Idorsia’s JERAYGO (aprocitentan) approved in Canada for the treatment of resistant hypertension




Idorsia’s JERAYGO (aprocitentan) approved in Canada for the treatment of resistant hypertension

• Idorsia receives approval from Health Canada for JERAYGO^™ (aprocitentan) as the first and only endothelin receptor antagonist (ERA) for the treatment of resistant hypertension.
• JERAYGO is a new oral antihypertensive therapy – the first systemic hypertension treatment to target a new pathway in over 30 years.

Allschwil, Switzerland – January 5, 2026
Idorsia Ltd (SIX: IDIA) announces that Health Canada has granted marketing authorization for JERAYGO^™ (aprocitentan) for the treatment of resistant hypertension in adult patients in combination with at least three antihypertensive medicinal products.¹ The recommended dose is 12.5 mg orally once daily. The dose can be increased to 25 mg once daily for patients tolerating the 12.5 mg dose and in need of tighter blood pressure (BP) control.¹

Hypertension remains a leading global health challenge and the number one modifiable risk factor for early morbidity and mortality. Despite advances in treatment, many patients still struggle with uncontrolled blood pressure, leaving them at significantly higher risk of heart attack, stroke, kidney failure, and premature death.

Approximately 10% of hypertensive patients have resistant hypertension^3,4 – defined by uncontrolled blood pressure despite receiving at least three antihypertensive medications from different classes, at optimal doses – underscoring the urgent need for more effective therapies.

Srishti Gupta, MD, Chief Executive Officer of Idorsia, commented:
“JERAYGO is the first and only hypertension treatment to target the endothelin pathway, a fundamental yet previously unaddressed driver of disease onset, progression, and complications. The results of PRECISION show that targeting the endothelin pathway is crucial to adequately manage uncontrolled blood pressure. JERAYGO has demonstrated rapid, durable, and clinically significant double-digit blood pressure reduction across a broad spectrum of challenging patient populations, including those with obesity, chronic kidney disease, or type 2 diabetes. I am very proud of our team for achieving this milestone.”

Idorsia is engaged in discussions to maximize the ability to make JERAYGO available to patients.

For more information on the marketing authorization of JERAYGO in Canada and important safety information, please review the Product Monograph.

Notes to the editor

About the Phase 3 PRECISION study^1,5
The efficacy of aprocitentan was evaluated in one randomized, double-blind (DB), placebo-controlled Phase 3 multicenter study. Patients with uncontrolled blood pressure (systolic blood pressure [SBP] ≥140 mmHg) despite the use of at least three antihypertensive medicinal products and following exclusion of pseudo-resistant hypertension (e.g., white coat effect, inappropriate blood pressure measurement, secondary causes of hypertension) were considered to have resistant hypertension. The patients were switched to standardized background antihypertensive therapy consisting of an angiotensin receptor blocker (valsartan 160 mg), a calcium channel blocker (amlodipine 5 or 10 mg), and a diuretic (hydrochlorothiazide 25 mg) throughout the study. Patients with concomitant use of beta-blockers continued this treatment throughout the study, in addition to the standardized background antihypertensive therapy and study treatment. A total of 730 patients received either aprocitentan 12.5 mg, aprocitentan 25 mg, or placebo once daily during the initial 4-week DB treatment (part 1). Thereafter, patients received aprocitentan 25 mg once daily during the 32-week single-blind treatment (part 2). At the end of the 32 weeks, patients were re-randomized to receive either aprocitentan 25 mg or placebo, once daily, during the 12-week double-blind withdrawal (DB-WD) treatment (part 3).

The primary efficacy endpoint was the change in sitting SBP (SiSBP) from baseline to Week 4 during DB treatment (part 1), measured at trough by unattended automated office blood pressure (uAOBP). The key secondary endpoint was the change in SiSBP measured at trough by uAOBP from DB-WD baseline (Week 36) to Week 40 (part 3).

Patients had a mean age of 61.7 years (range 24 to 84 years; 34.1% were ≥ 65 and < 75 years; 9.9% were ≥ 75 years) and 59.5% were male. Patients were White (82.9%), African American (11.2%) or Asian (5.2%). The mean body weight was 97.6 kg (range 46 to 196 kg) and mean BMI was 33.7 kg/m2 (range 18 to 64 kg/m2). Patients had a medical history of type 2 diabetes mellitus (54.1%), ischemic heart disease (30.8%), central nervous system vascular disorders (23.0%), chronic kidney disease stages 3 and 4 (22.2%; 19.3% of patients had eGFR 30–59 mL/min/1.73 m2 and 2.9% had eGFR 15–29 mL/min/1.73 m2), congestive heart failure (19.6%), and sleep apnea syndrome (14.1%). 63.0% of patients had four or more antihypertensive medicinal products.

Key PRECISION findings^1,5
Doses of aprocitentan 12.5 and 25 mg showed a statistically significant reduction vs placebo on SiSBP at Week 4. The treatment effect was consistent for sitting diastolic blood pressure (SiDBP). The persistence of the BP-lowering effect of aprocitentan was shown in DB-WD treatment (part 3). In patients re-randomized to placebo, the mean SiSBP increased, whereas in patients re-randomized to aprocitentan 25 mg the mean effect on SiSBP was stable, resulting in a statistically significant difference. The treatment effect was consistent for SiDBP. The effect was also consistent across SBP and DBP measured by ambulatory BP monitoring (ABPM) and assessed as daytime, night-time, and 24h periods at Week 4 and Week 40. A substantial proportion (i.e., at least 90%) of the BP-lowering effect was observed within the first two weeks of treatment with aprocitentan. The effect of aprocitentan was consistent across subgroups of age (including patients ≥ 75 years), sex, race (including patients with Black or African American origin), BMI, baseline urine albumin-to-creatinine ratio (UACR), baseline eGFR and medical history of diabetes.

The most frequently reported adverse reactions with aprocitentan were edema/fluid retention (mostly peripheral edema) (9.1%, 12.5 mg; 18.4%, 25 mg) and hemoglobin decreased (3.7%, 12.5 mg; 1.2%, 25 mg).

JERAYGO is contraindicated for use in women who are pregnant, breast-feeding, in women of childbearing potential who are not using reliable contraception, patients with severe hepatic impairment, and in patients with hypersensitivity to the active substance or to any of the excipients.

About aprocitentan
Aprocitentan is Idorsia’s once-daily, orally active, dual endothelin receptor antagonist, which inhibits the binding of ET-1 to ET_A and ET_B receptors. Aprocitentan is approved as TRYVIO™ in the US for the treatment of systemic hypertension in combination with other antihypertensives and has been commercially available since October 2024. Aprocitentan is approved as JERAYGO™ for the treatment of resistant hypertension in combination with at least three antihypertensives in the European Union, the UK, and Switzerland, and now in Canada.

Idorsia Pharmaceuticals Ltd has transferred its rights for aprocitentan (including JERAYGO™) to Idorsia Investments SARL to allow the repayment of notes issued in connection with the repurchase offer completed in August 2025. More details on the transfer can be found in the press release issued on May 21, 2025 and on the exchange offer in the press release issued on August 27, 2025.

References

1. JERAYGO^™ Product Monograph
2. NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants. Lancet 2021; 398:957-80.
3. Noubiap JJ, et al. Global prevalence of resistant hypertension: a meta-analysis of data from 3·2 million patients. Heart 2019; 105: 98–105.
4. Williams B, et al. 2018 ESC/ESH guidelines for the management of arterial hypertension. Eur Heart J 2018; 39: 3021–104.
5. Schlaich MP, et al. A randomized controlled trial of the dual endothelin antagonist aprocitentan for resistant hypertension. The Lancet, 2022; Dec 3;400(10367):1927-1937.

About Idorsia
The purpose of Idorsia is to challenge accepted medical paradigms, answering the questions that matter most. To achieve this, we will discover, develop, and commercialize transformative medicines – either with in-house capabilities or together with partners – and evolve Idorsia into a leading biopharmaceutical company, with a strong scientific core.

Headquartered near Basel, Switzerland – a European biotech hub – Idorsia has a highly experienced team of dedicated professionals, covering all disciplines from bench to bedside; QUVIVIQ™ (daridorexant), a different kind of insomnia treatment with the potential to revolutionize this mounting public health concern; strong partners to maximize the value of our portfolio; a promising in-house development pipeline; and a specialized drug discovery engine focused on small-molecule drugs that can change the treatment paradigm for many patients. Idorsia is listed on the SIX Swiss Exchange (ticker symbol: IDIA).

For further information, please contact:
Investor & Media Relations
Idorsia Pharmaceuticals Ltd, Hegenheimermattweg 91, CH-4123 Allschwil
+41 58 844 10 10
investor.relations@idorsia.com – media.relations@idorsia.com – www.idorsia.com

The above information contains certain “forward-looking statements”, relating to the company’s business, which can be identified by the use of forward-looking terminology such as “intend”, “estimates”, “believes”, “expects”, “may”, “are expected to”, “will”, “will continue”, “should”, “would be”, “seeks”, “pending” or “anticipates” or similar expressions, or by discussions of strategy, plans or intentions. Such statements include descriptions of the company’s investment and research and development programs, business development activities and anticipated expenditures in connection therewith, descriptions of new products expected to be introduced by the company and anticipated customer demand for such products and products in the company’s existing portfolio. Such statements reflect the current views of the company with respect to future events and are subject to certain risks, uncertainties and assumptions. Many factors could cause the actual results, performance or achievements of the company to be materially different from any future results, performances or achievements that may be expressed or implied by such forward-looking statements. Should one or more of these risks or uncertainties materialize, or should underlying assumptions prove incorrect, actual results may vary materially from those described herein as anticipated, believed, estimated or expected.

Attachment

• Press Release PDF

argenx Announces Leadership Transition Marking Next Evolution of Growth




argenx Announces Leadership Transition Marking Next Evolution of Growth

Tim Van Hauwermeiren to transition from CEO to Non-Executive Director and Chairman of Board of Directors and Karen Massey to transition from COO to CEO and Executive Director

January 5, 2026 7:00 a.m. CET

Amsterdam, the Netherlands – argenx SE (Euronext & Nasdaq: ARGX), a global immunology company committed to improving the lives of people suffering from severe autoimmune diseases, today announced that Karen Massey, current Chief Operating Officer, will transition to Chief Executive Officer and Executive Director and Tim Van Hauwermeiren, current Chief Executive Officer, will transition to non-Executive Director and Chairman of the Board of Directors. Tim will succeed Peter Verhaeghe, who is retiring from the Board of Directors after dedicated service to the company since 2008. These changes are subject to shareholder approval at the Annual General Meeting on May 6, 2026, which allows for a comprehensive transition period.

“This leadership evolution comes at the right time and represents a natural step as we prepare for the next phase of growth at argenx – a long-term future that remains bold, patient-focused, and built to last,” said Peter Verhaeghe, Chairman of the Board of Directors. “I am proud to have been part of this journey in building a leading biotech company from the start. The Board and I move forward with strong confidence in Tim as our incoming Chairman, Karen as our trusted COO and incoming CEO, and the entire leadership team, to guide the organization towards Vision 2030 and beyond.”

“My ambition has always been to build a strong, independent biotech company for the long-term. This transition is the next step in that evolution and Karen is the right person to lead our company forward. Karen has delivered exceptional impact since joining argenx three years ago – accelerating VYVGART’s launch, building a future-proof commercial engine, being a leading ambassador of our culture, and connecting to and inspiring our teams,” said Tim Van Hauwermeiren, co-founder and current Chief Executive Officer. “As Chairman, I will be a sounding board to Karen and the team on long-term strategy, stay close to the innovation mission by engaging with the external ecosystem and lead the Board’s evolution to facilitate our next phase of growth. I am deeply grateful to the Board of Directors for this opportunity, and especially to Peter, for his leadership and partnership as we’ve built this company.”

“This is a special company with a bright future that is founded on the strength of our science, our entrepreneurial culture, and the deep accountability of our talented teams to transform the lives of our patients,” said Karen Massey, current Chief Operating Officer. “My commitment is to elevate the unique argenx DNA as we execute on Vision 2030 and beyond and to ensure we are making the most of this bold opportunity to build the biotech company of the future. I’m humbled to lead argenx, alongside our network of exceptional teams, partners and the Board, into this next chapter of growth.”

Biographies of Karen, Tim and Peter can be accessed on the argenx website.

About argenx
argenx is a global immunology company committed to improving the lives of people suffering from severe autoimmune diseases. Partnering with leading academic researchers through its Immunology Innovation Program (IIP), argenx aims to translate immunology breakthroughs into a world-class portfolio of novel antibody-based medicines. argenx developed and is commercializing the first approved neonatal Fc receptor (FcRn) blocker and is evaluating its broad potential in multiple serious autoimmune diseases while advancing several earlier stage experimental medicines within its therapeutic franchises. For more information, visit www.argenx.com and follow us on LinkedIn, Instagram, Facebook, and YouTube.

This press release contains inside information within the meaning of Article 7(1) of the EU Market Abuse Regulation (Regulation 596/2014).

Contacts

Media:

Ben Petok

bpetok@argenx.com

Investors:

Alexandra Roy
aroy@argenx.com

Forward-looking Statements

The contents of this announcement include statements that are, or may be deemed to be, “forward-looking statements.” These forward-looking statements can be identified by the use of forward-looking terminology, including the terms “aim,” “are,” “can,” “continue,” “may,” and “will” and include statements argenx makes concerning argenx’s proposed leadership and board transition as well as the company’s ability to execute on Vision 2020 and its other objectives and initiatives. By their nature, forward-looking statements involve risks and uncertainties and readers are cautioned that any such forward-looking statements are not guarantees of future performance. argenx’s actual results may differ materially from those predicted by the forward-looking statements as a result of various important factors, including but not limited to, whether shareholders approve the proposed leadership and board transition proposal, the results of argenx’s clinical trials; expectations regarding the inherent uncertainties associated with the development of novel drug therapies; preclinical and clinical trial and product development activities and regulatory approval requirements; the acceptance of its products and product candidates by its patients as safe, effective and cost-effective; the impact of governmental laws and regulations, including tariffs, export controls, sanctions and other regulations on its business; its reliance on third-party suppliers, service providers and manufacturers; inflation and deflation and the corresponding fluctuations in interest rates; and regional instability and conflicts. A further list and description of these risks, uncertainties and other risks can be found in argenx’s U.S. Securities and Exchange Commission (SEC) filings and reports, including in argenx’s most recent annual report on Form 20-F filed with the SEC as well as subsequent filings and reports filed by argenx with the SEC. Given these uncertainties, the reader is advised not to place any undue reliance on such forward-looking statements. These forward-looking statements speak only as of the date of publication of this document. argenx undertakes no obligation to publicly update or revise the information in this press release, including any forward-looking statements, except as may be required by law.

HUTCHMED Initiates Phase III Stage of the Ongoing Trial of the Combination of Surufatinib and Camrelizumab for Treatment-Naïve Pancreatic Ductal Adenocarcinoma




HUTCHMED Initiates Phase III Stage of the Ongoing Trial of the Combination of Surufatinib and Camrelizumab for Treatment-Naïve Pancreatic Ductal Adenocarcinoma

HONG KONG and SHANGHAI and FLORHAM PARK, N.J., Jan. 05, 2026 (GLOBE NEWSWIRE) — HUTCHMED (China) Limited (“HUTCHMED”) (Nasdaq/AIM:​HCM; HKEX:​13) today announces that it has initiated the Phase III part of the Phase II/III trial to evaluate the efficacy of the combination of surufatinib, camrelizumab, nab-paclitaxel and gemcitabine as a first-line treatment for patients with metastatic pancreatic ductal adenocarcinoma (“PDAC”) in China. The first patient received the first dose on December 30, 2025.

PDAC is a highly aggressive form of cancer, representing over 90% of pancreatic cancer cases. Globally, an estimated 511,000 people were diagnosed with pancreatic cancer, leading to approximately 467,000 deaths in 2022, with an average five-year survival rate of less than 10%. In China, an estimated 119,000 people were diagnosed with pancreatic cancer, causing approximately 106,000 deaths in 2022.¹ Treatments such as chemotherapy, surgery and radiation are commonly employed, but have not shown significant improvement in patient outcomes. Under 20% of metastatic pancreatic cancer patients survive for more than a year. ²

The trial is a multicenter, randomized, open-label, active-controlled Phase II/III study to evaluate the efficacy and safety of surufatinib combined with camrelizumab, nab-paclitaxel and gemcitabine (“S+C+AG”) versus nab-paclitaxel plus gemcitabine (“AG”) in adults with metastatic pancreatic cancer who have not previously received systemic anti-tumor therapy. A total of 62 patients were enrolled in the Phase II part, with plans to enroll approximately 400 additional patients in the Phase III part. The primary endpoint for the Phase III part is overall survival (OS). Secondary endpoints include progression-free survival (“PFS”), objective response rate (“ORR”), duration of response (DoR), disease control rate (“DCR”), quality of life and safety. Professor Shukui Qin of China Pharmaceutical University Nanjing Tianyinshan Hospital and Professor Jihui Hao of Tianjin Medical University Cancer Institute and Hospital are the leading principal investigators of this study. Additional details may be found at clinicaltrials.gov, using identifier NCT06361888.

Results from the Phase II part were recently presented at the 2025 European Society for Medical Oncology (ESMO) Asia Congress.³ As of the data cut-off of July 24, 2025, the median PFS follow-up duration was 8.15 months. The S+C+AG regimen demonstrated a median PFS of 7.20 months compared to 5.52 months for the AG arm (stratified hazard ratio [HR] 0.499, log-rank p=0.0407), representing a 50.1% reduction in the risk of progression or death. Consistent benefits were observed across other key efficacy endpoints, including ORR (67.7% vs 41.9%, p=0.0430) and DCR (93.5% vs 71.0%, p=0.0149). Although overall survival data were immature at the time of analysis, a favorable trend was observed (not reached vs 8.48 months, unstratified HR 0.555), with 9 events in the S+C+AG arm (N=31) and 15 events in the AG arm (N=31). The safety profile was manageable. Treatment-emergent adverse events (TEAEs) of grade 3 or above occurred in 80.6% of patients in the S+C+AG arm compared to 61.3% in the AG arm.

About Surufatinib

Surufatinib is a novel, oral angio-immuno kinase inhibitor that selectively inhibits the tyrosine kinase activity associated with vascular endothelial growth factor receptors (VEGFRs) and fibroblast growth factor receptor (FGFR), which both inhibit angiogenesis, and colony stimulating factor-1 receptor (CSF-1R), which regulates tumor-associated macrophages, promoting the body’s immune response against tumor cells. Surufatinib is marketed in China by HUTCHMED under the brand name SULANDA^®. HUTCHMED currently retains all rights to surufatinib worldwide.

About Camrelizumab

Camrelizumab (SHR-1210) is a humanized monoclonal antibody targeting the programmed death-1 (PD-1) receptor. Camrelizumab has been approved in China for multiple indications in areas such as lung cancer, liver cancer, esophageal cancer, nasopharyngeal cancer and cervical cancer. Camrelizumab is marketed in China by Hengrui Pharma under the brand name AiRuiKa^®.

About HUTCHMED

HUTCHMED (Nasdaq/AIM:​HCM; HKEX:​13) is an innovative, commercial-stage, biopharmaceutical company. It is committed to the discovery and global development and commercialization of targeted therapies and immunotherapies for the treatment of cancer and immunological diseases. Since inception it has focused on bringing drug candidates from in-house discovery to patients around the world, with its first three medicines marketed in China, the first of which is also approved around the world including in the US, Europe and Japan. For more information, please visit: www.hutch-med.com or follow us on LinkedIn.

Forward-Looking Statements

This press release contains forward-looking statements within the meaning of the “safe harbor” provisions of the US Private Securities Litigation Reform Act of 1995. These forward-looking statements reflect HUTCHMED’s current expectations regarding future events, including its expectations regarding the therapeutic potential of surufatinib for the treatment of PDAC and the further development of surufatinib in this and other indications. Forward-looking statements involve risks and uncertainties. Such risks and uncertainties include, among other things, assumptions regarding the timing and outcome of clinical studies and the sufficiency of clinical data to support a new drug application submission of surufatinib for the treatment of PDAC or other indications in China or other jurisdictions, its potential to gain approvals from regulatory authorities on an expedited basis or at all, the efficacy and safety profile of surufatinib, HUTCHMED’s ability to fund, implement and complete its further clinical development and commercialization plans for surufatinib and the timing of these events. In addition, as certain studies rely on the use of other drug products such as camrelizumab, nab-paclitaxel and gemcitabine as combination therapeutics with surufatinib, such risks and uncertainties include assumptions regarding the safety, efficacy, supply and continued regulatory approval of these therapeutics. Existing and prospective investors are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. For further discussion of these and other risks, see HUTCHMED’s filings with the US Securities and Exchange Commission, The Stock Exchange of Hong Kong Limited and on AIM. HUTCHMED undertakes no obligation to update or revise the information contained in this press release, whether as a result of new information, future events or circumstances or otherwise.

Medical Information

This press release contains information about products that may not be available in all countries, or may be available under different trademarks, for different indications, in different dosages, or in different strengths. Nothing contained herein should be considered a solicitation, promotion or advertisement for any prescription drugs including the ones under development.

CONTACTS

______________________________

CystoSmart™, an AI Software Tool for Bladder Cancer Detection, Developed with Cutting-Edge Technology Receives Clearance from Health Sciences Authority Singapore




CystoSmart™, an AI Software Tool for Bladder Cancer Detection, Developed with Cutting-Edge Technology Receives Clearance from Health Sciences Authority Singapore

SINGAPORE and LONDON and NEW YORK, Jan. 04, 2026 (GLOBE NEWSWIRE) — Intelligent Scopes Corp (“ISC”), specializing in state-of-the-art image enhancement and precision AI software solutions for urology and gastroenterology, is pleased to announce that CystoSmart™ has received regulatory clearance from Health Sciences Authority (HSA), the National Regulatory Agency for medical products and devices in Singapore.

CystoSmart™, an AI software tool for bladder tumor detection in patients undergoing screening and surveillance endoscopic examination of the bladder is brand agnostic and compatible with flexible and rigid scopes, including single-use scopes. The device is intended to be used with white light cystoscopy to aid clinicians in improving detection accuracy of bladder tumors in real-time and post processing conditions.

The HSA clearance for CystoSmart™, which comes eleven months after it was approved by ANVISA, the Brazilian medical devices regulator, marks a significant milestone. Not only does it clear CystoSmart™ for use in Singapore, but, through the ‘Access Consortium’ collaboration, it paves the way for accelerated regulatory clearances in Australia, Canada, Switzerland and United Kingdom, countries that are part of the Access Consortium group.

Bladder cancer is the tenth most common cancer worldwide, and the sixth most common malignancy in men. With increasing incidence globally, bladder cancer has a high rate of progression and recurrence (up to 80%) requiring repeated follow up examinations. White light cystoscopy is the standard and most widely used method for bladder tumor detection and surveillance, however, as per published studies, between 10% and 20% of bladder tumors are regularly missed by standard white light cystoscopy.

Dr Rajesh Nair, Chief Surgical Officer of ISC, commented, “Early identification of cancer translates to improved clinical outcomes, impacting positively on the patient journey and overall health economy.  Accurate exclusion reduces inappropriate investigations which carry a physical and psychological burden for patients. Early detection or exclusion of bladder cancer allows for more effective resource utilisation.” He added, “CystoSmart™ can be used as an aid for urologists to improve detection accuracy: to reduce missed tumors and reduce unnecessary invasive biopsies and interventions.”

As per clinical and technical evaluations conducted, CystoSmart has a sensitivity (true positive rate) of over 95% and a specificity (true negative rate) of over 98% in bladder tumor detection thereby aiding clinicians to improve accuracy.

About Intelligent Scopes Corp

Intelligent Scopes Corp, subsidiary of Claritas HealthTech, leads global deployment of endoscopic solutions. The company provides state-of-the-art image processing and enhancement software medical devices and AI diagnostic tools for the fields of urology and gastroenterology. The company focuses on image processing, image enhancement, AI diagnostic tools, and robotic guidance systems for endoscopy procedures to improve detection rates, reduce unnecessary biopsies and enhance patient outcomes.

For more information, please visit: www.intelligentscopes.com.

For Enquiries, please contact:
Devika Dutt
COO
Intelligent Scopes Corp
d.dutt@intelligentscopes.com

Best Male Enhancement Pills 2026: Launched By Performer 8′ Over The Counter ED Pills For Erectile Dysfunction, Growth & Last Longer for Men




Best Male Enhancement Pills 2026: Launched By Performer 8′ Over The Counter ED Pills For Erectile Dysfunction, Growth & Last Longer for Men

best male enhancement pills sold in stores’ Pills for Erectile dysfunction for men, Effective Formula for last longer and testosterones booster Quality Criteria Examined in New Industry Analysis New

York City,, Jan. 04, 2026 (GLOBE NEWSWIRE) —

In 2026 Having erectile dysfunction or poor performance in the bedroom can ruin a man’s self-esteem, crush their confidence, and leave their partner feeling empty and sexually unfulfilled.

Luckily, there are Best male enhancement pills on the market that can help you get your groove back. In fact, thousands of men all over the world rely on male enhancement supplements for bigger erections, increased libido, and improved sexual performance.

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Best Male Enhancement Pills of 2026

• Performer 8: Best overall

#1 Performer 8: Best Overall

Performer 8 is our top choice for the best male enhancement pill of 2026. While women receive a “second peak” of sexual boost in their 40s, men tend to see their libidos decline. Some of Europe’s most highly regarded scientists and industry experts are changing that with male enhancement pills. The result: Performer 8.

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Best Male Enhancement Pills 2026: What This Analysis Covers and Who It Is For

If you’re researching the best male enhancement pills for men in 2026, chances are you’ve already seen bold ads and big promises online—and decided to look for real information before making a purchase. That’s a smart move. The male enhancement market is crowded, competitive, and often driven more by marketing hype than by facts. Knowing how to evaluate products properly helps protect both your health and your money.

This analysis is created for men who are considering natural male enhancement supplements as part of their sexual wellness goals in 2026. It’s especially useful for men who want to understand how these products work, what ingredients matter, and how to spot quality formulas instead of relying solely on promotional claims. It’s also for men who want clear, honest insight into what supplements can realistically support—and when professional medical advice may be the better option.

In this guide, the term “best” is used only as a comparison tool. It refers to how products measure up against commonly researched criteria such as ingredient transparency, formulation quality, safety standards, and available research—not as a promise of results or a guarantee of performance for any individual.

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Additional background resources may be referenced for educational purposes only. They are included to support independent research and do not imply endorsement or medical approval.

How Do Natural Male Enhancement Pills Work?

Many male enhancement pills work the same way. They elevate the body’s nitric oxide production, increasing blood flow to the muscle as a result. Of course, this mechanism doesn’t apply to all male enhancement supplements. Some products, like Semenax, work because the ingredients tell the testes to create more sperm.

Nitric oxide is the key that unlocks superior sexual performance and health. It can make erections stronger and firmer within minutes. It’s why erectile dysfunction products like Cialis, Levitra, and Viagra use elevated nitric oxide levels as a treatment. The compound serves multiple functions in the body. These include relaxing the muscles in the blood vessels. When the male muscles relax, that act allows the body to circulate more blood through the main vein. In other words, nitric oxide works as a vasodilator.

While you can find nitric oxide in leafy green vegetables and citrus fruits, your body may not make enough of it naturally. The best male enhancement pills send signals to your system to produce more. This process is not the same as the supplements containing nitric oxide because, in this case, your body is making more of it.

Your blood vessels aren’t the only things that benefit from nitric oxide. The biological messenger can combat inflammation and soreness, making it ideal as a post-workout supplement. Other benefits include improved memory, sleep quality, athletic performance, immune system, strength, and oxygen levels in the blood.

Older men stand to benefit the most from vasodilators. They tend to have an increased risk for erectile dysfunction and may suffer lower sex drive and testosterone levels. The right male enhancement supplement can combat aging, blood flow problems, and lifestyle factors such as high alcohol consumption and smoking.

Things to Look for When Buying the Best Male Enhancement Supplements

Quality Ingredients:

What you put in your body matters. Make sure your male enhancement pills have high-quality, potent ingredients that deliver optimized benefits with no side effects. Some performance-enhancing natural ingredients to look for include Ginkgo biloba, Tribulus terrestris, Panax ginseng, L-methionine, and L-arginine HCL.

Every ingredient has a distinctive purpose. When researching male enhancement supplements, double-check that the formula helps you achieve your goals. For example, Ginkgo biloba increases blood flow to the male, while Tribulus terrestris can improve urinary tract health, reduce inflammation, and boost testosterone production for males over 40.

Clean Labeling:

Clean labeling is a must when purchasing male enhancement pills. You should know every ingredient that goes into your body. The last thing you want is to have an allergic reaction because a manufacturer claims to have a proprietary formula. While there’s a time and place for proprietary formula, male enhancement supplements are not one of them. The discreet approach lets unscrupulous companies put fillers and synthetic compounds into the sex pills so that they can turn a quick profit. The best male enhancement pills have clean labels that list the ingredients in the supplement.

Money-Back Guarantee:

Money-back guarantees provide peace of mind to consumers. If a male enhancement pill doesn’t deliver results, you can return it for a complete refund. All of the companies on our list let users try the supplement for two to three months risk-free. Money-back guarantees give you a chance to see how effective a product is. Do you notice changes to your testosterone levels or sexual desire? Do you have higher energy levels and lower rates of erectile dysfunction? The trial period allows you to answer those questions without financial risk.

Positive Feedback:

Customer reviews provide a behind-the-scenes look at the consumer experience after people purchase male enhancement supplements. They let you know if products work for real people like they do in the commercials. Thorough and informative customer reviews can provide the push you need to select one pill over another.

We prioritized male enhancement pills that had glowing reviews. Products like VigRX Plus and Max Performer receive consistent critical praise and have scientific studies backing their efficacy. You can have confidence knowing that these pills will improve your testosterone levels, sexual desire, and male size instead of only claiming that they can. You can also read detailed testo max here.

Made in the USA:

It’s never been more important to invest in American-made products. Instead of sending your hard-earned dollars abroad, you can bolster your local economy and support blue-collar jobs. Buying male enhancement pills that say “Made in the USA” ensures that your dollars will support American workers and their families.

You don’t have to worry about quality when you buy pills produced in the USA. The Food and Drug Administration oversees manufacturing facilities, checking that they have up-to-date equipment and clean work environments. This oversight guarantees the highest-caliber working conditions possible.

Benefits of Taking Male Enhancement Pills

Most men take male enhancement pills to improve their sex life. The supplements work for users of all ages as they overcome everything from erectile dysfunction to low libido. Products like Performer 8 deliver a wide range of benefits that amplify male sexual performance.

Some pills have narrowly tailored benefits, like Semenax. This supplement magnifies orgasm intensity, making each climax more rewarding. It increases penile sensitivity during intercourse, making the experience more satisfying for you and your partner.

Other men want longer-lasting erections. VigRX Plus prolongs erections by relaxing the blood vessels and generating more blood flow to their members. Men that take VigRX Plus report stronger and more enduring erections.

Finally,male enhancement pills can make men feel like “men” again. Some products increase testosterone levels, instilling guys with the strength and vigor they had in their youth. The supplements can seem to turn back time and, in the process, make sex more exciting and rewarding.

Male Enhancement 

Some people use male enhancement and male enlargement synonymously, but they are different things. Male enhancement supplement products focus on boosting male sexual health, while male enlargement tools involve lengthening the genitalia. Understanding the difference can help you make an informed decision when shopping for supplements and male enlargement devices.

We’ve already touched on male enhancement products. Most of these oral supplements increase blood flow to the male, resulting in firmer and thicker erections. Some pills provide a natural boost of testosterone production and energy, too.

Male enhancement products cater to individuals who want to upgrade their sex lives. Perhaps you struggle with erectile dysfunction or a low sperm count. These supplements resolve underlying issues, restoring your sex drive to that of a 20-year-old.

male enlargement comes in several forms. The three most common methods are male pumps, traction devices, and male surgery. While each option makes the genitalia longer, each does so in distinct ways.

A male pump creates a high-pressure environment that increases blood flow to your male temporarily. Men that use such a device can maintain a firm erection for half an hour or more. It makes penetrative sex with a partner more manageable and efficient.

A male pump goes over your genitals, forming a tight seal with the skin around the base. If you haven’t shaved your pubic hair, you should do so before using the device. It’s no fun having stray hairs snag in the tube.

Once the device is in place, turn on the motor or use the hand pump to remove the air. As the chamber pressurizes, it draws blood toward the tip of the male. The result is a thicker erection without the need for prescription medication or surgical intervention.

Traction devices, also known as male extenders, are medical products to correct Peyronie’s disease. This condition involves an unnatural curvature of the male due to plaque or fibrous tissue. Individuals have to wear the device for several hours per day to straighten and lengthen their male.

A study from Live Science had 15 men use traction devices for six months. The men increased the amount of tension on the shaft from 1.3 pounds to 2.6 pounds midway through the experiment. The result was a 0.9-inch improvement in flaccid male length.

Outside of surgery, traction devices are the only way to enhance male size permanently. The products use carefully calibrated tension to lengthen the genitalia through micro-tears. However, men must wear them for roughly eight hours a day, making them painful and cumbersome at times.

male surgery serves as the most extreme form of male enlargement. It involves a surgeon placing a silicon sheath underneath the skin to lengthen the male. Insurance does not cover this procedure, so you will have to pay the approximately $15,000 medical bills out-of-pocket.

male surgery is simple and straightforward. A surgeon places you under general anesthesia and inserts the sheath. You’ll have to go to a follow-up appointment two or three days after the operation.

According to Dr. James J. Elist, a Beverly Hills urologist specializing in penile treatments, male surgery can improve male length and girth. The average man stands to add 1.5 inches in length and one inch in girth while flaccid. People that have male surgery have average erections of 7.7 inches after the procedure.

Who Should Take Male Enhancement Pills?

Erectile dysfunction is more common than you might think. According to a Danish study from 2018, roughly one-third of men have some form of erectile dysfunction. The condition appears more frequently and becomes more severe the older you get.

Why do older men have higher rates of erectile dysfunction? There isn’t one answer. Instead, erectile dysfunction is a byproduct of aging, with older men having lower energy levels, testosterone levels, and sex drive.

Male enhancement pills provide a safe and reliable way to combat aging. They can revitalize your sexual desire, giving you the stamina and erection quality you need to please your partner. The supplements let you fight back against Father Time and Mother Nature.

You don’t have to be in middle age or retirement to need male enhancement supplements. Some men have poor circulation, making it challenging for them to achieve erections despite being in excellent health otherwise. Other individuals take supplements like Semenax to raise their odds of conception since it can improve sperm count and motility.

Even the best male enhancement pills can’t work miracles, though. If you want to overcome erectile dysfunction or low testosterone levels, you should use them with diet and exercise. The holistic approach ensures that your body is the fittest and healthiest version of itself.

Do Male Enhancement Pills Have Any Side Effects?

Most organic male enhancement pills have no side effects. The wholesome formulas deliver the increased sex drive and blood flow you want with minimal chance for an allergic reaction.

Note that you do have a slim chance of experiencing side effects, though. Some people have dry mouths, nausea, and low energy levels. These side effects should only last for a few hours. If symptoms persist for several days, you should contact your primary care physician.

People have used compounds like Asian red ginseng and Tribulus terrestris for centuries. These practical and reliable compounds give you the best chance of taking your sex drive up a notch.

Always make sure to read the label before purchasing supplements. Leading manufacturers include a complete list of ingredients on the label so that you can do your research ahead of time. If you’re unsure about the formula, talk with your local doctor.

Does Performer 8 Actually Work?

Research cited within the male enhancement supplement category shows that certain ingredient combinations have been associated with improvements in sexual performance markers when compared to placebo over 12-week periods. Studies on similar formulations have reported statistically meaningful results. However, these findings do not represent direct clinical testing of the finished Performer 8 product. Individual results vary—some men notice clear benefits, while others may experience minimal changes. The satisfaction guarantee allows users to try Performer 8 and evaluate its effectiveness with reduced financial risk.

How Long Does Performer 8 Take to Work?

Performer 8 is formulated as a daily supplement intended to support the body gradually. According to manufacturer guidance and category research, noticeable results typically develop with consistent use over several weeks, with many studies assessing outcomes around 12 weeks. This is not an instant or on-demand product.

Is Performer 8 Safe?

Performer 8 contains natural, plant-based ingredients. However, natural supplements are not automatically suitable for everyone. Men with medical conditions, those taking prescription medications, or individuals with specific health risks should consult a healthcare professional before use.

Is Performer 8 FDA Approved?

Performer 8 is a dietary supplement, not a prescription medication. Dietary supplements are regulated differently and are not approved by the FDA for effectiveness prior to sale. The standard disclaimer applies: this product is not intended to diagnose, treat, cure, or prevent any disease.

How Does Performer 8 Compare to Prescription Options?

Prescription treatments for erectile dysfunction are FDA-approved and supported by extensive clinical data with defined timelines. Performer 8 is a natural supplement that works through a different mechanism and evidence profile. It requires consistent daily use over time, and results can vary significantly between individuals.

Can I Take Performer 8 With My Medications?

This should be discussed with your healthcare provider. Some botanical ingredients may interact with medications, especially those related to heart health, blood pressure, blood thinning, diabetes, or circulation.

How Does Performer 8 Compare to Other Products From the Same Manufacturer?

The manufacturer offers several male wellness supplements, each designed for different performance and health goals. Some men explore more than one option to find the best fit. The shared guarantee policy helps reduce financial risk during evaluation.

Can Performer 8 Help With Fertility?

Performer 8 is formulated to support sexual performance, not fertility. While some ingredients have been researched in fertility contexts, the product is not positioned or marketed as a fertility supplement. Men with fertility concerns should seek professional medical advice.

Why Do Some Reviews Say Performer 8 Doesn’t Work?

Responses to supplements vary widely. Factors such as age, baseline health, consistency of use, expectations, and underlying causes of sexual concerns all influence results. Mixed reviews are common in this category and reflect normal individual differences.

What If Performer 8 Does Not Work for Me?

According to company policy, customers can request a refund under the satisfaction guarantee if the product does not meet expectations. If supplements are insufficient, consulting a medical professional to explore other options may be appropriate.

Final Considerations: Making Your Decision

Choosing a male enhancement solution is a personal decision based on health status, goals, and preferences. This information is intended to support informed decision-making, not replace medical advice.

Key Takeaways

• Quality male enhancement supplements are evaluated based on ingredient research, formulation transparency, manufacturing standards, safety information, and refund policies.
• Performer 8 aligns with many commonly cited quality benchmarks based on publicly available disclosures.
• Supplements work best when combined with healthy lifestyle habits.
• Medical consultation is important for men with health conditions or those taking medications.

Next Steps

If Performer 8 fits your needs, review the latest label details, policies, and availability on the official website.
Always consult a healthcare provider before starting any new supplement.
If natural options do not deliver adequate results, professional medical evaluation may help identify alternative solutions.

Can You Buy male Enhancement Pills Over-the-Counter?

Yes, you can find over-the-counter natural male enhancement supplements. Most of these pills treat erectile dysfunction, like sildenafil. They stimulate blood flow to the male, making it easier for men to achieve an erection.

The problem is that over-the-counter medications you can find at your local pharmacy don’t have the same power as the stuff you find online. These male enhancers have lower levels of key ingredients, making them less effective overall. Shop online if you want the best possible results for your erection quality and male size.

Official Website: :https://performer8.com/

Contact Details: Performer 8

Email: support@performer8.com

Phone: +1(929) 242-4275

Advertise with us: Info@allprsolution.com

Best Over The counter Sleep Aid 2026: Launched By NooCube Strongest natural sleep aid, Pills For Sleep And Anxiety Without Side effects




Best Over The counter Sleep Aid 2026: Launched By NooCube Strongest natural sleep aid, Pills For Sleep And Anxiety Without Side effects

Strongest sleep aid over the counter sleep Pills NooCube best for sleep and anxiety read side effects, benefits, ingredients of NooCube supplement

New York City, Jan. 04, 2026 (GLOBE NEWSWIRE) —

In 2026 Getting good sleep is more like a habit that some people cannot make due to hectic lifestyles. Over the counter, sleeping pills aren’t synthetic drugs but natural supplements which we are going to discuss below. 

They do not have side effects like most pharmaceuticals prescription-based sleeping pills available in the pharmacy. Speaking of OTC sleeping pills, NooCube Sleep is the best otc sleeping aid supplement to attain unmatched effectiveness and sleep quality. Click here to visit noocube sleep official website.

Sleep is like charging the battery of humans which gives you enough rest to carry on with the next day. Getting good sleep is closely linked to a healthy life and healthy brain functioning. Those people who take a good night’s sleep regularly tend to be sharp learners, memorizers, and good rapid decision makers because their cognitive skills are just to the point.

Insufficient sleep is associated with many serious and life-threatening diseases such as cardiovascular incidents, obesity, diabetes, and loss of focus or concentration. Sleep is a natural phenomenon that occurs daily but still around 20% of people are unable to get it every night, thus they develop occasional symptoms of insomnia.

Studies by the National Sleep Foundation show that sleep problems are more commonly reported now than ever before, so it should be no surprise that demand for sleeping medications is at an all time high. There are some people dealing with sleep issues that still find themselves asking are sleeping pills safe though.

A lot of this confusion comes from a lack of understanding on the difference between prescription drugs and over the counter sleep aids. While both can be used to treat severe insomnia patients, that latter is undoubtedly much safer and a far better choice for people who just have a little trouble falling asleep.

That is why we have created our guide to the best OTC sleep aids and prescription sleep medications. This will give you all of the information that you need to choose the perfect sleep aid to help combat any sleep disorder, optimise your sleep wake cycle, or simply just improve sleep habits, no matter your own situation.

Best Sleeping Pills Over the Counter

The thing about OTC medicines is they can be purchased without a prescription and most of them are sold in every pharmacy nearby. OTC medications can also be found in many supermarkets and drug stores since they don’t require direct FDA approval, however, the active ingredient must be FDA-approved. Click here to read more about sleeping pills online

FDA is responsible for the streaming of the best sleeping pills in the market and also their distribution takes place in the right hand.

There are countless brands of the counter sleeping pills most of which are antihistamines that are used against allergies. Since allergy medication induces drowsiness, this made them used as OTC sleeping aid.

Best Over the Counter Sleeping Pills

OTC sleeping aids are preferred over sleeping drugs because OTC versions improve the overall sleep experiences of the users.

Melatonin is put in most natural sleep aids as studies on behavioral sleep medicine show it is among the very best ways to help you sleep. However, some people avoid it as it can cause side effects like nightmares or frequent urination in certain people, making it even harder to sleep.

NooCube Sleep Upgrade is one of the most popular natural sleep aids for people in this group, as it specifically omits melatonin from its formula.

It instead contains:

• Magnesium
• Calcium
• Vitamin d
• Lemon balm leaf powder
• Lavender extract

Sleeping aids for which you don’t need a prescription and are available over the counter are:

      1.   Melatonin

Melatonin is a natural hormone produced by the body to make it sleep. The hormone makes signaling to the brain that it’s time to sleep, however, in sleep-deficient people the levels of melatonin are greatly reduced. Melatonin production and release depends on the time of the day, typically it increases naturally in the evening and falls in the morning.

Melatonin supplements are popular sleeping aid in 2026 and are mainly used by individuals having an impaired melatonin cycle. In many studies, a connection was established between melatonin production and daytime sleep quality. Men and women such as shift workers whose schedule requires them to sleep during the daytime.

Melatonin does not just improve sleep quality but it can also mend fewer sleep disorders. The compound reduces the time people need to fall asleep or in other words, sleep latency, and it increases the total amount of time you sleep.

      2.   Valerian Root

Searching for the best OTC sleeping pills, you may always find valerian root which is a common treatment for anxiety, depression, and menopause symptoms. In US, Europe, and Asia, Valerian Root supplements are the most common sleeping aid which shares different results based on a person’s mental health.

Valerian supplements tend to work better in menopausal and postmenopausal women whose sleep quality was greatly affected before. After taking valerian, they claimed to have better sleep quality with diminished symptoms of a sleep disorder.

      3.   Glycine

Glycine is a typical amino acid that plays a main role in the central nervous system by improving sleep patterns. The exact mechanism of action of glycine is unknown, but it is thought to play a main part in lowering the body temperature during sleep.

In a study conducted in 2006, participants who consumed around 3 grams of Glycine slept more immediately than those who took a placebo. Individuals in the glycine group also reported less fatigue the next morning with feelings of liveliness and mental clarity. You can find Glycine supplements as the counter sleeping aid in nearby stores.

      4.   Cannabidiol

CBD is a hemp-derived compound that features oils, capsules, tinctures, and balms. Since CBD contains no or less amount of THC so the psychoactive effects are absent but the CBD gets you the highest quality sleep.

In many studies, it was confirmed that CBD alleviates anxiety and acts as a natural sleeping aid. Many studies confirmed CBD could reduce the symptoms of insomnia when used alone.

      5.   Lavender

Lavender plant is found in numerous regions of the world, the plant bears purple flowers that are dried and then used for medicinal and household purposes. Lavender has a distinct and soothing fragrance that enhances sleepy feelings. Several studies confirm that just smelling lavender oil before sleep is enough to improve sleep quality, esp in individuals with insomnia complaints.

A study with older adults with dementia suggested going under aromatherapy with lavender oil. The therapy is effective at improving sleep disturbances symptoms. The total sleep time of users also increased with only a few people waking up early and being unable to get back to sleep.

      6.   Magnesium

Hundreds of minerals are there but only magnesium is involved with hundreds of processes in the body including brain and heart functions. Magnesium is a trace mineral that could make it easier for a person to sleep by inducing quietness.

Studies have suggested magnesium has relaxing effects which can be potentially beneficial for regulating melatonin production. Magnesium relaxes the muscles and induces sleep!

There are many forms of magnesium available but most people combine magnesium with other sleeping aids including glycine and melatonin. One study demonstrated the effects of the magnesium, vitamin B, and melatonin combination which were greatly effective for treating asymptomatic insomnia.

Magnesium is the key to increasing GABA levels, Gamma Aminobutyric Acid is a messenger in the brain with calming effects as its features.

      7.   Passionflower

Also known as PassifloraIncarnata is an herbal remedy for insomnia. This species of flower is associated with sleep improvements that first came from North America. Passionflower sleeping aid benefits have been tested in animal studies although more data is to be compiled for human subjects.

A study compared the effect of passionflower tea and a placebo made from parsley leaves, each participant drank each tea about an hour before bedtime for 1 week. Participants who drank passionflower tea noticed lucid dreaming and immediate sleep more than the placebo group.

Best Sleeping Pills by NooCube

Struggling to sleep is like fighting a never-ending battle and switching sides to another in bed continuously. Insomnia is a distressing condition that can take out all the liveliness in your life and it makes you cranky, tired, and less creative with impaired mental and physical performances.

There is so much commonality among insomnia patients as 35% of the adults deal with different severe conditions. There are three types of insomnia and chronic insomnia is the most severe one.

To resolve this issue, the best thing according to the experts is over-the-counter sleeping pills available on the market.

Currently, millions of people are searching for the right sleeping aids but most prefer the OTC ones.

This section is to tell whether you can buy the best sleeping pills in the stores online.

• Best OTC Sleeping Pills GNC

At GNC, you can find CBS gummies that may not be the right solution since it comes along. Although melatonin lozenges didn’t work in most people who purchased it from GNC and tried it for almost a year. Note, to make melatonin work, you may take it in capsule form or higher dosages. GNC may be a good place for dietary supplements but it doesn’t have the best sleeping aid of 2026 – which means NooCube Sleep.

• Sleeping Pill Walmart

Walmart has several sleeping aids and most of them contain Diphenhydramine HCL which is not OTC sleeping aid. Even if you can buy these products over the counter, you may be informed about the negative consequences of Diphenhydramine which affects the cardiovascular as well as the entire nervous system.

Nearly 90% of sleeping pills at Walmart have pharmaceutical chemicals inside and not the ones we speculated about and mentioned above. Such chemicals hold the ability to habit-forming and they can be purchased from any pharmacy nearby.

• Over the Counter Sleeping Pills Walgreens

Just what we were talking about, even Walgreens are short of over-the-counter sleeping pills. The products related to sleep you can find there have doxylamine succinate or diphenhydramine which is again, a habit-forming chemical and is not recommended for someone battling against insomnia. Most sleeping aid products on Walgreens have FDA-approved drugs but unless the doctor hasn’t prescribed you the medication, it would be risky to rely on such compounds for sleep induction.

• Best Sleeping Pills Over the Counter

Only a small number of melatonin supplements are found on Amazon and there is nothing you can find in there besides chemical-based sleeping pills. Organic nighttime sleeping aid are available on Amazon but there is a need for looking out for their manufacturer as most products sold on Amazon have no manufacturing details. These are the products from third-party sellers who may or may not be trustworthy.

Sleeping Pills Near Me

If you are looking for sleeping pills nearby, you should stop your quest right now because the best OTC sleeping aid can be found online.

Men and women from different countries of the world search for the same thing although the search engine presents them according to their region.

Let us see which country sleeping pills are becoming popular and what should they do to get their hands on the best one.

• Best Sleeping Pills USA

There are countless sleeping pills in the USA most of which are found in cough syrup and antihistamine medications. Despite the FDA warnings, US people abuse sleeping pills as they get a different type of arousal from consuming them. This is why the trend of OTC sleeping aids is rising fast in the US for putting drug abuse to an end.

• Best Over the Counter Sleeping Pills UK

You may see UK people chugging Benadryl syrup because it contains multiple antihistamines which induce sleep immediately. You can also find the best over-the-counter sleeping pills in the UK but that wouldn’t be from Barrett and Hodgson or boots pharmacy. Again, you have to go online and find the website of our best-sold and top-ranked sleeping pills over the counter.

• Sleeping Pills Canada

By the reports, nearly 1/3rd people of in Canada take sleeping pills on regular basis. These are either sedative or hypnotics or tranquilizers which affects the brain or spinal cord. Doctors and healthcare providers only prescribe these drugs for critical sleep problems. You can find these drugs are also being used whenever you see someone struggling with anxiety or alcohol withdrawal symptoms.

• Best Sleeping OTC Pills Australia

In Australia, the laws of TGA are very strict, especially about Schedule compounds including sleeping pills. Doxylamine is the most prescribed and strongest OTC sleeping aid in there which again is an antihistamine. It is only prescribed to sleep-deficient individuals for short-term use and whoever prescribes it will assess the patient’s history first.

Best OTC Sleeping Pills – 2026 Updates

Let’s begin our quest for the safest sleeping pills by presenting the best one in the business.

For anyone who is battling against sleeplessness and occasional insomnia, NooCube Sleep Upgrade is effective one they can get.

When we discussed the best over-the-counter sleeping aid in the world that involves Melatonin and Glycine, nearly all of these compounds can be found in the NooCube Sleep Upgrade formula which is combined under the supervision of experts.

NooCube Sleep Upgrade is a dietary supplement that contains numerous sleep and cognition-friendly ingredients such as BacopaMonnieri, GABA, Alpha GPC, Oat Straw, Cat’s claw extract, L-Theanine, etc. The best part about NooCube Sleep Upgrade is no caffeine is available to stimulate mental jitteriness.

It works faster, it is safer than most compounds found in sleeping pills and the dosage of 4 pills per day will ignite your sleep cycle and let you sleep like a baby after a long time.

Pros

• Caffeine-free and over the counter sleeping aid with no synthetic melatonin
• NooCube Sleep Upgrade boosts the synthesis of natural hormones that are required for you to sleep with peace
• As a herbal supplement, the NooCube Sleep formula has no side effects that are commonly observed with prescription sleeping pills
• NooCube Sleep Upgrade reduces anxiety and stress levels which affect symptoms of insomnia positively. Users of NooCube reviewed as they experienced a lack of anxiety and mental stress after taking the supplement on a regular basis
• It aids concentration level and works for better focus, affecting overall lifestyle which is the best choice for insomnia patients
• Works for adults and individuals who are 55 years or older

Cons

• NooCube Sleep Upgrade is expensive to some because it contains a whole supply for a month
• As a natural sleeping aid, the NooCube Sleep Upgrade supplement is hard to find in many countries
• It can be ordered from the official website of Wolfson Berg Limited

NooCube Over the Counter Sleeping Aid Pricing

The official website of NooCube Sleep Upgrade proposed these packages which can save you 70% of your cash.

• One-month supply package of NooCube Sleep Upgrade will cost users $64.99
• Two-month supply package is available for $129.99
• Five-month supply of NooCube Sleep Upgrade will cost around $194.99

Just when you’ve found out NooCube Sleep Upgrade is a natural sleeping aid and has no side effects, what is even more surprising is the money-back guarantee it provides. NooCube offers a full 60-day money-back guarantee. If the customer is not happy with his/her purchase for any reason, they can simply return it within 60 days, and the manufacturers will refund your purchase price in full.

Conclusion – Over the Counter Sleeping Pills with No Risks!

Sleep cycle interruption could unleash a variety of mental sicknesses and it impacts the overall general creativity of a person. If you are an adult and dealing with insomnia, it is better to find a way rather than making it linger even more so it could turn into a serious thing.

Insomnia is treatable and you can’t believe even a small number of ingredients can be tremendously helpful – the only thing is to consider using it on regular basis. Medicines that you can find at the drugstore or nearby markets will have a heap of compounds that are not natural and may lead to a list of side effects.

NooCube Sleep Upgrade is a effective OTC sleeping aid that can help you attain those good night sleeps faster. 

It has no caffeine so taking it at night won’t limit your creativity or passion for work. Ensuring you will get maximum bedtime and limit screen exposure before going to the bed is the key to attaining faster results from NooCube Sleep Upgrade.

CONTACT:

Company: NooCube

Email: support@noocube.com

Order Phone Support: UK: +44 191 743 4476 / US: +1 (970) 671-7706 (Monday-Friday, 9:00am-5:00pm)

Advertise with us: Info@allprsolution.com

Crinetics Pharmaceuticals to Provide PALSONIFY Business Update and Announce Topline Results from Fourth Cohort of Phase 2 Trial of Atumelnant in Congenital Adrenal Hyperplasia




Crinetics Pharmaceuticals to Provide PALSONIFY Business Update and Announce Topline Results from Fourth Cohort of Phase 2 Trial of Atumelnant in Congenital Adrenal Hyperplasia

SAN DIEGO, Jan. 04, 2026 (GLOBE NEWSWIRE) — Crinetics Pharmaceuticals, Inc. (Nasdaq: CRNX), today announced that the company will host a conference call and webcast on Monday, January 5, 2026 at 8:30 a.m. ET to provide an update on PALSONIFY™ (paltusotine) commercialization and disclose topline results from the fourth cohort of the Phase 2 trial of atumelnant in congenital adrenal hyperplasia.

Conference Call and Webcast Details
Management will hold a live conference call and webcast on Monday, January 5, 2026 at 8:30 a.m. ET. A live question-and-answer session will follow the prepared remarks. To access the live audio-only webcast, click here. The archived webcast will also be accessible on the Events & Presentations page in the Investors section of the Crinetics’ website at www.crinetics.com/events. To participate, please dial 1-833-470-1428 (domestic) or 1-646-844-6383 (international) and refer to Access Code 640078.

ABOUT CRINETICS PHARMACEUTICALS
Crinetics Pharmaceuticals is a global pharmaceutical company committed to transforming the treatment of endocrine diseases and endocrine-related tumors through science rooted in patient needs. Crinetics is focused on discovering, developing, and commercializing novel therapies, with a core expertise in targeting G-protein coupled receptors (GPCRs) with small molecules that have specifically tailored pharmacology and properties.

Crinetics’ lead product, PALSONIFY™ (paltusotine), is the first once-daily, oral treatment approved by the U.S. FDA for the treatment of adults with acromegaly who had an inadequate response to surgery and/or for whom surgery is not an option. Paltusotine is also in clinical development for carcinoid syndrome associated with neuroendocrine tumors. Crinetics’ deep pipeline of 10+ disclosed programs includes late-stage investigational candidate atumelnant, which is currently in development for congenital adrenal hyperplasia and ACTH-dependent Cushing’s syndrome, and CRN09682, a nonpeptide drug conjugate candidate that is being developed to treat SST2 expressing neuroendocrine tumors and other SST2 expressing solid tumors. Additional discovery programs address a variety of endocrine conditions such as neuroendocrine tumors, Graves’ disease (including Graves’ hyperthyroidism and Graves’ orbitopathy, or thyroid eye disease), polycystic kidney disease, hyperparathyroidism, diabetes, obesity, and GPCR-targeted oncology indications.

Investors:
Gayathri Diwakar
Head of Investor Relations
gdiwakar@crinetics.com
(858) 345-6340

Media:
Natalie Badillo
Head of Corporate Communications
nbadillo@crinetics.com
(858) 345-6075