IPSEN – Buy-back programme – Art 5 of MAR – Week 38 – 2025

IPSEN – Buy-back programme – Art 5 of MAR – Week 38 – 2025




IPSEN – Buy-back programme – Art 5 of MAR – Week 38 – 2025

Aggregated presentation by day and by market

Statement of transactions in own shares from September 15th to September 19th 2025

             
Name of the issue Identity code of the issuer
(Legal Entity Identifier)
Day of the transaction Identity code of the financial instrument Total daily volume (in number of shares) Daily weighted average purchase price of the shares Market (MIC Code)
IPSEN 549300M6SGDPB4Z94P11 15/09/2025 FR0010259150 300 118,40 AQEU
IPSEN 549300M6SGDPB4Z94P11 15/09/2025 FR0010259150 600 118,40 CCXE
IPSEN 549300M6SGDPB4Z94P11 15/09/2025 FR0010259150 300 118,40 TQEX
IPSEN 549300M6SGDPB4Z94P11 15/09/2025 FR0010259150 3400 119,279 XPAR
IPSEN 549300M6SGDPB4Z94P11 16/09/2025 FR0010259150 300 117,10 AQEU
IPSEN 549300M6SGDPB4Z94P11 16/09/2025 FR0010259150 600 117,30 CCXE
IPSEN 549300M6SGDPB4Z94P11 16/09/2025 FR0010259150 300 117,20 TQEX
IPSEN 549300M6SGDPB4Z94P11 16/09/2025 FR0010259150 3226 117,19544 XPAR
IPSEN 549300M6SGDPB4Z94P11 17/09/2025 FR0010259150 300 115,70 AQEU
IPSEN 549300M6SGDPB4Z94P11 17/09/2025 FR0010259150 600 115,90 CCXE
IPSEN 549300M6SGDPB4Z94P11 17/09/2025 FR0010259150 300 115,63333 TQEX
IPSEN 549300M6SGDPB4Z94P11 17/09/2025 FR0010259150 3299 115,75171 XPAR
IPSEN 549300M6SGDPB4Z94P11 18/09/2025 FR0010259150 192 114,46875 AQEU
IPSEN 549300M6SGDPB4Z94P11 18/09/2025 FR0010259150 600 114,80 CCXE
IPSEN 549300M6SGDPB4Z94P11 18/09/2025 FR0010259150 300 114,00 TQEX
IPSEN 549300M6SGDPB4Z94P11 18/09/2025 FR0010259150 3239 115,16554 XPAR
IPSEN 549300M6SGDPB4Z94P11 19/09/2025 FR0010259150 300 115,30 AQEU
IPSEN 549300M6SGDPB4Z94P11 19/09/2025 FR0010259150 600 115,60 CCXE
IPSEN 549300M6SGDPB4Z94P11 19/09/2025 FR0010259150 300 115,30 TQEX
IPSEN 549300M6SGDPB4Z94P11 19/09/2025 FR0010259150 3400 114,85218 XPAR
        22456 116,41844  

Attachment

Semnur Pharmaceuticals, Inc. (“Semnur”), a Majority Owned Subsidiary of Scilex Holding Company (Nasdaq: SCLX, “Scilex”) Announces Signing of a Securities Purchase Agreement with an Institutional Investor for the Purchase of $100 Million of shares of Semnur Common Stock in Exchange for $100 Million in Bitcoin

Semnur Pharmaceuticals, Inc. (“Semnur”), a Majority Owned Subsidiary of Scilex Holding Company (Nasdaq: SCLX, “Scilex”) Announces Signing of a Securities Purchase Agreement with an Institutional Investor for the Purchase of $100 Million of shares of Semnur Common Stock in Exchange for $100 Million in Bitcoin




Semnur Pharmaceuticals, Inc. (“Semnur”), a Majority Owned Subsidiary of Scilex Holding Company (Nasdaq: SCLX, “Scilex”) Announces Signing of a Securities Purchase Agreement with an Institutional Investor for the Purchase of $100 Million of shares of Semnur Common Stock in Exchange for $100 Million in Bitcoin

PALO ALTO, Calif., Sept. 23, 2025 (GLOBE NEWSWIRE) — Semnur Pharmaceuticals, Inc. (“Semnur” or the “Company”) (OTC: SMNR, SMNRW) , a clinical late-stage specialty pharmaceutical company focused on the development and commercialization of novel non-opioid pain therapies, today announced that it has entered into a Securities Purchase Agreement (“SPA”) with the institutional investor for the purchase of $100 million of shares of Semnur common stock in exchange for $100 million in Bitcoin (BTC).

The institutional investor will receive an aggregate of 6,250,000 shares of Semnur common stock at a purchase price of $16.00 per share (in each case subject to adjustment for stock splits, stock dividends, recapitalizations, reorganizations, reclassification, combinations, reverse stock splits or other similar events occurring after the date of the SPA). The transactions contemplated by the SPA are subject to customary closing conditions, including regarding the accuracy of the parties’ respective representations and warranties as well as the performance of the parties’ respective covenants, and is expected to close in the near future.

The offer and sale of the shares of Semnur common stock pursuant to the SPA are being made in transactions not involving a public offering and have not been registered pursuant to Section 4(a)(2) of the Securities Act of 1933, as amended (the “Securities Act”), and/or Rule 506(b) of Regulation D promulgated thereunder and have not been registered under the Securities Act or applicable state securities laws. Accordingly, the shares of Semnur common stock sold pursuant to the SPA may not be reoffered or resold in the United States except pursuant to an effective registration statement or an applicable exemption from the registration requirements of the Securities Act and such applicable state securities laws.

This press release shall not constitute an offer to sell or a solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such state or jurisdiction.

Semnur has engaged Biconomy.com (“Biconomy”) to collaborate on future crypto currency strategies which includes crypto currency reserve build up, treasury management, and strategy implementation. Biconomy will provide professional services to assist Semnur’s crypto market entry. “I am very excited to work with Semnur on their next endeavor in the crypto space. The experience, forward-thinking, and the services that we have in the crypto space will prove to be a valuable asset to Semnur in various crypto currency projects,” said Dmitry Sheludko, CEO of Bioconomy.com.

JW Capital Securities Limited served as the financial advisor for this transaction.

For more information on Semnur Pharmaceuticals, Inc., refer to www.semnurpharma.com.

About Semnur Pharmaceuticals, Inc.

Semnur is a clinical late-stage specialty pharmaceutical company focused on the development and commercialization of novel non-opioid pain therapies. Semnur’s product candidate, SP-102 (SEMDEXA™), is the first non-opioid novel gel formulation administered epidurally in development for patients with moderate to severe chronic radicular pain/sciatica.

Semnur Pharmaceuticals, Inc. is headquartered in Palo Alto, California.

About Scilex Holding Company

Scilex is an innovative revenue-generating company focused on acquiring, developing and commercializing non-opioid pain management products for the treatment of acute and chronic pain and neurodegenerative and cardiometabolic disease. Scilex targets indications with high unmet needs and large market opportunities with non-opioid therapies for the treatment of patients with acute and chronic pain and is dedicated to advancing and improving patient outcomes. Scilex’s commercial products include: (i) ZTlido® (lidocaine topical system) 1.8%, a prescription lidocaine topical product approved by the U.S. Food and Drug Administration (the “FDA”) for the relief of neuropathic pain associated with postherpetic neuralgia, which is a form of post-shingles nerve pain; (ii) ELYXYB®, a potential first-line treatment and the only FDA-approved, ready-to-use oral solution for the acute treatment of migraine, with or without aura, in adults; and (iii) Gloperba®, the first and only liquid oral version of the anti-gout medicine colchicine indicated for the prophylaxis of painful gout flares in adults.

In addition, Scilex has three product candidates: (i) SP-102 (10 mg, dexamethasone sodium phosphate viscous gel) (“SEMDEXA” or “SP-102”), which is owned by Semnur and is a novel, viscous gel formulation of a widely used corticosteroid for epidural injections to treat lumbosacral radicular pain, or sciatica, for which Scilex has completed a Phase 3 study and was granted Fast Track status from the FDA in 2017; (ii) SP-103 (lidocaine topical system) 5.4%, (“SP-103”), a next-generation, triple-strength formulation of ZTlido, for the treatment of acute pain and for which Scilex has recently completed a Phase 2 trial in acute low back pain. SP-103 has been granted Fast Track status from the FDA in low back pain; and (iii) SP-104 (4.5 mg, low-dose naltrexone hydrochloride delayed-release capsules) (“SP-104”), a novel low-dose delayed-release naltrexone hydrochloride being developed for the treatment of fibromyalgia.

Scilex is headquartered in Palo Alto, California.

Forward-Looking Statements        

This press release includes forward-looking statements that involve risks and uncertainties. Forward-looking statements are statements that are not historical facts and may be accompanied by words that convey projected future events or outcomes, such as “believe,” “may,” “will,” “estimate,” “continue,” “anticipate,” “intend,” “expect,” “should,” “would,” “plan,” “predict,” “potential,” “seem,” “seek,” “future,” “outlook” or variations of such words or by expressions of similar meaning. These forward-looking statements include, but are not limited to, statements regarding future events, timing to complete the transactions contemplated by the SPA and the anticipated proceeds thereof, the SPA, the estimated or anticipated future results and benefits of the transactions contemplated by the SPA and the engagement of Biconomy, Semnur’s future plans for crypto currency reserve build up, treasury management and strategy implementation with BTC, future opportunities for Semnur and its subsidiaries, the future business strategies, long-term objectives and commercialization plans of Semnur and its subsidiaries, the current and prospective product candidates, planned clinical trials and preclinical activities and potential product approvals, as well as the potential for market acceptance of any approved products and the related market opportunity of Scilex and its subsidiaries, statements regarding SP-102, if approved by the FDA, Semnur’s potential to attract new capital and avoid the effects of negative debt leverage and other statements that are not historical facts. These statements are based on management’s current expectations of and are not predictions of actual performance. These forward-looking statements are provided for illustrative purposes only and are not intended to serve as, and must not be relied on, by any investor as a guarantee, an assurance, a prediction or a definitive statement of fact or probability. Actual events and circumstances are difficult or impossible to predict and will differ from assumptions. Many actual events and circumstances are beyond the control of Semnur. These statements are subject to a number of risks and uncertainties regarding Semnur’s businesses and the transactions contemplated by the SPA and the engagement of Biconomy, and actual results may differ materially. These risks and uncertainties include, but are not limited to, general economic, political and business conditions; the ability of Semnur and its subsidiaries to achieve the benefits of the transactions contemplated by the SPA, including future financial and operating results; risks related to the outcome of any legal proceedings that may be instituted against the parties regarding the transactions contemplated by the SPA or the engagement of Biconomy; the risk that the transactions contemplated by the SPA or the engagement of Biconomy disrupts current plans and operations; the ability of Semnur and its subsidiaries to develop and successfully market products; the ability of Semnur and its subsidiaries to grow and manage growth profitably and retain its key employees; the risk that the potential product candidates that Semnur develops may not progress through clinical development or receive required regulatory approvals within expected timelines or at all; risks relating to uncertainty regarding the regulatory pathway for Semnur’s product candidates; the risk that Semnur’s product candidates may not be beneficial to patients or successfully commercialized; the risk that Semnur has overestimated the size of the target patient population, their willingness to try new therapies and the willingness of physicians to prescribe these therapies; risks that the prior results of the clinical trials may not be replicated; regulatory and intellectual property risks; the risk of failure to realize the anticipated benefits of the transactions contemplated by the SPA or the engagement of Biconomy and other risks and uncertainties indicated from time to time and other risks set forth in Semnur’s filings with the SEC. There may be additional risks that Semnur presently does not know or that Semnur currently believes are immaterial that could also cause actual results to differ from those contained in the forward-looking statements. In addition, forward-looking statements provide Semnur’s expectations, plans or forecasts of future events and views as of the date of the communication. Semnur anticipates that subsequent events and developments will cause such assessments to change. However, while Semnur may elect to update these forward-looking statements at some point in the future, Semnur specifically disclaims any obligation to do so. These forward-looking statements should not be relied upon as representing Semnur’s assessments as of any date subsequent to the date of this communication. Accordingly, investors are cautioned not to place undue reliance on these forward-looking statements.

Contacts:

Investors and Media
Semnur Pharmaceuticals, Inc.
960 San Antonio Road
Palo Alto, CA 94303
Office: (650) 422-7515

Email: investorrelations@semnurpharma.com 

Website: www.semnurpharma.com

SEMDEXA™ (SP-102) is a trademark owned by Semnur Pharmaceuticals, Inc., a majority-owned subsidiary of Scilex Holding Company. A proprietary name review by the FDA is planned.

All other trademarks are the property of their respective owners.

© 2025 Semnur Pharmaceuticals, Inc. All Rights Reserved.

3 Day Virtual Biostatistics for the Non-Statistician Training Course: Understand Statistical Concepts and Findings As Applies to Clinical Research (ONLINE EVENT: October 22-24, 2025) – ResearchAndMarkets.com

3 Day Virtual Biostatistics for the Non-Statistician Training Course: Understand Statistical Concepts and Findings As Applies to Clinical Research (ONLINE EVENT: October 22-24, 2025) – ResearchAndMarkets.com




3 Day Virtual Biostatistics for the Non-Statistician Training Course: Understand Statistical Concepts and Findings As Applies to Clinical Research (ONLINE EVENT: October 22-24, 2025) – ResearchAndMarkets.com

DUBLIN–(BUSINESS WIRE)–The “Biostatistics for the Non-Statistician Training Course (Oct 22nd – Oct 24th, 2025)” training has been added to ResearchAndMarkets.com’s offering.


Learn Biostatistics for the Non-Statistician

The focus of the seminar is to give you the information and skills necessary to understand statistical concepts and findings as applies to clinical research, and to confidently convey the information to others.

Statistics is a useful decision making tool in the clinical research arena. When working in a field where a p-value can determine the next steps on development of a drug or procedure, it is imperative that decision makers understand the theory and application of statistics.

Many statistical softwares are now available to professionals. However, these softwares were developed for statisticians and can often be daunting to non-statisticians. How do you know if you are pressing the right key, let alone performing the best test?

This seminar provides a non-mathematical introduction to biostatistics and is designed for non-statisticians. And it will benefit professionals who must understand and work with study design and interpretation of findings in a clinical or biotechnology setting.

Emphasis will be placed on the actual statistical (a) concepts, (b) application, and (c) interpretation, and not on mathematical formulas or actual data analysis. A basic understanding of statistics is desired, but not necessary.

Learning objectives

  • Understand the statistical portions of most articles in medical journals.
  • Do simple calculations, especially ones that help in interpreting published literature.
  • Avoid being misled by foolish findings.
  • Knowledge of which test when, why, and how.
  • Perform simple analyses in statistical software.
  • Communicate statistical findings to others more clearly.

Who Should Attend:

  • Physicians
  • Clinical Research Associates
  • Clinical Project Managers/Leaders
  • Sponsors
  • Regulatory Professionals who use statistical concepts/terminology in reporting
  • Medical Writers who need to interpret statistical reports
  • Clinical research organizations, hospitals, researchers in health and biotech fields.
  • Persons working in the medical or health sciences, pharmaceutical and or nutriceutical industries, clinical trials, clinical research, and clinical research organizations, physicians, medical students, graduate students in the biological sciences, researchers, and medical writers who need to interpret statistical reports.

Key Topics Covered:

Agenda Day 1: Basics

Session 1: Why Statistics

  • Do we really need statistical tests?
  • Sample vs. Population
  • I’m a statistician not a magician! What statistics can and can’t do
  • Descriptive statistics and measures of variability

Session 2: The many ways of interpretation

  • Confidence intervals
  • p-values
  • Effect sizes
  • Clinical vs. meaningful significance

Break – 10 mins

Session 3: Types of Data and Descriptive Statistics

  • Levels of data: Continuous, Ordinal, Nominal
  • Normal distribution and it’s importance
  • Graphical representations of data
  • Data transformations, when and how

Break 10 mins

Session 4: Common Statistical Tests

  • Comparative tests
  • Simple and Multiple regression analysis
  • Non-parametric techniques

Q&A

Agenda Day 2: Special Topics

Session 1: Logistic Regression

  • When and why?
  • Interpretation of odd ratios
  • Presentation of logistic regression analysis and interpretation
  • Fun with contingency tables

Session 2: Survival Curves and Cox Regression

  • History, theory, and nomenclature of survival analysis
  • Kaplan-Meier Curves and Log Rank Tests
  • Proportional Hazards
  • Interpretation of hazard ratios
  • Presentation of KM curves and Cox regression analysis and interpretation

Break 10 mins

Session 3: Bayesian Logics

  • A different way of thinking
  • Bayesian methods and statistical significance
  • Bayesian applications to diagnostics testing
  • Bayesian applications to genetics

Break 10 mins

Session 4: Systematic Reviews and Meta-Analysis

  • Why perform a systematic reviews and/or meta-analysis?
  • A bit of history and reasoning for systematic reviews and/or meta analysis
  • Terminology
  • Steps in Performing a Systematic Review
  • Steps in Performing a Meta-Analysis

Agenda Day 3: Further Understanding in Clinical Research

Session 1: Other Tests

  • Non-Parametric tests
  • Test for equivalency
  • Test for non-inferiority

Break 10 mins

Session 2: Power and Sample Size

  • Theory, steps, and formulas for determining sample sizes
  • Demonstration of sample size calculations with GPower software

Session 3: How to Review a Journal Article

  • General steps on article review
  • Determining the quality of a journal or journal article
  • Looking for limitations (all studies have them)

Break 10 mins

Session 4: Developing a Statistical Analysis Plan

  • Using FDA (for the U.S. audience) or MHRA (for the U.K. audience) guidance as a foundation, learn the steps and criteria needed to develop a statistical analysis plan (SAP)
  • An SAP template will be given to all attendees

Speakers:

Elaine Eisenbeisz

Owner & Principal

Omega Statistics

Elaine Eisenbeisz is a private practice statistician and owner of Omega Statistics, a statistical consulting firm based in Southern California. Elaine has over 30 years of experience in creating data and information solutions for industries ranging from governmental agencies and corporations, to start-up companies and individual researchers.

Elaine’s love of numbers began in elementary school where she placed in regional and statewide mathematics competitions. She attended the University of California, Riverside, as a National Science Foundation scholar, where she earned a B.S. in Statistics with a minor in Quantitative Management, Accounting. Elaine received her Master’s Certification in Applied Statistics from Texas A&M, and is currently finishing her graduate studies at Rochester Institute of Technology.

For more information about this training visit https://www.researchandmarkets.com/r/gqkq08

About ResearchAndMarkets.com

ResearchAndMarkets.com is the world’s leading source for international market research reports and market data. We provide you with the latest data on international and regional markets, key industries, the top companies, new products and the latest trends.

Contacts

ResearchAndMarkets.com

Laura Wood, Senior Press Manager

press@researchandmarkets.com
For E.S.T Office Hours Call 1-917-300-0470

For U.S./ CAN Toll Free Call 1-800-526-8630

For GMT Office Hours Call +353-1-416-8900

Confluent Health Appoints Jim Greenwood as New Board Chair

Confluent Health Appoints Jim Greenwood as New Board Chair




Confluent Health Appoints Jim Greenwood as New Board Chair

Veteran healthcare executive to lead Board of Directors as company accelerates national growth in musculoskeletal care

LOUISVILLE, Ky., Sept. 23, 2025 (GLOBE NEWSWIRE) — Confluent Health, a national leader in musculoskeletal (MSK) health and physical therapy services, is pleased to announce the appointment of Jim Greenwood as Chair of its Board of Directors.

Greenwood, a mission-driven executive with decades of experience scaling healthcare organizations, brings deep expertise in provider services, value-based care models, and strategic growth. His appointment marks a new chapter in Confluent Health’s efforts to build a stronger nationwide network of MSK experts grounded in clinical excellence, whole-person care and nationwide access to solutions.

“We are thrilled to welcome Jim Greenwood as our new Board Chair,” said Dr. Kristi Henderson, CEO of Confluent Health. “Jim’s reputation as a transformative leader, his passion for mentorship and his ability to scale organizations while maintaining clinical integrity and culture make him the ideal partner for this next chapter of growth.”

Greenwood brings extensive leadership experience across a range of healthcare services. He spent nearly two decades at Concentra, culminating in the role of CEO, where he played a key role in its expansion from a 30-physician group to over 1,000 affiliated physicians through more than 150 acquisitions and an IPO before its acquisition by Humana. As CEO of Vision Source, Greenwood led the nation’s largest network of private optometry practices through its sale to Essilor-Luxottica. Most recently, he served as Executive Chairman of Retina Consultants of America, which was acquired by Cencora for $4.6 billion in early 2025.

“I’m honored to serve as Board Chair for an organization as impactful and purpose driven as Confluent Health,” said Greenwood. “This is a company built on clinical excellence and innovative care models. I’m excited to partner with Kristi, the executive team and our outstanding clinicians to help guide the organization’s continued growth and national leadership in MSK care.”

“Jim’s track record of leadership in building world-class healthcare companies will be very valuable in continuing Confluent Health’s mission and momentum,” said Piotr Biezychudek, Managing Director, Private Equity, at Partners Group, one of the largest firms in the global private markets industry, which acquired Confluent Health in 2019, on behalf of its clients. “We are confident he will help accelerate Confluent Health’s growth trajectory while preserving its patient-centered culture.”

Greenwood assumes the role of Board Chair effective immediately.

About Confluent Health
Confluent Health, a nationwide network of physical and occupational therapy companies, is at the forefront of advancing musculoskeletal solutions that make us all stronger. We deliver better patient outcomes, reduce costs of care, improve workplace wellness, provide best-in-class education services, help prevent injuries and play a crucial role in shaping industry best practices. For more information, visit confluenthealth.com or find us on LinkedIn.

About Partners Group
Partners Group is one of the largest firms in the global private markets industry, with around 1’800 professionals and over USD 174 billion in assets under management. The firm has investment programs and custom mandates spanning private equity, private credit, infrastructure, real estate, and royalties. With its heritage in Switzerland and its primary presence in the Americas in Colorado, Partners Group is built differently from the rest of the industry. The firm leverages its differentiated culture and its operationally oriented approach to identify attractive investment themes and to build businesses and assets into market leaders. For more information, please visit www.partnersgroup.com or follow us on LinkedIn.

Media Contact:
Caitlin Greenwell
270-668-7886
cgreenwell@goconfluent.com

A photo accompanying this announcement is available at https://www.globenewswire.com/NewsRoom/AttachmentNg/9b94d988-d154-4c20-a18d-1c18772cf960

Confluent Health Appoints Jim Greenwood as New Board Chair

Confluent Health Appoints Jim Greenwood as New Board Chair




Confluent Health Appoints Jim Greenwood as New Board Chair

Veteran healthcare executive to lead Board of Directors as company accelerates national growth in musculoskeletal care

LOUISVILLE, Ky., Sept. 23, 2025 (GLOBE NEWSWIRE) — Confluent Health, a national leader in musculoskeletal (MSK) health and physical therapy services, is pleased to announce the appointment of Jim Greenwood as Chair of its Board of Directors.

Greenwood, a mission-driven executive with decades of experience scaling healthcare organizations, brings deep expertise in provider services, value-based care models, and strategic growth. His appointment marks a new chapter in Confluent Health’s efforts to build a stronger nationwide network of MSK experts grounded in clinical excellence, whole-person care and nationwide access to solutions.

“We are thrilled to welcome Jim Greenwood as our new Board Chair,” said Dr. Kristi Henderson, CEO of Confluent Health. “Jim’s reputation as a transformative leader, his passion for mentorship and his ability to scale organizations while maintaining clinical integrity and culture make him the ideal partner for this next chapter of growth.”

Greenwood brings extensive leadership experience across a range of healthcare services. He spent nearly two decades at Concentra, culminating in the role of CEO, where he played a key role in its expansion from a 30-physician group to over 1,000 affiliated physicians through more than 150 acquisitions and an IPO before its acquisition by Humana. As CEO of Vision Source, Greenwood led the nation’s largest network of private optometry practices through its sale to Essilor-Luxottica. Most recently, he served as Executive Chairman of Retina Consultants of America, which was acquired by Cencora for $4.6 billion in early 2025.

“I’m honored to serve as Board Chair for an organization as impactful and purpose driven as Confluent Health,” said Greenwood. “This is a company built on clinical excellence and innovative care models. I’m excited to partner with Kristi, the executive team and our outstanding clinicians to help guide the organization’s continued growth and national leadership in MSK care.”

“Jim’s track record of leadership in building world-class healthcare companies will be very valuable in continuing Confluent Health’s mission and momentum,” said Piotr Biezychudek, Managing Director, Private Equity, at Partners Group, one of the largest firms in the global private markets industry, which acquired Confluent Health in 2019, on behalf of its clients. “We are confident he will help accelerate Confluent Health’s growth trajectory while preserving its patient-centered culture.”

Greenwood assumes the role of Board Chair effective immediately.

About Confluent Health
Confluent Health, a nationwide network of physical and occupational therapy companies, is at the forefront of advancing musculoskeletal solutions that make us all stronger. We deliver better patient outcomes, reduce costs of care, improve workplace wellness, provide best-in-class education services, help prevent injuries and play a crucial role in shaping industry best practices. For more information, visit confluenthealth.com or find us on LinkedIn.

About Partners Group
Partners Group is one of the largest firms in the global private markets industry, with around 1’800 professionals and over USD 174 billion in assets under management. The firm has investment programs and custom mandates spanning private equity, private credit, infrastructure, real estate, and royalties. With its heritage in Switzerland and its primary presence in the Americas in Colorado, Partners Group is built differently from the rest of the industry. The firm leverages its differentiated culture and its operationally oriented approach to identify attractive investment themes and to build businesses and assets into market leaders. For more information, please visit www.partnersgroup.com or follow us on LinkedIn.

Media Contact:
Caitlin Greenwell
270-668-7886
cgreenwell@goconfluent.com

A photo accompanying this announcement is available at https://www.globenewswire.com/NewsRoom/AttachmentNg/9b94d988-d154-4c20-a18d-1c18772cf960

PathAI Launches Industry-Backed AIM-HI UC Model on GCP-Compliant Platform to Standardize Histological Assessment in Ulcerative Colitis Trials

PathAI Launches Industry-Backed AIM-HI UC Model on GCP-Compliant Platform to Standardize Histological Assessment in Ulcerative Colitis Trials




PathAI Launches Industry-Backed AIM-HI UC Model on GCP-Compliant Platform to Standardize Histological Assessment in Ulcerative Colitis Trials

BOSTON, Sept. 23, 2025 (GLOBE NEWSWIRE) — PathAI, the global leader in AI-powered pathology, today announced the integration of AIM-HI UC1, an advanced AI model for Ulcerative Colitis (UC) histology endpoint assessment, on to AISight™ Clinical Trials, PathAI’s GCP and GCLP-compliant platform.

AIM-HI UC1 was developed by the Foundation for the National Institutes of Health (FNIH) Biomarkers Consortium’s Mucosal Healing in Ulcerative Colitis Project Team, a collaboration uniting eight of the world’s leading biopharmaceutical companies, representatives from the U.S. Food and Drug Administration (FDA), and renowned researchers in UC. This integration marks a significant step toward advancing standardized, AI-driven histological evaluation in clinical trials for Ulcerative Colitis.

AIM-HI UC was developed and evaluated for exploratory or secondary clinical trial endpoint use. The availability of this algorithm on AISight™ Clinical Trials creates a powerful, end-to-end solution for biopharmaceutical clinical trial sponsors, combining industry-leading AI technology with PathAI’s comprehensive histology lab services.

AIM-HI UC is an AI-assist product designed to enhance the pathologist’s reading experience. Using routine, H&E-stained UC biopsies, the algorithm provides pathologists with a highly reproducible, consensus-trained first read, standardizing the assessment of histological disease activity and reducing the well-known variability of manual scoring. A key feature of the tool is its ability to simultaneously generate scores for all three of the main histological scoring systems—the Geboes Score, Robarts Histopathology Index (RHI), and Nancy Histologic Index (NHI)—providing a comprehensive and standardized output from a single read.

“The collaborative development of this algorithm through the FNIH Biomarkers Consortium represents a landmark achievement in standardizing histological endpoints for Ulcerative Colitis,” said Ben Glass, SVP of Product, Research and AI at PathAI. “By co-developing this product with industry partners and integrating into our AISight Clinical Trials platform, we are offering a solution that is not only scientifically robust but also operationally seamless. It pairs directly with our end-to-end histology services at our biopharma lab in Memphis, providing our partners with a single, GCLP-compliant vendor for their complete clinical trial pathology needs.”

The challenges in IBD drug development are often compounded by the subjectivity of histological assessment. Through providing quantitative and reproducible UC histology scores, AIM-HI UC helps de-risk clinical programs and enables more informed decision-making for secondary and exploratory endpoints.

“AI assisted histopathology will be like central reading to endoscopy in clinical trials. It will enhance objectivity and refine reporting. The implications for future practice are substantial,” said Professor Simon Travis of the University of Oxford.

The development and evaluation of the algorithm will be highlighted in a poster presentation at the upcoming United European Gastroenterology (UEG) conference, from October 4-7, 2025.

To learn more about how PathAI is transforming IBD clinical trials, visit https://www.pathai.com/aim-hiuc.

1AIM-HI UC is for Research Use Only. Not for use in diagnostic procedures.

About PathAI

PathAI is a leading provider of integrated AI and digital pathology solutions dedicated to transforming workflow and operational efficiency in pathology labs worldwide. Through innovative technologies and strategic partnerships, PathAI aims to enhance patient outcomes and drive the future of medical diagnostics. For more information, visit www.pathai.com.

Company Contact
Liz Storti
Chief People Officer
elizabeth.storti@pathai.com

Media Contact
Owen Blaschak
LifeSci Communications
oblaschak@lifescicomms.com

PathAI Launches Industry-Backed AIM-HI UC Model on GCP-Compliant Platform to Standardize Histological Assessment in Ulcerative Colitis Trials

PathAI Launches Industry-Backed AIM-HI UC Model on GCP-Compliant Platform to Standardize Histological Assessment in Ulcerative Colitis Trials




PathAI Launches Industry-Backed AIM-HI UC Model on GCP-Compliant Platform to Standardize Histological Assessment in Ulcerative Colitis Trials

BOSTON, Sept. 23, 2025 (GLOBE NEWSWIRE) — PathAI, the global leader in AI-powered pathology, today announced the integration of AIM-HI UC1, an advanced AI model for Ulcerative Colitis (UC) histology endpoint assessment, on to AISight™ Clinical Trials, PathAI’s GCP and GCLP-compliant platform.

AIM-HI UC1 was developed by the Foundation for the National Institutes of Health (FNIH) Biomarkers Consortium’s Mucosal Healing in Ulcerative Colitis Project Team, a collaboration uniting eight of the world’s leading biopharmaceutical companies, representatives from the U.S. Food and Drug Administration (FDA), and renowned researchers in UC. This integration marks a significant step toward advancing standardized, AI-driven histological evaluation in clinical trials for Ulcerative Colitis.

AIM-HI UC was developed and evaluated for exploratory or secondary clinical trial endpoint use. The availability of this algorithm on AISight™ Clinical Trials creates a powerful, end-to-end solution for biopharmaceutical clinical trial sponsors, combining industry-leading AI technology with PathAI’s comprehensive histology lab services.

AIM-HI UC is an AI-assist product designed to enhance the pathologist’s reading experience. Using routine, H&E-stained UC biopsies, the algorithm provides pathologists with a highly reproducible, consensus-trained first read, standardizing the assessment of histological disease activity and reducing the well-known variability of manual scoring. A key feature of the tool is its ability to simultaneously generate scores for all three of the main histological scoring systems—the Geboes Score, Robarts Histopathology Index (RHI), and Nancy Histologic Index (NHI)—providing a comprehensive and standardized output from a single read.

“The collaborative development of this algorithm through the FNIH Biomarkers Consortium represents a landmark achievement in standardizing histological endpoints for Ulcerative Colitis,” said Ben Glass, SVP of Product, Research and AI at PathAI. “By co-developing this product with industry partners and integrating into our AISight Clinical Trials platform, we are offering a solution that is not only scientifically robust but also operationally seamless. It pairs directly with our end-to-end histology services at our biopharma lab in Memphis, providing our partners with a single, GCLP-compliant vendor for their complete clinical trial pathology needs.”

The challenges in IBD drug development are often compounded by the subjectivity of histological assessment. Through providing quantitative and reproducible UC histology scores, AIM-HI UC helps de-risk clinical programs and enables more informed decision-making for secondary and exploratory endpoints.

“AI assisted histopathology will be like central reading to endoscopy in clinical trials. It will enhance objectivity and refine reporting. The implications for future practice are substantial,” said Professor Simon Travis of the University of Oxford.

The development and evaluation of the algorithm will be highlighted in a poster presentation at the upcoming United European Gastroenterology (UEG) conference, from October 4-7, 2025.

To learn more about how PathAI is transforming IBD clinical trials, visit https://www.pathai.com/aim-hiuc.

1AIM-HI UC is for Research Use Only. Not for use in diagnostic procedures.

About PathAI

PathAI is a leading provider of integrated AI and digital pathology solutions dedicated to transforming workflow and operational efficiency in pathology labs worldwide. Through innovative technologies and strategic partnerships, PathAI aims to enhance patient outcomes and drive the future of medical diagnostics. For more information, visit www.pathai.com.

Company Contact
Liz Storti
Chief People Officer
elizabeth.storti@pathai.com

Media Contact
Owen Blaschak
LifeSci Communications
oblaschak@lifescicomms.com

LogicMark Launches Predictive Activity Metrics in Freedom Alert Max Device

LogicMark Launches Predictive Activity Metrics in Freedom Alert Max Device




LogicMark Launches Predictive Activity Metrics in Freedom Alert Max Device

Revolutionary AI-powered technology shifts from reactive emergency response to proactive fall prevention through continuous health monitoring

LOUISVILLE, Ky., Sept. 23, 2025 (GLOBE NEWSWIRE) — LogicMark, Inc. (OTC: LGMK) (the “Company”), a provider of personal emergency response systems (PERS), health communication devices, and technology for the growing care economy, today announced the launch of Activity Metrics in its Freedom Alert Max device. This breakthrough feature introduces activity tracking capabilities powered by predictive AI analytics, fundamentally transforming medical alert technology from reactive emergency response to proactive health crisis prevention.

Activity Metrics enables the Freedom Alert Max medical alert and health communication device to continuously track users’ daily steps and active time, providing caregivers with real-time insights and a complete seven-day activity history through LogicMark’s Care Village app. This data is critical for maintaining senior health and longevity, as regular physical activity directly correlates with vitality and fall prevention in aging adults; decreased activity can often signal underlying issues.

Activity Metrics is one of many services provided as part of LogicMark’s patented Care Processing Technology, which analyzes patterns of aging adults using proprietary AI algorithms. This data establishes a comprehensive, baseline user wellness profile via patent-pending Care Village Digital Twin technology. Through the digital twin, LogicMark is building a back-end mirror image of its users’ physical capabilities and mobility. The technology enables care processing to recognize patterns across individuals and generate the prediction of potential fall risks before actual falls or other emergencies happen. This approach allows for a proactive and preventative approach to caregiving and safer environments for seniors overall.

“We’re transforming medical alert technology by shifting from waiting for an emergency to proactive health monitoring, preventing emergencies and falls before they happen,” said Chia-Lin Simmons, CEO of LogicMark. “Activity Metrics combined with features like our recently launched Medication Reminders, represent our commitment to proactive and preventative senior safety. Now, we can identify potential health issues and fall risks early, giving families and healthcare providers the insights they need to intervene before a crisis occurs.”

LogicMark’s Activity Metrics continues to differentiate the Freedom Alert Max in the medical alert and health communication device market, as the most advanced personal emergency response system available, providing 24/7 monitoring and emergency assistance both at home and on-the-go. The integration of predictive AI analytics with comprehensive activity tracking creates an unmatched health monitoring ecosystem that goes far beyond traditional medical alert devices. The Freedom Alert Max hosts a variety of additional vital features, including Caretaker App, 24/7 US-based monitoring, fall detection, geofencing for memory care alzheimer roaming, emergency caregiver video calling, GPS location services, Medicine reminders, unlimited calling to friends and family, and 988 Suicide and Crisis Lifeline pre-programmed into the device.

LogicMark’s proprietary fall detection technology senses falls and sudden movements and immediately calls for help, even if the person cannot speak or use the device. As falls and movements are detected, the LogicMark algorithm can learn patterns to prevent false positives and use that information to predict when future falls are likely to happen.

Robust GPS location and geofencing capabilities eliminate the concern of aging adults with Alzheimer’s and other forms of dementia wandering off, while still offering independence and the ability to age in place. Geofencing allows caregivers to set a map boundary and receive alert notifications when the device crosses those areas.

Activity Metrics is now available on all Freedom Alert Max devices. The Care Village app can be downloaded for iPhone here and Android here.

About LogicMark, Inc. 
LogicMark, Inc. (OTC: LGMK) is on a mission to enable people of all ages to lead lives with dignity, independence, and the joy of possibility. LogicMark provides PERS, health communications devices, personal safety apps, services, and technologies to create a Connected Care Platform.

LogicMark is dedicated to building a “Care Village” with proprietary technology and innovative solutions for the care economy. A team of leading technologists with a deep understanding of IoT, AI, and machine learning is passionately focused on understanding consumer needs. The Company’s PERS technologies are sold through the United States Veterans Health Administration, dealers and distributors, and directly to consumers. LogicMark has been awarded a contract by the U.S. General Services Administration that enables it to distribute products to federal, state, and local governments. 

To learn more, visit www.investors.logicmark.com and www.logicmark.com.

Media Contact:
logicmark@relativity.ventures

LogicMark Launches Predictive Activity Metrics in Freedom Alert Max Device

LogicMark Launches Predictive Activity Metrics in Freedom Alert Max Device




LogicMark Launches Predictive Activity Metrics in Freedom Alert Max Device

Revolutionary AI-powered technology shifts from reactive emergency response to proactive fall prevention through continuous health monitoring

LOUISVILLE, Ky., Sept. 23, 2025 (GLOBE NEWSWIRE) — LogicMark, Inc. (OTC: LGMK) (the “Company”), a provider of personal emergency response systems (PERS), health communication devices, and technology for the growing care economy, today announced the launch of Activity Metrics in its Freedom Alert Max device. This breakthrough feature introduces activity tracking capabilities powered by predictive AI analytics, fundamentally transforming medical alert technology from reactive emergency response to proactive health crisis prevention.

Activity Metrics enables the Freedom Alert Max medical alert and health communication device to continuously track users’ daily steps and active time, providing caregivers with real-time insights and a complete seven-day activity history through LogicMark’s Care Village app. This data is critical for maintaining senior health and longevity, as regular physical activity directly correlates with vitality and fall prevention in aging adults; decreased activity can often signal underlying issues.

Activity Metrics is one of many services provided as part of LogicMark’s patented Care Processing Technology, which analyzes patterns of aging adults using proprietary AI algorithms. This data establishes a comprehensive, baseline user wellness profile via patent-pending Care Village Digital Twin technology. Through the digital twin, LogicMark is building a back-end mirror image of its users’ physical capabilities and mobility. The technology enables care processing to recognize patterns across individuals and generate the prediction of potential fall risks before actual falls or other emergencies happen. This approach allows for a proactive and preventative approach to caregiving and safer environments for seniors overall.

“We’re transforming medical alert technology by shifting from waiting for an emergency to proactive health monitoring, preventing emergencies and falls before they happen,” said Chia-Lin Simmons, CEO of LogicMark. “Activity Metrics combined with features like our recently launched Medication Reminders, represent our commitment to proactive and preventative senior safety. Now, we can identify potential health issues and fall risks early, giving families and healthcare providers the insights they need to intervene before a crisis occurs.”

LogicMark’s Activity Metrics continues to differentiate the Freedom Alert Max in the medical alert and health communication device market, as the most advanced personal emergency response system available, providing 24/7 monitoring and emergency assistance both at home and on-the-go. The integration of predictive AI analytics with comprehensive activity tracking creates an unmatched health monitoring ecosystem that goes far beyond traditional medical alert devices. The Freedom Alert Max hosts a variety of additional vital features, including Caretaker App, 24/7 US-based monitoring, fall detection, geofencing for memory care alzheimer roaming, emergency caregiver video calling, GPS location services, Medicine reminders, unlimited calling to friends and family, and 988 Suicide and Crisis Lifeline pre-programmed into the device.

LogicMark’s proprietary fall detection technology senses falls and sudden movements and immediately calls for help, even if the person cannot speak or use the device. As falls and movements are detected, the LogicMark algorithm can learn patterns to prevent false positives and use that information to predict when future falls are likely to happen.

Robust GPS location and geofencing capabilities eliminate the concern of aging adults with Alzheimer’s and other forms of dementia wandering off, while still offering independence and the ability to age in place. Geofencing allows caregivers to set a map boundary and receive alert notifications when the device crosses those areas.

Activity Metrics is now available on all Freedom Alert Max devices. The Care Village app can be downloaded for iPhone here and Android here.

About LogicMark, Inc. 
LogicMark, Inc. (OTC: LGMK) is on a mission to enable people of all ages to lead lives with dignity, independence, and the joy of possibility. LogicMark provides PERS, health communications devices, personal safety apps, services, and technologies to create a Connected Care Platform.

LogicMark is dedicated to building a “Care Village” with proprietary technology and innovative solutions for the care economy. A team of leading technologists with a deep understanding of IoT, AI, and machine learning is passionately focused on understanding consumer needs. The Company’s PERS technologies are sold through the United States Veterans Health Administration, dealers and distributors, and directly to consumers. LogicMark has been awarded a contract by the U.S. General Services Administration that enables it to distribute products to federal, state, and local governments. 

To learn more, visit www.investors.logicmark.com and www.logicmark.com.

Media Contact:
logicmark@relativity.ventures

X-Chem Launches Chemomics: Applying Omics-Scale Chemistry Data to Yield New Candidate-Quality Molecules

X-Chem Launches Chemomics: Applying Omics-Scale Chemistry Data to Yield New Candidate-Quality Molecules




X-Chem Launches Chemomics: Applying Omics-Scale Chemistry Data to Yield New Candidate-Quality Molecules

Intersection of best-in-class DEL, medicinal chemistry and innovative computation sciences launches era of high-throughput insights for drug discovery

WALTHAM, Mass., Sept. 23, 2025 (GLOBE NEWSWIRE) — X-Chem, a global leader in data-driven drug discovery, today announced the launch of chemomics: a transformational framework that harnesses the full scale of DNA-encoded library (DEL) technology with computational sciences and AI/ML to extract years’ worth of structure-activity relationship (SAR) insights, generate highly predictive models, and unveil a diversity of starting points. Chemomics uniquely equips discovery programs at their inception with an unprecedented data foundation – empowering teams to reach clinical candidates with transformative speed and confidence.

Chemomics is built on X-Chem’s high signal-to-noise DEL technology, delivering reliable data at true omics scale. Rather than treating DEL as a one-step screen, chemomics establishes a discovery framework that pairs billions of high-quality data points with advanced modeling, design, and analysis – driving predictive insights that fuel actionable, data-grounded decisions earlier.

Chemomics emerged from X-Chem’s drive to unlock the true value of DEL, moving beyond hit lists to reveal the depth of information contained in billions of data points. It addresses the longstanding need for defensible data and clear rationale in decision-making. The approach also has the advantage of transparency – with no “black box” – and hypotheses confirmed through high-throughput synthesis and testing. Chemomics provides actionable insights earlier in discovery, helping teams make confident decisions with speed and clarity.

“The real promise of chemomics is its impact to redefine small molecule drug discovery, enabling unprecedented knowledge building by leveraging billions of data points,” said Karen Lackey, CEO of X-Chem. “Our mission is to be the partner organization of choice, making a difference in bringing life-changing therapies closer to patients.”

Through DEL-ML, pharmacophore modeling, and SAR analysis, chemomics gives discovery teams practical tools to recognize meaningful trends and guide molecule design. Built on years of investment in high signal-to-noise DEL technology, chemomics makes this unprecedented scale of data meaningful. This gives discovery teams confidence in their path forward and marks a new era of discovery powered by DEL’s unprecedented data dimensions.

X-Chem will present chemomics during Discovery on Target this week in Boston. Attendees can visit Booth #303 in the exhibit hall and join the chemomics launch reception on September 24 from 5:00 to 7:00 p.m. at The Fens, Boston Sheraton.

About X-Chem

X-Chem is redefining small molecule drug discovery through a powerful combination of computational sciences, discovery chemistry and data-driven insight. As the pioneer and global leader in DNA-encoded library (DEL) technology, X-Chem provides the foundation for smarter hit identification, accelerated lead progression and greater confidence in early discovery. X-Chem partners globally to turn complex discovery challenges into actionable solutions. Learn more at www.x-chemrx.com.

Media Contact:
Alli Cooke
Alli.Cooke@llyc.global
616.258.5769