Adicet Bio Announces Reverse Stock Split

Adicet Bio Announces Reverse Stock Split




Adicet Bio Announces Reverse Stock Split

REDWOOD CITY, Calif.–(BUSINESS WIRE)–Adicet Bio, Inc. (Nasdaq: ACET), a clinical stage biotechnology company discovering and developing allogeneic gamma delta T cell therapies for autoimmune diseases and cancer, today announced that its board of directors has determined to effect a one-for-16 reverse stock split of Adicet’s common stock, par value $0.0001 per share.

The reverse stock split ratio approved by the board of directors is within the previously disclosed range of ratios for a reverse stock split authorized by the stockholders of the company at the 2025 Special Meeting of Stockholders of Adicet held on December 19, 2025. The reverse stock split will take effect at 12:01 a.m. Eastern Time on December 30, 2025, and Adicet’s common stock will begin trading on a split-adjusted basis on The Nasdaq Capital Market as of the opening of trading on December 30, 2025. The CUSIP number of 007002207 will be assigned to Adicet’s common stock when the reverse stock split becomes effective.

When the reverse stock split becomes effective, every sixteen (16) of Adicet’s issued shares of common stock will be combined into one issued share of common stock, without any change to the par value per share. This will reduce the number of outstanding shares of common stock from approximately 153.3 million shares to approximately 9.6 million shares. The reverse stock split will not affect the absolute number of Adicet’s authorized shares of common stock, which will remain at 300,000,000, but the total number of shares of Adicet’s common stock available for future issuance will increase.

Proportional adjustments will also be made to the number of shares of common stock awarded and available for issuance under Adicet’s equity incentive plans, as well as the exercise price and the number of shares issuable upon the exercise or conversion of Adicet’s outstanding stock options and other equity securities under Adicet’s equity incentive plans. All outstanding pre-funded warrants will also be adjusted in accordance with their terms, which will result in proportionate adjustments being made to the number of shares issuable upon exercise of such warrants and to the exercise prices of such warrants, as applicable.

No fractional shares will be issued in connection with the reverse stock split. Stockholders who would otherwise be entitled to receive fractional shares will automatically be entitled to receive cash in lieu of such fractional share.

Stockholders with shares held in book-entry form or through a bank, broker, or other nominee are not required to take any action and will see the consequence of the reverse stock split reflected in their accounts on or after December 30, 2025. Such beneficial holders may contact their bank, broker, or nominee for more information.

The reverse stock split is intended to enable Adicet to regain compliance with the minimum bid price requirement for continued listing on the Nasdaq Capital Market.

About Adicet Bio, Inc.

Adicet Bio, Inc. is a clinical stage biotechnology company discovering and developing allogeneic gamma delta T cell therapies for autoimmune diseases and cancer. Adicet is advancing a pipeline of “off-the-shelf” gamma delta T cells, engineered with chimeric antigen receptors (CARs), to facilitate durable activity in patients. For more information, please visit our website at https://www.adicetbio.com.

Forward-Looking Statements

This press release contains “forward-looking statements” of Adicet within the meaning of the Private Securities Litigation Reform Act of 1995 relating to the business and operations of Adicet. The words “anticipate,” “believe,” “continue,” “could,” “estimate,” “expect,” “intend,” “may,” “plan,” “potential,” “predict,” “project,” “should,” “target,” “would” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. These forward-looking statements include, but are not limited to, express or implied statements regarding: the timing and completion of the reverse stock split, the intended effects of the reverse stock split and trading of Adicet’s common stock on a split-adjusted basis, and the effect the reverse stock split will have on Adicet’s ability to regain compliance with the Nasdaq listing standards.

Any forward-looking statements in this press release are based on management’s current expectations and beliefs of future events, and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in or implied by such forward-looking statements, including without limitation, the effect of global economic conditions and public health emergencies on Adicet’s business and financial results, including with respect to disruptions to our preclinical and clinical studies, business operations, employee hiring and retention, and ability to raise additional capital; Adicet’s ability to execute on its strategy including obtaining the requisite regulatory approvals on the expected timeline, if at all; that positive results, including interim results, from a preclinical or clinical study may not necessarily be predictive of the results of future or ongoing studies; clinical studies may fail to demonstrate adequate safety and efficacy of Adicet’s product candidates, which would prevent, delay, or limit the scope of regulatory approval and commercialization; and regulatory approval processes of the U.S. Food and Drug Administration and comparable foreign regulatory authorities are lengthy, time-consuming, and inherently unpredictable; and Adicet’s ability to meet production and product release expectations. For a discussion of these and other risks and uncertainties, and other important factors, any of which could cause Adicet’s actual results to differ from those contained in the forward-looking statements, see the section entitled “Risk Factors” in Adicet’s most recent annual report on Form 10-K, quarterly reports on Form 10-Q and subsequent filings with the U.S. Securities and Exchange Commission (SEC), as well as discussions of potential risks, uncertainties, and other important factors in Adicet’s other filings with the SEC. All information in this press release is as of the date of the release, and Adicet undertakes no duty to update this information unless required by law.

Contacts

Adicet Bio, Inc.
Investor and Media Contacts
Anne Bowdidge

abowdidge@adicetbio.com

Penelope Belnap
Precision AQ
212-362-1200

Penelope.belnap@precisionaq.com

Thermo Fisher Scientific to Hold Earnings Conference Call on Thursday, January 29, 2026

Thermo Fisher Scientific to Hold Earnings Conference Call on Thursday, January 29, 2026




Thermo Fisher Scientific to Hold Earnings Conference Call on Thursday, January 29, 2026

WALTHAM, Mass.–(BUSINESS WIRE)–Thermo Fisher Scientific Inc. (NYSE: TMO), the world leader in serving science, announced that it will release its financial results for the fourth quarter and full year 2025 before the market opens on Thursday, January 29, 2026, and will hold a conference call on the same day at 8:30 a.m. ET. During the call, the company will discuss its financial performance, as well as future expectations.


The call will be webcast live on the “Investors” section of our website, www.thermofisher.com. You can access the conference call by dialing (833) 470-1428 within the U.S. or +1 (646) 844-6383 outside the U.S. The access code is 054943.

The earnings press release and related information can also be found in that section of our website, under the heading “Financials”. A replay of the call will be available under “News, Events & Presentations” through Wednesday, April 22, 2026.

About Thermo Fisher Scientific

Thermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue over $40 billion. Our Mission is to enable our customers to make the world healthier, cleaner and safer. Whether our customers are accelerating life sciences research, solving complex analytical challenges, increasing productivity in their laboratories, improving patient health through diagnostics or the development and manufacture of life-changing therapies, we are here to support them. Our global team delivers an unrivaled combination of innovative technologies, purchasing convenience and pharmaceutical services through our industry-leading brands, including Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab Services, Patheon and PPD. For more information, please visit www.thermofisher.com.

Contacts

Media Contact Information:

Sandy Pound

Phone: 781-622-1223

E-mail: sandy.pound@thermofisher.com
Website: www.thermofisher.com

Investor Contact Information:

Rafael Tejada

Phone: 781-622-1356

E-mail: rafael.tejada@thermofisher.com

Arcadia Biosciences (RKDA) Receives Termination Notice of the Proposed Business Combination with Roosevelt Resources

Arcadia Biosciences (RKDA) Receives Termination Notice of the Proposed Business Combination with Roosevelt Resources




Arcadia Biosciences (RKDA) Receives Termination Notice of the Proposed Business Combination with Roosevelt Resources

DALLAS, Dec. 26, 2025 (GLOBE NEWSWIRE) — Arcadia Biosciences, Inc.® (Nasdaq: RKDA), a producer and marketer of innovative wellness products, today announced that on December 24, 2025, it received a notice from Roosevelt Resources, LP, terminating the Securities Exchange Agreement between Arcadia and Roosevelt dated December 4, 2024, pursuant to the terms of the agreement. The agreement provided for a proposed business combination transaction between the two companies.

“In light of these circumstances, Arcadia will resume the process of evaluating strategic alternatives in order to create value for our shareholders.” said T.J. Schaefer, CEO of Arcadia.

Schaefer continued, “Over the last two-and-a-half years, we have streamlined our operations, significantly reduced our operating expenses and grown the Zola® coconut water brand while avoiding the use of long-term debt. We continue to own approximately 2.7 million shares of Above Food Ingredients Inc. common stock and believe we are entitled to additional consideration and compensation relating to our May 2024 sale of GoodWheatTM. We believe these assets, along with our Nasdaq public listing and our Zola business, should make Arcadia an attractive candidate for a merger or other strategic transaction.”

About Arcadia Biosciences, Inc.
Since 2002, Arcadia Biosciences (Nasdaq: RKDA) has been innovating high-value, healthy ingredients to meet consumer demands for healthier choices. With its roots in agricultural innovation, Arcadia cultivates next-generation wellness products. For more information, visit www.arcadiabio.com.

Safe Harbor Statement
This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements include those that express plans, anticipation, intent, contingencies, goals, targets, or future developments or otherwise are not statements of historical fact. These statements relate to future events or future results of operations, including, but not limited to statements concerning the following matters: the company’s anticipated financial position, cash needs and ability to continue operations; the company’s beliefs concerning its ability to pursue and enter into alternative strategic transactions and its attractiveness as a candidate for a strategic transaction; the company’s beliefs concerning its entitlement to additional shares of common stock of Above Foods Ingredients Inc. (“ABVE”) and concerning principal and interest payments owed by Above Foods Corp.; and the company’s beliefs concerning the availability of adequate funding to support the company’s future operations from available cash resources, revenues from future sales of products, proceeds from sales of assets including shares of ABVE that it holds (if such shares may be sold pursuant to Rule 144 or otherwise), sale of equity or debt securities, or other transactions. Forward-looking statements concerning anticipated future activities assume that the company has sufficient funding to continue its operations and planned activities, which may not be the case. Arcadia will require additional funding in the near future to continue its operations and planned activities. There are no assurances that required funding will be available at all or will be available in sufficient amounts or on reasonable terms. The company may seek to raise additional funds through equity or debt financings. Any sale of additional equity securities could result in material dilution to company stockholders. If the company is not able to secure adequate additional funding, it could be required to reduce or suspend activities, liquidate assets, or initiate dissolution and liquidation or bankruptcy proceedings. In the event of such proceedings, Arcadia’s creditors would have first claim on the value of the company’s assets which, other than remaining cash, would most likely be liquidated in one or more transactions or a bankruptcy sale, and the common stock of Arcadia likely would have little or no value. Any of these actions would have a material adverse effect on its business, results of operations and financial condition. Forward-looking statements are only predictions and involve known and unknown risks, uncertainties, and other factors that may cause the company’s actual results to be materially different from the results anticipated by such forward-looking statements. Undue reliance should not be placed on any forward-looking statements. Risks and uncertainties relating to the company’s business and future prospects also include, but are not limited to, the risks set forth in filings that the company makes with the Securities and Exchange Commission (SEC) from time to time, including in Arcadia’s Annual Report on Form 10-K for the year ended December 31, 2024, as amended, quarterly reports on Form 10-Q filed with the SEC during the 2025 year, the registration statement on Form S-4 initially filed with the SEC on February 14, 2025 and amended July 31, 2025, and other filings that the company makes with the SEC, all of which are available free of charge on the SEC’s web site at http://www.sec.gov. Further, any forward-looking statement speaks only as of the date as of which it was made, and except as required by law, Arcadia Biosciences, Inc. disclaims any obligation to update forward-looking statements or to reflect events or circumstances arising after the date of this press release.

Arcadia Biosciences Contact:
T.J. Schaefer
ir@arcadiabio.com

United States Semaglutide Market Forecast and Company Analysis Report 2025-2033 Featuring Novo Nordisk, Eli Lilly and Co, AstraZeneca, Biocon, Johnson and Johnson, Pfizer, AbbVie, and Sanofi – ResearchAndMarkets.com

United States Semaglutide Market Forecast and Company Analysis Report 2025-2033 Featuring Novo Nordisk, Eli Lilly and Co, AstraZeneca, Biocon, Johnson and Johnson, Pfizer, AbbVie, and Sanofi – ResearchAndMarkets.com




United States Semaglutide Market Forecast and Company Analysis Report 2025-2033 Featuring Novo Nordisk, Eli Lilly and Co, AstraZeneca, Biocon, Johnson and Johnson, Pfizer, AbbVie, and Sanofi – ResearchAndMarkets.com

DUBLIN–(BUSINESS WIRE)–The “United States Semaglutide Market Report by Product, Application, Distribution Channel, States and Company Analysis, 2025-2033” report has been added to ResearchAndMarkets.com’s offering.


United States Semaglutide Market is expected to expand from US$ 8.17 Billion in 2024 to US$ 17.29 Billion in 2033 at a Compound Annual Growth Rate (CAGR) of 8.68% during 2025-2033

The growth is fueled by rising awareness regarding obesity control, increasing incidence of diabetes, and expanded use of novel therapies. Expansion of the market signifies a high demand for successful weight loss and diabetic control treatments.

Aside from its application in diabetes, Semaglutide has also been popular for its efficiency in weight management. The U.S. Food and Drug Administration (FDA) also approved a higher-dose formulation of Semaglutide for chronic weight management in adults with excessive weight or obesity, and it is now a useful means to combat the obesity crisis. In summary, Semaglutide is an effective choice for patients wanting to control their diabetes and weight.

Growth Drivers in United States Semaglutide Market

Increased Incidence of Obesity and Type 2 Diabetes

The United States has witnessed a shocking increase in obesity and type 2 diabetes, making semaglutide therapies essential for disease management. Almost half of the American adults are obese, and diabetes strikes millions of people across the country. Semaglutide, under brands Ozempic and Wegovy, treats both conditions by enhancing glycemic control as well as causing substantial weight loss. Its dual therapeutic value has made it a physician and patient favorite. The growing load of chronic diseases also taxes the health expenditure, necessitating efficient interventions to keep long-term complications at bay.

As lifestyle disorders gain traction, semaglutide use is gaining momentum in the U.S. healthcare system. Its increasing disease prevalence guarantees long-term demand and ranks it as one of the key drivers of growth in the market. The rampant health care and economic expenditures will be just as widespread, with more than 260 million individuals in the USA, more than a third of all children and adolescents, projected to be living with overweight or obesity by 2050. United action and swift investments must be made to change these ominous trajectories and provide an improved future for existing as well as future generations.

Increasing Applications in Weight Management

Though semaglutide was originally developed to treat type 2 diabetes, its ability to aid in weight loss has expanded its use. Clinical trials have confirmed significant weight loss in patients taking semaglutide, and thus, it has been widely used to treat obesity. The FDA approval of Wegovy to treat chronic weight also opened up the drug’s potential market to not just diabetic patients but to those with obesity-related illnesses. Increased education on obesity as a medical condition that needs treatment has further fueled demand. Insurers and employers are also realizing the economic benefits of providing weight-loss treatments, increasing semaglutide access.

Strong Physician and Patient Acceptance

Physician and patient acceptance has been a primary driver of semaglutide growth in the U.S. Physicians prefer to prescribe semaglutide because of its better clinical outcomes over older GLP-1 receptor agonists. Patients gain from both enhanced glycemic control and significant weight loss, promoting increased adherence and satisfaction. The weekly injection regimen also increases convenience, lessening treatment fatigue and improving compliance.

Extensive media exposure to semaglutide as a “game-changer” medication has also driven consumer demand, especially for weight management. The strong brand reputation of drugs such as Ozempic and Wegovy has fostered intense brand loyalty in the market. As more patients and healthcare providers recognize its clinical effectiveness and lifestyle benefits, semaglutide continues to see rapid adoption. This positive reception across stakeholders strongly contributes to its ongoing market growth in the U.S.

Challenges in the United States Semaglutide Market

High Cost and Limited Insurance Coverage

Despite its clinical success, the high cost of semaglutide remains a barrier to widespread adoption. Monthly treatment costs are substantial, sometimes several hundred dollars without insurance. Though numerous insurance programs cover semaglutide for the treatment of diabetes, obesity coverage is not consistent. Patients trying Wegovy for weight control frequently must pay out of pocket, which restricts accessibility.

The cost detours long-term use, especially for lower-income groups. Employers and insurers are starting to consider coverage because of the long-term healthcare cost savings that come with treating obesity, but take-up is sluggish. Without wider insurance coverage, affordability continues to be an issue for patients and a stumbling block to increasing market penetration. Price sensitivity in the U.S. healthcare system continues to limit semaglutide’s potential despite the high level of demand.

Supply Shortages and Manufacturing Constraints

Another significant issue in the U.S. semaglutide market is chronic supply shortages due to excessive demand and manufacturing constraints. Soaring prescriptions for diabetes and obesity therapy have taxed manufacturing capacities, resulting in periodic stockouts. Patients usually find it difficult to receive regular supplies, interrupting treatment continuity and reducing satisfaction.

Production of intricate biologics such as semaglutide is sophisticated and increasing production to match increasing demand is capital-intensive. These supply concerns also impact healthcare providers, who experience challenges in managing patient expectation and treatment timelines. Although manufacturers are undertaking capacity additions, demand remains ahead of supply, leading to market volatility. Addressing the supply chain difficulties will be essential to providing stable access and achieving long-run market growth in the United States.

Key Attributes:

Report Attribute Details
No. of Pages 200
Forecast Period 2024 – 2033
Estimated Market Value (USD) in 2024 $8.17 Billion
Forecasted Market Value (USD) by 2033 $17.29 Billion
Compound Annual Growth Rate 8.6%
Regions Covered United States

 

Key Players Analysis

  • Novo Nordisk A/S
  • Eli Lilly and Company
  • AstraZeneca plc
  • Biocon Ltd
  • Johnson and Johnson
  • Pfizer Inc
  • AbbVie Inc.
  • Sanofi S.A.

Market Segmentations

Product

  • Ozempic
  • Rybelsus
  • Wegovy
  • Others

Application

  • Type 2 Diabetes
  • Obesity
  • Cardiovascular Risk Reduction

Distribution Channel

  • Retail Pharmacies
  • Hospital Pharmacies
  • Online Pharmacies

Top States

  • California
  • Texas
  • New York
  • Florida
  • Illinois
  • Pennsylvania
  • Ohio
  • Georgia
  • New Jersey
  • Washington
  • North Carolina
  • Massachusetts
  • Virginia
  • Michigan
  • Maryland
  • Colorado
  • Tennessee
  • Indiana
  • Arizona
  • Minnesota
  • Wisconsin
  • Missouri
  • Connecticut
  • South Carolina
  • Oregon
  • Louisiana
  • Alabama
  • Kentucky
  • Rest of United States

For more information about this report visit https://www.researchandmarkets.com/r/ngb4h

About ResearchAndMarkets.com

ResearchAndMarkets.com is the world’s leading source for international market research reports and market data. We provide you with the latest data on international and regional markets, key industries, the top companies, new products and the latest trends.

Contacts

ResearchAndMarkets.com

Laura Wood, Senior Press Manager

press@researchandmarkets.com
For E.S.T Office Hours Call 1-917-300-0470

For U.S./ CAN Toll Free Call 1-800-526-8630

For GMT Office Hours Call +353-1-416-8900

GLP-1 Agonists (Ozempic, Wegovy, Mounjaro) Market – Global Forecast to 2033: Growing Shift of Weekly Injectables Toward Orals and Multi-Agonists – ResearchAndMarkets.com

GLP-1 Agonists (Ozempic, Wegovy, Mounjaro) Market – Global Forecast to 2033: Growing Shift of Weekly Injectables Toward Orals and Multi-Agonists – ResearchAndMarkets.com




GLP-1 Agonists (Ozempic, Wegovy, Mounjaro) Market – Global Forecast to 2033: Growing Shift of Weekly Injectables Toward Orals and Multi-Agonists – ResearchAndMarkets.com

DUBLIN–(BUSINESS WIRE)–The “GLP-1 Agonists Market by Product (Ozempic, Wegovy, Mounjaro), Molecule (semaglutide, Tirzepatide), Type (Patented, Biosimilars), Format (Single Dose, Multi-dose, Tablets), ROA (SC, Oral), Indication (Diabetes, Obesity) – Global Forecast to 2033” report has been added to ResearchAndMarkets.com’s offering.


The GLP-1 agonists market is expected to reach USD 170.75 billion in 2033 from USD 64.42 billion in 2025 at a CAGR of 13.0%

The report will help market leaders/new entrants by providing the closest approximations of the revenue numbers for the overall GLP-1 agonists market and its subsegments. It will also help stakeholders better understand the competitive landscape and gain more insights to position their business better and make suitable go-to-market strategies. This report will enable stakeholders to understand the market’s pulse and provide them with information on the key market drivers, restraints, opportunities, and challenges.

The GLP-1 agonists market has expanded rapidly due to several key drivers. One prominent factor is the growing number of new indication approvals for GLP-1 drugs by regulatory agencies. These approvals extend the uses of GLP-1 agonists beyond initial indications, allowing for treatments in broader patient populations, including newer indications such as cardiovascular conditions, Alzheimer’s disease, obstructive sleep apnea, and obesity.

The rising prevalence of these chronic conditions globally further supports strong market growth, as more patients require effective therapies for diabetes and obesity. In parallel, GLP-1 agonists offer proven clinical benefits such as improved glycemic control and significant weight reduction, increasing their adoption rates among healthcare providers.

The patented products segment accounted for the largest share of the GLP-1 agonists market by type in 2024.

Based on type, the GLP-1 agonists market is segmented into patented products and biosimilars. In 2024, the patented products accounted for the largest share of the market. As biosimilars are expected to gain adoption post-2026, patented products currently account for the complete market. However, with the semaglutide patent expiring in 2026 onwards, the market for biosimilars is expected to grow significantly thereafter.

Patented GLP-1 agonists dominate prescribing patterns due to their robust clinical data, extensive safety profiles, and premium marketing investments. Additionally, the original GLP-1 makers have established broad insurance coverage, ensuring patient access despite high list prices. These factors are expected to support market growth.

By end user, the home-care settings and fitness/ weight management facilities accounted for the largest share in the GLP-1 agonists market in 2024.

Based on end user, the GLP-1 agonists market is segmented into home-care settings and fitness/ weight management facilities, long-term care facilities, and hospitals & specialty clinics. In 2024, the home-care settings and fitness/weight management facilities segment accounted for the largest share of the GLP-1 agonists market. The large share of this end-user segment can be attributed to the evolving patient needs and broader trends in obesity and diabetes management.

Home care settings offer convenience and flexible dosing schedules for patients, especially as most GLP-1 therapies are available in easy-to-administer, subcutaneous or oral formats. This increases patient adherence, with many preferring to self-administer medications, particularly for long-term therapies targeting obesity and type 2 diabetes. The spike in obesity prevalence and the mainstreaming of preventive health have also made GLP-1 usage in home environments much more common, driving share growth in this segment.

The US dominated the GLP-1 agonists market in 2024.

In 2024, the US dominated the GLP-1 agonists market due to a convergence of demographic, healthcare, regulatory, and commercial factors. The US has one of the highest prevalence rates globally for both obesity and type 2 diabetes, which significantly expands the patient pool eligible for GLP-1 treatment. Advanced healthcare infrastructure and widespread physician awareness ensure swift adoption of new therapies, while robust insurance coverage and reimbursement help broad patient access.

List of Companies Profiled in the Report:

  • Novo Nordisk A/S (Denmark)
  • Eli Lilly and Company (US)
  • Sanofi (France)
  • Hansoh Pharmaceutical Group Co., Ltd. (China)
  • Boehringer Ingelheim International GmbH (Germany)
  • Innovent (China)
  • Sun Pharmaceutical Industries Ltd. (India)
  • Pegbio Co. Ltd (China)
  • Structure Therapeutics (US)
  • Viking Therapeutics (US)
  • Amgen Inc. (Switzerland)
  • Altimmune (US)
  • Glenmark (India)
  • Biocon (India)
  • Teva Pharmaceuticals (Israel)
  • Terns Pharmaceuticals, Inc. (US)
  • VTV Therapeutics (US)
  • F. Hoffmann-La Roche Ltd (Switzerland)
  • Hanmi Pharm Co., Ltd. (South Korea)
  • Jiangsu Hengrui Pharmaceuticals Co., Ltd. (China)
  • Pfizer Inc. (US)
  • MetaVia Inc (US)
  • SCOHIA PHARMA, Inc. (Japan)
  • Sciwind Biosciences Co., Ltd. (China)
  • i2o Therapeutics, Inc. (US)
  • Biomed Industries, Inc. (US)
  • Neuraly Inc. (US)

The report provides insights into the following pointers:

  • Analysis of key drivers (expanding manufacturing capacity, shift of GLP-1 drugs from diabetes specialty to broader treatment option, growing prevalence of obesity and type 2 diabetes), restraints (stringent cost and payer controls), opportunities (increasing studies on oral GLP-1), and challenges (counterfeits and compounded GLP-1 gray market, safety, tolerability, persistence issues) influencing the growth of the market.
  • Product Development/Innovation: Detailed insights on newly approved and launched products of the GLP-1 agonists market
  • Market Development: Comprehensive information about lucrative markets – the report analyzes the market across varied regions.
  • Market Diversification: Exhaustive information about new services, untapped geographies, recent developments, and investments in the GLP-1 agonists market
  • Competitive Assessment: In-depth assessment of market shares, growth strategies, and product offerings of key players, including Novo Nordisk (Denmark), Eli Lilly (US), and Sanofi (France), among other players. A detailed analysis of the key industry players has been conducted to provide insights into their key strategies, product approvals and launches, acquisitions, partnerships, agreements, collaborations, expansions, recent developments, investment and funding activities, brand/product comparative analysis, and vendor valuation and financial metrics of the GLP-1 agonists market.

Key Attributes:

Report Attribute Details
No. of Pages 456
Forecast Period 2025 – 2033
Estimated Market Value (USD) in 2025 $64.42 Billion
Forecasted Market Value (USD) by 2033 $170.75 Billion
Compound Annual Growth Rate 13.0%
Regions Covered Global

Premium Insights

  • Global Glp-1 Agonists Market Snapshot
  • North America: Glp-1 Agonists Market, by Indication and Country, 2024
  • Glp-1 Agonists Market, by Format, 2024
  • Glp-1 Agonists Market, by End-user, 2024
  • Glp-1 Agonists Market: Geographic Growth Opportunities
  • Unmet Needs & White Spaces
  • Strategic Analysis of Growth Opportunities
  • Strategic Analysis of Growth Opportunities
  • Emerging Business Models & Ecosystem Shifts
  • Interconnected Markets & Cross-Sector Opportunities
  • Glp-1 Agonists Production Capacity Highlights
  • Key Drug Launches Expected, 2025-2033
  • Sustainability Impact & Regulatory Policy Initiatives

Market Dynamics

Drivers

  • Expanding Manufacturing Capacities of Large Pharmaceutical Companies
  • Shift of Glp-1 Drugs from Diabetes Specialty to Broader Treatment Options
  • Rising Prevalence of Obesity and Type-2 Diabetes

Restraints

  • Stringent Cost and Payer Controls

Opportunities

  • Increasing Studies on Oral Glp-1

Challenges

  • Counterfeits and Compounded Glp-1 Gray Market
  • Safety, Tolerability, and Persistence Issues

Trends/Disruptions Impacting Customers’ Businesses

  • Key Glp-1 Agonists Pipeline & Expected Launches

Pricing Analysis

  • Average Selling Price Trend of Glp-1 Agonist Products, by Key Player, 2022-2024
  • Average Selling Price Trend of Glp-1 Agonist Products, by Region, 2022-2024
  • Factors Impacting Glp-1 Agonists Pricing

Industry Trends

  • Shift of Weekly Injectables Toward Orals and Multi-Agonists
  • Vertical Integration and Capacity Scale-Up to Meet Demand

Technology Analysis

Key Technologies

  • Chemical Synthesis
  • Recombinant DNA Technology

Complementary Technologies

  • Peptelligence
  • Pegylation and Polymer Encapsulation

Adjacent Technologies

  • Hydrogel Depot Technologies
  • Technologies for Oral Delivery of Glp-1 Analogues

Impact of AI/Gen AI on Glp-1 Agonists Market

  • Impact at Development and Manufacturing Stages
  • AI Use Cases
  • Key Companies Implementing AI
  • Future of AI/Gen AI in Glp-1 Agonist Drug Development Ecosystem

Companies Featured

  • Novo Nordisk A/S
  • Eli Lilly and Company
  • Sanofi
  • Hansoh Pharmaceutical Group Company Limited
  • Boehringer Ingelheim International GmbH
  • Innovent
  • Pegbio Co. Ltd.
  • Sciwind Biosciences Co. Ltd.
  • Zealand Pharma
  • Structure Therapeutics, Inc.
  • Viking Therapeutics
  • Sun Pharmaceutical Industries Ltd.
  • Vtv Therapeutics
  • Altimmune
  • Amgen Inc.
  • Glenmark Pharmaceuticals Ltd.
  • Biocon
  • Teva Pharmaceutical Industries Ltd.
  • F. Hoffmann-La Roche Ltd.
  • Terns Pharmaceuticals, Inc.
  • Metavia
  • Scohia Pharma, Inc.
  • Regor Therapeutics Group
  • Neuraly Inc.
  • I2O Therapeutics, Inc.
  • Pfizer Inc.
  • Hanmi Pharm Co.,Ltd.
  • Jiangsu Hengrui Pharmaceuticals Co. Ltd.
  • Biomed Industries, Inc.

For more information about this report visit https://www.researchandmarkets.com/r/wzbkbm

About ResearchAndMarkets.com

ResearchAndMarkets.com is the world’s leading source for international market research reports and market data. We provide you with the latest data on international and regional markets, key industries, the top companies, new products and the latest trends.

Contacts

ResearchAndMarkets.com

Laura Wood, Senior Press Manager

press@researchandmarkets.com

For E.S.T Office Hours Call 1-917-300-0470

For U.S./ CAN Toll Free Call 1-800-526-8630

For GMT Office Hours Call +353-1-416-8900

Liraglutide and Semaglutide Global Strategic Business Analysis Report 2025-2030: Regulatory Pipeline for Pediatric and Adolescents With Obesity Creates Long-Term Market Opportunities – ResearchAndMarkets.com

Liraglutide and Semaglutide Global Strategic Business Analysis Report 2025-2030: Regulatory Pipeline for Pediatric and Adolescents With Obesity Creates Long-Term Market Opportunities – ResearchAndMarkets.com




Liraglutide and Semaglutide Global Strategic Business Analysis Report 2025-2030: Regulatory Pipeline for Pediatric and Adolescents With Obesity Creates Long-Term Market Opportunities – ResearchAndMarkets.com

DUBLIN–(BUSINESS WIRE)–The “Liraglutide and Semaglutide – Global Strategic Business Report” report has been added to ResearchAndMarkets.com’s offering.


The global market for Liraglutide and Semaglutide was valued at US$17.1 Billion in 2024 and is projected to reach US$29.8 Billion by 2030, growing at a CAGR of 9.7% from 2024 to 2030. This comprehensive report provides an in-depth analysis of market trends, drivers, and forecasts, helping you make informed business decisions.

Liraglutide and semaglutide, two prominent glucagon-like peptide-1 (GLP-1) receptor agonists, have emerged as game-changers in the management of type 2 diabetes and obesity. These medications work by enhancing insulin secretion, suppressing appetite, and slowing gastric emptying, leading to improved blood sugar control and significant weight loss. The increasing prevalence of diabetes and obesity worldwide has driven a surge in demand for these therapeutics, as they offer superior efficacy compared to traditional antidiabetic medications.

Unlike insulin therapy, GLP-1 receptor agonists like liraglutide and semaglutide provide a lower risk of hypoglycemia while promoting weight management, making them an attractive choice for patients and healthcare providers alike. With growing clinical evidence supporting their cardiovascular benefits, regulatory agencies and medical organizations continue to endorse their use, further boosting adoption rates. As pharmaceutical companies invest in further research and innovation, the role of these GLP-1 analogs in metabolic disorders is expected to expand, solidifying their market position in diabetes and weight management therapies.

What Are the Latest Innovations in Liraglutide and Semaglutide Formulations?

Technological advancements and research developments have led to notable improvements in the formulations of liraglutide and semaglutide, enhancing their effectiveness, patient compliance, and administration convenience. One of the most significant breakthroughs is the introduction of oral semaglutide, which eliminates the need for subcutaneous injections, addressing a major barrier to patient adherence. This innovation has expanded accessibility, particularly among individuals who prefer oral medications over injectables.

Additionally, sustained-release formulations and higher-dose versions have been developed to optimize weight loss outcomes and improve glycemic control. The combination of GLP-1 receptor agonists with other metabolic drugs, such as sodium-glucose co-transporter-2 (SGLT2) inhibitors, is also being explored to create synergistic effects in diabetes management. Pharmaceutical companies are also investing in pre-filled pens and auto-injectors that enhance ease of administration while minimizing discomfort. With ongoing clinical trials investigating the broader therapeutic potential of these drugs, including applications in non-alcoholic fatty liver disease (NAFLD) and cardiovascular health, the formulation advancements in liraglutide and semaglutide continue to shape the future of metabolic disease treatment.

How Is Market Demand Influencing the Growth of GLP-1 Therapies?

The global demand for GLP-1 receptor agonists such as liraglutide and semaglutide has surged due to the rising burden of type 2 diabetes and obesity, both of which have reached epidemic proportions. With healthcare providers prioritizing effective and long-term solutions for metabolic diseases, GLP-1 therapies have gained widespread acceptance. The growing preference for non-insulin therapies that promote weight loss and cardiovascular benefits has further contributed to their market expansion. Additionally, the expansion of telehealth and digital health platforms has improved patient access to these medications, as online consultations and e-prescriptions facilitate treatment initiation and adherence.

The rising health awareness and proactive management of metabolic disorders among patients have also driven the demand for GLP-1 therapies, as individuals seek treatments that align with holistic wellness goals. Furthermore, pharmaceutical companies are expanding their marketing efforts, targeting not only diabetes patients but also the obesity management sector, which represents a significant growth opportunity. As reimbursement policies become more favorable and generic alternatives enter the market, accessibility to liraglutide and semaglutide is expected to increase, reinforcing their role as cornerstone treatments for metabolic disorders.

What Are the Primary Growth Drivers Fueling the Liraglutide and Semaglutide Market?

The growth in the liraglutide and semaglutide market is driven by several key factors, including the rising global prevalence of obesity and diabetes, increased adoption of GLP-1 receptor agonists in treatment guidelines, and continuous pharmaceutical advancements. The increasing emphasis on personalized medicine and patient-centered care has bolstered demand for therapies that offer both glycemic control and weight management benefits. Additionally, expanding research into the cardiovascular benefits of GLP-1 therapies has further positioned these medications as essential treatments for high-risk diabetic patients.

The surge in obesity-related comorbidities, such as hypertension and dyslipidemia, has also prompted healthcare providers to adopt a holistic treatment approach, integrating GLP-1 receptor agonists into multimodal therapy plans. Another crucial growth driver is the strong pipeline of novel GLP-1-based treatments, with pharmaceutical companies actively developing next-generation formulations that improve efficacy, reduce side effects, and enhance patient adherence. The growing trend of lifestyle modifications and preventive healthcare initiatives has further encouraged early adoption of these medications, solidifying their role in long-term metabolic disease management. With increasing awareness, improved accessibility, and continuous medical advancements, the liraglutide and semaglutide market is set to witness sustained growth, transforming the landscape of diabetes and obesity treatment worldwide.

Report Features:

  • Comprehensive Market Data: Independent analysis of annual sales and market forecasts in US$ Million from 2024 to 2030.
  • In-Depth Regional Analysis: Detailed insights into key markets, including the U.S., China, Japan, Canada, Europe, Asia-Pacific, Latin America, Middle East, and Africa.
  • Company Profiles: Coverage of players such as ABB Ltd., AFC Cable Systems (Atkore), Anamet Electrical, Inc., Carlon (ABB Ltd.), Electri-Flex Company and more.
  • Complimentary Updates: Receive free report updates for one year to keep you informed of the latest market developments.

Key Insights:

  • Market Growth: Understand the significant growth trajectory of the Pills Form segment, which is expected to reach US$17.4 Billion by 2030 with a CAGR of a 8%. The Liquid Form segment is also set to grow at 12.5% CAGR over the analysis period.
  • Regional Analysis: Gain insights into the U.S. market, valued at $4.6 Billion in 2024, and China, forecasted to grow at an impressive 13% CAGR to reach $6.0 Billion by 2030. Discover growth trends in other key regions, including Japan, Canada, Germany, and the Asia-Pacific.

Report Scope

  • Segments: Product Type (Pills, Liquid); Administration Route (Parenteral Administration, Oral Administration); Distribution Channel (Hospital Pharmacies, Retail Pharmacies); Application (Type 2 Diabetes Mellitus, Obesity).
  • Geographic Regions/Countries: World; United States; Canada; Japan; China; Europe (France; Germany; Italy; United Kingdom; Spain; Russia; and Rest of Europe); Asia-Pacific (Australia; India; South Korea; and Rest of Asia-Pacific); Latin America (Argentina; Brazil; Mexico; and Rest of Latin America); Middle East (Iran; Israel; Saudi Arabia; United Arab Emirates; and Rest of Middle East); and Africa.

Key Attributes:

Report Attribute Details
No. of Pages 451
Forecast Period 2024 – 2030
Estimated Market Value (USD) in 2024 $17.1 Billion
Forecasted Market Value (USD) by 2030 $29.8 Billion
Compound Annual Growth Rate 9.7%
Regions Covered Global

 

 

Key Topics Covered:

MARKET OVERVIEW

  • Trade Shocks, Uncertainty, and the Structural Rewiring of the Global Economy
  • How Trump’s Tariffs Impact the Market? The Big Question on Everyone’s Mind
  • Liraglutide and Semaglutide – Global Key Competitors Percentage Market Share in 2025 (E)
  • Competitive Market Presence – Strong/Active/Niche/Trivial for Players Worldwide in 2025 (E)

MARKET TRENDS & DRIVERS

  • Rising Prevalence of Type 2 Diabetes and Obesity Worldwide Drives Demand for Liraglutide and Semaglutide Therapies
  • Expansion of GLP-1 Receptor Agonist Usage Throws the Spotlight on Cardiometabolic Health Benefits
  • OEM Focus on Weekly and Daily Dosing Regimens Strengthens Adherence Across Patient Populations
  • Growth in Off-Label Use for Weight Loss and Metabolic Syndrome Spurs Market Expansion Beyond Diabetes
  • Regulatory Approvals for Cardiovascular Risk Reduction in High-Risk Patients Enhance Therapeutic Utility
  • OEM Innovation in Oral Semaglutide Delivery Platforms Expands Options for Injection-Averse Patients
  • Increased Access Through National Formularies and Reimbursement Programs Accelerates Prescription Uptake
  • Surge in Patient Preference for Once-Weekly GLP-1 Agonists Fuels Market Shift Toward Long-Acting Agents
  • Expansion of Obesity Treatment Guidelines by Global Health Authorities Strengthens Clinical Case for GLP-1 Agonists
  • OEM Collaboration With Digital Health Platforms and Patient Engagement Tools Enhances Treatment Adherence
  • Rising Demand for Personalized Dosing and Titration Algorithms Supports Patient-Centric Formulation Development
  • Growth in Telemedicine and Virtual Clinics Promotes Access to GLP-1 Therapy for Underserved Populations
  • OEM Emphasis on Cardiovascular and Renal Outcome Trials Builds Evidence for Expanded Label Indications
  • Increased Focus on Pre-Diabetes and Early Intervention Strategies Strengthens Demand for Preventive Use
  • Surge in Global Obesity-Related Health Costs Supports Government-Backed Adoption of Weight-Reduction Agents
  • OEM Partnerships With Retail Pharmacies and Care Management Networks Enhance Dispensing and Compliance
  • Regulatory Pipeline for Pediatric and Adolescents With Obesity Creates Long-Term Market Opportunities
  • Rising Investment in Fixed-Dose Combinations and Co-Formulations With Insulin or SGLT2 Inhibitors Enhances Value
  • Emergence of Biosimilars and Price Competition Expected to Reshape Market Access and Affordability Dynamics
  • Focus on Real-World Evidence and Health Economic Outcomes Strengthens Payer and Provider Confidence

FOCUS ON SELECT PLAYERS: Some of the 34 companies featured in this Liraglutide and Semaglutide market report

  • AbbVie Inc.
  • AstraZeneca
  • Bachem Holding AG
  • Biocon Limited
  • Boehringer Ingelheim International GmbH
  • Bristol Myers Squibb (BMS)
  • Cadila Pharmaceuticals
  • Daiichi Sankyo Company, Limited
  • Dr. Reddy’s Laboratories Ltd.
  • Eli Lilly and Company
  • GlaxoSmithKline plc (GSK)
  • Johnson & Johnson
  • Kyowa Kirin Co., Ltd.
  • Merck & Co., Inc.
  • Novartis International AG
  • Novo Nordisk A/S
  • Otsuka Holdings Co., Ltd.
  • Pfizer Inc.
  • Sanofi
  • Teva Pharmaceutical Industries Ltd.

For more information about this report visit https://www.researchandmarkets.com/r/cu0yzk

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IBA signs contract for a three-room Proteus®PLUS solution to be installed at the Seoul St. Mary’s Hospital

IBA signs contract for a three-room Proteus®PLUS solution to be installed at the Seoul St. Mary’s Hospital




IBA signs contract for a three-room Proteus®PLUS solution to be installed at the Seoul St. Mary’s Hospital

Louvain-La-Neuve, Belgium, December 26, 2025 – IBA (Ion Beam Applications S.A., EURONEXT), the world leader in particle accelerator technology and the world’s leading provider of proton therapy solutions for the treatment of cancer, today announces it has signed a contract with the Catholic University of Korea, Seoul St. Mary’s Hospital, one of the largest hospital in South Korea, for a Proteus®PLUS1 solution to be installed in Seoul.

The contract includes the equipment of a Proteus®PLUS solution with three gantry-room as well as a multi-year service contract. The system will also include DynamicARC®2 beam delivery capabilities, once this feature has received regulatory clearance.

The Seoul St. Mary’s Hospital plans to begin patient treatments by the end of 2029. Upon full completion, the center will have eight floors, including underground levels, and a total area of 37,851 square meters.

Olivier Legrain, Chief Executive Officer of IBA, commented: “We are pleased to partner with Seoul St. Mary’s Hospital to bring the latest proton therapy technology in South Korea, expanding the number of centers in the country that benefit from IBA’s proton therapy solutions. This contract highlights the relevance of our offering in markets where demand for this cutting-edge treatment modality is strongly increasing. We look forward to working with the expert medical team of Seoul St. Mary’s to make this technology more accessible to patients.”

LEE Ji Youl, MD, PhD, President of Seoul St. Mary’s Hospital, added: “We are pleased to have signed this contract with IBA, the world leader in proton therapy technology, for the introduction of cutting-edge latest-generation equipment. The construction of the center is the final step in completing the Seoul St. Mary’s Hospital complex. Our hospital will provide world-best treatment not only in the field of blood cancers, for which it has earned a global reputation, but also in the treatment of solid tumors.

The typical end-user price for a three-room Proteus®PLUS system with a multi-year maintenance contract ranges between € 80 and 100 million.

***ENDS***

About IBA

IBA (Ion Beam Applications S.A.) is the world leader in particle accelerator technology. The company is the leading supplier of equipment and services in the fields of proton therapy, considered as one of the most advanced forms of radiation therapy available today, as well as industrial sterilization, radiopharmaceuticals and dosimetry. The company, based in Louvain-la-Neuve, Belgium, employs approximately 2,100 people worldwide. IBA is a certified B Corporation (B Corp) meeting the highest standards of verified social and environmental performance.

IBA is listed on the pan-European stock exchange EURONEXT (IBA: Reuters IBAB.BR and Bloomberg IBAB.BB). More information can be found at: www.iba-worldwide.com

About Seoul St Mary’s Hospital

Seoul St. Mary’s Hospital is one of Korea’s top academic hospitals and the flagship institution of the Catholic Medical Center. It provides comprehensive care across 45 departments and 27 specialized centers, including the Cardio-Cerebro-Vascular Hospital, Catholic Hematology Hospital, and Comprehensive Cancer Hospital. With pioneering achievements such as Korea’s first kidney and bone marrow transplants and Korea’s first artificial cornea transplant, the hospital provides world-class care. Trusted by both domestic and international patients, Seoul St. Mary’s Hospital has treated over 30,000 international patients from more than 100 countries. The hospital continues to enhance the quality of its services and has trained more than 900 international physicians through its fellowship programs.

For further information, please contact:

IBA Investor Relations
Thomas Pevenage
+32 10 475 890
investorrelations@iba-group.com
IBA Corporate Communication
Olivier Lechien
+32 10 475 890
communication@iba-group.com


1 Proteus®PLUS is a brand name of Proteus®235.

2 DynamicARC® is a registered brand of the IBA’s Proton Arc therapy solution currently under development phase.

Attachment

Modalis Announces Publication in Human Gene Therapy of Study Demonstrating Efficient LAMA1 Gene Activation for the Treatment of LAMA2-CMD

Modalis Announces Publication in Human Gene Therapy of Study Demonstrating Efficient LAMA1 Gene Activation for the Treatment of LAMA2-CMD




Modalis Announces Publication in Human Gene Therapy of Study Demonstrating Efficient LAMA1 Gene Activation for the Treatment of LAMA2-CMD

  • CRISPR-GNDM® platform achieves potent and specific activation of LAMA1 with therapeutic benefit in preclinical models
  • Favorable safety and pharmacodynamics demonstrated in non-human primates

TOKYO & WALTHAM, Mass.–(BUSINESS WIRE)–#Crispr–Modalis Therapeutics Corporation (TOKYO: 4883) today announced that its research article titled “Efficient LAMA1 gene activation by epigenome editing as a therapeutic approach for LAMA2-CMD” has been published in the peer-reviewed journal Human Gene Therapy.


The publication highlights compelling preclinical evidence that Modalis’ proprietary CRISPR-GNDM® epigenome editing technology can safely and robustly activate the LAMA1 gene as a novel therapeutic strategy for LAMA2-related congenital muscular dystrophy (LAMA2-CMD), a severe pediatric neuromuscular disorder with no approved treatments.

Key findings include:

  • Robust, muscle-specific activation of LAMA1 following a single administration of muscle-tropic AAV vectors encoding the GNDM activator
  • Marked improvement in survival and muscle function in DyW mouse models, including dose-dependent increases in grip strength and normalization of muscle histology
  • Favorable safety and pharmacodynamic profiles in non-human primates (NHPs), with strong LAMA1 induction observed even at half-doses in infant NHPs

“This work represents one of the first demonstrations of systemic, single-vector epigenome activation in large animals,” said Tetsuya Yamagata, MD, Ph.D. CSO of Modalis. “By enabling targeted activation of large genes that are not compatible with conventional AAV gene replacement approaches, this study opens the door to a new class of treatments for a wide range of genetic diseases.”

Haru Morita, CEO, added: “The publication of this study demonstrates that the nonclinical results supporting our lead program MDL-101 have been recognized by the global scientific community as clear evidence of both efficacy and safety. These data form the scientific foundation for our planned clinical trials next year and significantly reinforce confidence in the broader CRISPR-GNDM® platform. Development of MDL-101 is progressing smoothly, with GLP toxicology studies and GMP manufacturing well underway. We intend to submit an investigational new drug application upon their completion, and remain committed to advancing this program to deliver a transformative, one-time treatment option for patients living with LAMA2-CMD.”

About the Publication

Authors: Yuanbo Qin, Talha Akbulut, Rajakumar Mandraju, Keith Connolly, Seth Levy, Tetsuya Yamagata, et al. (Modalis Therapeutics)

About MDL-101

MDL-101 is an investigational epigenetic gene-activation therapy being developed for the treatment of LAMA2-Congenital Muscular Dystrophy (LAMA2-CMD).

The therapy utilizes:

  • a guide RNA targeting LAMA1, a highly homologous compensatory gene to LAMA2
  • a nuclease-null Cas9 (dCas9) fused to a transcriptional activator
  • a muscle-specific promoter packaged within a muscle-tropic AAV vector

MDL-101 is designed to upregulate endogenous LAMA1 expression to compensate for loss-of-function caused by LAMA2 mutations. The program has the potential to be a one-time, durable treatment for individuals living with LAMA2-CMD.

About Modalis

Modalis Therapeutics (TOKYO: 4883) is a biotechnology company pioneering epigenetic gene modulation using its proprietary CRISPR-GNDM® platform, which enables precise control of gene expression without cutting DNA. The company is advancing a pipeline of novel therapeutics for genetic diseases with high unmet medical need, leveraging in vivo AAV delivery for safe, durable, and scalable treatment modalities.

For more information, please visit https://www.modalistx.com/en.

Forward-Looking Statements

This press release contains forward-looking statements regarding future events and the potential development and commercialization of Modalis Therapeutics Corporation’s products. These statements are based on current expectations and assumptions and involve risks and uncertainties that may cause actual results to differ materially from those expressed or implied. Modalis undertakes no obligation to update these statements except as required by law.

Contacts

Investor and Media Contact
Modalis Therapeutics Corporation

IR & Corporate Communications

Email: ir@modalistx.com
Website: https://www.modalistx.com

Mountain Valley MD Provides Year-End Business Update, Advances Commercialization Across Core Platforms

Mountain Valley MD Provides Year-End Business Update, Advances Commercialization Across Core Platforms




Mountain Valley MD Provides Year-End Business Update, Advances Commercialization Across Core Platforms

TORONTO–(BUSINESS WIRE)–Mountain Valley MD Holdings Inc. (the “Company” or “MVMD”) (CSE: MVMD) (OTCQB: MVMDF) (FRA: 20MP) provides a year-end business update on its commercialization progress across its three core areas of focus:


  1. Nutraceuticals – Innovations through the Company’s Quicksome™ technology, designed to improve the administration and efficacy of nutraceutical health and wellness products;
  2. Agriculture – The Company’s licensed Agrarius agricultural plant signaling technology, designed to organically drive increased crop yields, reduce fertilizer and pesticide usage where desired, and enhance plant health; and
  3. Husbandry Animals and Aquatic Species – The application of solubilized drug formulations through the Company’s Quicksol™ technology, designed to positively impact the health of husbandry animals and aquatic species.

“Throughout 2025, we have remained focused on disciplined execution across each of our business lines,” said Dennis Hancock, President and CEO of Mountain Valley MD. “We believe the progress we have made in product development, field validation, and commercial foundations positions the Company for the next phase of measured growth.”

NUTRACEUTICALS

Quicksome™ Technology, Commercialization, and Business Development Progress

MVMD’s patented liposomal Quicksome™ technology uses proprietary formulations and stabilizing agents to encapsulate active ingredients with the goal of optimizing molecule delivery in sublingual nutraceutical applications. The Company’s Quicksome™ platform continues to focus on delivering molecules where enhanced efficacy, precise dosing, reduced variability, and dose sparing are valued.

“Our Quicksome™ technology continues to demonstrate to us its adaptability across multiple product formulations,” Mr. Hancock noted. “We believe the platform’s delivery characteristics and dose-sparing potential remain compelling for partners seeking differentiated products in competitive wellness categories.”

MVMD continues to advance its nutraceutical strategy through its exclusive manufacturing and licensing arrangement with a U.S.-based GMP production partner (the “Lead Manufacturer”), which maintains GMP and OTC drug manufacturing capabilities and has installed proprietary equipment to support Quicksome™ sublingual and dermal formulations.

The Lead Manufacturer continues to work with the Company to support production obligations under MVMD’s license agreement with Circadian Wellness Corp. (“Circadian”), as well as MVMD’s proprietary “Mountains Of…” product line and other business development initiatives. During 2025, scaled production and commercial activity continued for Circadian’s “Eons Dialed” and “Eons Deeper Sleep” sublingual products, both incorporating Quicksome™ technology. Circadian reported continued positive consumer reception and sales volumes of its Quicksome™-based products during the year.

In parallel, MVMD has continued business development initiatives to secure additional nutraceutical licensing partnerships through the development of novel formulation work for new clients in multiple human benefit areas including novel hot flash and night sweat symptoms relief in peri menopausal and post-menopausal women, post-workout muscle recovery, anti-inflammation, and joint health. The Company also remains engaged with a U.S.-based multi-level marketing client for a novel fenugreek glycosides testosterone formulation utilizing Quicksome™ quick-dissolve tablet technology. The formulation has supported documented performance in male subjects, and iterative product evaluations related to taste and dissolution have continued, with commercial discussions expected to advance as partner review processes progress. Additional client discussions have taken place in the fourth quarter and the Company expects the launch of a fenugreek glycosides testosterone formulation through a licensee in the first half of 2026.

The Company’s “Mountains Of…” proprietary brand continues to hold U.S. trademark protection across multiple product categories, including Sleep, Energy, Relief, Libido, and Lean, to support ongoing GMP sample development and business development activities. Distribution partners may elect to market MVMD’s branded products or pursue proprietary white-label versions under their own brands.

AGRICULTURE

Agrarius Business Development and Commercialization Progress

“We believe the continued validation of Agrarius across diverse crops and geographies reinforces its potential role in sustainable agricultural practices,” said Mr. Hancock. “Our focus remains on building a strong, data-driven foundation to support long-term commercial adoption.”

MVMD continues to advance commercialization in its agricultural division, which is focused on the licensed distribution of the Agrarius™ plant signaling technology. Under its exclusive license agreement with Agrarius Corp. (“AC”), MVMD holds the exclusive rights to sell the Agrarius product throughout North America, Central America, South America, and the Caribbean (the “Exclusive Territory”).

The Agrarius product is mixed with water or other agricultural inputs at the point of application and applied via sprayer at targeted stages of a plant’s lifecycle. Agrarius has been tested across numerous crops and has demonstrated its ability to naturally increase yields, improve plant resilience, and support reduced fertilizer usage, with results varying by crop and environment.

Brazil Citrus Trials, Including Positive Younger Tree Results

MVMD has been working with a client-directed third-party agricultural partner, FARMATAC, in Brazil to assess the impact of the application of the Agrarius product on both mature and young citrus orchards. FARMATAC has extensive experience designing and managing advanced citrus trials and has completed the contracted evaluations in commercial citrus orchards.

The Company previously reported the following results from mature Hamlin and Valencia orange trees:

  • Hamlin Variety: Agrarius-treated orchards demonstrated improved plant condition and a productivity increase of approximately 15% per hectare. Juice yield analysis showed that the treated oranges required 20 fewer boxes to produce one ton of juice compared to the control, resulting in an approximate total yield increase of 22%. Independent agronomists also observed a visual reduction in symptoms associated with Huanglongbing (HLB), also known as citrus greening disease.
  • Valencia Variety: The Agrarius-treated block achieved a 49% average yield increase. Treated trees also exhibited stronger vigor and canopy density, consistent with improved nutrient uptake and photosynthetic activity.

Building on the mature orchard results, newly completed trials on additional citrus blocks, including younger orchards and additional varietals at the client’s site, have now demonstrated further compelling outcomes. In trials that included treatments on younger trees, Agrarius-treated areas showed materially stronger plant vigor, improved flowering and fruit set, enhanced resilience to stress, including during periods of drier growing conditions, and significantly higher productivity when compared to control blocks. Notably, productivity gains of greater than 50 percent were recorded in Pera varietals, alongside results consistent with prior Hamlin and Valencia performance, reinforcing the potential lifecycle impact of Agrarius when applied earlier in orchard development and its potential role in helping mitigate yield variability under increasingly challenging climatic conditions.

“The Brazil citrus trial demonstrates to us that Agrarius™, under real farm conditions and third-party monitoring, delivered substantial yield improvements, stronger plant health, and meaningful mitigation of Greening stress in citrus,” continued Hancock. “Our agronomy team recently reviewed the trial results with the client’s leadership team and it is believed the findings will support commercial expansion in 2026, positioning Agrarius as a high-impact, low-disruption tool for Brazilian citriculture.”

The Company believes that the continued observation of reduced visible HLB symptoms across its Brazil citrus programs, including in younger orchards, represents one of the most meaningful indicators emerging from its citrus field work to date. These results are consistent with citrus trials previously reported by the Company and support the potential lifecycle relevance of Agrarius in orchards impacted by citrus greening disease.

“HLB has fundamentally altered citrus production in many regions, and producers still face the reality that there is no known cure,” said Hancock. “Seeing similar trends not only in mature trees but also in younger orchards strengthens our view that, if sustained, Agrarius could become an important organic tool to help growers manage greening pressure while building healthier, more productive orchards over time.”

Broad Crop Validation and LATAM Expansion

In addition to citrus, Agrarius trials conducted during the year across key crops in Brazil and Colombia in partnership with universities, private agronomy labs, and farmer networks continued to demonstrate to the Company positive outcomes, including:

  • Corn – Yield gains of approximately 14.8 percent and 11.2 percent in UNESP trials, associated with improved chlorophyll concentration and root development.
  • Sugarcane – Yield improvements of 8 to 12 tons per hectare, increased sugar content, and reduced pest damage in Agroquatro trials, alongside improved early development in seedling clone studies.
  • Soybeans – Average yield gains of 6.34 sacs per hectare across 14 farmer validations, with high-performance producers achieving gains exceeding 15 percent.
  • Cotton – Increases in bolls per plant and overall yield supported by improved photosynthetic efficiency.
  • Potatoes – Productivity increases of approximately 18.5 percent in summer harvest trials.

Of particular note, during extended dry periods observed in Brazil field programs, Agrarius-treated crops experienced notably lower yield losses than untreated controls, supporting the product’s potential to improve water-use efficiency and maintain productivity under drought stress as part of an integrated agronomic program.

“The recent citrus trialing activity has produced results that reinforce what we are seeing across multiple crops in Brazil, that Agrarius is not only driving yield improvement, but also helping plants stay productive when conditions are less than ideal,” continued Hancock. “In markets where growers face increasing climate variability, this kind of resilience can be just as important as top-line yield gains.”

In Colombia, MVMD is completing its large-scale pasture grass productivity program in partnership with FEDEGAN, the national cattle growers’ federation representing approximately 43 million hectares of pastureland, and the National University of Colombia, with preliminary results demonstrating improved vegetation health, faster regrowth, and enhanced pasture quality, supported by satellite analysis and laboratory validation. Final results are expected in the first quarter of 2026.

HUSBANDRY ANIMALS / AQUATIC SPECIES

Soluvec™ 1% Commercialization Update and Strategic Review

MVMD has applied its patented Quicksol™ solubilization technology to ivermectin to create its Soluvec™ 1% formulation, which was designed to provide a safer and more effective solution for administration across husbandry animals and aquatic species. The Soluvec™ 1% formulation has demonstrated nine-month stability at room and refrigerated temperatures through third-party validation and remains the Company’s primary Quicksol™-based commercial asset.

The Company’s commercialization strategy for Soluvec™ 1% has been to advance the technology through third-party licensing. In Bangladesh, MVMD entered into an exclusive license agreement with an arm’s length, privately held partner to manufacture and distribute Soluvec™ 1% products in injectable and feed coating formats, in return for royalty payments based on net sales. As previously disclosed, the licensee has produced approximately 200 tonnes of Soluvec™ 1% coated fish feed and distributed product through local channels.

While this activity represented an important first step in demonstrating large-scale manufacturing and application of the Soluvec™ formulation, royalty revenues and overall commercial traction during 2025 have remained below management’s expectations. External market disruption, including impacts from Cyclone Remal in 2024, has affected industry conditions in the region, and MVMD continues to assess the most effective pathway to advance broader adoption of the technology.

“We continue to believe in the strength of the underlying science and formulation behind Soluvec™,” stated Hancock. “At the same time, we recognize that realizing its commercial potential requires partners with the right operational scale, market reach, and strategic alignment.”

As part of its assessment, the Company is undertaking a strategic review of its Soluvec™ 1% licensing structure, including evaluating options to modify or restructure territorial exclusivity in Bangladesh, subject to contractual rights and ongoing discussions between relevant parties. The objective is to ensure MVMD has the flexibility to work with partners best positioned to drive effective commercialization.

With a continued focus on disciplined capital allocation, MVMD intends to prioritize low-capital, royalty-based licensing opportunities for Soluvec™ 1% rather than direct investment in manufacturing or market buildout. In this context, management has initiated discussions with potential new licensees in Latin America, where demand for scalable and cost-effective husbandry and aquaculture health solutions remains significant and where the Company’s patent strategy supports future commercial development.

Global interest in Soluvec™ continues in management’s view, supported by the Company’s peer-reviewed data demonstrating improved bioavailability, efficacy, and stability relative to conventional ivermectin formulations. While the Company does not anticipate near-term material revenues until additional licensing arrangements are secured, MVMD believes that a more selective and partner-aligned approach can better position Soluvec™ for sustainable royalty growth over time.

“Soluvec™ remains an important asset for the Company, and we are working to align it with partners who can advance this opportunity effectively as we move into 2026,” Hancock added.

ABOUT MOUNTAIN VALLEY MD HOLDINGS INC.

Mountain Valley MD is building a world-class organization centered around the implementation, licensing and reselling of key technologies and formulations:

  • patented Quicksome™ oral formulation and delivery technologies,
  • patented Quicksol™ solubility formulation technology
  • licensed product reseller of Agrarius™, a novel agricultural plant signaling technology

Consistent with its vision towards “More Life”, MVMD applies its owned and licensed technologies to its work for advanced delivery of molecules for human and husbandry animal applications, including the development of products for pain management, weight loss, energy, focus, sleep, anxiety, and more. Additionally, MVMD’s work with Agrarius is focused on generating a positive impact on crop yields and reducing fertilizer usage.

MVMD’s patented Quicksome™ technology utilizes proprietary formulations and stabilizing molecules to encapsulate and formulate active ingredients into highly efficient product formats. The result is a new generation of product formulations that could be capable of delivering nutraceutical and drug molecules into the body faster, with greater impact, efficiency and accuracy.

MVMD’s patented Quicksol™ technology covers all highly solubilized macrocyclic lactones that could be effectively applied in multiple viral applications that could positively impact human and animal health globally.

MVMD’s licensed Agrarius™ agricultural plant signaling technology is designed to be applied to crops to naturally increase yields, reduce fertilizer usage, and increase general resilience to pests and climate change.

For more Company information and contact details, visit www.MVMD.com.

CAUTIONARY STATEMENT REGARDING FORWARD-LOOKING INFORMATION

Certain statements contained in this news release may constitute forward-looking information. Forward-looking information is often, but not always, identified by the use of words such as “anticipate”, “plan”, “estimate”, “expect”, “may”, “will”, “intend”, “should”, and similar expressions. Forward-looking information involves known and unknown risks, uncertainties and other factors that may cause actual results or events to differ materially from those anticipated in such forward-looking information.

The Company’s actual results could differ materially from those anticipated in this forward-looking information as a result of regulatory decisions, competitive factors in the industries in which the Company operates, prevailing economic conditions, and other factors, many of which are beyond the control of the Company.

The Company is making forward-looking statements, including but not limited to: the continued advancement of the Company’s lines of business; anticipated license arrangements and launches and the timing thereof with regard to the Company’s Quicksome™ technology; continued trials and anticipated results of the Company’s licensed Agrarius™ product and the timing thereof; and the securing of additional licensing arrangements, and the structure and timing thereof, regarding the Company’s Soluvec™ product.

The Company believes that the expectations reflected in the forward-looking information are reasonable, but no assurance can be given that these expectations will prove to be correct and such forward-looking information should not be unduly relied upon. Any forward-looking information contained in this news release represents the Company’s expectations as of the date hereof and is subject to change after such date. The Company disclaims any intention or obligation to update or revise any forward-looking information whether as a result of new information, future events or otherwise, except as required by applicable securities legislation.

Neither the CSE nor OTC has reviewed or approved the contents of this press release.

Contacts

Dennis Hancock

President and Chief Executive Officer

Mountain Valley MD Holdings Inc.

Investor Relations @ 647-725-9755

Email: info@mvmd.com
www.MVMD.com

XTL Announces Receipt of Nasdaq Notification Letter Regarding Minimum Bid Price Deficiency

XTL Announces Receipt of Nasdaq Notification Letter Regarding Minimum Bid Price Deficiency




XTL Announces Receipt of Nasdaq Notification Letter Regarding Minimum Bid Price Deficiency

RAMAT GAN, ISRAEL, Dec. 24, 2025 (GLOBE NEWSWIRE) — XTL Biopharmaceuticals Ltd. (Nasdaq:XTLB) (TASE:XTLB.TA) (the “Company” or “XTL”), announced today that it has received a notification letter from The Listing Qualifications Department of The Nasdaq Stock Market LLC (“Nasdaq”), dated December 22, 2025, notifying the Company that based on XTL’s closing bid price for the last 30 consecutive business days, the Company currently does not meet the continued listing requirement of Nasdaq, under Nasdaq Listing Rules 5550(a)(2), to maintain a minimum bid price of $1 per share.

The Nasdaq notification letter does not result in the immediate delisting of the Company’s American Depositary Shares (“ADSs”), and the ADSs will continue to trade uninterrupted under the symbol “XTLB”.

Pursuant to Nasdaq Listing Rule 5810(c)(3)(A), the Company has a compliance period of 180 calendar days, or until June 22, 2026, to regain compliance. If at any time during this 180-day period the closing bid price of the Company’s security is at least $1 for a minimum of ten consecutive business days, Nasdaq will provide XTL with written confirmation of compliance and this matter will be closed.

In the event the Company does not regain compliance, XTL may be eligible for additional time. To qualify, the Company will be required to meet the continued listing requirement for market value of publicly held shares and all other initial listing standards for The Nasdaq Capital Market, with the exception of the bid price requirement, and will need to provide written notice of its intention to cure the deficiency during the second compliance period, by effecting a reverse stock split, if necessary. If XTL meets these requirements, Nasdaq will inform the Company that it has been granted an additional 180 calendar days. However, if it appears to Nasdaq that the Company will not be able to cure the deficiency, or if the Company is otherwise not eligible, Nasdaq will provide notice that its securities will be subject to delisting.

XTL is currently evaluating options to regain compliance and intends to timely regain compliance with Nasdaq’s continued listing requirements. Although XTL will use all reasonable efforts to achieve compliance with Rule 5550(a)(2), there can be no assurance that the Company will be able to regain compliance with that rule or will otherwise be in compliance with other Nasdaq continued listing requirements.

About XTL Biopharmaceuticals Ltd.

XTL is an IP portfolio company.  XTL holds 100% of the share capital of The Social Proxy Ltd. (the “Social Proxy”), a web data company, and has sublicensed out an IP portfolio surrounding hCDR1 for the treatment of Lupus disease. The Social Proxy is a web data AI company, developing and powering a unique ethical, IP based, proxy data extraction platform for AI and BI applications at scale.

Cautionary Note Regarding Forward-Looking Statements

This communication contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Any statements contained in this communication that are not statements of historical fact may be deemed forward-looking statements. Words such as “continue,” “will,” “may,” “could,” “should,” “expect,” “expected,” “plans,” “intend,” “anticipate,” “believe,” “estimate,” “predict,” “potential,” and similar expressions are intended to identify such forward-looking statements. All forward-looking statements involve significant risks and uncertainties that could cause actual results to differ materially from those expressed or implied in the forward-looking statements, many of which are generally outside the control of the Company and are difficult to predict. Examples of such risks and uncertainties include, but are not limited to (i) whether to the Company will be able to receive sub-licensing fees relating to its Hcdr1 intellectual property, (ii) the Company’s ability to successfully manage and integrate The Social Proxy and any other joint ventures, acquisitions of businesses, solutions or technologies; (iii) unanticipated operating costs, transaction costs and actual or contingent liabilities; (iv) the ability to attract and retain qualified employees and key personnel; (v) adverse effects of increased competition on the Company’s future business; (vi) the Company’s ability to protect its intellectual property; and (vii) local, industry and general business and economic conditions. Additional factors that could cause actual results to differ materially from those expressed or implied in the forward-looking statements can be found in the most recent annual report on Form 20-F and current reports on Form 6-K filed by the Company with the Securities and Exchange Commission. The Company anticipates that subsequent events and developments may cause its plans, intentions and expectations to change. The Company assumes no obligation, and it specifically disclaims any intention or obligation, to update any forward-looking statements, whether as a result of new information, future events or otherwise, except as expressly required by law. Forward-looking statements speak only as of the date they are made and should not be relied upon as representing the Company’s plans and expectations as of any subsequent date.

For further information, please contact:

Investor Relations, XTL Biopharmaceuticals Ltd.
Tel: +972 3 611 6666
Email: info@xtlbio.com
www.xtlbio.com