FDA Accepts Supplemental New Drug Application for Arcutis’ ZORYVE® (roflumilast) Cream 0.3% for the Treatment of Plaque Psoriasis in Children Ages 2 to 5

FDA Accepts Supplemental New Drug Application for Arcutis’ ZORYVE® (roflumilast) Cream 0.3% for the Treatment of Plaque Psoriasis in Children Ages 2 to 5




FDA Accepts Supplemental New Drug Application for Arcutis’ ZORYVE® (roflumilast) Cream 0.3% for the Treatment of Plaque Psoriasis in Children Ages 2 to 5

  • Prescription Drug User Fee Act (PDUFA) target action date set for June 29, 2026
  • If approved, ZORYVE cream 0.3% would be the first and only topical PDE4 inhibitor indicated for plaque psoriasis in children as young as 2

WESTLAKE VILLAGE, Calif., Nov. 17, 2025 (GLOBE NEWSWIRE) — Arcutis Biotherapeutics, Inc. (Nasdaq: ARQT), a commercial-stage biopharmaceutical company focused on developing meaningful innovations in immuno-dermatology, today announced the FDA acceptance of a supplemental New Drug Application (sNDA) for ZORYVE® (roflumilast) cream 0.3%, a once-daily, advanced targeted topical phosphodiesterase-4 (PDE4) inhibitor, to expand the indication for the topical treatment of plaque psoriasis to include children 2 to 5 years old. The FDA has set a PDUFA target action date of June 29, 2026, for this application.

“Plaque psoriasis in young children can be particularly challenging to manage, as it often affects sensitive areas such as the face and intertriginous skin,” said Amy Paller, MS, MD, attending physician, dermatology, Walter J. Hamlin Professor and chair of dermatology, professor of pediatrics, Northwestern University Feinberg School of Medicine. “Effective and well-tolerated treatment options that are gentle enough for these areas are critical to support long-term disease control and improve quality of life for children and their families.” 

“This milestone brings us closer to helping families and clinicians caring for young children with plaque psoriasis,” said Frank Watanabe, president and CEO of Arcutis. “If approved, ZORYVE cream 0.3% would be the first and only topical PDE4 inhibitor indicated for children as young as two, offering a steroid-free option that delivers both efficacy and tolerability for this particularly vulnerable group. We remain deeply committed to advancing care for people of all ages living with immune-mediated skin diseases, offering innovative, advanced targeted topicals to elevate the standard of care—including children as young as age two.”

ZORYVE cream 0.3% is currently approved for plaque psoriasis in adults and children down to age 6. This sNDA is supported by data from a 4-week Maximal Usage Systemic Exposure (MUSE) study in children aged 2 to 5 years with plaque psoriasis, as well as data from a long-term open-label study that included children in that age range. Results from this long-term study demonstrate consistent favorable long-term safety and tolerability as well as persistence of efficacy across all age ranges studied.

About Plaque Psoriasis
Psoriasis is a common, chronic, inflammatory skin disease that affects nearly 9 million people in the United States. Symptoms include itch, scaling, redness, flaking, and pain. On darker skin tones, plaques may appear more grayish, purplish, or brown. Psoriasis can appear anywhere on the body, including the knees, elbows, torso and thin-skinned areas like the face, genitals and intertriginous areas, which are areas where skin touches skin, such as the armpits, under the breasts, stomach folds, between the buttocks, and in the groin. In children, psoriasis more commonly affects these sensitive areas and intertriginous regions, posing treatment challenges and quality-of-life burdens for patients and families.

About ZORYVE® (roflumilast)
ZORYVE is the number one prescribed branded topical therapy across three major inflammatory dermatoses combined—atopic dermatitis, seborrheic dermatitis, and plaque psoriasis.  ZORYVE cream is a topical formulation of roflumilast, an advanced targeted topical phosphodiesterase type 4 (PDE4) inhibitor. Inhibiting PDE4, an intracellular enzyme that is an established target in dermatology, decreases the production of pro-inflammatory mediators. This decreases inflammation in the skin and balances the skin’s immune system.

Demonstrating both clinical impact and broad industry recognition, ZORYVE has been honored with multiple prestigious awards and recommendations. ZORYVE was recently awarded by Allure with the “2025 Best of Beauty Breakthrough Award,” making it the first FDA-approved medication for atopic dermatitis, plaque psoriasis, and seborrheic dermatitis to win this prominent award. ZORYVE cream 0.3% and ZORYVE foam 0.3% were also awarded the National Psoriasis Foundation’s Seal of Recognition—the first FDA-approved prescription brand to receive the honor. Additionally, the American Academy of Dermatology (AAD) issued a strong recommendation for the use of ZORYVE cream 0.15% in adult patients with mild to moderate atopic dermatitis, according to updated guidelines released in June 2025. In 2024, ZORYVE cream 0.15% was awarded Glamour’s Beauty and Wellness Award for “Best Eczema Product.”

About Arcutis
Arcutis Biotherapeutics, Inc. (Nasdaq: ARQT) is a commercial-stage medical dermatology company that champions meaningful innovation to address the urgent needs of individuals living with immune-mediated dermatological diseases and conditions. With a commitment to solving the most persistent patient challenges in dermatology, Arcutis has a growing portfolio of advanced targeted topicals approved to treat three major inflammatory skin diseases. Arcutis’ unique dermatology development platform coupled with our dermatology expertise allows us to develop differentiated therapies against biologically validated targets, and has produced a robust pipeline for a range of inflammatory dermatological conditions. For more information, visit www.arcutis.com or follow Arcutis on LinkedIn, Facebook, Instagram, and X.

INDICATIONS
ZORYVE cream, 0.3%, is indicated for topical treatment of plaque psoriasis, including intertriginous areas, in adult and pediatric patients 6 years of age and older.

IMPORTANT SAFETY INFORMATION
ZORYVE is contraindicated in patients with moderate to severe liver impairment (Child-Pugh B or C).

The most common adverse reactions reported (≥1%) for ZORYVE cream 0.3% for plaque psoriasis were diarrhea (3.1%), headache (2.4%), insomnia (1.4%), nausea (1.2%), application site pain (1.0%), upper respiratory tract infection (1.0%), and urinary tract infection (1.0%).

Please see full Prescribing Information for ZORYVE cream.

Forward-Looking Statements
This press release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. For example, statements contained in this press release regarding matters that are not historical facts are forward-looking statements. These statements are based on the Company’s current beliefs and expectations. Such forward-looking statements include, but are not limited to, statements regarding the potential FDA approval of ZORYVE cream 0.3% for plaque psoriasis for children ages 2 to 5 years, and the potential of ZORYVE cream to advance the standard of care for plaque psoriasis and other inflammatory dermatological conditions. These statements are subject to substantial known and unknown risks, uncertainties and other factors that may cause our actual results, levels of activity, performance, or achievements to be materially different from the information expressed or implied by these forward-looking statements. Risks and uncertainties that may cause our actual results to differ include risks inherent in our business, reimbursement and access to our products, the impact of competition and other important factors discussed in the “Risk Factors” section of our Form 10-K filed with the U.S. Securities and Exchange Commission (SEC) on February 25, 2025, as well as any subsequent filings with the SEC. Any forward-looking statements that the company makes in this press release are made pursuant to the Private Securities Litigation Reform Act of 1995, as amended, and speak only as of the date of this press release. Except as required by law, we undertake no obligation to revise or update information herein to reflect events or circumstances in the future, even if new information becomes available.

Contacts:
Media
Amanda Sheldon, Head of Corporate Communications
media@arcutis.com

Investors
Brian Schoelkopf, Head of Investor Relations
ir@arcutis.com

Solid Biosciences Announces Licensing Agreement with Andelyn Biosciences for the Use of Proprietary Next-Generation Capsid AAV-SLB101

Solid Biosciences Announces Licensing Agreement with Andelyn Biosciences for the Use of Proprietary Next-Generation Capsid AAV-SLB101




Solid Biosciences Announces Licensing Agreement with Andelyn Biosciences for the Use of Proprietary Next-Generation Capsid AAV-SLB101

– Non-exclusive license providing Solid’s proprietary, next-generation capsid, AAV-SLB101, to Andelyn Biosciences, a full-service cell and gene therapy Contract Development and Manufacturing Organization (CDMO) –

– AAV-SLB101 has been generally well tolerated in the 23 participants dosed in the Phase 1/2 INSPIRE DUCHENNE clinical trial as of a safety cutoff of October 31, 2025 –

– Solid continues to expand collaborative efforts for AAV-SLB101 with over 30 agreements including licenses executed

CHARLESTOWN, Mass., Nov. 17, 2025 (GLOBE NEWSWIRE) — Solid Biosciences Inc. (Nasdaq: SLDB) (the “Company” or “Solid”), a life sciences company developing precision genetic medicines for neuromuscular and cardiac diseases, today announced a non-exclusive worldwide license and collaboration agreement with Andelyn Biosciences (Andelyn), a pioneering and patient-focused cell and gene therapy Contract Development and Manufacturing Organization (CDMO), for the use of Solid’s proprietary, next-generation capsid, AAV-SLB101.

Under the terms of the agreement, Solid grants Andelyn a non-exclusive worldwide license to provide its gene therapy clients with access to utilize AAV-SLB101 in combination with Andelyn’s suspension and adherent modular platform process, the AAV Curator® Platform, which brings a modular approach to gene therapy CMC processes by optimizing manufacturing and using configurable materials. Specific financial terms of the agreement have not been disclosed.

AAV-SLB101 is Solid’s rationally designed capsid developed for enhanced skeletal muscle and cardiac tropism and reduced biodistribution to the liver. As of the recently reported safety cutoff of October 31, 2025, AAV-SLB101 has been generally well tolerated in the 23 pediatric participants who have been dosed in Solid’s Phase 1/2 INSPIRE DUCHENNE clinical trial (NCT06138639) evaluating investigational Duchenne muscular dystrophy gene therapy SGT-003, which utilizes AAV-SLB101. Robust cardiac and skeletal muscle transduction and biodistribution have been demonstrated in preclinical studies as well as in early clinical data from INSPIRE DUCHENNE.

Bo Cumbo, President and CEO of Solid Biosciences, said, “We are excited to announce a new non-exclusive license for AAV-SLB101 with Andelyn Biosciences. This collaboration reflects our shared mission to accelerate the next generation of gene therapies built upon cutting-edge technologies designed to enhance safety and efficacy. With more than 30 agreements and licenses already in place for the use of AAV-SLB101, we expect our partnership with Andelyn to help trailblaze a brighter future for gene therapy. Their pioneering and configurable CDMO model will broaden access to our proprietary capsid, enabling early-stage gene therapy programs to harness next-generation technology and benefit from the differentiated profile of AAV-SLB101.”

Matt Niloff, Chief Commercial Officer of Andelyn, said, “We are eager to provide our clients with access to Solid’s novel capsid, AAV-SLB101. By integrating this next-generation technology into our AAV Curator® Platform, we can offer an advanced gene therapy vector that has been clinically validated and ultimately may allow for faster and more cost-effective development. Our collaboration with Solid underscores our commitment to providing best-in-class solutions for our clients, empowering researchers and helping to advance transformative medicines for patients.”

About AAV-SLB101
AAV-SLB101 is a proprietary, rationally designed capsid developed for enhanced skeletal muscle and cardiac tropism and reduced liver biodistribution. With a robust preclinical package in mice and nonhuman primates, AAV-SLB101 has demonstrated increased transduction speed, enhanced skeletal and cardiac muscle tropism, decreased liver biodistribution and improved efficiency when compared to first generation capsids. The incorporation of AAV-SLB101 into AAV delivered therapies has the potential to be a step forward in the treatment of neuromuscular and cardiac diseases. Solid Biosciences aims to license AAV-SLB101 broadly to both companies and academic institutions pursuing treatments for rare diseases. Solid has existing agreements, including licenses, with more than 30 corporations, institutions and academic labs for the use of AAV-SLB101.

About Solid Biosciences
Solid Biosciences is a precision genetic medicine company focused on advancing a portfolio of gene therapy candidates targeting rare neuromuscular and cardiac diseases, including SGT-003 for Duchenne muscular dystrophy (Duchenne), SGT-212 for Friedreich’s ataxia (FA), SGT-501 for catecholaminergic polymorphic ventricular tachycardia (CPVT), SGT-601 for TNNT2-mediated dilated cardiomyopathy and additional fatal, genetic cardiac diseases. The Company is also focused on developing innovative libraries of genetic regulators and other enabling technologies with promising potential to significantly impact gene therapy delivery cross-industry. Solid is advancing its diverse pipeline and delivery platform in the pursuit of uniting experts in science, technology, disease management, and care. Patient-focused and founded by those directly impacted by Duchenne, Solid’s mission is to improve the daily lives of patients living with devastating rare diseases. For more information, please visit www.solidbio.com.

About Andelyn Biosciences, Inc.
Andelyn Biosciences is a full-service cell and gene therapy CDMO focused on the development, characterization, and production of viral vectors for gene therapy. With more than 20 years of experience, Andelyn’s deep scientific expertise has resulted in the production of cGMP material for more than 450 clinical batches and 75 global clinical trials. Operating out of its development and manufacturing facilities in Columbus, Ohio, Andelyn supports its clients in developing cell and gene therapies from concept through plasmid engineering and manufacturing, process and analytical development, and cGMP clinical and commercial manufacturing. Andelyn can accelerate programs and deliver high-quality products by developing and manufacturing processes on its configurable, data-driven AAV Curator® Platform or tech transfer in an established client program. Capabilities include cGMP manufacturing for suspension processes up to a 2,000-liter and adherent processes. A rigorous quality system, regulatory support, and supply chain vertical integration further advantages clients in bringing their critical therapies to market. For more information, visit andelynbio.com.

Forward-Looking Statements
This press release contains “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995, including statements regarding future expectations, plans and prospects for the Company; the ability to successfully achieve and execute on the company’s goals, priorities and achieve key clinical milestones; the Company’s pipeline of capsid products, including SLB-101, and programs for neuromuscular and cardiac diseases, including its SGT-003 candidate and other clinical and pre-clinical programs and expectations for clinical development, initiation and enrollment in clinical trials, dosing, availability of clinical trial data and potential accelerated approval;; and other statements containing the words “anticipate,” “believe,” “continue,” “could,” “estimate,” “expect,” “intend,” “may,” “plan,” “potential,” “predict,” “project,” “should,” “target,” “would,” “working” and similar expressions. Any forward-looking statements are based on management’s current expectations of future events and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in, or implied by, such forward-looking statements. These risks and uncertainties include, but are not limited to, risks associated with the company’s ability to advance and license AAV-SLB101 and advance SGT-003 and its other clinical and preclinical programs and capsid libraries on the timelines expected or at all; obtain and maintain necessary approvals from the FDA and other regulatory authorities; replicate in clinical trials positive results found in preclinical studies and early-stage clinical trials of the company’s product candidates; obtain, maintain or protect intellectual property rights related to its capsid libraries and product candidates; compete successfully with other companies that are seeking to develop capsids, capsid libraries, Duchenne, Friedreich’s ataxia and other neuromuscular and cardiac treatments and gene therapies;, achieve its other business objectives and continue as a going concern. For a discussion of other risks and uncertainties, and other important factors, any of which could cause the company’s actual results to differ from those contained in the forward-looking statements, see the “Risk Factors” section, as well as discussions of potential risks, uncertainties and other important factors, in the company’s most recent filings with the Securities and Exchange Commission. In addition, the forward-looking statements included in this press release represent the company’s views as of the date hereof and should not be relied upon as representing the company’s views as of any date subsequent to the date hereof. The company anticipates that subsequent events and developments will cause the company’s views to change. However, while the company may elect to update these forward-looking statements at some point in the future, the company specifically disclaims any obligation to do so.

Solid Biosciences Investor Contact:
Nicole Anderson
Director, Investor Relations and Corporate Communications
Solid Biosciences Inc.
investors@solidbio.com

Media Contact:
Glenn Silver
FINN Partners
glenn.silver@finnpartners.com

Ramsay Sante : conditions of availability and consultation of the preparatory documents for the Ramsay Générale de Santé General Meeting of December 11, 2025

Ramsay Sante : conditions of availability and consultation of the preparatory documents for the Ramsay Générale de Santé General Meeting of December 11, 2025




Ramsay Sante : conditions of availability and consultation of the preparatory documents for the Ramsay Générale de Santé General Meeting of December 11, 2025

        PRESS RELEASE
                Paris, 14th November 2025

COMBINED GENERAL MEETING OF DECEMBER 11, 2025

Conditions of availability and consultation of the preparatory documents for the Ramsay Générale de Santé General Meeting of December 11, 2025

The shareholders of Ramsay Générale de Santé are invited to participate in the Combined General Meeting on Thursday, December 11, 2025, which will take place at 10 a.m. at the Apostrophe 83 avenue Marceau 75116 Paris.

The preliminary meeting notice was published in the French BALO (Bulletin des Annonces Légales Obligatoires) on Monday, November 3, 2025 and contains the agenda, the draft resolutions and the main terms of participation and voting at this General Meeting. This notice is also available on the Company’s website (www.ramsaysante.eu).

The convening notice will be published within the applicable legal requirements on the BALO website and in a legal gazette, and will also be available on the Company’s website.

All the documents and information provided for in article R. 22-10-23 of the French Commercial Code can be accessed on the Company’s website (www.ramsaysante.eu section “Finance and investors / Shareholder’s Meetings”) under the applicable legal and regulatory conditions.

The documents referred to in Article R. 225-83 of the French Commercial Code are made available to Shareholders as from the date of the convening notice for the Meeting in accordance with applicable regulations:

  • Shareholders holding registered shares may, up to and including the fifth day prior to the Meeting, request that the Company sends these documents to them free of charge. For shareholders holding bearer shares, the exercise of this right is subject to the provision of a certificate of registration in the accounts of the bearer shares issued by the authorized intermediary;
  • Shareholders may consult these documents at the Company’s registered office, 39, rue Mstislav Rostropovitch 75017 Paris, under the conditions provided for by applicable regulations.

In accordance with the provisions of Article R. 225-84 of the French Commercial Code, shareholders may ask written questions to the Chairman of the Board of Directors. These questions must be addressed to the company’s registered office : Ramsay Générale de Santé (Assemblée générale) 39, rue Mstislav Rostropovitch CS 60053 – 75850 Paris Cedex 17, by registered letter with acknowledgment of receipt or by electronic means to the following address: questions@ramsaysante.fr no later than the fourth working day preceding the date of the General Meeting, i.e., December 5, 2025. They must be accompanied by an account registration certificate.

The 2025 General Meeting will be broadcast live and made available for replayon the Company’s website: www.ramsaysante.fr, section “Finance and investors / Shareholder’s Meetings”.

Shareholders are invited to regularly consult the Company’s website to be informed of the latest communications.

About Ramsay Santé

Ramsay Santé is the European leader in private hospitalisation and primary care. With 40,000 employees and 10,000 practitioners, the group welcomes 13 million patients each year in 492 facilities across five countries (France, Sweden, Norway, Denmark and Italy).

As a mission-driven company, Ramsay Santé covers the entire care pathways in medicine, surgery, obstetrics, medical and rehabilitation care, mental health and primary care centres, with constant innovation to improves everyone’s health and ensures equitable access to secure and qualitative care.

Facebook: https://www.facebook.com/RamsaySante 
Instagram: https://www.instagram.com/ramsaysante 
Twitter: https://twitter.com/RamsaySante 
LinkedIn: https://www.linkedin.com/company/ramsaysante 
YouTube: https://www.youtube.com/c/RamsaySante 

Code ISIN and Euronext Paris: FR0000044471 
Website:  www.ramsaysante.fr 

Investor / Analyst Relations        Press Relations

Clément Lafaix        Brigitte Cachon
Tél. +33 1 87 86 21 52        Tél. +33 1 87 86 22 11
clement.lafaix@ramsaysante.fr        brigitte.cachon@ramsaysante.fr

Attachment

Ramsay Sante : conditions of availability and consultation of the preparatory documents for the Ramsay Générale de Santé General Meeting of December 11, 2025

Ramsay Sante : conditions of availability and consultation of the preparatory documents for the Ramsay Générale de Santé General Meeting of December 11, 2025




Ramsay Sante : conditions of availability and consultation of the preparatory documents for the Ramsay Générale de Santé General Meeting of December 11, 2025

        PRESS RELEASE
                Paris, 14th November 2025

COMBINED GENERAL MEETING OF DECEMBER 11, 2025

Conditions of availability and consultation of the preparatory documents for the Ramsay Générale de Santé General Meeting of December 11, 2025

The shareholders of Ramsay Générale de Santé are invited to participate in the Combined General Meeting on Thursday, December 11, 2025, which will take place at 10 a.m. at the Apostrophe 83 avenue Marceau 75116 Paris.

The preliminary meeting notice was published in the French BALO (Bulletin des Annonces Légales Obligatoires) on Monday, November 3, 2025 and contains the agenda, the draft resolutions and the main terms of participation and voting at this General Meeting. This notice is also available on the Company’s website (www.ramsaysante.eu).

The convening notice will be published within the applicable legal requirements on the BALO website and in a legal gazette, and will also be available on the Company’s website.

All the documents and information provided for in article R. 22-10-23 of the French Commercial Code can be accessed on the Company’s website (www.ramsaysante.eu section “Finance and investors / Shareholder’s Meetings”) under the applicable legal and regulatory conditions.

The documents referred to in Article R. 225-83 of the French Commercial Code are made available to Shareholders as from the date of the convening notice for the Meeting in accordance with applicable regulations:

  • Shareholders holding registered shares may, up to and including the fifth day prior to the Meeting, request that the Company sends these documents to them free of charge. For shareholders holding bearer shares, the exercise of this right is subject to the provision of a certificate of registration in the accounts of the bearer shares issued by the authorized intermediary;
  • Shareholders may consult these documents at the Company’s registered office, 39, rue Mstislav Rostropovitch 75017 Paris, under the conditions provided for by applicable regulations.

In accordance with the provisions of Article R. 225-84 of the French Commercial Code, shareholders may ask written questions to the Chairman of the Board of Directors. These questions must be addressed to the company’s registered office : Ramsay Générale de Santé (Assemblée générale) 39, rue Mstislav Rostropovitch CS 60053 – 75850 Paris Cedex 17, by registered letter with acknowledgment of receipt or by electronic means to the following address: questions@ramsaysante.fr no later than the fourth working day preceding the date of the General Meeting, i.e., December 5, 2025. They must be accompanied by an account registration certificate.

The 2025 General Meeting will be broadcast live and made available for replayon the Company’s website: www.ramsaysante.fr, section “Finance and investors / Shareholder’s Meetings”.

Shareholders are invited to regularly consult the Company’s website to be informed of the latest communications.

About Ramsay Santé

Ramsay Santé is the European leader in private hospitalisation and primary care. With 40,000 employees and 10,000 practitioners, the group welcomes 13 million patients each year in 492 facilities across five countries (France, Sweden, Norway, Denmark and Italy).

As a mission-driven company, Ramsay Santé covers the entire care pathways in medicine, surgery, obstetrics, medical and rehabilitation care, mental health and primary care centres, with constant innovation to improves everyone’s health and ensures equitable access to secure and qualitative care.

Facebook: https://www.facebook.com/RamsaySante 
Instagram: https://www.instagram.com/ramsaysante 
Twitter: https://twitter.com/RamsaySante 
LinkedIn: https://www.linkedin.com/company/ramsaysante 
YouTube: https://www.youtube.com/c/RamsaySante 

Code ISIN and Euronext Paris: FR0000044471 
Website:  www.ramsaysante.fr 

Investor / Analyst Relations        Press Relations

Clément Lafaix        Brigitte Cachon
Tél. +33 1 87 86 21 52        Tél. +33 1 87 86 22 11
clement.lafaix@ramsaysante.fr        brigitte.cachon@ramsaysante.fr

Attachment

Clue Expands Wearable Integrations with Withings, Ultrahuman, WHOOP, Huawei, Polar, Fitbit, Noise and Luna, Unlocking Deeper Insights into Women’s Health

Clue Expands Wearable Integrations with Withings, Ultrahuman, WHOOP, Huawei, Polar, Fitbit, Noise and Luna, Unlocking Deeper Insights into Women’s Health




Clue Expands Wearable Integrations with Withings, Ultrahuman, WHOOP, Huawei, Polar, Fitbit, Noise and Luna, Unlocking Deeper Insights into Women’s Health

LONDON, Nov. 17, 2025 (GLOBE NEWSWIRE) — Clue, the #1 women-led period and cycle tracker trusted by over 100 million worldwide, has today announced expanded integrations with leading wearable partners Withings, Ultrahuman, WHOOP, Huawei, Polar, Fitbit, Luna and Noise – giving women and people with cycles access to a richer picture of their health. These new partnerships follow Clue’s existing relationship with ŌURA, which has been in place in 2023, and are part of the brand’s continued mission to help women better understand their bodies.

With wearable devices and fitness trackers having taken off in recent years, Clue’s data highlights just how strong the demand is for this kind of experience: more than 60% of respondents use or would use a wearable device primarily for monitoring their health or physical activity, and almost 40% of respondents would be interested in monitoring their menstrual cycle with a wearable to discover cycle patterns and understand their body better. With more than 80% of respondents wearing their device every day, and body temperature and sleep amongst the most valued biometrics, Clue’s new integrations take wearables one step further, connecting daily health data with menstrual and hormonal patterns.

How it works
The new integrations will see the addition of sleep duration and temperature tracking included within the context of other cycle data, allowing Clue members to gain deeper insight into their wellbeing via three key steps:

  • Continuous tracking: Wearables record skin temperature and sleep duration passively in the background.
  • Smart sync: Data is securely transferred and displayed in Clue, alongside self-tracked symptoms and cycle information.
  • Contextual insights: By combining wearable data with Clue tracking, members can see patterns that may relate to their menstrual cycle, perimenopause, or other phases of life.

Members will be able to identify how sleep and temperature change in different phases of their cycle so they can make correlations between things like temperature trends and ovulation, sleep and energy levels or sleep and mood. These combined insights provide women with a broader picture of their health, allowing them to spot changes, monitor health goals, and adapt routines in ways that feel aligned with their bodies.

Our mission at Clue is to help women and people with cycles understand their bodies and take control of their health,” said Rhiannon White, CEO of Clue. “We know the appetite for cycle-aware wearables is growing quickly, and expanding our partner ecosystem is not only good for our members — it’s fueling Clue’s growth as the most trusted platform for women’s health data globally. With this suite of new partners, we’re building a connected experience that gives women more choice and agency than ever before.”

To make these integrations widely available, Clue and its partners are offering exclusive bundles and discounts:

Live now

  • Withings
    • Temperature¹ & sleep duration tracking²
    • Clue Plus x Withings bundle available on the Withings site, including an annual Clue Plus subscription with every ScanWatch 2 purchase (US price: $379.95, EU price: 359.90 euros, UK price: 319.95 GBP)
    • Clue Plus members get 10% off all Withings devices via Clue Perks
  • Ultrahuman
    • Temperature & sleep duration tracking
    • 10% off Ultrahuman Ring for Clue Plus members
    • Bundled Ultrahuman Ring + Clue Plus annual subscription ($9.99, normally $39.99)
  • WHOOP
    • Temperature & sleep duration tracking
    • Three months free Clue Plus via the Whoop app
    • Clue Plus subscribers get $30 Off WHOOP Peak or Life Membership
  • Polar
    • Temperature & sleep duration tracking
    • Three months free Clue Plus, included with new purchase of Polar devices
    • Clue Plus subscribers get 15% off select Polar devices via Clue Perks
  • Fitbit
    • Temperature & sleep duration tracking
    • Three months free Clue Plus, offered to Fitbit Premium users starting in US, CA, UK, and AU
  • Luna
    • Temperature & sleep duration tracking
    • Clue Plus members get 15% off all Luna devices via Clue Perks
    • Three months free Clue Plus for all Luna users

Coming soon

  • Huawei
    • Temperature & sleep duration tracking
    • Three months free Clue Plus, included with new purchase of Huawei Watch GT 6 Series and Ultimate 2
  • Noise (available from Q1 2026)
    • Temperature & sleep duration tracking
    • Three months free Clue Plus via the Noise Fitness app

Alexi Coffey, VP of Product at WHOOP, commented: We’re proud to partner with Clue to help women better understand their health across every stage of life. Building on the existing WHOOP Menstrual Cycle Insights and WHOOP Advanced Labs experiences, this collaboration creates a more complete picture of women’s health — connecting recovery, sleep, and hormonal patterns to small daily choices that shape long-term wellbeing for women.”

“This collaboration is about providing women with choice and confidence in their health journey,” added Kate Davies, VP Medical, Women’s Health & Longevity at Ultrahuman. “By combining the biomarker insights of the Ring AIR with Clue Plus, we are enabling seamless, cycle-aware health tracking that helps women reflect on their bodies with greater ease.”

All wearable and app integrations are exclusively for Clue Plus subscribers and work with any of Clue’s tracking modes: Clue Period Tracking, Clue Conceive, Clue Pregnancy, Clue Perimenopause, and Clue Tracking (without periods). To learn more about Clue and access evidence-based women’s health education, visit helloclue.com.

About the Consumer Survey
Data in this release comes from an anonymous and aggregated survey of 1,382 Clue members. Responses were self-reported and collected via the Clue app.

About Clue
Clue is the #1 women-led period and cycle tracker, loved by over 100 million women and people with cycles around the world.

Beyond period tracking, Clue helps you turn your cycle into a powerful tool to help navigate your health journey by making sense of your hormones and discovering your unique patterns.

Whether you want to simply understand your cycle, try to conceive,
track your pregnancy, or navigate perimenopause, Clue is your intelligent, science-backed, data-driven health guide.

Join the movement that’s changing the future of female health, one data point at a time. Try Clue free, today.

Responsible use & disclaimer

  • Clue Plus + wearables integration is designed to support self-awareness, not replace medical care.
  • Data from wearable devices does not equal or replace a medical diagnosis.
  • Temperature and sleep patterns can be influenced by many factors beyond the menstrual cycle.
  • Temperature data from wearable devices cannot be used as a method of contraception.
  • Always consult a healthcare professional for questions about contraception, fertility, perimenopause, or other medical concerns.

¹Skin temperature measurements can only be synced with the Clue app via Withings BeamO and Thermo.

²Sleep duration measurements can only be synced with the Clue app via Withings ScanWatch 2, ScanWatch Light, ScanWatch Nova, and ScanWatch Nova Brilliant.

Infographics accompanying this announcement are available at:

https://www.globenewswire.com/NewsRoom/AttachmentNg/59721204-e75e-49a0-9a1c-ca94da39212a

https://www.globenewswire.com/NewsRoom/AttachmentNg/cad43f2a-d9ac-4b18-9744-32da788ddd17

https://www.globenewswire.com/NewsRoom/AttachmentNg/e537a60b-2907-490f-85ed-d5f7e554b962

https://www.globenewswire.com/NewsRoom/AttachmentNg/339d15f1-8e99-4512-b46e-dbe4b1b67cde

CONTACT: Contact: press@helloclue.com

Clue Expands Wearable Integrations with Withings, Ultrahuman, WHOOP, Huawei, Polar, Fitbit, Noise and Luna, Unlocking Deeper Insights into Women’s Health

Clue Expands Wearable Integrations with Withings, Ultrahuman, WHOOP, Huawei, Polar, Fitbit, Noise and Luna, Unlocking Deeper Insights into Women’s Health




Clue Expands Wearable Integrations with Withings, Ultrahuman, WHOOP, Huawei, Polar, Fitbit, Noise and Luna, Unlocking Deeper Insights into Women’s Health

LONDON, Nov. 17, 2025 (GLOBE NEWSWIRE) — Clue, the #1 women-led period and cycle tracker trusted by over 100 million worldwide, has today announced expanded integrations with leading wearable partners Withings, Ultrahuman, WHOOP, Huawei, Polar, Fitbit, Luna and Noise – giving women and people with cycles access to a richer picture of their health. These new partnerships follow Clue’s existing relationship with ŌURA, which has been in place in 2023, and are part of the brand’s continued mission to help women better understand their bodies.

With wearable devices and fitness trackers having taken off in recent years, Clue’s data highlights just how strong the demand is for this kind of experience: more than 60% of respondents use or would use a wearable device primarily for monitoring their health or physical activity, and almost 40% of respondents would be interested in monitoring their menstrual cycle with a wearable to discover cycle patterns and understand their body better. With more than 80% of respondents wearing their device every day, and body temperature and sleep amongst the most valued biometrics, Clue’s new integrations take wearables one step further, connecting daily health data with menstrual and hormonal patterns.

How it works
The new integrations will see the addition of sleep duration and temperature tracking included within the context of other cycle data, allowing Clue members to gain deeper insight into their wellbeing via three key steps:

  • Continuous tracking: Wearables record skin temperature and sleep duration passively in the background.
  • Smart sync: Data is securely transferred and displayed in Clue, alongside self-tracked symptoms and cycle information.
  • Contextual insights: By combining wearable data with Clue tracking, members can see patterns that may relate to their menstrual cycle, perimenopause, or other phases of life.

Members will be able to identify how sleep and temperature change in different phases of their cycle so they can make correlations between things like temperature trends and ovulation, sleep and energy levels or sleep and mood. These combined insights provide women with a broader picture of their health, allowing them to spot changes, monitor health goals, and adapt routines in ways that feel aligned with their bodies.

Our mission at Clue is to help women and people with cycles understand their bodies and take control of their health,” said Rhiannon White, CEO of Clue. “We know the appetite for cycle-aware wearables is growing quickly, and expanding our partner ecosystem is not only good for our members — it’s fueling Clue’s growth as the most trusted platform for women’s health data globally. With this suite of new partners, we’re building a connected experience that gives women more choice and agency than ever before.”

To make these integrations widely available, Clue and its partners are offering exclusive bundles and discounts:

Live now

  • Withings
    • Temperature¹ & sleep duration tracking²
    • Clue Plus x Withings bundle available on the Withings site, including an annual Clue Plus subscription with every ScanWatch 2 purchase (US price: $379.95, EU price: 359.90 euros, UK price: 319.95 GBP)
    • Clue Plus members get 10% off all Withings devices via Clue Perks
  • Ultrahuman
    • Temperature & sleep duration tracking
    • 10% off Ultrahuman Ring for Clue Plus members
    • Bundled Ultrahuman Ring + Clue Plus annual subscription ($9.99, normally $39.99)
  • WHOOP
    • Temperature & sleep duration tracking
    • Three months free Clue Plus via the Whoop app
    • Clue Plus subscribers get $30 Off WHOOP Peak or Life Membership
  • Polar
    • Temperature & sleep duration tracking
    • Three months free Clue Plus, included with new purchase of Polar devices
    • Clue Plus subscribers get 15% off select Polar devices via Clue Perks
  • Fitbit
    • Temperature & sleep duration tracking
    • Three months free Clue Plus, offered to Fitbit Premium users starting in US, CA, UK, and AU
  • Luna
    • Temperature & sleep duration tracking
    • Clue Plus members get 15% off all Luna devices via Clue Perks
    • Three months free Clue Plus for all Luna users

Coming soon

  • Huawei
    • Temperature & sleep duration tracking
    • Three months free Clue Plus, included with new purchase of Huawei Watch GT 6 Series and Ultimate 2
  • Noise (available from Q1 2026)
    • Temperature & sleep duration tracking
    • Three months free Clue Plus via the Noise Fitness app

Alexi Coffey, VP of Product at WHOOP, commented: We’re proud to partner with Clue to help women better understand their health across every stage of life. Building on the existing WHOOP Menstrual Cycle Insights and WHOOP Advanced Labs experiences, this collaboration creates a more complete picture of women’s health — connecting recovery, sleep, and hormonal patterns to small daily choices that shape long-term wellbeing for women.”

“This collaboration is about providing women with choice and confidence in their health journey,” added Kate Davies, VP Medical, Women’s Health & Longevity at Ultrahuman. “By combining the biomarker insights of the Ring AIR with Clue Plus, we are enabling seamless, cycle-aware health tracking that helps women reflect on their bodies with greater ease.”

All wearable and app integrations are exclusively for Clue Plus subscribers and work with any of Clue’s tracking modes: Clue Period Tracking, Clue Conceive, Clue Pregnancy, Clue Perimenopause, and Clue Tracking (without periods). To learn more about Clue and access evidence-based women’s health education, visit helloclue.com.

About the Consumer Survey
Data in this release comes from an anonymous and aggregated survey of 1,382 Clue members. Responses were self-reported and collected via the Clue app.

About Clue
Clue is the #1 women-led period and cycle tracker, loved by over 100 million women and people with cycles around the world.

Beyond period tracking, Clue helps you turn your cycle into a powerful tool to help navigate your health journey by making sense of your hormones and discovering your unique patterns.

Whether you want to simply understand your cycle, try to conceive,
track your pregnancy, or navigate perimenopause, Clue is your intelligent, science-backed, data-driven health guide.

Join the movement that’s changing the future of female health, one data point at a time. Try Clue free, today.

Responsible use & disclaimer

  • Clue Plus + wearables integration is designed to support self-awareness, not replace medical care.
  • Data from wearable devices does not equal or replace a medical diagnosis.
  • Temperature and sleep patterns can be influenced by many factors beyond the menstrual cycle.
  • Temperature data from wearable devices cannot be used as a method of contraception.
  • Always consult a healthcare professional for questions about contraception, fertility, perimenopause, or other medical concerns.

¹Skin temperature measurements can only be synced with the Clue app via Withings BeamO and Thermo.

²Sleep duration measurements can only be synced with the Clue app via Withings ScanWatch 2, ScanWatch Light, ScanWatch Nova, and ScanWatch Nova Brilliant.

Infographics accompanying this announcement are available at:

https://www.globenewswire.com/NewsRoom/AttachmentNg/59721204-e75e-49a0-9a1c-ca94da39212a

https://www.globenewswire.com/NewsRoom/AttachmentNg/cad43f2a-d9ac-4b18-9744-32da788ddd17

https://www.globenewswire.com/NewsRoom/AttachmentNg/e537a60b-2907-490f-85ed-d5f7e554b962

https://www.globenewswire.com/NewsRoom/AttachmentNg/339d15f1-8e99-4512-b46e-dbe4b1b67cde

CONTACT: Contact: press@helloclue.com

Nxera Pharma Shares Video Interviews with Major Shareholders on Its Official YouTube Channel

Nxera Pharma Shares Video Interviews with Major Shareholders on Its Official YouTube Channel




Nxera Pharma Shares Video Interviews with Major Shareholders on Its Official YouTube Channel

  • Perspectives from Nxera’s major shareholders provide deeper insights into their investment views and confidence in the Company’s strategy

Tokyo, Japan and Cambridge and London, UK, 17 November 2025 – Nxera Pharma Co., Ltd. (“Nxera” or “the Company”; TSE 4565) announces the release of two video interviews with its major shareholders, available on the Company’s official YouTube channel.

Nxera invited its major shareholders to share their perspectives on the Company’s strategy, operations and investment appeal, offering valuable insights for all stakeholders, including shareholders and investors, to better understand Nxera’s business.

In the first interview, conducted in July 2025, Nxera welcomed Mr. Yoshiharu Asai, a venture capitalist from JIC Venture Growth Investments Co., Ltd. (“JIC VGI”), part of the Japan Investment Corporation (“JIC”) Group. In the second interview, Nxera spoke with Mr. Daisuke Gomi, an individual shareholder.

Nxera continues to value open and proactive engagement with its stakeholders, including shareholders and investors, as part of its commitment to sustainable growth and long-term value creation. These initiatives reflect Nxera’s focus on fostering a deeper understanding of the Company’s corporate strategy and business initiatives.

Interview with Mr. Yoshiharu Asai, JIC VGI | 3 July 2025

Session topics:

  1. Background of the Investment in Nxera
  2. Valuation Approach
  3. Notable Pipeline in Nxera’s Platform Business
  4. Focus Areas in Nxera’s Commercial Business
  5. Impressions of the Management Team

Watch the full interview here:
https://www.youtube.com/watch?v=mFQoJhf8TE0

Interview with Mr. Daisuke Gomi | 17 November 2025

Session topics:

  1. Focus Areas When Making Investment Decisions
  2. Reasons for Investing in Nxera and Other Bio-ventures
  3. Expectations of Nxera
  4. Evaluation of Nxera (Business, Management, etc.)
  5. Future Expectations

Watch the full interview here:
https://www.youtube.com/watch?v=IWcjMri3jQ4

–END–

About Nxera Pharma
Nxera Pharma is a technology powered biopharma company in pursuit of new specialty medicines to improve the lives of patients with unmet needs in Japan and globally.

We have built an agile, new-generation commercial business in Japan to develop and commercialize innovative medicines, including several launched products, to address this high value, large and growing market and those in the broader APAC region.

Behind that, and powered by our unique NxWave™ discovery platform, we are advancing an extensive pipeline of over 30 active programs from discovery through to late clinical stage internally and in partnership with leading pharma and biotech companies. This pipeline of potentially first- and best-in-class candidates is focused on addressing major unmet needs in some of the fastest-growing areas of medicine across obesity and metabolic disorders, neurology/neuropsychiatry and immunology and inflammation.

Nxera employs approximately 400 talented people at key locations in Tokyo and Osaka (Japan), London and Cambridge (UK), Basel (Switzerland) and Seoul (South Korea) and is listed on the Tokyo Stock Exchange (ticker: 4565).

For more information, please visit www.nxera.life
LinkedIn: @NxeraPharma | X: @NxeraPharma | YouTube: @NxeraPharma

Enquiries:

Media and Investor Relations
Shinya Tsuzuki, VP, Head of Investor Relations
Shinichiro Nishishita, VP Investor Relations, Head of Regulatory Disclosures
Maya Bennison, Communications Manager
+81 (0)3 5962 5718 | +44 (0)1223 949390 |IR@Nxera.life

MEDiSTRAVA (for International Media)
Mark Swallow, Frazer Hall, Erica Hollingsworth
+44 (0)203 928 6900 | Nxera@medistrava.com

Forward-looking statements
This press release contains forward-looking statements, including statements about the discovery, development, and commercialization of products. Various risks may cause Nxera Pharma Group’s actual results to differ materially from those expressed or implied by the forward looking statements, including: adverse results in clinical development programs; failure to obtain patent protection for inventions; commercial limitations imposed by patents owned or controlled by third parties; dependence upon strategic alliance partners to develop and commercialize products and services; difficulties or delays in obtaining regulatory approvals to market products and services resulting from development efforts; the requirement for substantial funding to conduct research and development and to expand commercialization activities; and product initiatives by competitors. As a result of these factors, prospective investors are cautioned not to rely on any forward-looking statements. We disclaim any intention or obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise.

Nxera Pharma Shares Video Interviews with Major Shareholders on Its Official YouTube Channel

Nxera Pharma Shares Video Interviews with Major Shareholders on Its Official YouTube Channel




Nxera Pharma Shares Video Interviews with Major Shareholders on Its Official YouTube Channel

  • Perspectives from Nxera’s major shareholders provide deeper insights into their investment views and confidence in the Company’s strategy

Tokyo, Japan and Cambridge and London, UK, 17 November 2025 – Nxera Pharma Co., Ltd. (“Nxera” or “the Company”; TSE 4565) announces the release of two video interviews with its major shareholders, available on the Company’s official YouTube channel.

Nxera invited its major shareholders to share their perspectives on the Company’s strategy, operations and investment appeal, offering valuable insights for all stakeholders, including shareholders and investors, to better understand Nxera’s business.

In the first interview, conducted in July 2025, Nxera welcomed Mr. Yoshiharu Asai, a venture capitalist from JIC Venture Growth Investments Co., Ltd. (“JIC VGI”), part of the Japan Investment Corporation (“JIC”) Group. In the second interview, Nxera spoke with Mr. Daisuke Gomi, an individual shareholder.

Nxera continues to value open and proactive engagement with its stakeholders, including shareholders and investors, as part of its commitment to sustainable growth and long-term value creation. These initiatives reflect Nxera’s focus on fostering a deeper understanding of the Company’s corporate strategy and business initiatives.

Interview with Mr. Yoshiharu Asai, JIC VGI | 3 July 2025

Session topics:

  1. Background of the Investment in Nxera
  2. Valuation Approach
  3. Notable Pipeline in Nxera’s Platform Business
  4. Focus Areas in Nxera’s Commercial Business
  5. Impressions of the Management Team

Watch the full interview here:
https://www.youtube.com/watch?v=mFQoJhf8TE0

Interview with Mr. Daisuke Gomi | 17 November 2025

Session topics:

  1. Focus Areas When Making Investment Decisions
  2. Reasons for Investing in Nxera and Other Bio-ventures
  3. Expectations of Nxera
  4. Evaluation of Nxera (Business, Management, etc.)
  5. Future Expectations

Watch the full interview here:
https://www.youtube.com/watch?v=IWcjMri3jQ4

–END–

About Nxera Pharma
Nxera Pharma is a technology powered biopharma company in pursuit of new specialty medicines to improve the lives of patients with unmet needs in Japan and globally.

We have built an agile, new-generation commercial business in Japan to develop and commercialize innovative medicines, including several launched products, to address this high value, large and growing market and those in the broader APAC region.

Behind that, and powered by our unique NxWave™ discovery platform, we are advancing an extensive pipeline of over 30 active programs from discovery through to late clinical stage internally and in partnership with leading pharma and biotech companies. This pipeline of potentially first- and best-in-class candidates is focused on addressing major unmet needs in some of the fastest-growing areas of medicine across obesity and metabolic disorders, neurology/neuropsychiatry and immunology and inflammation.

Nxera employs approximately 400 talented people at key locations in Tokyo and Osaka (Japan), London and Cambridge (UK), Basel (Switzerland) and Seoul (South Korea) and is listed on the Tokyo Stock Exchange (ticker: 4565).

For more information, please visit www.nxera.life
LinkedIn: @NxeraPharma | X: @NxeraPharma | YouTube: @NxeraPharma

Enquiries:

Media and Investor Relations
Shinya Tsuzuki, VP, Head of Investor Relations
Shinichiro Nishishita, VP Investor Relations, Head of Regulatory Disclosures
Maya Bennison, Communications Manager
+81 (0)3 5962 5718 | +44 (0)1223 949390 |IR@Nxera.life

MEDiSTRAVA (for International Media)
Mark Swallow, Frazer Hall, Erica Hollingsworth
+44 (0)203 928 6900 | Nxera@medistrava.com

Forward-looking statements
This press release contains forward-looking statements, including statements about the discovery, development, and commercialization of products. Various risks may cause Nxera Pharma Group’s actual results to differ materially from those expressed or implied by the forward looking statements, including: adverse results in clinical development programs; failure to obtain patent protection for inventions; commercial limitations imposed by patents owned or controlled by third parties; dependence upon strategic alliance partners to develop and commercialize products and services; difficulties or delays in obtaining regulatory approvals to market products and services resulting from development efforts; the requirement for substantial funding to conduct research and development and to expand commercialization activities; and product initiatives by competitors. As a result of these factors, prospective investors are cautioned not to rely on any forward-looking statements. We disclaim any intention or obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise.

Inventiva announces full exercise of Underwriters’ Option, bringing proceeds of Offering to approximately $172.5M

Inventiva announces full exercise of Underwriters’ Option, bringing proceeds of Offering to approximately $172.5M




Inventiva announces full exercise of Underwriters’ Option, bringing proceeds of Offering to approximately $172.5M

Daix (France), New York City (New York, United States), November 17, 2025 – Inventiva (Euronext Paris and Nasdaq: IVA) (“Inventiva” or the “Company“), a clinical-stage biopharmaceutical company focused on the development of oral therapies for the treatment of metabolic dysfunction-associated steatohepatitis (“MASH“), today announced that the underwriters of the previously announced public offering in the United States (the “Offering“) of 38,961,038 American Depositary Shares (“ADSs“), each representing one ordinary share of the Company with a nominal value of €0.01, have exercised in full their option (the “Underwriters’ Option“) to purchase 5,844,155 additional ADSs (the “Additional ADSs“). The additional ADSs are expected to be delivered on November 18, 2025.

Following the exercise in full of the Underwriters’ Option, the total number of ADSs issued in the Offering will amount to 44,805,193, resulting in gross proceeds for the Company of approximately $172.5 million (€149.0 million1) and the estimated net proceeds of the Offering, after deducting underwriting fees, commissions and estimated expenses payable by the Company, will be approximately of $161.2 million (€139.3 million1).

The Company intends to apply the net proceeds from the sale of Additional ADSs on a pro rata basis to the use of proceeds identified with respect to the base offering.

The offering price of $3.85 per ADS and Additional ADS (corresponding to €3.33 per ordinary share based on the exchange rate of €1.00 = $1.1576 as published by the European Central Bank on November 12, 2025) is equal to the volume-weighted average price of the share of the Company on the regulated market of Euronext in Paris (“Euronext“) for the last trading session preceding the pricing date of the Offering, less a discount of 0.89%. The offering price was determined by the Chief Executive Officer in accordance with a sub-delegation of powers from the Company’s Board of Directors (Conseil d’Administration) on October 27, 2025, pursuant to the 25th resolution of the Company’s combined shareholders’ meeting held on May 22, 2025

The Company’s ADSs are listed on the Nasdaq Global Market under the ticker symbol “IVA” and the Company’s ordinary shares are listed on Euronext under the symbol “IVA”.

The exercise of the Underwriters’ Option is part of stabilization activities carried out since the announcement of the Offering. The stabilization period is now closed.

A shelf registration statement on Form F-3 (including a prospectus) relating to the Company’s securities was filed with the Securities and Exchange Commission (the “SEC“) in the United States on October 14, 2025 and became effective on November 3, 2025. The Company has also filed with the SEC a final prospectus supplement (and accompanying prospectus) relating to and describing the terms of the Offering (the “Final Prospectus Supplement“). These documents may be obtained free of charge by visiting EDGAR on the SEC’s website at www.sec.gov. Alternatively, a copy of the Final Prospectus Supplement (and accompanying prospectus) may be obtained from Leerink Partners LLC, Attention: Syndicate Department, 53 State Street, 40th Floor, Boston, MA 02109, by telephone at (800) 808-7525, ext. 6105, or by email at syndicate@leerink.com; or from Piper Sandler & Co., Attention: Prospectus Department, 350 North 5th Street, Suite 1000, Minneapolis, MN 55401 or by email at prospectus@psc.com.

The Offering was not subject to a prospectus requiring an approval of the French Financial Markets Authority (Autorité des Marchés Financiers) (the “AMF“). In accordance with Article 1(5) (ba) of the Regulation (EU) 2017/1129 of the European Parliament and of the Council of 14 June 2017, as amended (the “Prospectus Regulation“), the Company has filed with the AMF a document containing the information set out in Annex IX of the Prospectus Regulation (the “Information Document“) considering that the Offering represents a dilution above 30% of the current share capital of the Company. A copy of the Information Document is available on the Company’s website (www.inventivapharma.com). 

About Inventiva

Inventiva is a clinical-stage biopharmaceutical company focused on the research and development of oral small molecule therapies for the treatment of patients with MASH. The Company is currently evaluating lanifibranor, a novel pan-PPAR agonist, in the NATiV3 pivotal Phase 3 clinical trial for the treatment of adult patients with MASH, a common and progressive chronic liver disease.

Inventiva is a public company listed on compartment B of the regulated market of Euronext Paris (ticker: IVA, ISIN: FR0013233012) and on the Nasdaq Global Market in the United States (ticker: IVA). http://www.inventivapharma.com   

Contacts 

Inventiva
Pascaline Clerc
EVP, Strategy and Corporate Affairs
media@inventivapharma.com
+1 202 499 8937
ICR Healthcare
Media Relations
Alexis Feinberg 
inventivapr@icrhealthcare.com

+1 203 939 2225

ICR Healthcare
Investor relations
Patricia L. Bank
patti.bank@icrhealthcare.com

+1 415 513 1284

Important Notice

This press release contains certain “forward-looking statements” within the meaning of the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. All statements, other than statements of historical facts, included in this press release are forward-looking statements. These statements include, but are not limited to, Inventiva’s expectations regarding its ability to consummate the Offering, and the timing, size and use of proceeds of the Offering, future activities, expectations, plans, growth and prospects of Inventiva, and the absence of material adverse events. Certain of these statements, forecasts and estimates can be recognized by the use of words such as, without limitation, “believes”, “anticipates”, “expects”, “intends”, “plans”, “seeks”, “estimates”, “may”, “will”, “would”, “could”, “might”, “should”, “designed”, “hopefully”, “target”, “potential”, “opportunity”, “possible”, “aim”, and “continue” and similar expressions. Such statements are not historical facts but rather are statements of future expectations and other forward-looking statements that are based on management’s beliefs. These statements reflect such views and assumptions prevailing as of the date of the statements and involve known and unknown risks and uncertainties that could cause future results, performance, or future events to differ materially from those expressed or implied in such statements. Actual events are difficult to predict and may depend upon factors that are beyond Inventiva’s control. There can be no guarantees with respect to pipeline product candidates that the clinical trial results will be available on their anticipated timeline, that future clinical trials will be initiated as anticipated, that product candidates will receive the necessary regulatory approvals, or that any of the anticipated milestones by Inventiva or its partners will be reached on their expected timeline, or at all. Future results may turn out to be materially different from the anticipated future results, performance or achievements expressed or implied by such statements, forecasts and estimates due to a number of factors, including the completion of financial closing procedures, that interim data or data from any interim analysis of ongoing clinical trials may not be predictive of future trial results, that the recommendation of the DMC may not be indicative of a potential marketing approval, Inventiva cannot provide assurance on the impacts of the Suspected Unexpected Serious Adverse Reaction on the results or timing of the NATiV3 trial or regulatory matters with respect thereto, that Inventiva is a clinical-stage company with no approved products and no historical product revenues, Inventiva has incurred significant losses since inception and has never generated any revenue from product sales, Inventiva will require additional capital to finance its operations, in the absence of which, Inventiva may be required to significantly curtail, delay or discontinue one or more of its research or development programs or be unable to expand its operations or otherwise capitalize on its business opportunities and may be unable to continue as a going concern, Inventiva’s ability to obtain financing and to enter into potential transactions, on the expected timing or at all, and whether, when and to what extent the dilutive instruments may be exercised, and by which holders, Inventiva’s future success is dependent on the successful clinical development, regulatory approval and subsequent commercialization of its lanifibranor, preclinical studies or earlier clinical trials are not necessarily predictive of future results and the results of Inventiva’s and its partners’ clinical trials may not support Inventiva’s and its partners’ product candidate claims, Inventiva’s expectations with respect to its clinical trials may prove to be wrong and regulatory authorities may require additional holds and/or additional amendments to Inventiva’s clinical trials, Inventiva’s expectations with respect to the clinical development plan for lanifibranor for the treatment of MASH may not be realized and may not support the approval of a New Drug Application, Inventiva’s ability to identify additional products or product candidates with significant commercial potential, Inventiva’s expectations with respect to its pipeline prioritization plan and related workforce reduction, including the timing, potential benefits, expenses and consequences relating thereto, Inventiva’s ability to execute on its commercialization, marketing and manufacturing capabilities and strategy, Inventiva’s ability to successfully cooperate with existing partners or enter into new partnerships, and to fulfill its obligations under any agreements entered into in connection with such partnerships, the benefits of its existing and future partnerships on the clinical development, regulatory approvals and, if approved, commercialization of its product candidates, and the achievement of milestones thereunder and the timing thereof, Inventiva and its partners may encounter substantial delays beyond expectations in their clinical trials or fail to demonstrate safety and efficacy to the satisfaction of applicable regulatory authorities, the ability of Inventiva and its partners to recruit and retain patients in clinical studies, enrollment and retention of patients in clinical trials is an expensive and time-consuming process and could be made more difficult or rendered impossible by multiple factors outside Inventiva’s and its partners’ control, Inventiva’s product candidates may cause adverse drug reactions or have other properties that could delay or prevent their regulatory approval, or limit their commercial potential, Inventiva faces substantial competition and Inventiva’s business, and pre-clinical studies and clinical development programs and timelines, its financial condition and results of operations could be materially and adversely affected by changes in laws and regulations, unfavorable conditions in its industry, geopolitical events, such as the conflict between Russia and Ukraine and related sanctions, the conflict in the Middle East and the related risk of a larger conflict, health epidemics, and macroeconomic conditions, including developments in international trade policies, global inflation, financial and credit market fluctuations, tariffs and other trade barriers, political turmoil, and natural catastrophes, uncertain financial markets and disruptions in banking systems. Given the risks and uncertainties, no representations are made as to the accuracy or fairness of such forward-looking statements, forecasts, and estimates. Furthermore, forward-looking statements, forecasts and estimates only speak as of the date of this press release. Readers are cautioned not to place undue reliance on any of these forward-looking statements.

Please refer to the Universal Registration Document for the year ended December 31, 2024 filed with the Autorité des Marchés Financiers on April 15, 2025, the interim financial report for the six months ended June 30, 2025 published on September 29, 2025 and the Annual Report on Form 20-F for the year ended December 31, 2024 filed with the Securities and Exchange Commission (the “SEC“) on April 15, 2025 for other risks and uncertainties affecting Inventiva, including those described under the caption “Risk Factors”, and in future filings with the SEC. Other risks and uncertainties of which Inventiva is not currently aware may also affect its forward-looking statements and may cause actual results and the timing of events to differ materially from those anticipated. All information in this press release is as of the date of the release. Except as required by law, Inventiva has no intention and is under no obligation to update or review the forward-looking statements referred to above. Consequently, Inventiva accepts no liability for any consequences arising from the use of any of the above statements.

Disclaimers 

This press release does not constitute an offer to sell or the solicitation of an offer to buy securities in any jurisdiction, and shall not constitute an offer, solicitation or sale in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of that jurisdiction.

The distribution of this document may, in certain jurisdictions, be restricted by local legislations. Persons into whose possession this document comes are required to inform themselves about and to observe any such potential local restrictions.

France

The securities offered as part of the Offering have not been and will not be offered or sold to the public in France (except for public offerings defined in Article L.411-2 1° of the French Monetary and Financial Code).

The securities offered as part of the Offering may only be offered or sold in France pursuant to Article L. 411-2 1° of the French Monetary and Financial Code to “qualified investors” (investisseurs qualifiés) (as such term is defined in Article 2(e) of Prospectus Regulation) acting for their own account, and in accordance with Articles L. 411-1, L. 411-2 and D. 411-2 to D.411-4 of the French Monetary and Financial Code.

This announcement is not an advertisement and not a prospectus within the meaning of the Prospectus Regulation.

European Economic Area

In relation to each Member State of the European Economic Area (each, a “Member State”) no offer to the public of securities may be made in that Member State other than:

  • to any legal entity which is a ‘‘qualified investor’’ as defined in the Prospectus Regulation;
  • to fewer than 150 natural or legal persons (other than a qualified investor as defined in the Prospectus Regulation), subject to obtaining the prior consent of the representatives of the placement agents for any such offer; or
  • in any other circumstances falling within Article 1(4) of the Prospectus Regulation, provided that no such offer of securities shall require us or any placement agent to publish a prospectus pursuant to Article 3 of the Prospectus Regulation or supplement a prospectus pursuant to Article 23 of the Prospectus Regulation and each person who initially acquires any shares or to whom any offer is made will be deemed to have represented, acknowledged and agreed to and with each of the placement agents and the Company that it is a ‘‘qualified investor’’ as defined in the Prospectus Regulation.

For the purposes of this provision, the expression an “offer to the public” in relation to any securities in any Member State means the communication in any form and by any means of sufficient information on the terms of the offer and any securities to be offered so as to enable an investor to decide to purchase any ordinary shares.

United Kingdom

This document is only being distributed to, and is only directed at, persons in the United Kingdom that (i) are “investment professionals” falling within Article 19(5) of the Financial Services and Markets Act 2000 (Financial Promotion) Order 2005 (as amended, the “Order“), (ii) are persons falling within Article 49(2)(a) to (d) (“high net worth companies, unincorporated associations, etc.”) of the Order, or (iii) are persons to whom an invitation or inducement to engage in investment activity (within the meaning of Article 21 of the Financial Services and Markets Act 2000) in connection with the issuance or sale of any securities may otherwise lawfully be communicated or caused to be communicated (all such persons together being referred to as “Relevant Persons“). This document is directed only at Relevant Persons and must not be acted on or relied on by persons who are not Relevant Persons. Any investment or investment activity to which this document relates is available only to Relevant Persons and will be engaged in only with Relevant Persons.

This press release has been prepared in both French and English. In the event of any differences between the two texts, the French language version shall supersede.


1 Based on the exchange rate of €1.00 = $1.1576 as published by the European Central Bank on November 12, 2025.

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Inventiva announces full exercise of Underwriters’ Option, bringing proceeds of Offering to approximately $172.5M

Inventiva announces full exercise of Underwriters’ Option, bringing proceeds of Offering to approximately $172.5M




Inventiva announces full exercise of Underwriters’ Option, bringing proceeds of Offering to approximately $172.5M

Daix (France), New York City (New York, United States), November 17, 2025 – Inventiva (Euronext Paris and Nasdaq: IVA) (“Inventiva” or the “Company“), a clinical-stage biopharmaceutical company focused on the development of oral therapies for the treatment of metabolic dysfunction-associated steatohepatitis (“MASH“), today announced that the underwriters of the previously announced public offering in the United States (the “Offering“) of 38,961,038 American Depositary Shares (“ADSs“), each representing one ordinary share of the Company with a nominal value of €0.01, have exercised in full their option (the “Underwriters’ Option“) to purchase 5,844,155 additional ADSs (the “Additional ADSs“). The additional ADSs are expected to be delivered on November 18, 2025.

Following the exercise in full of the Underwriters’ Option, the total number of ADSs issued in the Offering will amount to 44,805,193, resulting in gross proceeds for the Company of approximately $172.5 million (€149.0 million1) and the estimated net proceeds of the Offering, after deducting underwriting fees, commissions and estimated expenses payable by the Company, will be approximately of $161.2 million (€139.3 million1).

The Company intends to apply the net proceeds from the sale of Additional ADSs on a pro rata basis to the use of proceeds identified with respect to the base offering.

The offering price of $3.85 per ADS and Additional ADS (corresponding to €3.33 per ordinary share based on the exchange rate of €1.00 = $1.1576 as published by the European Central Bank on November 12, 2025) is equal to the volume-weighted average price of the share of the Company on the regulated market of Euronext in Paris (“Euronext“) for the last trading session preceding the pricing date of the Offering, less a discount of 0.89%. The offering price was determined by the Chief Executive Officer in accordance with a sub-delegation of powers from the Company’s Board of Directors (Conseil d’Administration) on October 27, 2025, pursuant to the 25th resolution of the Company’s combined shareholders’ meeting held on May 22, 2025

The Company’s ADSs are listed on the Nasdaq Global Market under the ticker symbol “IVA” and the Company’s ordinary shares are listed on Euronext under the symbol “IVA”.

The exercise of the Underwriters’ Option is part of stabilization activities carried out since the announcement of the Offering. The stabilization period is now closed.

A shelf registration statement on Form F-3 (including a prospectus) relating to the Company’s securities was filed with the Securities and Exchange Commission (the “SEC“) in the United States on October 14, 2025 and became effective on November 3, 2025. The Company has also filed with the SEC a final prospectus supplement (and accompanying prospectus) relating to and describing the terms of the Offering (the “Final Prospectus Supplement“). These documents may be obtained free of charge by visiting EDGAR on the SEC’s website at www.sec.gov. Alternatively, a copy of the Final Prospectus Supplement (and accompanying prospectus) may be obtained from Leerink Partners LLC, Attention: Syndicate Department, 53 State Street, 40th Floor, Boston, MA 02109, by telephone at (800) 808-7525, ext. 6105, or by email at syndicate@leerink.com; or from Piper Sandler & Co., Attention: Prospectus Department, 350 North 5th Street, Suite 1000, Minneapolis, MN 55401 or by email at prospectus@psc.com.

The Offering was not subject to a prospectus requiring an approval of the French Financial Markets Authority (Autorité des Marchés Financiers) (the “AMF“). In accordance with Article 1(5) (ba) of the Regulation (EU) 2017/1129 of the European Parliament and of the Council of 14 June 2017, as amended (the “Prospectus Regulation“), the Company has filed with the AMF a document containing the information set out in Annex IX of the Prospectus Regulation (the “Information Document“) considering that the Offering represents a dilution above 30% of the current share capital of the Company. A copy of the Information Document is available on the Company’s website (www.inventivapharma.com). 

About Inventiva

Inventiva is a clinical-stage biopharmaceutical company focused on the research and development of oral small molecule therapies for the treatment of patients with MASH. The Company is currently evaluating lanifibranor, a novel pan-PPAR agonist, in the NATiV3 pivotal Phase 3 clinical trial for the treatment of adult patients with MASH, a common and progressive chronic liver disease.

Inventiva is a public company listed on compartment B of the regulated market of Euronext Paris (ticker: IVA, ISIN: FR0013233012) and on the Nasdaq Global Market in the United States (ticker: IVA). http://www.inventivapharma.com   

Contacts 

Inventiva
Pascaline Clerc
EVP, Strategy and Corporate Affairs
media@inventivapharma.com
+1 202 499 8937
ICR Healthcare
Media Relations
Alexis Feinberg 
inventivapr@icrhealthcare.com

+1 203 939 2225

ICR Healthcare
Investor relations
Patricia L. Bank
patti.bank@icrhealthcare.com

+1 415 513 1284

Important Notice

This press release contains certain “forward-looking statements” within the meaning of the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. All statements, other than statements of historical facts, included in this press release are forward-looking statements. These statements include, but are not limited to, Inventiva’s expectations regarding its ability to consummate the Offering, and the timing, size and use of proceeds of the Offering, future activities, expectations, plans, growth and prospects of Inventiva, and the absence of material adverse events. Certain of these statements, forecasts and estimates can be recognized by the use of words such as, without limitation, “believes”, “anticipates”, “expects”, “intends”, “plans”, “seeks”, “estimates”, “may”, “will”, “would”, “could”, “might”, “should”, “designed”, “hopefully”, “target”, “potential”, “opportunity”, “possible”, “aim”, and “continue” and similar expressions. Such statements are not historical facts but rather are statements of future expectations and other forward-looking statements that are based on management’s beliefs. These statements reflect such views and assumptions prevailing as of the date of the statements and involve known and unknown risks and uncertainties that could cause future results, performance, or future events to differ materially from those expressed or implied in such statements. Actual events are difficult to predict and may depend upon factors that are beyond Inventiva’s control. There can be no guarantees with respect to pipeline product candidates that the clinical trial results will be available on their anticipated timeline, that future clinical trials will be initiated as anticipated, that product candidates will receive the necessary regulatory approvals, or that any of the anticipated milestones by Inventiva or its partners will be reached on their expected timeline, or at all. Future results may turn out to be materially different from the anticipated future results, performance or achievements expressed or implied by such statements, forecasts and estimates due to a number of factors, including the completion of financial closing procedures, that interim data or data from any interim analysis of ongoing clinical trials may not be predictive of future trial results, that the recommendation of the DMC may not be indicative of a potential marketing approval, Inventiva cannot provide assurance on the impacts of the Suspected Unexpected Serious Adverse Reaction on the results or timing of the NATiV3 trial or regulatory matters with respect thereto, that Inventiva is a clinical-stage company with no approved products and no historical product revenues, Inventiva has incurred significant losses since inception and has never generated any revenue from product sales, Inventiva will require additional capital to finance its operations, in the absence of which, Inventiva may be required to significantly curtail, delay or discontinue one or more of its research or development programs or be unable to expand its operations or otherwise capitalize on its business opportunities and may be unable to continue as a going concern, Inventiva’s ability to obtain financing and to enter into potential transactions, on the expected timing or at all, and whether, when and to what extent the dilutive instruments may be exercised, and by which holders, Inventiva’s future success is dependent on the successful clinical development, regulatory approval and subsequent commercialization of its lanifibranor, preclinical studies or earlier clinical trials are not necessarily predictive of future results and the results of Inventiva’s and its partners’ clinical trials may not support Inventiva’s and its partners’ product candidate claims, Inventiva’s expectations with respect to its clinical trials may prove to be wrong and regulatory authorities may require additional holds and/or additional amendments to Inventiva’s clinical trials, Inventiva’s expectations with respect to the clinical development plan for lanifibranor for the treatment of MASH may not be realized and may not support the approval of a New Drug Application, Inventiva’s ability to identify additional products or product candidates with significant commercial potential, Inventiva’s expectations with respect to its pipeline prioritization plan and related workforce reduction, including the timing, potential benefits, expenses and consequences relating thereto, Inventiva’s ability to execute on its commercialization, marketing and manufacturing capabilities and strategy, Inventiva’s ability to successfully cooperate with existing partners or enter into new partnerships, and to fulfill its obligations under any agreements entered into in connection with such partnerships, the benefits of its existing and future partnerships on the clinical development, regulatory approvals and, if approved, commercialization of its product candidates, and the achievement of milestones thereunder and the timing thereof, Inventiva and its partners may encounter substantial delays beyond expectations in their clinical trials or fail to demonstrate safety and efficacy to the satisfaction of applicable regulatory authorities, the ability of Inventiva and its partners to recruit and retain patients in clinical studies, enrollment and retention of patients in clinical trials is an expensive and time-consuming process and could be made more difficult or rendered impossible by multiple factors outside Inventiva’s and its partners’ control, Inventiva’s product candidates may cause adverse drug reactions or have other properties that could delay or prevent their regulatory approval, or limit their commercial potential, Inventiva faces substantial competition and Inventiva’s business, and pre-clinical studies and clinical development programs and timelines, its financial condition and results of operations could be materially and adversely affected by changes in laws and regulations, unfavorable conditions in its industry, geopolitical events, such as the conflict between Russia and Ukraine and related sanctions, the conflict in the Middle East and the related risk of a larger conflict, health epidemics, and macroeconomic conditions, including developments in international trade policies, global inflation, financial and credit market fluctuations, tariffs and other trade barriers, political turmoil, and natural catastrophes, uncertain financial markets and disruptions in banking systems. Given the risks and uncertainties, no representations are made as to the accuracy or fairness of such forward-looking statements, forecasts, and estimates. Furthermore, forward-looking statements, forecasts and estimates only speak as of the date of this press release. Readers are cautioned not to place undue reliance on any of these forward-looking statements.

Please refer to the Universal Registration Document for the year ended December 31, 2024 filed with the Autorité des Marchés Financiers on April 15, 2025, the interim financial report for the six months ended June 30, 2025 published on September 29, 2025 and the Annual Report on Form 20-F for the year ended December 31, 2024 filed with the Securities and Exchange Commission (the “SEC“) on April 15, 2025 for other risks and uncertainties affecting Inventiva, including those described under the caption “Risk Factors”, and in future filings with the SEC. Other risks and uncertainties of which Inventiva is not currently aware may also affect its forward-looking statements and may cause actual results and the timing of events to differ materially from those anticipated. All information in this press release is as of the date of the release. Except as required by law, Inventiva has no intention and is under no obligation to update or review the forward-looking statements referred to above. Consequently, Inventiva accepts no liability for any consequences arising from the use of any of the above statements.

Disclaimers 

This press release does not constitute an offer to sell or the solicitation of an offer to buy securities in any jurisdiction, and shall not constitute an offer, solicitation or sale in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of that jurisdiction.

The distribution of this document may, in certain jurisdictions, be restricted by local legislations. Persons into whose possession this document comes are required to inform themselves about and to observe any such potential local restrictions.

France

The securities offered as part of the Offering have not been and will not be offered or sold to the public in France (except for public offerings defined in Article L.411-2 1° of the French Monetary and Financial Code).

The securities offered as part of the Offering may only be offered or sold in France pursuant to Article L. 411-2 1° of the French Monetary and Financial Code to “qualified investors” (investisseurs qualifiés) (as such term is defined in Article 2(e) of Prospectus Regulation) acting for their own account, and in accordance with Articles L. 411-1, L. 411-2 and D. 411-2 to D.411-4 of the French Monetary and Financial Code.

This announcement is not an advertisement and not a prospectus within the meaning of the Prospectus Regulation.

European Economic Area

In relation to each Member State of the European Economic Area (each, a “Member State”) no offer to the public of securities may be made in that Member State other than:

  • to any legal entity which is a ‘‘qualified investor’’ as defined in the Prospectus Regulation;
  • to fewer than 150 natural or legal persons (other than a qualified investor as defined in the Prospectus Regulation), subject to obtaining the prior consent of the representatives of the placement agents for any such offer; or
  • in any other circumstances falling within Article 1(4) of the Prospectus Regulation, provided that no such offer of securities shall require us or any placement agent to publish a prospectus pursuant to Article 3 of the Prospectus Regulation or supplement a prospectus pursuant to Article 23 of the Prospectus Regulation and each person who initially acquires any shares or to whom any offer is made will be deemed to have represented, acknowledged and agreed to and with each of the placement agents and the Company that it is a ‘‘qualified investor’’ as defined in the Prospectus Regulation.

For the purposes of this provision, the expression an “offer to the public” in relation to any securities in any Member State means the communication in any form and by any means of sufficient information on the terms of the offer and any securities to be offered so as to enable an investor to decide to purchase any ordinary shares.

United Kingdom

This document is only being distributed to, and is only directed at, persons in the United Kingdom that (i) are “investment professionals” falling within Article 19(5) of the Financial Services and Markets Act 2000 (Financial Promotion) Order 2005 (as amended, the “Order“), (ii) are persons falling within Article 49(2)(a) to (d) (“high net worth companies, unincorporated associations, etc.”) of the Order, or (iii) are persons to whom an invitation or inducement to engage in investment activity (within the meaning of Article 21 of the Financial Services and Markets Act 2000) in connection with the issuance or sale of any securities may otherwise lawfully be communicated or caused to be communicated (all such persons together being referred to as “Relevant Persons“). This document is directed only at Relevant Persons and must not be acted on or relied on by persons who are not Relevant Persons. Any investment or investment activity to which this document relates is available only to Relevant Persons and will be engaged in only with Relevant Persons.

This press release has been prepared in both French and English. In the event of any differences between the two texts, the French language version shall supersede.


1 Based on the exchange rate of €1.00 = $1.1576 as published by the European Central Bank on November 12, 2025.

Attachment