key word(s): Forecast / Other

Ad hoc: Evotec announces preliminary nine-months 2026 results above market expectations, reaffirming full-year 2026 guidance

13-Oct-2026 / 22:37 CET/CEST

Disclosure of an inside information acc. to Article 17 MAR of the Regulation (EU) No 596/2014, transmitted by EQS News – a service of EQS Group.

The issuer is solely responsible for the content of this announcement.


Ad hoc: Evotec announces preliminary nine-months 2026 results above market expectations, reaffirming full-year 2026 guidance
 

Hamburg, Germany – Evotec SE (NASDAQ: EVO; Frankfurt Prime Standard: EVT) today announced preliminary unaudited financial results for first nine months of 2026. Full financial results for the third quarter and the first nine months of 2026 will be published on November 5, 2026, as scheduled.

Based on preliminary figures, Evotec expects Group revenues for the first nine months of 2026 of approximately €465.0 million and adjusted Group EBITDA of approximately -€42.8 million. These figures are above current market expectations, with the variance driven largely by the phasing of consensus estimates.

Evotec reaffirms its full-year 2026 guidance, which projects Group revenues of approximately €570 to €610 million (€595 to €635 million at CER) and adjusted Group EBITDA of approximately -€70 to -€105 million (-€60 to -€90 million at CER).
 

– End of the ad hoc release –
 

Contact: Dr. Sarah Fakih, EVP Head of Global Communications and Investor Relations, Evotec SE, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany, Phone: +49 (0) 151 7068 8784 (m), sarah.fakih@evotec.com

End of Inside Information


13-Oct-2026 CET/CEST The EQS Distribution Services include Regulatory Announcements, Financial/Corporate News and Press Releases.


Language: English
Company: Evotec SE
Manfred Eigen Campus / Essener Bogen 7
22419 Hamburg
Germany
Phone: +49 (0)40 560 81-0
E-mail: info@evotec.com
Internet: www.evotec.com
ISIN: DE0005664809
WKN: 566480
Indices: SDAX, TecDAX
Listed: Regulated Market in Frankfurt (Prime Standard), Tradegate BSX; Regulated Unofficial Market in Dusseldorf, Hamburg, Hanover, Munich, Stuttgart; Nasdaq
LEI Code: 529900F9KI6OYITO9B12
EQS News ID: 2415242

 
End of Announcement EQS News Service

2415242  13-Oct-2026 CET/CEST

Eckert & Ziegler and TerThera Sign Supply Agreement to Bring Next-Generation GMP Terbium-161 Radiopharmaceutical Therapies to Brazilian Patient

Eckert & Ziegler SE

/ Key word(s): Contract

Eckert & Ziegler and TerThera Sign Supply Agreement to Bring Next-Generation GMP Terbium-161 Radiopharmaceutical Therapies to Brazilian Patient

13.10.2026 / 14:00 CET/CEST

The issuer is solely responsible for the content of this announcement.


Berlin/Breda, 13 October 2026. Eckert & Ziegler Brazil, a regional subsidiary of the global nuclear medicine group Eckert & Ziegler SE (ISIN DE0005659700, TecDAX), and TerThera announced today the signing of a strategic supply agreement for the precursor Terbium-161.

Under the terms of the agreement, TerThera will supply its GMP-compliant non-carrier-added (n.c.a.) Terbium-161 (Tb-161) to Eckert & Ziegler Brazil. This partnership establishes a critical and reliable supply chain for the innovative isotope in South America, directly providing Brazilian patients access to the next generation of radioligand therapies. Moreover, the availability of GMP-grade Tb-161 will allow local pharmaceutical developers and clinical institutions to investigate the combination of Tb-161 with novel peptides, antibodies, and FAP-inhibitors to target a broad spectrum of oncological indications. The agreement, between Eckert & Ziegler Brazil and TerThera, will bring the next generation of Radioligand Therapy (RLT) to Brazil and allow access to a novel radiopharmaceutical for cancer healthcare.

Terbium-161, a carrier free lanthanide produced by neutron activation, is a highly promising radionuclide for Radioligand Therapy (RLT) exhibiting comparable chemical characteristics to known radiolanthanides that has the potential, due to highest addition of Auger electronic emission with a higher linear energy transfer, to improve anti-tumor capabilities for primary and (micro)metastasized cancers. The latest clinical results have shown a promising and effective anti-tumor response, even after treatment stops of conventional medicine, providing for a new therapy option by depositing a highest but localized tumor dose with limited impact on healthy tissue.

Expanding Local Theranostic Infrastructure

“It is a great milestone that after six years of absence we are back in Brazil with a potentially better radionuclide,” said Philippe van Overeem, CEO of TerThera. “Having supplied Lutetium-177 to Brazil for almost two decades, I know firsthand the passion and capability of the local nuclear medicine community. Returning to this market with GMP-grade Terbium-161 allows us to build on that legacy and give Brazilian doctors and researchers a powerful, next-generation tool to treat micro-metastases and complex tumors more effectively.”

The agreement leverages Eckert & Ziegler’s robust presence in Latin America, combining TerThera’s unique isotope production capabilities with a powerful regional distribution and manufacturing network.

“We are proud to partner with TerThera to bring this highly promising isotope to South America,” stated Fabrício Diel, the Managing Director of Eckert & Ziegler Brazil. “Integrating Terbium-161 into our portfolio perfectly aligns with our mission of “Contributing to saving lives” and our goal to expand local access to strategic theranostic solutions. By combining this premium radionuclide with advanced targeting agents here in Brazil, we are shortening the supply chain and opening new clinical horizons for oncology patients across the region.”

About Eckert & Ziegler
Eckert & Ziegler SE, with more than 1,100 employees, is THE leading independent radioisotope supplier and a specialist in isotope-related components for nuclear medicine and radiation therapy. The company offers a broad range of services and products for the radiopharmaceutical industry, from early development work to contract manufacturing and distribution. Eckert & Ziegler shares (ISIN DE0005659700) are listed in the TecDAX index of Deutsche Börse.
www.ezag.com

About TerThera BV
TerThera is a radionuclide production focused company based in The Netherlands. The founders and the staff of TerThera have decades of experience in the nuclear medicine industry and are giving their full focus on the production of the innovative radionuclide Terbium-161 (Tb-161). TerThera is building a global platform to meet the growing demand for radionuclides in oncology and nuclear medicine.
www.terthera.com

Your contact:
Eckert & Ziegler SE, Karolin Riehle, Investor Relations
Robert-Rössle-Str. 10, 13125 Berlin, Germany
Tel.: +49 (0) 30 / 94 10 84-138, karolin.riehle@ezag.de, www.ezag.com 


13.10.2026 CET/CEST Dissemination of a Corporate News, transmitted by EQS News – a service of EQS Group.
The issuer is solely responsible for the content of this announcement.

The EQS Distribution Services include Regulatory Announcements, Financial/Corporate News and Press Releases.


Language: English
Company: Eckert & Ziegler SE
Robert-Rössle-Str.10
13125 Berlin
Germany
Phone: +49 30 941084-138
Fax: +49 30 941084-0
Internet: www.ezag.de
ISIN: DE0005659700
WKN: 565970
Indices: SDAX, TecDax,
Listed: Regulated Market in Frankfurt (Prime Standard); Regulated Unofficial Market in Dusseldorf, Hamburg, Munich, Stuttgart, Tradegate BSX
LEI Code: 391200EUDABLUKXCKG48
EQS News ID: 2414828

 
End of News EQS News Service

2414828  13.10.2026 CET/CEST

NVision Deploys POLARIS at UCLouvain to Advance Cancer Metabolism Research

NVision Quantum

/ Key word(s): Miscellaneous

NVision Deploys POLARIS at UCLouvain to Advance Cancer Metabolism Research

13.10.2026 / 10:00 CET/CEST

The issuer is solely responsible for the content of this announcement.


NVision Deploys POLARIS at UCLouvain to Advance Cancer Metabolism Research

●  Installation at UCLouvain’s NEST imaging platform will support research into treatment response and resistance in melanoma, triple-negative breast cancer and metastatic disease

ULM, Germany and BRUSSELS, Belgium, October 13, 2026 – NVision, a quantum technology company, today announced the deployment of its POLARIS quantum-enhanced MRI platform at UCLouvain’s Nuclear and Electron Spin Technologies (NEST) imaging platform in Belgium. Researchers will use the system to study cancer metabolism in preclinical models of melanoma, triple-negative breast cancer and metastatic disease, with an initial focus on identifying metabolic changes associated with treatment response and resistance.

The installation marks the latest expansion of NVision’s growing network of quantum-enhanced MRI research sites. In recent weeks, new POLARIS systems have also been deployed at IBEC in Barcelona and the University of Antwerp through the EU-funded Q-AID initiative, following NVision’s deployment at Hokkaido University in Japan. NVision is working toward approximately 20 POLARIS installations across Europe, North America and Asia by early next year.

The expansion comes as European research programs continue to advance quantum-enhanced metabolic imaging toward broader research and clinical use. In September, the German Federal Ministry of Research, Technology and Space extended the  QuE-MRT project by two years until August 2028, bringing the project volume to nearly €20 million. Together, these initiatives are helping put quantum-enhanced MRI into the hands of researchers investigating how metabolism can reveal new information about disease and treatment response.

“UCLouvain brings together exactly the kind of scientific expertise and infrastructure that can push metabolic imaging into new areas of cancer research,” said Prof. Myriam Chaumeil, Head of Research at NVision. “Our goal with POLARIS is to make quantum-enhanced MRI accessible to leading research teams so they can focus on the biological questions that matter. UCLouvain is an important step in this vision, with expertise in hyperpolarized 13C imaging and preclinical cancer models spanning melanoma, triple-negative breast cancer and metastatic disease. Their work will use metabolic imaging to reveal how tumors adapt to therapy, identify early markers of treatment response, and uncover metabolic changes associated with resistance, with NVision providing ongoing scientific and technical support throughout the studies.”

UCLouvain’s NEST platform combines a broad range of magnetic resonance technologies, including MRI, nuclear magnetic resonance (NMR), electron paramagnetic resonance (EPR) and hyperpolarization. This combination allows researchers to study multiple aspects of the tumor microenvironment and cancer biology within a single research environment.

POLARIS adds an automated, standardized approach to parahydrogen-induced polarization, or PHIP, a method of hyperpolarization that boosts the MRI signal of metabolic molecules by more than 10,000 times. The system produces hyperpolarized metabolic imaging agents in approximately three minutes, enabling researchers to visualize metabolic processes in real time using standard MRI systems.

At UCLouvain, researchers will initially use POLARIS to assess metabolic shifts across different cancer models as a surrogate for long-term markers for treatment response and resistance. The aim is to identify metabolic biomarkers that could provide an earlier indication of whether a therapy is working, while also uncovering metabolic vulnerabilities that could potentially be targeted therapeutically.

“The future of cancer monitoring may depend on our ability to capture the biology behind treatment response, revealing changes in tumor metabolism beyond glucose uptake, and the microenvironment before conventional imaging can detect them,” said Prof. Bénédicte Jordan of UCLouvain and Academic Lead of the NEST platform.

The first studies will focus on melanoma, triple-negative breast cancer and metastatic disease in preclinical models. By combining POLARIS with the complementary magnetic resonance capabilities already available through NEST, the UCLouvain team will be able to investigate changes in tumor metabolism alongside other characteristics of the tumor microenvironment.

The deployment is part of NVision’s broader effort to establish a distributed research network around quantum-enhanced metabolic MRI. Across its growing installed base, researchers are using POLARIS to investigate disease biology in oncology, cardiology, neurology, and immunology. This includes studying disease progression and treatment response, while building the scientific evidence and workflows needed to advance metabolic imaging toward wider clinical use.

About NVision Quantum Technologies

NVision is a quantum technology company focused on healthcare, with deep expertise in engineering and controlling the quantum properties of organic molecules. This approach underpins both its POLARIS platform, which enables real-time measurement of metabolism on standard MRI systems, and its quantum computing platform, Photonic Integrated Quantum Circuits (PIQC, pronounced “Pixie”). Together, these capabilities are helping bridge the gap between understanding disease and delivering effective therapies. Founded in 2015 and headquartered in Ulm, Germany, NVision is backed by Playground Global, Entrée Capital, Matterwave/b2venture, Lauder Partners, Pathena Investments, The European Investment Bank and others. Learn more at nvision-quantum.com.

 
Company Contact:
 
                               Media Contact:
Leah Wiedenmann                                Dr. Cora Kaiser
NVision Quantum Technologies                                MC Services AG
leah.wiedenmann@nvision-quantum.com                                nvision@mc-services.eu
 


13.10.2026 CET/CEST Dissemination of a Corporate News, transmitted by EQS News – a service of EQS Group.
The issuer is solely responsible for the content of this announcement.

The EQS Distribution Services include Regulatory Announcements, Financial/Corporate News and Press Releases.


2414242  13.10.2026 CET/CEST

PL BioScience Launches PL Synergy to Simplify and Standardize MSC Research

PL BioScience GmbH

/ Key word(s): Product Launch

PL BioScience Launches PL Synergy to Simplify and Standardize MSC Research

13.10.2026 / 10:00 CET/CEST

The issuer is solely responsible for the content of this announcement.


PL BioScience Launches PL Synergy to Simplify and Standardize MSC Research

Two-component culture kit combines PL Base and PL Boost for streamlined xeno-free MSC expansion.

Aachen, Germany, 13 October 2026 – PL BioScience GmbH, a German life science company specializing in the production and development of Human Platelet Lysate (HPL) for cell expansion and development, today announced the launch of PL Synergy, a research-grade culture kit designed to simplify and standardize the expansion of Mesenchymal Stromal Cells (MSCs) in academic and translational research.

PL Synergy combines two components optimized for joint use: PL Base, a custom-formulated basal medium developed for MSC growth and proliferation, and PL Boost, a proprietary supplement that eliminates the need for Fetal Bovine Serum (FBS). The two-component system requires no additional preparation and provides researchers with a streamlined, optimized MSC culture workflow.

By removing the need for performance and compatibility assessment of independent media and supplements, PL Synergy is designed to simplify laboratory protocols while reducing the lot-to-lot variability associated with animal-derived serum. The xeno-free system is enhanced for MSC viability and kinetics compared with standard α-MEM + FBS formulations, supporting more consistent and reproducible research workflows.

“MSC researchers need culture workflows that combine performance with consistency and ease of use,” said Dr. Hatim Hemeda, CEO of PL BioScience. “PL Synergy brings together two components designed to work as one system, reducing the burden associated with technical validation, while providing researchers with a straightforward, xeno-free option for MSC expansion. With this launch, we are expanding the tools available to academic and translational researchers working to generate more reliable and reproducible results by using a single, optimized system.”

PL Synergy is intended for academic research laboratories conducting MSC studies, biotechnology companies developing cell culture models for mechanistic research or drug screening, and regenerative medicine researchers working in early and pre-clinical research. The kit is supplied jointly as PL Base and PL Boost and is intended for Research Use Only.

For more information about PL Synergy and its potential to support streamlined MSC research workflows, meet the PL BioScience team at BIO-EUROPE Cologne, on November 9-11, at the BIO.NRW booth (8-50). We look forward to discussing this latest innovation and exploring opportunities for collaboration.

 

About PL BioScience:

PL BioScience GmbH, a life science company located in Aachen, Germany, specializes in the production and development of Human Platelet Lysate (HPL). The company has pioneered proprietary technology to produce fully artificial HPL, allowing for a fully lab-made, scalable supply of HPL. PL BioScience currently offers a comprehensive portfolio of donor-derived, natural HPL products tailored for a range of applications – the ELAREM™platform. From academic and preclinical research to cell therapy and biopharmaceutical manufacturing, ELAREM™ ensures seamless translations of regenerative medicine breakthroughs – from the lab to patients in need. The company’s latest addition, PL Synergy, is a research-grade, xeno-free two-component culture kit — combining PL Base basal medium with the PL Boost supplement pack — designed to simplify Mesenchymal Stromal Cell expansion workflows and support MSC viability and proliferation without the need for FBS. PL BioScience is the only company worldwide holding a patent for the gamma-irradiation of HPL, covering the manufacturing process for ELAREM™ Ultimate-FD PLUS.

For more information on PL BioScience and the ELAREM™ platform, visit: https://www.pl-bioscience.com/

About Human Platelet Lysate:

Human Platelet Lysate (HPL) is an innovative, human-derived cell culture supplement used to support the growth and expansion of cells in research and clinical development, particularly in cell therapy, stem cell, and regenerative medicine applications. It is produced from donated human blood platelets that are no longer suitable for transfusion and would otherwise be discarded – making it a sustainable and resource-efficient alternative to traditional cell culture supplements.

In cell culture, HPL provides essential growth factors and nutrients that promote healthy, robust cell proliferation. Compared to conventional products such as Fetal Bovine Serum (FBS), which is harvested from unborn calves, HPL delivers more consistent results in cell growth, is free from animal-derived pathogens, and aligns with the increasing demand for animal-free and ethically responsible laboratory practices.

ELAREM™, PL BioScience’s line of xeno-free HPL products, can be used from early-stage research to the production of cell-based therapies under Good Manufacturing Practice (GMP) conditions for the treatment of patients.

Contact:

Dr. Hatim Hemeda, CEO
PL BioScience GmbH
+49(0)24195719-100
info@pl-bioscience.com

Media contact:
MC Services AG
Raimund Gabriel, Dr. Regina Lutz
+49 (0)89 210 228 0

U.S.: Catherine Featherston
+1-203-444-4393
E-Mail: pl-bioscience@mc-services.eu

 


13.10.2026 CET/CEST Dissemination of a Corporate News, transmitted by EQS News – a service of EQS Group.
The issuer is solely responsible for the content of this announcement.

The EQS Distribution Services include Regulatory Announcements, Financial/Corporate News and Press Releases.


Language: English
Company: PL BioScience GmbH
Auf der Hüls 184-186
52068 Aachen
Germany
E-mail: info@pl-bioscience.com
Internet: www.pl-bioscience.com
EQS News ID: 2414374

 
End of News EQS News Service

2414374  13.10.2026 CET/CEST

Mursla Bio Publishes Peer-Reviewed Validation of Tissue-Specific Extracellular Vesicle Platform for Liquid Biopsy

Mursla Bio Publishes Peer-Reviewed Validation of Tissue-Specific Extracellular Vesicle Platform for Liquid Biopsy




Mursla Bio Publishes Peer-Reviewed Validation of Tissue-Specific Extracellular Vesicle Platform for Liquid Biopsy

  • Study published in Journal of Extracellular Vesicles validates platform for new class of liquid biopsy: multiomic disease biology of living cells from a chosen tissue, starting with the liver
  • Platform underpins FDA Breakthrough Device-designated EvoLiver™ and precision medicine programs with pharmaceutical partners

CAMBRIDGE, England & BOSTON–(BUSINESS WIRE)–Mursla Bio, a precision medicine and diagnostics company built on tissue-specific extracellular vesicles (TS-EVs), today announced publication of a peer-reviewed study in the Journal of Extracellular Vesicles (impact factor 21.7), the founding journal of the International Society for Extracellular Vesicles. This validates the TS-EV platform for a new class of liquid biopsy: the multiomic disease biology of living cells in a chosen tissue, read from blood, starting with the liver.


In this study, which builds on work first released as a preprint in June 2025, Mursla Bio’s NEXPLOR technology selectively enriched hepatocyte-derived EVs (h-EVs) over EVs from other tissues (lung, kidney, breast, adipose and muscle) and from the blood cells that dominate plasma. The multiomic content of h-EVs was analyzed against bulk EV preparations of the same clinical plasma samples, each under 2 mL, from patients with hepatocellular carcinoma (HCC) or cirrhosis and from healthy donors.

H-EVs accessed a different part of the hepatocyte proteome, identifying 57% more proteins than those bulk EVs, with better reproducibility. Bulk EVs were dominated by the plasma proteins the liver secretes, such as albumin, while h-EVs were enriched in the internal machinery of hepatocytes: membrane, cytosolic and mitochondrial proteins, including EV-defining markers1. The h-EV fraction revealed 86 proteins uniquely detected or significantly increased in liver disease against healthy donors, compared with 4 unique proteins and no significant differential signal in bulk EVs. These 86 reflected what cirrhosis and HCC shared: fibrosis, disordered fat metabolism and inflammation. Comparing HCC with cirrhosis, the h-EV fraction resolved HCC-defining proteins, and a wider set of proteins that cohered as a network. Paired bulk EVs yielded neither.

Small-RNA sequencing supported a similar conclusion in a second molecular layer. In the same comparison, the h-EV fraction yielded fewer differentially expressed microRNAs than paired bulk EVs, yet only the h-EV microRNAs mapped to HCC signaling, while the bulk set mapped to a more generalized inflammatory response. The same h-EVs were present in the bulk EV preparation, suggesting that the lack of tissue specificity holding back microRNAs as liquid biopsy biomarkers2 could be overcome.

The NEXPLOR technology described in the manuscript is a core component of Mursla Bio’s broader TS-EV platform. The hepatocyte panel is Mursla Bio’s first; the discovery and orthogonal validation route behind it is designed to extend to other tissues, and further panels are in development.

The platform has wide applications across clinical diagnostics, from disease surveillance to molecular residual disease (MRD), and precision medicine, including patient stratification, pharmacodynamic biomarkers and companion diagnostics.

Dr Tomás Dias, Chief Scientific Officer of Mursla Bio, said: “EVs are released by virtually every tissue into the bloodstream. They carry health and disease markers that can be traced back to their origin, much as a tissue biopsy would. To our knowledge, this is the most comprehensive validation to date of a platform for tissue-specific EV isolation from human plasma.”

Pierre Arsène, Founder and CEO of Mursla Bio, added: “Much of liquid biopsy has focused on measuring more analytes. Our thesis is that biological context matters as much as analytical depth. That is the foundation of EvoLiver and of the precision medicine programs we are building with pharma partners.”

  1. Tissue-specific isolation of hepatocyte extracellular vesicles from human plasma enables tissue-resolved proteomic and miRNA profiling, Journal of Extracellular Vesicles, 2026; 15:e70372. https://doi.org/10.1002/jev2.70372
  2. MicroRNAs in oncology: a translational perspective in the era of AI, Nature Reviews Clinical Oncology, 2026.

Contacts

Media contact
Dr Ben Rutter
Zyme Communications
Tel: +44(0)7920 770 935
Email: ben.rutter@zymecommunications.com

Undecimal Bio launches with $18 million oversubscribed Seed financing to address ‘liver trap’ in siRNA therapeutic delivery

Undecimal Bio launches with $18 million oversubscribed Seed financing to address ‘liver trap’ in siRNA therapeutic delivery




Undecimal Bio launches with $18 million oversubscribed Seed financing to address ‘liver trap’ in siRNA therapeutic delivery

  • A spin-out focused on AI-enabled decoding of the deliverome
  • Proprietary synthetic biology platform identifies conjugates that target RNA medicines beyond the liver, with initial focus on renovascular disease
  • Round co-led by 4BIO Capital and IQ Capital, with participation from Verve Ventures, Harel Tech, Entree Capital, Kerna Ventures and Saras Capital

CAMBRIDGE, England & TEL AVIV, Israel–(BUSINESS WIRE)–Undecimal Bio (“Undecimal”), a platform biotechnology company advancing targeted delivery of siRNA therapeutics, today announced an oversubscribed $18 million USD seed financing. The Company, a spin-out from Eleven Therapeutics, will use the funding to expand DELiveri®, its proprietary AI-enabled platform for identifying conjugates that can direct RNA medicines to defined cell types, addressing a major constraint in genetic medicine delivery.


RNA interference has transformed the treatment of liver-expressed diseases, but reaching tissues beyond the liver remains a key obstacle limiting the broader potential of the modality. DELiveri addresses this challenge as a groundbreaking technology that screens massive-scale combinatorial libraries of candidate ligands, converting cells to act as molecular radars that detect productive delivery at single molecule resolution. This high throughput data is analysed by agentic AI to decode the resulting structure-activity data and identify conjugates capable of carrying siRNA into target cells.

Undecimal is initially applying the DELiveri platform in renovascular diseases, which pose significant unmet clinical need. Existing treatments of these indications largely address symptoms rather than the underlying etiological factors. Targeted siRNA delivery holds the potential to bring the digital-like precision of genetic medicines, enabling durable, target-specific silencing of the disease-driving pathways.

The round was co-led by 4BIO Capital and IQ Capital, with participation from Verve Ventures, Harel Tech, Entree Capital, Kerna Ventures and Saras Capital. The funding will be used to further development of the DELiveri platform, progress Undecimal’s renovascular programmes and enable expansion of the team at the Company’s laboratories based at the Cancer Research UK Cambridge Institute.

Undecimal has entered several research collaborations with big pharma companies, which are yet to be disclosed.

The Board of Directors comprises representatives of 4BIO Capital, IQ Capital and Harel Technologies, together with co-founders Dr. Yaniv Erlich and Shaul Ilan. Alongside the financing, Verve Ventures joins the Board as an observer.

“The hard problem in RNAi was never the silencing, it was getting the molecule to the right cell,” said Dr. Yaniv Erlich, CEO and Co-Founder of Undecimal Bio. “Our in-vivo validated DELiveri platform can screen large chemical spaces at an unprecedented pace, generating massive data for our legions of AI agents to decipher the structure-activity relationship and score the best candidates. We are excited to bring these advances to develop the next generation of siRNA therapeutics for the benefit of patients.”

Contacts

Notes to Editors

For further information please contact:

Zyme Communications
Lily Jeffery
Tel: +44(0)7891 477 378
Email: lily.jeffery@zymecommunications.com

Undecimal Bio
Dr. Yaniv Erlich
Email: contact@undecimalbio.com

PolyPeptide Group: Provisional interim result of the public tender offer of Samsung Biologics Co., Ltd.

PolyPeptide Group / Key word(s): Tender Offer

PolyPeptide Group: Provisional interim result of the public tender offer of Samsung Biologics Co., Ltd.

13-Oct-2026 / 07:10 CET/CEST

Release of an ad hoc announcement pursuant to Art. 53 LR

The issuer is solely responsible for the content of this announcement.


Media Release – ad hoc announcement pursuant to Art. 53 LR

Provisional interim result of the public tender offer of Samsung Biologics Co., Ltd.

Baar, Switzerland, 13 October 2026 – Samsung Biologics Co., Ltd. (“Samsung Biologics”), through its direct subsidiary Samsung Peptide AG (“Samsung Peptide”), today published the provisional interim result of its public tender offer (the “Offer”) for all publicly held registered shares of PolyPeptide Group AG (“PolyPeptide”) (SIX: PPGN).

The main offer period of the Offer ended on 12 October 2026, at 4:00 p.m. Swiss time. According to the provisional interim result as published by Samsung Peptide,

  • the participation of Samsung Peptide and the persons acting in concert with Samsung Peptide amounts to 29,123,892 PolyPeptide shares in aggregate, corresponding to 87.92% of the issued share capital and voting rights of PolyPeptide (participation rate); and
  • 29,014,418 PolyPeptide shares were tendered into the Offer until the end of the main offer period of the Offer, corresponding to 87.59% of the issued share capital and voting rights of PolyPeptide and 87.88% of all PolyPeptide shares to which the Offer relates (success rate).

The interim result that has been published today by Samsung Peptide is provisional and is available at https://samsungbiologics.com/offer. The definitive interim result is expected to be published on 16 October 2026. The provisional and the definitive end result of the Offer will be published after the end of the additional acceptance period (see below).

According to the provisional interim result as published by Samsung Peptide,

  • subject to confirmation of the preliminary numbers in the definitive interim result, the offer condition pursuant to section B.7.1(a) (Minimum Acceptance Rate) of the offer prospectus of Samsung Peptide dated 31 August 2026 (the “Offer Prospectus”) has been satisfied; and
  • in addition, the offer condition pursuant to section B.7.1(d) (No Material Adverse Effect) of the Offer Prospectus has also been satisfied.

The Offer remains subject to customary offer conditions, including the receipt of regulatory approvals in certain jurisdictions as well as the removal of the transfer restrictions and voting limitations from PolyPeptide’s articles of association and the election of the persons nominated by Samsung Biologics to the board of directors of PolyPeptide by resolution of an extraordinary general meeting of PolyPeptide. PolyPeptide has invited for an extraordinary general meeting to be held on 26 October 2026 to resolve on these matters.

According to the provisional interim result as published by Samsung Peptide, if the Offer is declared successful (zustande gekommen) in the definitive notice of the interim result, the additional acceptance period of ten (10) trading days for the subsequent acceptance of the Offer will commence on 19 October 2026 and end on 30 October 2026, 4:00 p.m. Swiss time, in accordance with section B.6 (Additional Acceptance Period) of the Offer Prospectus.

 

Contact

PolyPeptide Group AG
Strategic Marketing and Corporate Communications
Laura Rosso
mediateam@polypeptide.com
T: +41 43 502 0580

PolyPeptide Group AG
Finance / Investor Relations
Tim Brandl
investorrelations@polypeptide.com
T: +41 43 502 0580 
 

About PolyPeptide

PolyPeptide Group AG and its consolidated subsidiaries (“PolyPeptide”) is a specialized Contract Development & Manufacturing Organization (CDMO) for peptide-based active pharmaceutical ingredients. By supporting its customers mainly in pharma and biotech, it contributes to the health of millions of patients across the world. PolyPeptide serves a fast-growing market, offering products and services from pre-pre-clinical to commercial stages. Its broad portfolio reflects the opportunities in drug therapies across areas and with significant exposure to metabolic diseases, including GLP-1. Dating back to 1952, PolyPeptide today runs a global network of six GMP-certified facilities in Europe, the U.S. and India. PolyPeptide’s shares (SIX: PPGN) are listed on SIX Swiss Exchange. For more information, please visit polypeptide.com.

@PolyPeptide — follow us on LinkedIn

About Samsung Peptide and Samsung Biologics

Samsung Peptide is a direct subsidiary of Samsung Biologics. Samsung Biologics and PolyPeptide have concluded a transaction agreement on 17 July 2026 regarding the Offer. Samsung Peptide is acting as the formal offeror of the Offer. Samsung Biologics (KRX: 207940.KS) is a leading Contract Development & Manufacturing Organization (CDMO), offering end-to-end integrated services that range from late discovery to commercial manufacturing. With a combined biomanufacturing capacity of 785,000 liters across Bio Campus I and II in Korea, and 60,000 from the acquisition of a manufacturing facility in Rockville, Maryland, U.S., Samsung Biologics holds total global manufacturing capacity of 845,000 liters. Samsung Biologics has also secured land for Bio Campus III, laying the groundwork for future capacity expansion to support next-generation therapies and emerging modalities. Samsung Biologics leverages cutting-edge technologies and expertise to advance diverse modalities, including multispecific antibodies, fusion proteins, antibody-drug conjugates, and mRNA therapeutics. By implementing the ExellenS™ framework across its manufacturing network with standardized designs, unified processes, and advanced digitalization, Samsung Biologics ensures plant equivalency and speed for manufacturing continuity. Samsung Biologics’ global manufacturing and commercial network spans Korea, the U.S., and Japan. Samsung Biologics America supports clients based in the U.S. and Europe, while its Tokyo sales office serves the APAC region. Samsung Biologics continues to invest in new capabilities to maximize operational and quality excellence, ensuring flexibility and agility for clients. Samsung Biologics is committed to the on-time, in-full delivery of safe, high-quality biomedicines, as well as to making sustainable business decisions for the betterment of society and global health. For more information, please visit https://samsungbiologics.com. 

Legal Notice and Disclaimer

No Offer / Offer Restrictions

The information in this media release is for informational purposes only. It does not constitute, or form part of, any offer or invitation to purchase, sell, exchange or issue, or any solicitation of an offer to sell, purchase, exchange or subscribe to, any registered shares or other securities of PolyPeptide or any other person, nor shall it form the basis of, or be relied upon in connection with, any contract in relation thereto. This media release is not part of Samsung Peptide’s publication of the provisional interim result of the Offer or any other publication, communication or other documentation of Samsung Peptide or Samsung Biologics relating to the Offer, including without limitation the Offer Prospectus (the “Offer Documentation”). Terms and conditions of the Offer have been published by Samsung Peptide and Samsung Biologics in the Offer Documentation. Shareholders of PolyPeptide are urged to read the Offer Documentation, which is available at https://samsungbiologics.com/offer.

This announcement is not for publication, release or distribution in any country or jurisdiction in which it would be considered unlawful or otherwise violate any applicable laws or regulations, or which would require Samsung Peptide or Samsung Biologics to change or amend the terms or conditions of the Offer in any way, to make an additional filing with any governmental, regulatory or other authority or take additional action in relation to the Offer. Full Offer restrictions can be found in Samsung Peptide’s Offer Prospectus at https://samsungbiologics.com/offer.

Forward-looking Information and Statements

This media release has been prepared by PolyPeptide and includes forward-looking information and statements concerning the outlook for the Group’s business. These statements are based on current expectations, estimates and projections about the factors that may affect the Group’s future performance. These expectations, estimates and projections are generally identifiable by statements containing words such as ‘expects’, ‘believes’, ‘estimates’, ‘targets’, ‘plans’, ‘projects’, ‘outlook’ or similar expressions. There are numerous risks, uncertainties and other factors, many of which are beyond PolyPeptide’s control, that could cause the group’s actual results to differ materially from the forward-looking information and statements made in this media release and that could affect the group’s ability to achieve its stated targets. Although PolyPeptide believes that its expectations reflected in any such forward-looking statement are based upon reasonable assumptions, it can give no assurance that those expectations will be achieved.

Except as otherwise required by law, PolyPeptide disclaims any intention or obligation to update any forward-looking statements as a result of developments.

 

Additional features:

File: 20261013_PolyPeptide_Media Release_Tender Offer


End of Inside Information


Language: English
Company: PolyPeptide Group
Neuhofstrasse 24
6340 Baar
Switzerland
Phone: +41435020580
E-mail: mediateam@polypeptide.com
Internet: www.polypeptide.com
ISIN: CH1110760852
Valor: 111076085
Listed: SIX Swiss Exchange
EQS News ID: 2414494

 
End of Announcement EQS News Service

2414494  13-Oct-2026 CET/CEST

New Galderma Research Reveals More Than Half of Women Mistake Menopause-Related Skin Changes for Signs of Ageing

New Galderma Research Reveals More Than Half of Women Mistake Menopause-Related Skin Changes for Signs of Ageing




New Galderma Research Reveals More Than Half of Women Mistake Menopause-Related Skin Changes for Signs of Ageing

New clinical data identify optimized injectable aesthetics treatment protocol for menopause-induced skin changes




  • 56% of women have experienced ‘The Menopausal Skin Misread’, admitting they first put menopause-related skin changes down to ageing, while fewer than a third (29%) recognized menopause as the cause1
  • A significant knowledge gap remains: one in two women are unaware that hormonal changes during perimenopause and menopause can affect the skin, and 82% agree that better understanding the difference between menopause-related skin changes and general ageing would help them feel more informed and in control of their skincare decisions1
  • New data from an investigator-initiated trial (IIT) led by Dr. Andreas Nikolis and supported by Galderma, demonstrated that a sequenced treatment approach using Restylane Skinboosters followed by Sculptra delivered significant improvements in skin hydration and remodeling across the face and décolletage in menopausal women, highlighting the value of preconditioning the skin to optimize regenerative outcomes2-4

ZUG, Switzerland–(BUSINESS WIRE)–Galderma (SIX: GALD) today announced new global research revealing that more than half (56%) of women first put menopause-related skin changes down to general ageing, while only less than a third of women (29%) initially recognized the link to menopause.1 The research shines a light on ‘The Menopausal Skin Misread’, showing how aesthetic changes in the skin linked to menopause are still being misunderstood, mislabeled and too often attributed to ageing alone.1 Ahead of World Menopause Day, Galderma is calling attention to the misunderstood impact of menopause on the skin, helping to close the knowledge gap and empower women with the understanding needed to recognize and navigate menopause-related skin and aesthetic changes.

“Too many women are navigating changes in their skin without recognizing that menopause may be playing a role. Our research shows the scale of this knowledge gap and the need to move beyond a one-size-fits-all ageing narrative. At Galderma, we are committed to advancing the understanding of menopausal skin and providing women with clear, trusted information and science-backed solutions, so they can make informed choices and feel confident in their skin throughout this important stage of life.”

ANNE-CÉCILE CHEVRIER

GLOBAL HEAD, INJECTABLE AESTHETICS

GALDERMA

New international survey uncovers a significant lack of awareness between menopause-related aesthetic changes in the skin and those associated with ageing

Despite the impact menopause can have on the skin, Galderma’s research reveals that the topic remains largely overlooked in the wider menopause conversation, leaving many women unaware of the role hormonal changes may be playing in the aesthetic changes they see in their skin.1,2 More than half of women (56%) initially interpreted these changes as signs of ageing, while only 29% connected them to menopause.1 One in two women remain unaware that hormonal fluctuations during perimenopause and menopause can have a significant impact on skin, underscoring the need for greater education in this area.1

This misread is also influencing skincare purchases: 70% have bought products designed to address signs of ageing because they believed they would help with skin changes experienced during perimenopause or menopause.1 Finding the right information can be challenging too: 62% of women have felt overwhelmed by skincare advice during the menopause or perimenopause, with almost half of those struggling to find clear information saying advice was too general and focused on ageing rather than menopause.1

There is a clear appetite for greater clarity, with over 80% of women agreeing that better understanding the difference between general ageing and menopause-related skin changes would help them feel more informed and in control of their skincare decisions.1

New clinical data identify optimized injectable aesthetics treatment protocol for menopause-induced skin changes

New results from an eight-month investigator-initiated trial (IIT) supported by Galderma and conducted by Dr. Andreas Nikolis, both on the face and the décolletage, demonstrated that the combination of Restylane Skinboosters and Sculptra delivered sustained improvements in skin hydration, quality, remodeling, as well as patient satisfaction in menopausal women.2 Patients were divided into two groups and treated with either Restylane Skinboosters-first, Sculptra-second, or Sculptra-first, Restylane Skinboosters-second.2

Women treated with Restylane Skinboosters-first, followed by Sculptra, demonstrated an earlier visible clinical response and greater dermal remodeling, with facial dermal thickness increasing by 27.3% compared with 15.7% in the Sculptra-first, Restylane Skinboosters-second group, highlighting the value of preconditioning the skin to maximize regenerative outcomes.2

“This first-of-its-kind clinical study provides compelling evidence that sequencing treatments can deliver significantly greater benefits than either approach alone in menopausal skin. By first using Restylane Skinboosters to rapidly improve hydration and optimize the skin microenvironment, followed by Sculptra to stimulate collagen production and progressive tissue remodeling, more favorably, we are now able to address both the immediate and longer-term biologic changes associated with menopause. The result is a strongly supported scientific treatment strategy that combines rapid improvement in hydration with sustained enhancement in skin quality and remodeling, while achieving high levels of patient satisfaction. These findings provide clinicians with a new evidence-based framework for treating menopausal skin.”

DR. ANDREAS NIKOLIS

BOARD-CERTIFIED PLASTIC SURGEON

MONTREAL, CANADA

Both groups achieved meaningful hydration improvements and high satisfaction levels, with 98% reporting natural-looking results, 96% saying they would recommend the treatments and 92% stating they would undergo treatment again, highlighting the complementary benefits of both products in addressing the skin changes associated with menopause.2

As part of its commitment to support women during this transition, Galderma has announced the launch of a new ‘Rewriting the Future of Your Skin, Own your Menopause Story’ campaign, bringing together science and the real experiences of women to shine a light on menopausal skin and help close the knowledge gap revealed by the research. More information here.

Ahead of World Menopause Day on 18 October, Galderma is calling for a new conversation around menopausal skin: one that recognizes the role hormonal changes can play, separates menopausal skin and aesthetic changes from generic ageing narratives and gives women clearer information to understand what is happening to their skin to make more informed choices about what it needs.

ENDS

Notes to editors:

The research was conducted by Perspectus Global among a sample of 5,090 women who have experienced or are experiencing perimenopause or menopause across the UK, US, Brazil and China. The data was collected between 25 August and 1 September 2026.

About Galderma

Galderma (SIX: GALD) is the pure-play dermatology category leader, present in approximately 90 countries. We deliver an innovative, science-based portfolio of premium flagship brands and services that span the full spectrum of the fast-growing dermatology market through Injectable Aesthetics, Dermatological Skincare and Therapeutic Dermatology. Since our foundation in 1981, we have dedicated our focus and passion to the human body’s largest organ – the skin – meeting individual consumer and patient needs with superior outcomes in partnership with healthcare professionals. Because we understand that the skin we are in shapes our lives, we are advancing dermatology for every skin story. For more information: www.galderma.com.

References

  1. Galderma. Data on file. Menopause patient survey; Wave 2 research. September 2026.
  2. Nikolis A. Prospective evaluation of treatment sequencing in menopausal patients: The role of preconditioning. Data on file. September 2026
  3. Restylane® Skinboosters Vital Lidocane™. EU Instructions for Use.
  4. Sculptra®. EU Instructions for Use.

Contacts

Christian Marcoux, M.Sc.

Chief Communications Officer

christian.marcoux@galderma.com
+41 76 315 26 50

Richard Harbinson

Corporate Communications Director

richard.harbinson@galderma.com
+41 76 210 60 62

Céline Buguet

Franchises and R&D Communications Director

celine.buguet@galderma.com
+41 76 249 90 87

Emil Ivanov

Head of Strategy, Investor Relations, and ESG

emil.ivanov@galderma.com
+41 21 642 78 12

Jessica Cohen

Investor Relations and Strategy Director

jessica.cohen@galderma.com
+41 21 642 76 43

TWINBIRD Launches Ultra-Low Temperature Portable Freezer SC-UF25 to Enable a Dry-Ice-Free Cold Chain for Research Samples

TWINBIRD Launches Ultra-Low Temperature Portable Freezer SC-UF25 to Enable a Dry-Ice-Free Cold Chain for Research Samples




TWINBIRD Launches Ultra-Low Temperature Portable Freezer SC-UF25 to Enable a Dry-Ice-Free Cold Chain for Research Samples

TSUBAME, Japan–(BUSINESS WIRE)–#ColdChain—TWINBIRD Corporation has announced the launch of the SC-UF25 Ultra-Low Temperature Portable Freezer, a compact 25-litre freezer capable of reaching temperatures as low as −86°C. Scheduled for release in November 2026, the new product expands the company’s line-up of solutions powered by its Free-Piston Stirling Cooler (FPSC) technology.




As life-science fields such as regenerative medicine, cell therapy and drug discovery continue to advance, reliable ultra-low-temperature management of research samples is becoming increasingly important. Although storage technologies have evolved, transport and temporary storage often depend on dry ice, posing challenges to temperature stability, operational efficiency and environmental impact. This has increased demand among researchers, laboratories and research organisations for sustainable cold-chain solutions that can maintain ultra-low temperatures from storage through to transport.

To address these challenges, TWINBIRD developed the SC-UF25 using its FPSC technology, which employs helium gas as a refrigerant. The freezer achieves temperatures down to −86°C while remaining compact and lightweight. It supports standard AC power input of 100–240 V, 50/60 Hz, enabling flexible use for stationary storage as well as transport within research facilities and between locations.

Key features include precise temperature control from −86°C to −20°C in 1°C increments, low-vibration and a compact design suitable for laboratories and research institutions where installation space is limited. The product also incorporates precision components manufactured in the renowned Tsubame-Sanjo region of Japan, drawing on advanced engineering expertise developed through decades of manufacturing excellence.

By enabling storage and transport in a −86°C environment, the SC-UF25 helps reduce dependence on dry ice while improving the stability and efficiency of ultra-low temperature cold-chain operations. Through the application of FPSC technology, TWINBIRD aims to support the preservation of high-value research materials and contribute to the advancement of life-science research and operations.

The SC-UF25 will be showcased at MEDICA 2026, one of the world’s largest trade fairs for the medical and life-science sectors, held in Düsseldorf, Germany, from 16 to 19 November 2026, where TWINBIRD will highlight the product’s contribution to sustainable ultra-low temperature cold-chain applications for research, laboratory and life-science use.

Disclaimer: The SC-UF25 is for research, laboratory and life-science cold-chain use only. It is not registered under the EU Medical Device Regulation and is not intended for diagnosis, treatment, clinical decisions, or patient care.

Contacts

SC Business Sales, TWINBIRD Corporation fpsc@twinbird.co.jp